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Sense of Coherence and Mortality in Men and Women in the EPIC-Norfolk United Kingdom Prospective Cohort Study
Abstract
This study tested the hypothesis that a personality disposition defined by a strong sense of coherence is associated with a reduced risk of mortality. The authors prospectively examined, for < or =6 years, the relation between a strong sense of coherence and mortality due to all causes, cardiovascular disease, and cancer among 20,579 participants aged 41-80 years from the European Prospective Investigation into Cancer (EPIC)-Norfolk Study in the United Kingdom. Data were collected in 1996-2002. Participants were recruited by post from general practice age-sex registers and subsequently completed a postal assessment of their sense of coherence. During follow-up, 1,024 deaths were recorded. A strong sense of coherence was associated with a 30% reduction in mortality from all causes (rate ratio=0.69, p<0.0001), cardiovascular disease (rate ratio=0.70, p=0.001), and cancer (rate ratio=0.74, p=0.003), independent of age, sex, and prevalent chronic disease. These associations were consistent by sex, except that no association was observed for cancer mortality in women. The association for all-cause mortality remained after adjustment for cigarette smoking history, social class, body mass index, systolic blood pressure, cholesterol, hostility, and neuroticism (rate ratio=0.76, p=0.002). Results suggest that a strong sense of coherence may confer some resilience to the risk of chronic disease.
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“In this UK cohort, the same pattern of findings emerged for those with low sense of coherence, although this trait was a risk for cancer mortality only in men [128].”
From Personality and Longevity: Knowns, Unknowns, and Implications for Public Health and Personalized Medicine (2011) · cites this paper as [128]
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“and for CVD mortality over 11 years, particularly in persons with low CVD risk [127, 128]”
From Personality and Longevity: Knowns, Unknowns, and Implications for Public Health and Personalized Medicine (2011) · cites this paper as [128]
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Metadata
- Authors
- Surtees, P.
- Affiliations
- University of Cambridge (GB)
- Corresponding author
- Surtees, P.
- Venue
- American Journal of Epidemiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-12-15
- Volume
- 158
- Issue
- 12
- Pages
- 1202-1209
- ISSN
- 0002-9262 (ISSN-L)
- OpenAlex
- W2101075322
- Cited by
- 252
- References
- 42
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 5 · 2023: 4 · 2022: 12 · 2021: 5 · 2020: 12 · 2019: 8 · 2018: 5 · 2017: 10 · 2016: 9 · 2015: 17 · 2014: 15 · 2013: 12 · 2012: 14
- FWCI
- 25.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Health Professions › General Health Professions › Health, psychology, and well-being
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Social Sciences › Health › Health disparities and outcomes
- Keywords
- sense of coherence, mortality, all-cause mortality, cardiovascular mortality, cancer mortality, personality, sex differences, EPIC-Norfolk cohort, chronic disease risk, resilience
- MeSH terms
- Adult, Aged, Attitude, Cardiovascular Diseases, Female, United Kingdom, Humans, Male, Middle Aged, Neoplasms, Personality, Prospective Studies, Cohort Studies
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