The DOI matches its Crossref record; 35 of the 39 references it cites were found in a registry or an index.
Polyunsaturated fatty acids in the food chain in the United States
Open accessAbstract
In the United States, intake of n-3 fatty acids is approximately 1.6 g/d ( approximately 0.7% of energy), of which 1.4 g is alpha-linolenic acid (ALA; 18:3) and 0.1-0.2 g is eicosapentaenoic acid (EPA; 20:5) and docosahexaenoic acid (DHA; 22:6). The primary sources of ALA are vegetable oils, principally soybean and canola. The predominant sources of EPA and DHA are fish and fish oils. Intake data indicate that the ratio of n-6 to n-3 fatty acids is approximately 9.8:1. Food disappearance data between 1985 and 1994 indicate that the ratio of n-6 to n-3 fatty acids has decreased from 12.4:1 to 10.6:1. This reflects a change in the profile of vegetable oils consumed and, in particular, an approximate 5.5-fold increase in canola oil use. The ratio of n-6 to n-3 fatty acids is still much higher than that recommended (ie, 2.3:1). Lower ratios increase endogenous conversion of ALA to EPA and DHA. Attaining the proposed recommended combined EPA and DHA intake of 0.65 g/d will require an approximately 4-fold increase in fish consumption in the United States. Alternative strategies, such as food enrichment and the use of biotechnology to manipulate the EPA and DHA as well as ALA contents of the food supply, will become increasingly important in increasing n-3 fatty acid intake in the US population.
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“Comparatively, U.S. consumption of total polyunsaturated fatty acids and ALA are around 6–7% and 0.6–0.7% of total energy intake, respectively[382,383].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [382]
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Fish Consumption, Fish Oil, Omega-3 Fatty Acids, and Cardiovascular Disease
Kris-Etherton, P. M., Harris, W. S., & Appel, L. J. (2002) · Circulation · doi:10.1161/01.cir.0000038493.65177.94 · Cited by 3,707
Self-citationOrigins and evolution of the Western diet: health implications for the 21st century1,2
Cordain, L., Eaton, S. B., Sebastian, A., Mann, N., Lindeberg, S., Watkins, B. A., O’Keefe, J. H., & Brand-Miller, J. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn.81.2.341 · Cited by 2,397
Fish Intake, Contaminants, and Human Health: Evaluating the Risks and the Benefits
Mozaffarian, D., & Rimm, E. B. (2006) · JAMA · doi:10.1001/jama.296.15.1885 · Cited by 1,966
Essential fatty acids in health and chronic disease
Simopoulos, A. P. (1999) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/70.3.560s · Cited by 1,703
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Metadata
- Authors
- Kris-Etherton, P., Taylor, D. S., Yu-Poth, S., Huth, P., Moriarty, K., Fishell, V., Hargrove, R. L., Zhao, G., & Etherton, T. D.
- Affiliations
- Pennsylvania State University (US)
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2000-01
- Volume
- 71
- Issue
- 1
- Pages
- 179S-188S
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W1907416804
- Cited by
- 1,023
- References
- 39
- Citations by year
- 2026: 4 · 2025: 17 · 2024: 11 · 2023: 17 · 2022: 16 · 2021: 28 · 2020: 25 · 2019: 34 · 2018: 34 · 2017: 42 · 2016: 39 · 2015: 43 · 2014: 52 · 2013: 66 · 2012: 49
- FWCI
- 3.66
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Aquaculture Nutrition and Growth
- Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
- Keywords
- omega-3 fatty acids, n-6/n-3 ratio, alpha-linolenic acid, eicosapentaenoic acid, docosahexaenoic acid, dietary intake, vegetable oils, canola oil, soybean oil, fish consumption, food disappearance, food enrichment, dietary recommendations
- MeSH terms
- Adolescent, Adult, Aged, Animals, Animal Feed, Biotechnology, Child, Dietary Fats, Unsaturated, Eating, Fatty Acids, Unsaturated, Female, Fish Oils, Fishes, Humans, Male, Middle Aged, Plant Oils, United States, Nutrition Policy, Dietary Supplements
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