The DOI matches its Crossref record; 49 of the 50 references it cites were found in a registry or an index.
Docosahexaenoic acid supplementation improves fasting and postprandial lipid profiles in hypertriglyceridemic men.
Open accessAbstract
Background The effects of docosahexaenoic acid (DHA) on the mean size and concentrations of VLDL, LDL, and HDL subclasses have not been previously studied.Objective We determined the effects of DHA supplementation on the concentrations of apoproteins; large, medium, and small VLDL, LDL, and HDL particles; and the mean diameters of these particles in fasting and postprandial plasma.Design Hypertriglyceridemic men aged 39-66 y (n = 34) participated in a double-blind, randomized, placebo-controlled parallel study. They received no supplements for the first 8 d and received either 7.5 g DHA oil/d (3 g DHA/d) or olive oil (placebo) for the last 90 d. Lipoprotein particle diameters and concentrations were measured by nuclear magnetic resonance spectroscopy.Results DHA supplementation for 45 d significantly (P < 0.05) decreased concentrations of fasting triacylglycerol (24%), large VLDL (92%), and intermediate-density lipoproteins (53%) and the mean diameter of VLDL particles (11.1 nm). It elevated concentrations of LDL cholesterol (12.6%), small VLDL particles (133%), and large LDL particles (120%) and the mean diameter of LDL particles (0.6 nm) in fasting plasma. Similar changes were observed for area under the curve for postprandial samples (0-6 h); however, the number of small dense LDL particles decreased significantly (21%), and the change in LDL cholesterol was not significant. Continued supplementation with DHA beyond 45 d caused no further changes; placebo treatment altered none of the responses tested.Conclusion DHA supplementation may improve cardiovascular health by lowering concentrations of triacylglycerols and small, dense LDL particles.
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“In the one study that gave 3 g/d of algal oil DHA, there was a further reduction in TG concentration (23).”
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“The greatest decrease in TG and greatest increase in LDL-C appeared in the two studies that included participants with elevated serum lipid concentrations at baseline (23,29).”
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“Dietary marine-derived omega-3 PUFA intake is very low, at Ͻ0.2 g of the Ϸ1.4 g of total omega-3 PUFA consumed daily in the United States.464,465”
From Triglycerides and Cardiovascular Disease: A Scientific Statement From the American Heart Association (2011) · cites this paper as [464]
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Triglycerides and Cardiovascular Disease: A Scientific Statement From the American Heart Association
Miller, M., Stone, N. J., Ballantyne, C., Bittner, V., Criqui, M. H., Ginsberg, H. N., Goldberg, A. C., Howard, W. J., Jacobson, M. S., Kris-Etherton, P. M., et al. (2011) · Circulation · doi:10.1161/cir.0b013e3182160726 · Cited by 1,871
A Systemic Review of the Roles of n-3 Fatty Acids in Health and Disease
Riediger, N. D., Othman, R. A., Suh, M., & Moghadasian, M. H. (2009) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2008.12.022 · Cited by 706
Mechanisms underlying the cardioprotective effects of omega-3 polyunsaturated fatty acids
Adkins, Y. C., & Kelley, D. S. (2010) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2009.12.004 · Cited by 577
Self-citationLorente‐Cebrián, S., Costa, A. G. V., Navas‐Carretero, S., Zabala, M., Martínez, J. A., & Moreno-Aliaga, M. J. (2013) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-013-0265-4 · Cited by 427
(n-3) Fatty Acids and Cardiovascular Health: Are Effects of EPA and DHA Shared or Complementary?
Mozaffarian, D., & Wu, J. H. Y. (2012) · The Journal of Nutrition · doi:10.3945/jn.111.149633 · Cited by 368
Metadata
- Authors
- Kelley, D. S., Siegel, D., Vemuri, M., & Mackey, B. E.
- Affiliations
- Agricultural Research Service (US)
- Corresponding author
- Kelley, Darshan S
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2007-08
- Volume
- 86
- Issue
- 2
- Pages
- 324-333
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W1937978193
- Cited by
- 179
- References
- 50
- Citations by year
- 2026: 2 · 2025: 2 · 2023: 3 · 2022: 7 · 2021: 4 · 2020: 8 · 2019: 5 · 2018: 9 · 2017: 6 · 2016: 8 · 2015: 17 · 2014: 16 · 2013: 15 · 2012: 12
- FWCI
- 13.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Agriculture (UL1 RR024146)
- National Institutes of Health (RR024146)
- Agricultural Research Service
- National Center for Research Resources (RR-024146, UL1RR024146)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- docosahexaenoic acid, omega-3 supplementation, hypertriglyceridemia, lipoprotein particle size, VLDL particles, LDL cholesterol, HDL cholesterol, small dense LDL, postprandial lipemia, triglycerides, apolipoproteins, olive oil placebo, cardiovascular health
- MeSH terms
- Adult, Aged, Docosahexaenoic Acids, Double-Blind Method, Fasting, Humans, Lipids, Lipoproteins, Lipoproteins, HDL, Lipoproteins, LDL, Cholesterol, LDL, Lipoproteins, VLDL, Male, Middle Aged, Placebos, Triglycerides, Hypertriglyceridemia, Patient Selection, Postprandial Period, Dietary Supplements
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