Trans-fatty acids and nonlipid risk factors
Abstract
Consumption of industrially produced trans-fatty acids (TFA) is associated with substantial risk of coronary heart disease (CHD). The magnitude of this relationship, as well as emerging associations with end points such as diabetes and sudden cardiac death, cannot be fully explained by the well-established adverse effects of TFA on serum lipids. We review the evidence for effects of TFA intake on nonlipid risk factors. Based on evidence from randomized controlled trials, observational studies, animal experiments, and in vitro studies, these include effects on systemic inflammation, endothelial dysfunction, visceral adiposity, insulin resistance, and arrhythmic risk. The types and strength of evidence for each of these nonlipid effects varies, but the overall constellation of findings is qualitatively and quantitatively unique among dietary fats. The multiple adverse effects and implicated pathways are consistent with the observed strong associations of TFA consumption with CHD risk. These nonlipid effects also explain why TFA consumption may adversely impact other non-CHD diseases and end points.
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TFA also appear to have many non-lipid adverse effects, promoting inflammation, endothelial vasodilator dysfunction, insulin resistance, visceral adiposity, and arrhythmia, although strength of evidence for these non-lipid effects varies.
“TFA also appear to have many non-lipid adverse effects, promoting inflammation, endothelial vasodilator dysfunction, insulin resistance, visceral adiposity, and arrhythmia, although strength of evidence for these non-lipid effects varies.378, 379”
From Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review (2016) · cites this paper as [379]
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“TFAs also appear to have nonlipid adverse effects, promoting inflammation, endothelial dysfunction, insulin resistance, visceral adiposity, and arrhythmia, although the strength of evidence for these different nonlipid effects varies.(378,379) In sum, the implicated pathways suggest that TFA-containing partially hydro…”
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- Authors
- Wallace, S. K., & Mozaffarian, D.
- Affiliations
- Brigham and Women's Hospital (US)
- Corresponding author
- Mozaffarian, Dariush
- Venue
- Current Atherosclerosis Reports
- Published
- 2009-11
- Volume
- 11
- Issue
- 6
- Pages
- 423-433
- ISSN
- 1523-3804 (ISSN-L)
- 1534-6242
- OpenAlex
- W2045872816
- Cited by
- 53
- References
- 56
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 4 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 5 · 2015: 5 · 2014: 4 · 2013: 6 · 2012: 7
- FWCI
- 0.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Current Atherosclerosis Reports (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- trans fatty acids, coronary artery disease, systemic inflammation, endothelial dysfunction, visceral fat, insulin resistance, cardiac arrhythmias, sudden cardiac death, diabetes mellitus, dietary fat
- MeSH terms
- Arrhythmias, Cardiac, Dietary Fats, Endothelium, Vascular, Humans, Inflammation, Insulin Resistance, Risk Factors, Trans Fatty Acids, Intra-Abdominal Fat
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