Algal Docosahexaenoic Acid Affects Plasma Lipoprotein Particle Size Distribution in Overweight and Obese Adults

Neff, Lisa M.; Culiner, Jill; Cunningham-Rundles, Susanna; Seidman, Cynthia; Meehan, Diane; Maturi, Janet; Wittkowski, Knut M.; Levine, Barbara; Breslow, Jan L.

doi:10.3945/jn.110.130021

Cited by 121Fatty Acid Research and HealthLipoproteins and Cardiovascular HealthNutritional Studies and Diet

Algal Docosahexaenoic Acid Affects Plasma Lipoprotein Particle Size Distribution in Overweight and Obese Adults

Open access

Neff, Lisa M., Culiner, Jill, Cunningham-Rundles, Susanna, Seidman, Cynthia, Meehan, Diane, Maturi, Janet, Wittkowski, Knut M., Levine, Barbara +1 more·2011·The Journal of Nutrition

DOI 10.3945/jn.110.130021PMC PMC3021440

Open this paper in CoChat — free account Open PDF

Abstract

Fish oils containing both EPA and DHA have been shown to have beneficial cardiovascular effects, but less is known about the independent effects of DHA. This study was designed to examine the effects of DHA on plasma lipid and lipoprotein concentrations and other biomarkers of cardiovascular risk in the absence of weight loss. In this randomized, controlled, double-blind trial, 36 overweight or obese adults were treated with 2 g/d of algal DHA or placebo for 4.5 mo. Markers of cardiovascular risk were assessed before and after treatment. In the DHA-supplemented group, the decrease in mean VLDL particle size (P ≤ 0.001) and increases in mean LDL (P ≤ 0.001) and HDL (P ≤ 0.001) particle sizes were significantly greater than changes in the placebo group. DHA supplementation also increased the concentrations of large LDL (P ≤ 0.001) and large HDL particles (P = 0.001) and decreased the concentrations of small LDL (P = 0.009) and medium HDL particles (P = 0.001). As calculated using NMR-derived data, DHA supplementation reduced VLDL TG (P = 0.009) and total TG concentrations (P = 0.006). Plasma IL-10 increased with DHA supplementation to a greater extent than placebo (P = 0.021), but no other significant changes were observed in glucose metabolism, insulin sensitivity, blood pressure, or markers of inflammation with DHA. In summary, DHA supplementation resulted in potentially beneficial changes in some markers of cardiometabolic risk, whereas other markers were unchanged.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3945/jn.110.130021

Cites

52 of 52 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

One study reported using standard methods for estimating LDL-C, and one did not report its method.
“One study reported using “standard” methods for estimating LDL-C (36) and one did not report its method (26).”
From A Meta-Analysis Shows That Docosahexaenoic Acid from Algal Oil Reduces Serum Triglycerides and Increases HDL-Cholesterol and LDL-Cholesterol in Persons without Coronary Heart Disease3 (2012) · cites this paper as [36]
Algal DHA extracts can produce other cardiovascular protective effects in humans by altering plasma lipoproteins at reasonably small doses (2 g algal DHA day−1 over 4.5 months).
“Algal DHA extracts can produce other cardiovascular protective effects in humans by altering plasma lipoproteins at reasonably small doses (2 g algal DHA day−1 over 4.5 months: Neff et al. 2011).”
From Algae as nutritional and functional food sources: revisiting our understanding. (2017) · cites this paper as Neff et al. 2011

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES
Folch, J., Lees, M., & Stanley, G. H. S. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64849-5 · Cited by 65,189 · see citing works
Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502 · see citing works
Magnesium Replacement Improves the Metabolic Profile in Obese and Pre-Diabetic Patients with Mild-to-Moderate Chronic Kidney Disease: A 3-Month, Randomised, Double-Blind, Placebo-Controlled Study
Toprak, Ö., Kurt, H., Sarı, Y., Şarkış, C., Us, H., & Kırık, A. (2017) · Kidney & Blood Pressure Research · doi:10.1159/000468530 · Cited by 29,769 · see citing works
Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron fluoride–methanol
Morrison, W. R., & Smith, L. M. (1964) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)40190-7 · Cited by 6,005 · see citing works
n−3 Polyunsaturated fatty acids, inflammation, and inflammatory diseases
Calder, P. C. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.6.1505s · Cited by 2,525 · see citing works
Omega-3 fatty acids in health and disease and in growth and development.
Simopoulos, A. (1991) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/54.3.438 · Cited by 2,162 · see citing works
Correct Homeostasis Model Assessment (HOMA) Evaluation Uses the Computer Program
Lévy, J., Matthews, D. R., & Hermans, M. P. (1998) · Diabetes Care · doi:10.2337/diacare.21.12.2191 · Cited by 1,997 · see citing works
n-3 fatty acids and serum lipoproteins: human studies
Harris, W. (1997) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/65.5.1645s · Cited by 1,243 · see citing works
Distribution, interconversion, and dose response of n-3 fatty acids in humans.
Arterburn, L. M., Hall, E. B., & Oken, H. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.6.1467s · Cited by 1,162 · see citing works
n−3 Fatty acids from fish or fish-oil supplements, but not α-linolenic acid, benefit cardiovascular disease outcomes in primary- and secondary-prevention studies: a systematic review
Wang, C., Harris, W. S., Chung, M., Lichtenstein, A. H., Balk, E. M., Kupelnick, B., Jordan, H. S., & Lau, J. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.1.5 · Cited by 980 · see citing works
Lipoprotein Particle Analysis by Nuclear Magnetic Resonance Spectroscopy
Jeyarajah, E. J., Cromwell, W. C., & Otvos, J. D. (2006) · Clinics in Laboratory Medicine · doi:10.1016/j.cll.2006.07.006 · Cited by 735 · see citing works
Blood pressure response to fish oil supplementation: metaregression analysis of randomized trials
Geleijnse, J. M., Giltay, E. J., Grobbee, D. E., Donders, A. R. T., & Kok, F. J. (2002) · Journal of Hypertension · doi:10.1097/00004872-200208000-00010 · Cited by 700 · see citing works
Clinical Prevention of Sudden Cardiac Death by n-3 Polyunsaturated Fatty Acids and Mechanism of Prevention of Arrhythmias by n-3 Fish Oils
Leaf, A., Kang, J. X., Xiao, Y.-F., & Billman, G. E. (2003) · Circulation · doi:10.1161/01.cir.0000069566.78305.33 · Cited by 605 · see citing works
Purified eicosapentaenoic and docosahexaenoic acids have differential effects on serum lipids and lipoproteins, LDL particle size, glucose, and insulin in mildly hyperlipidemic men
Mori, T. A., Burke, V., Puddey, I. B., Watts, G. F., O’Neal, D. N., Best, J. D., & Beilin, L. J. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.5.1085 · Cited by 588 · see citing works
Lipoprotein particle profiles by nuclear magnetic resonance compared with standard lipids and apolipoproteins in predicting incident cardiovascular disease in women.
Mora, S., Otvos, J. D., Rifai, N., Rosenson, R. S., Buring, J. E., & Ridker, P. M. (2009) · Circulation · doi:10.1161/circulationaha.108.816181 · Cited by 490 · see citing works
Low-Density Lipoprotein Subfractions and the Long-Term Risk of Ischemic Heart Disease in Men: 13-Year Follow-Up Data From the Québec Cardiovascular Study
St-Pierre, A. C., Cantin, B., Dagenais, G. R., Mauriège, P., Bernard, P.-M., Després, J.-P., & Lamarche, B. (2005) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000154144.73236.f4 · Cited by 422 · see citing works
Docosahexaenoic Acid but Not Eicosapentaenoic Acid Lowers Ambulatory Blood Pressure and Heart Rate in Humans
Mori, T. A., Bao, D. Q., Burke, V., Puddey, I. B., & Beilin, L. J. (1999) · Hypertension · doi:10.1161/01.hyp.34.2.253 · Cited by 407 · see citing works
Dietary reference intakes for DHA and EPA
Kris‐Etherton, P. M., Grieger, J. A., & Etherton, T. D. (2009) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2009.05.011 · Cited by 405 · see citing works
n−3 Fatty acids and cardiovascular disease
Breslow, J. L. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.6.1477s · Cited by 404 · see citing works
Self-citation
Does supplementation of diet with 'fish oil' reduce blood pressure? A meta-analysis of controlled clinical trials
Appel, L. J. (1993) · Archives of Internal Medicine · doi:10.1001/archinte.153.12.1429 · Cited by 380 · see citing works
Effects of purified eicosapentaenoic and docosahexaenoic acids on glycemic control, blood pressure, and serum lipids in type 2 diabetic patients with treated hypertension,,
Woodman, R. J., Mori, T. A., Burke, V., Puddey, I. B., Watts, G. F., & Beilin, L. J. (2002) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.5.1007 · Cited by 338 · see citing works
Dietary polyunsaturated fats of the W-6 and W-3 series reduce postprandial lipoprotein levels. Chronic and acute effects of fat saturation on postprandial lipoprotein metabolism.
Weintraub, M. S., Zechner, R., Brown, A., Eisenberg, S., & Breslow, J. L. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113806 · Cited by 331 · see citing works
Self-citation
Fish oil and glycemic control in diabetes. A meta-analysis.
Friedberg, C. E., Janssen, M. J. F. M., Heine, R. J., & Grobbee, D. E. (1998) · Diabetes Care · doi:10.2337/diacare.21.4.494 · Cited by 303 · see citing works
Does Supplementation of Diet With 'Fish Oil' Reduce Blood Pressure?
Appel, L. J. (1993) · Archives of Internal Medicine · doi:10.1001/archinte.1993.00410120017003 · Cited by 297 · see citing works
Dietary fatty acids in human thrombosis and hemostasis.
Knapp, H. R. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/65.5.1687s · Cited by 232 · see citing works
Decreasing Linoleic Acid with Constant α-Linolenic Acid in Dietary Fats Increases (n-3) Eicosapentaenoic Acid in Plasma Phospholipids in Healthy Men1
Liou, Y.-F., King, D. J., Zibrik, D., & Innis, S. M. (2007) · Journal of Nutrition · doi:10.1093/jn/137.4.945 · Cited by 230 · see citing works
High-Density Lipoprotein Particle Size and Concentration and Coronary Risk
Harchaoui, K. E., Arsenault, B. J., Franssen, R., Després, J., Hovingh, G. K., Stroes, E. S. G., Otvos, J. D., Wareham, N. J., Kastelein, J. J. P., Khaw, K., et al. (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-150-2-200901200-00006 · Cited by 228 · see citing works
Effect of fish oil on arrhythmias and mortality: systematic review.
Leon, H., Shibata, M. C., Sivakumaran, S., Dorgan, M., Chatterley, T., & Tsuyuki, R. T. (2008) · BMJ · doi:10.1136/bmj.a2931 · Cited by 223 · see citing works
The cardiovascular protective role of docosahexaenoic acid
McLennan, P. L., Howe, P. R. C., Abeywardena, M. Y., Müggli, R., Raederstorff, D., Mano, M. T., Rayner, T., & Head, R. J. (1996) · European Journal of Pharmacology · doi:10.1016/0014-2999(95)00861-6 · Cited by 197 · see citing works
Supplementation with an Algae Source of Docosahexaenoic Acid Increases (n-3) Fatty Acid Status and Alters Selected Risk Factors for Heart Disease in Vegetarian Subjects
Conquer, J. A., & Holub, B. J. (1996) · The Journal of Nutrition · doi:10.1093/jn/126.12.3032 · Cited by 181 · see citing works
Docosahexaenoic acid supplementation improves fasting and postprandial lipid profiles in hypertriglyceridemic men.
Kelley, D. S., Siegel, D., Vemuri, M., & Mackey, B. E. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.2.324 · Cited by 179 · see citing works
Differential eicosapentaenoic acid elevations and altered cardiovascular disease risk factor responses after supplementation with docosahexaenoic acid in postmenopausal women receiving and not receiving hormone replacement therapy
Stark, K. D., & Holub, B. J. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.5.765 · Cited by 177 · see citing works
Effects of n−3 fatty acids in subjects with type 2 diabetes: reduction of insulin sensitivity and time-dependent alteration from carbohydrate to fat oxidation
Mostad, I. L., Bjerve, K. S., Bjorgaas, M. R., Lydersen, S., & Grill, V. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.3.540 · Cited by 152 · cited 1× · see citing works
“Some previous studies have suggested that supplementation with both DHA and EPA may lead to a modest deterioration of insulin sensitivity or glycemic control, particularly in individuals with type 2 diabetes (38,39).”
Background
Dietary α-Linolenic Acid, EPA, and DHA Have Differential Effects on LDL Fatty Acid Composition but Similar Effects on Serum Lipid Profiles in Normolipidemic Humans
Egert, S., Kannenberg, F., Somoza, V., Erbersdobler, H. F., & Wahrburg, U. (2009) · The Journal of Nutrition · doi:10.3945/jn.108.103861 · Cited by 152 · see citing works
DHA Supplementation Decreases Serum C-Reactive Protein and Other Markers of Inflammation in Hypertriglyceridemic Men
Kelley, D. S., Siegel, D., Fedor, D. M., Adkins, Y. C., & Mackey, B. E. (2009) · Journal of Nutrition · doi:10.3945/jn.108.100354 · Cited by 139 · see citing works
Does supplementation of diet with 'fish oil' reduce blood pressure? A meta-analysis of controlled clinical trials.
Appel, L. J., Miller, E. R., Seidler, A. J., & Whelton, P. K. (1993) · PubMed · Cited by 137 · see citing works
Fish diet, fish oil and docosahexaenoic acid rich oil lower fasting and postprandial plasma lipid levels.
Ågren, J. J., Hänninen, O., Julkunen, A., Fogelholm, L., Vidgren, H. M., Schwab, U., Pynnönen, O., & Uusitupa, M. I. J. (1996) · PubMed · Cited by 117 · see citing works
Moderate Intake of n-3 Fatty Acids for 2 Months Has No Detrimental Effect on Glucose Metabolism and Could Ameliorate the Lipid Profile in Type 2 Diabetic Men: Results of a controlled study
Luo, J., Rizkalla, S. W., Vidal, H., Oppert, J., Colas, C., Boussairi, A., Guerre-Millo, M., Chapuis, A.-S., Chevalier, A., Durand, G., et al. (1998) · Diabetes Care · doi:10.2337/diacare.21.5.717 · Cited by 114 · see citing works
Fish oil, insulin sensitivity, insulin secretion and glucose tolerance in healthy people: Is there any effect of fish oil supplementation in relation to the type of background diet and habitual dietary intake of n-6 and n-3 fatty acids?
Giacco, R., Cuomo, V., Vessby, B. O., Uusitupa, M. I. J., Hermansen, K., Meyer, B. J., Riccardi, G., & Rivellese, A. A. (2006) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2006.06.006 · Cited by 105 · see citing works
LDL cholesterol-raising effect of low-dose docosahexaenoic acid in middle-aged men and women.
Theobald, H. E., Chowienczyk, P. J., Whittall, R., Humphries, S. E., & Sanders, T. A. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.4.558 · Cited by 101 · see citing works
Microalgal docosahexaenoic acid decreases plasma triacylglycerol in normolipidaemic vegetarians: a randomised trial.
Geppert, J., Kraft, V., Demmelmair, H., & Koletzko, B. (2006) · British Journal of Nutrition · doi:10.1079/bjn20051720 · Cited by 96 · see citing works
The effect of dietary docosahexaenoic acid on plasma lipoproteins and tissue fatty acid composition in humans
Nelson, G. J., Schmidt, P. C., Bartolini, G. L., Kelley, D. S., & Kyle, D. J. (1997) · Lipids · doi:10.1007/s11745-997-0146-5 · Cited by 92 · see citing works
Low-Dose Docosahexaenoic Acid Lowers Diastolic Blood Pressure in Middle-Aged Men and Women1
Theobald, H. E., Goodall, A. H., Sattar, N. A., Talbot, D. C. S., Chowienczyk, P., & Sanders, T. A. B. (2007) · Journal of Nutrition · doi:10.1093/jn/137.4.973 · Cited by 89 · see citing works
Effects of docosahexaenoic acid supplementation on blood lipids, estrogen metabolism, and in vivo oxidative stress in postmenopausal vegetarian women.
Wu, W. H., Lu, S. C., Wang, T. F., Jou, H. J., & Wang, T. A. (2006) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602328 · Cited by 70 · see citing works
Dose‐Dependent Effects of Docosahexaenoic Acid Supplementation on Blood Lipids in Statin‐Treated Hyperlipidaemic Subjects
Meyer, B. J., Hammervold, T., Rustan, A. C., & Howe, P. R. C. (2007) · Lipids · doi:10.1007/s11745-006-3014-4 · Cited by 69 · see citing works
Lipid Responses to a Dietary Docosahexaenoic Acid Supplement in Men and Women with Below Average Levels of High Density Lipoprotein Cholesterol
Maki, K. C., Elswyk, M. E. V., McCarthy, D., Hess, S. P., Veith, P. E., Bell, M., Subbaiah, P. V., & Davidson, M. H. (2005) · Journal of the American College of Nutrition · doi:10.1080/07315724.2005.10719465 · Cited by 67 · see citing works
Dietary supplementation with n‐3 fatty acids may impair glucose homeostasis in patients with non‐insulin‐dependent diabetes mellitus
Vessby, B., & Boberg, M. (1990) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.1990.tb00211.x · Cited by 64 · see citing works
Changes in abdominal and gluteal adipose-tissue fatty acid compositions in obese subjects after weight gain and weight loss
Hudgins, L., & Hirsch, J. (1991) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/53.6.1372 · Cited by 57 · see citing works
Docosahexaenoic Acid But Not Eicosapentaenoic Acid Increases LDL Particle Size in Treated Hypertensive Type 2 Diabetic Patients
Woodman, R. J., Mori, T. A., Burke, V., Puddey, I. B., Watts, G. F., Best, J. D., & Beilin, L. J. (2003) · Diabetes Care · doi:10.2337/diacare.26.1.253 · Cited by 48 · see citing works
The Triglyceride-Lowering Effects of a Modest Dose of Docosahexaenoic Acid Alone Versus in Combination with Low Dose Eicosapentaenoic Acid in Patients with Coronary Artery Disease and Elevated Triglycerides
Schwellenbach, L. J., Olson, K. L., McConnell, K. J., Stolcpart, R. S., Nash, J. D., Merenich, J. A., & for the Clinical Pharmacy Cardiac Risk Service Study Group (2006) · Journal of the American College of Nutrition · doi:10.1080/07315724.2006.10719562 · Cited by 48 · see citing works
Effects of Dietary α-Linolenic Acid, Eicosapentaenoic Acid or Docosahexaenoic Acid on Parameters of Glucose Metabolism in Healthy Volunteers
Egert, S., Fobker, M., Andersen, G., Somoza, V., Erbersdobler, H. F., & Wahrburg, U. (2008) · Annals of Nutrition and Metabolism · doi:10.1159/000172980 · Cited by 38 · see citing works
Glucose Tolerance, Insulin Sensitivity, and the Homeostasis Model Assessment Method
van Haeften, T. W. (1998) · Diabetes Care · doi:10.2337/diacare.21.4.673a · Cited by 14 · see citing works

Flagged first, then by citations

Research works printed but not linked: 1

Geppert J, Kraft V, Demmelmair H, Koletzko B. Microalgal docosahex- aenoic acid decreases plasma triacylglycerol in normolipidaemic vege- tarians: a randomized trial. Br J Nutr. 2006;95:779-86.

Sorted by citations

Omega-3 fatty acids EPA and DHA: Health benefits throughout life
Swanson, D., Block, R., & Mousa, S. A. (2012) · Advances in Nutrition · doi:10.3945/an.111.000893 · Cited by 1,575 · see citing works
Algae as nutritional and functional food sources: revisiting our understanding.
Wells, M. L., Potin, P., Craigie, J. S., Raven, J. A., Merchant, S. S., Helliwell, K. E., Smith, A. G., Camire, M. E., & Brawley, S. H. (2017) · Journal of Applied Phycology · doi:10.1007/s10811-016-0974-5 · Cited by 1,562 · see citing works
Dietary sources of omega 3 fatty acids: public health risks and benefits
Tur, J. A., Bibiloni, M. M., Sureda, A., & Pons, A. (2012) · British Journal of Nutrition · doi:10.1017/s0007114512001456 · Cited by 283 · see citing works
A Meta-Analysis Shows That Docosahexaenoic Acid from Algal Oil Reduces Serum Triglycerides and Increases HDL-Cholesterol and LDL-Cholesterol in Persons without Coronary Heart Disease3
Bernstein, A. M., Ding, E. L., Willett, W. C., & Rimm, E. B. (2012) · The Journal of Nutrition · doi:10.3945/jn.111.148973 · Cited by 148 · see citing works
Eicosapentaenoic acid and docosahexaenoic acid containing supplements modulate risk factors for cardiovascular disease: a meta‐analysis of randomised placebo‐control human clinical trials
AbuMweis, S., Jew, S., Tayyem, R., & Agraib, L. (2018) · Journal of Human Nutrition and Dietetics · doi:10.1111/jhn.12493 · Cited by 122 · see citing works
Omega‐3 Polyunsaturated Fatty Acids Intake and Blood Pressure: A Dose‐Response Meta‐Analysis of Randomized Controlled Trials
Zhang, X., Ritonja, J. A., Zhou, N., Chen, B. E., & Li, X. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.121.025071 · Cited by 122 · see citing works
Krill oil reduces plasma triacylglycerol level and improves related lipoprotein particle concentration, fatty acid composition and redox status in healthy young adults - a pilot study
Berge, R. K., Ramsvik, M. S., Bohov, P., Svardal, A., Nordrehaug, J. E., Rostrup, E., Bruheim, I., & Bjørndal, B. (2015) · Lipids in Health and Disease · doi:10.1186/s12944-015-0162-7 · Cited by 51 · see citing works
Protective Effects and Molecular Signaling of n-3 Fatty Acids on Oxidative Stress and Inflammation in Retinal Diseases
Suzumura, A., Terao, R., & Kaneko, H. (2020) · Antioxidants · doi:10.3390/antiox9100920 · Cited by 44 · see citing works
Marine-Based Omega-3 Fatty Acids and Metabolic Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Basirat, A., & Merino-Torres, J. F. (2025) · Nutrients · doi:10.3390/nu17203279 · Cited by 9 · see citing works

Plasma Lipoprotein Profile in Fasted and Refed Chickens of Two Strains Selected for High or Low Adiposity
Hermier, D., Chapman, M. J., & Leclercq, B. (1984) · Journal of Nutrition · doi:10.1093/jn/114.6.1112 · Cited by 80 · see citing works
Plasma Distribution of Cyclosporine Within Lipoproteins and “In Vitro” Transfer Between Very-Low-Density Lipoproteins, Low-Density Lipoproteins, and High-Density Lipoproteins
Hughes, T. A., Gaber, A. O., & Montgomery, C. E. (1991) · Therapeutic Drug Monitoring · doi:10.1097/00007691-199107000-00002 · Cited by 36 · see citing works
Biophysical Characterization of Human Lipoproteins for Diagnostic Assay Development
Klosterman, K. E., Lenz, K. D., Mukundan, H., et al. (2021) · Biophysical Journal · doi:10.1016/j.bpj.2020.11.1538
Time-related changes in the synthesis and secretion of very low density, low density and high density lipoproteins by cultured rat hepatocytes
Bell-Quint, J., & Forte, T. M. (1981) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(81)90196-x · Cited by 66 · see citing works
Metabolism of Very Low Density Lipoproteins
Eisenberg, S. (1976) · Springer eBooks · doi:10.1007/978-3-642-66323-9_6 · Cited by 39 · see citing works

Authors: Neff, L. M., Culiner, J., Cunningham-Rundles, S., Seidman, C., Meehan, D., Maturi, J., Wittkowski, K. M., Levine, B., & Breslow, J. L.
Affiliations: Rockefeller University (US)
Rockefeller University Hospital (US)
Corresponding author: Breslow, Jan L.
ORCID: Neff, Lisa M.
Wittkowski, Knut M.
Breslow, Jan L.
Venue: The Journal of Nutrition
Publisher: Elsevier BV
Published: 2011-02
Volume: 141
Issue: 2
Pages: 207-213
ISSN: 0022-3166 (ISSN-L)
DOI: 10.3945/jn.110.130021
PMC: PMC3021440
OpenAlex: W2166486864
Cited by: 121
References: 52
Citations by year: 2026: 3 · 2025: 4 · 2024: 14 · 2023: 8 · 2022: 7 · 2021: 10 · 2020: 5 · 2019: 7 · 2018: 5 · 2017: 6 · 2016: 13 · 2015: 9 · 2014: 8 · 2013: 8 · 2012: 10
FWCI: 6.67
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4385 d)
Locations: Journal of Nutrition (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (2m01rr000102-41)
National Center for Research Resources (M01-RR000102, UL1RR024143, KL2RR024142)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords: docosahexaenoic acid, algal oil, omega-3 supplementation, lipoprotein particle size, VLDL, low-density lipoprotein, HDL cholesterol, triglycerides, cardiovascular risk, overweight, obesity, IL-10, inflammation, cardiometabolic risk
MeSH terms: Adult, Rhodophyta, Cardiovascular Diseases, Dietary Fats, Docosahexaenoic Acids, Double-Blind Method, Female, Humans, Lipoproteins, Male, Middle Aged, Magnetic Resonance Spectroscopy, Obesity, Particle Size, Plant Extracts, Risk Factors, Triglycerides, Interleukin-10, Dietary Supplements, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Algal Docosahexaenoic Acid Affects Plasma Lipoprotein Particle Size Distribution in Overweight and Obese Adults

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks