Multicomponent methods: evaluation of new and traditional soft tissue mineral models by in vivo neutron activation analysis,,
Open accessAbstract
Background Practical and accurate methods for quantifying the soft tissue mineral component of multicomponent fat-estimation models are needed.Objectives The aims were to develop a new complete model for estimating soft tissue minerals based on measured total body water (TBW) and extracellular water (ECW) and a simplified new model based on TBW measurements only and to compare these estimates with those determined with 2 traditional models (ie, the Brozek and Selinger models) and with criterion estimates based on in vivo neutron activation (IVNA) analysis.Design The subjects were 156 healthy adults and 50 patients with AIDS. Total body potassium, sodium, chlorine, and calcium were measured by IVNA; TBW by (3)H(2)O or D(2)O dilution; ECW by bromide dilution; and bone mineral by dual-energy X-ray absorptiometry.Results The mean (+/- SD) mass of total-body soft tissue minerals in healthy adults was 467 +/- 62 g with the IVNA model, 492 +/- 62 g with the new model, and 487 +/- 59 g with the simplified new model. Compared with the IVNA model, the complete and simplified new models overestimated soft tissue minerals by 5.4% and 4.6% (both P < 0.001), respectively. In contrast, the Brozek and Selinger models overestimated overall mean soft tissue minerals by 35% and 99% (both P < 0.001), respectively. Overall results for soft tissue mineral prediction with the 2 new models were less satisfactory for the patients with AIDS, although the results were better than those with the traditional models.Conclusions The physiologically formulated complete new model for estimating soft tissue minerals provides the opportunity to upgrade the accuracy of current multicomponent models for estimating total body fat.
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Wang et al. presented a procedure based on a four-component model that is currently considered the state-of-art method for determining FFM and FM.
“For example, Wang et al. [3] presented a procedure based on a four-component model that is currently considered the state-of-art method for determining FFM and FM.”
From High-standard predictive equations for estimating body composition using bioelectrical impedance analysis: a systematic review (2024) · cites this paper as [3]
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- Authors
- Wang, Z., Pi-Sunyer, F. X., Kotler, D. P., Wielopolski, L., Withers, R. T., Pierson, R. N., & Heymsfield, S. B.
- Affiliations
- St. Luke's-Roosevelt Hospital Center (US)
- Columbia University (US)
- Brookhaven National Laboratory (US)
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2002-11
- Volume
- 76
- Issue
- 5
- Pages
- 968-974
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2139050640
- Cited by
- 151
- References
- 29
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 11 · 2023: 5 · 2022: 17 · 2021: 14 · 2020: 10 · 2019: 6 · 2018: 15 · 2017: 2 · 2016: 7 · 2015: 3 · 2014: 5 · 2013: 4 · 2012: 5
- FWCI
- 1.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service (42618)
- Topics
- Health Sciences › Medicine › Physiology › Body Composition Measurement Techniques
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Keywords
- total body water, extracellular water, in vivo neutron activation analysis, total body potassium, AIDS patients, bone mineral
- MeSH terms
- Acquired Immunodeficiency Syndrome, Adult, Body Composition, Body Water, Extracellular Space, Humans, Intracellular Fluid, Middle Aged, Minerals, Models, Biological, Neutron Activation Analysis, Reference Values
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