Cited by 179Fatty Acid Research and HealthLipoproteins and Cardiovascular HealthLipid metabolism and disorders

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Docosahexaenoic acid supplementation improves fasting and postprandial lipid profiles in hypertriglyceridemic men.

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Kelley, Darshan S, Siegel, David, Vemuri, Madhuri, Mackey, Bruce E·2007·The American Journal of Clinical Nutrition

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Abstract

Background The effects of docosahexaenoic acid (DHA) on the mean size and concentrations of VLDL, LDL, and HDL subclasses have not been previously studied.Objective We determined the effects of DHA supplementation on the concentrations of apoproteins; large, medium, and small VLDL, LDL, and HDL particles; and the mean diameters of these particles in fasting and postprandial plasma.Design Hypertriglyceridemic men aged 39-66 y (n = 34) participated in a double-blind, randomized, placebo-controlled parallel study. They received no supplements for the first 8 d and received either 7.5 g DHA oil/d (3 g DHA/d) or olive oil (placebo) for the last 90 d. Lipoprotein particle diameters and concentrations were measured by nuclear magnetic resonance spectroscopy.Results DHA supplementation for 45 d significantly (P < 0.05) decreased concentrations of fasting triacylglycerol (24%), large VLDL (92%), and intermediate-density lipoproteins (53%) and the mean diameter of VLDL particles (11.1 nm). It elevated concentrations of LDL cholesterol (12.6%), small VLDL particles (133%), and large LDL particles (120%) and the mean diameter of LDL particles (0.6 nm) in fasting plasma. Similar changes were observed for area under the curve for postprandial samples (0-6 h); however, the number of small dense LDL particles decreased significantly (21%), and the change in LDL cholesterol was not significant. Continued supplementation with DHA beyond 45 d caused no further changes; placebo treatment altered none of the responses tested.Conclusion DHA supplementation may improve cardiovascular health by lowering concentrations of triacylglycerols and small, dense LDL particles.

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Authors: Kelley, D. S., Siegel, D., Vemuri, M., & Mackey, B. E.
Affiliations: Agricultural Research Service (US)
Corresponding author: Kelley, Darshan S
Venue: The American Journal of Clinical Nutrition
Publisher: Elsevier BV
Published: 2007-08
Volume: 86
Issue: 2
Pages: 324-333
ISSN: 0002-9165 (ISSN-L)
DOI: 10.1093/ajcn/86.2.324
OpenAlex: W1937978193
Cited by: 179
References: 50
Citations by year: 2026: 2 · 2025: 2 · 2023: 3 · 2022: 7 · 2021: 4 · 2020: 8 · 2019: 5 · 2018: 9 · 2017: 6 · 2016: 8 · 2015: 17 · 2014: 16 · 2013: 15 · 2012: 12
FWCI: 13.61
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 5686 d)
Locations: American Journal of Clinical Nutrition (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Department of Agriculture (UL1 RR024146)
National Institutes of Health (RR024146)
Agricultural Research Service
National Center for Research Resources (RR-024146, UL1RR024146)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Keywords: docosahexaenoic acid, omega-3 supplementation, hypertriglyceridemia, lipoprotein particle size, VLDL particles, LDL cholesterol, HDL cholesterol, small dense LDL, postprandial lipemia, triglycerides, apolipoproteins, olive oil placebo, cardiovascular health
MeSH terms: Adult, Aged, Docosahexaenoic Acids, Double-Blind Method, Fasting, Humans, Lipids, Lipoproteins, Lipoproteins, HDL, Lipoproteins, LDL, Cholesterol, LDL, Lipoproteins, VLDL, Male, Middle Aged, Placebos, Triglycerides, Hypertriglyceridemia, Patient Selection, Postprandial Period, Dietary Supplements

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Docosahexaenoic acid supplementation improves fasting and postprandial lipid profiles in hypertriglyceridemic men.

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