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Cited by 495Fatty Acid Research and HealthEdible Oils Quality and AnalysisLipid metabolism and biosynthesis

The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.

Bioconversion of vaccenic acid to conjugated linoleic acid in humans

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Turpeinen, Anu M, Mutanen, Marja, Aro, Antti, Salminen, Irma, Basu, Samar, Palmquist, Donald L, Griinari, J Mikko·2002·The American Journal of Clinical Nutrition
DOI 10.1093/ajcn/76.3.504
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Abstract

Background Vaccenic acid (11-trans octadecenoic acid; VA), a major trans fatty acid in the fat of ruminants, is produced in the rumen and converted in tissues to rumenic acid (9-cis, 11-trans octadecenoic acid; RA), an isomer of conjugated linoleic acid, by Delta(9)-desaturase. There are indications that this conversion also occurs in humans.Objective The aim of this controlled intervention was to study the conversion of VA to RA in humans after consumption of diets with increasing amounts of VA.Design Thirty healthy subjects consumed a baseline diet rich in oleic acid for 2 wk. The subjects were then divided into 3 groups (n = 10 per group) and provided a diet containing 1.5, 3.0, or 4.5 g VA/d for 9 d. All diets contained equal amounts of macronutrients and differed only in their fatty acid compositions. The fats were mixed into conventional foods, and nearly all food was provided during the study.Results The proportion of VA in serum total fatty acids increased 94%, 307%, and 620% above baseline with the 1.5-, 3.0-, and 4.5-g diets, respectively. This was associated with a linear increase in the proportion of RA. The conversion rate was 19% on average, with significant interindividual differences with all 3 intakes of VA. The urinary excretion of 8-iso-prostaglandin F(2alpha) increased in all groups (P < 0.001).Conclusions The results quantify the desaturation of VA to RA in humans. Conversion is likely to contribute significantly to the amount of RA available to the body, and dietary intakes of VA should thus be taken into account when predicting RA status.

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Metadata

Authors
Turpeinen, A. M., Mutanen, M., Aro, A., Salminen, I., Basu, S., Palmquist, D. L., & Griinari, J. M.
Affiliations
Uppsala University (SE)
Corresponding author
Turpeinen, Anu M
ORCID
Turpeinen, Anu M
Venue
The American Journal of Clinical Nutrition
Publisher
Elsevier BV
Published
2002-09
Volume
76
Issue
3
Pages
504-510
ISSN
0002-9165 (ISSN-L)
DOI
10.1093/ajcn/76.3.504
OpenAlex
W1942808992
Cited by
495
References
49
Citations by year
2026: 7 · 2025: 8 · 2024: 5 · 2023: 5 · 2022: 8 · 2021: 14 · 2020: 16 · 2019: 15 · 2018: 28 · 2017: 17 · 2016: 25 · 2015: 28 · 2014: 22 · 2013: 34 · 2012: 34
FWCI
16.52
Type
journal article
Language
en
Open access
Licence
Locations
  • American Journal of Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
  • STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords
vaccenic acid, conjugated linoleic acid, rumenic acid, delta-9 desaturase, biotransformation, trans fatty acids, dietary intake, serum fatty acids, ruminant fat, oleic acid
MeSH terms
Adult, Animals, Diet, Dietary Fats, Fatty Acids, Female, Humans, Kinetics, Lipids, Lipoproteins, VLDL, Male, Oleic Acids, Rumen, Stearic Acids, Triglycerides, Dinoprost, Linoleic Acid, F2-Isoprostanes

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