Palm and partially hydrogenated soybean oils adversely alter lipoprotein profiles compared with soybean and canola oils in moderately hyperlipidemic subjects
Open accessAbstract
Background Partially hydrogenated fat has an unfavorable effect on cardiovascular disease risk. Palm oil is a potential substitute because of favorable physical characteristics. Objective We assessed the effect of palm oil on lipoprotein profiles compared with the effects of both partially hydrogenated fat and oils high in monounsaturated or polyunsaturated fatty acids. Design Fifteen volunteers aged > or =50 y with LDL cholesterol > or =130 mg/dL were provided with food for each of 4 diets (35 d/phase) varying in type of fat (partially hydrogenated soybean, soybean, palm, or canola; two-thirds fat, 20% of energy). Plasma fatty acid profiles, lipids, lipoproteins, apolipoprotein A-I, apolipoprotein B, lipoprotein(a), glucose, insulin, HDL subfractions, and indicators of lipoprotein metabolism (HDL-cholesterol fractional esterification rate, cholesteryl ester transfer protein, phospholipid transfer protein, and paraoxonase activities) were measured at the end of each phase. Results Plasma fatty acid profiles reflected the main source of dietary fat. Partially hydrogenated soybean and palm oils resulted in higher LDL-cholesterol concentrations than did soybean (12% and 14%, respectively; P Conclusion Palm and partially hydrogenated soybean oils, compared with soybean and canola oils, adversely altered the lipoprotein profile in moderately hyperlipidemic subjects without significantly affecting HDL intravascular processing markers.
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Among the 24 included trials, only 6 trials required participants to have an elevated LDL cholesterol; the remaining 18 trials included participants with normal and elevated LDL cholesterol.
“Among the 24 included trials, only 6 trials required participants to have an elevated LDL cholesterol [25,30,33,37,39,47]; the remaining 18 trials included participants with normal and elevated LDL cholesterol.”
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“Among the 24 included trials, only 6 trials required participants to have an elevated LDL cholesterol [25,30,33,37, 39,47]; the remaining 18 trials included participants with normal and elevated LDL cholesterol.”
- Authors
- Vega-López, S., Ausman, L. M., Jalbert, S. M., Erkkilä, A. T., & Lichtenstein, A. H.
- Affiliations
- Tufts University (US)
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2006-07
- Volume
- 84
- Issue
- 1
- Pages
- 54-62
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W1944305587
- Cited by
- 160
- References
- 6
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 7 · 2023: 6 · 2022: 3 · 2021: 7 · 2020: 11 · 2019: 6 · 2018: 8 · 2017: 13 · 2016: 5 · 2015: 11 · 2014: 7 · 2013: 14 · 2012: 4
- FWCI
- 7.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL054727, HL 54727)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Keywords
- palm oil, partially hydrogenated soybean oil, canola oil, soybean oil, dietary fat, lipoprotein profile, LDL cholesterol, HDL cholesterol, apolipoprotein B, apolipoprotein A-I, HDL subfractions, cholesteryl ester transfer protein, phospholipid transfer protein, paraoxonase, hyperlipidemia, cardiovascular risk, plasma fatty acid profile
- MeSH terms
- Palm Oil, Rapeseed Oil, Aged, Apolipoproteins, Apolipoproteins B, Blood Glucose, Cardiovascular Diseases, Fatty Acids, Fatty Acids, Monounsaturated, Female, Humans, Hydrogenation, Hyperlipidemias, Cholesterol, HDL, Cholesterol, LDL, Male, Middle Aged, Plant Oils, Risk Factors, Soybean Oil, Triglycerides, Lipoprotein(a), Cross-Over Studies
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