Neuropsychological correlates of methylphenidate treatment in adult ADHD with and without depression
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The purpose of this study was to characterize the neuropsychological profiles of adult patients with attention deficit hyperactivity disorder (ADHD) alone and ADHD with active comorbid depression, and to evaluate changes in the neuropsychological profile in these two groups following a trial of methylphenidate. Forty patients with ADHD were classified into two groups based on their affective status resulting in a group of 21 patients with ADHD alone and 19 patients with ADHD and active comorbid symptoms of depression (ADHD-D). All subjects received a comprehensive neuropsychological evaluation including measures of cognitive, motor and affective functioning before and after treatment. Fifteen normal controls were also assessed at a yoked time interval. At baseline, both patient groups showed impairment in verbal memory, motor and processing speed, visual scanning, and auditory and visual distractibility. Following treatment, both patient groups showed improvement across all neuropsychological measures while controls remained relatively stable over time. Improvement in neuropsychological test performance was not related to gender, affective status or referral source. Patients with active comorbid symptoms of depression show a similar neuropsychological profile and appear equally likely to benefit from methylphenidate intervention as patients with ADHD alone.
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ADHD patients with current or remitted MDD show similar neuropsychological profiles to those with ADHD alone.
“This extends earlier findings and suggest that ADHD patients diagnosed with current or remitted MDD show similar neuropsychological profiles as patients diagnosed with ADHD alone (Katz et al., 1998; Riordan et al., 1999).”
From Cognitive heterogeneity in adult attention deficit/hyperactivity disorder: A systematic analysis of neuropsychological measurements (2015) · cites this paper as Riordan et al., 1999
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- Authors
- Riordan, H. J., Flashman, L. A., Saykin, A. J., Frutiger, S. A., Carroll, K. E., & Huey, L.
- Affiliations
- New Hampshire Hospital (US)
- Corresponding author
- Flashman, L. A.
- Venue
- Archives of Clinical Neuropsychology
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-02-01
- Volume
- 14
- Issue
- 2
- Pages
- 217-233
- ISSN
- 0887-6177 (ISSN-L)
- 1873-5843
- OpenAlex
- W2132239847
- Cited by
- 75
- References
- 0
- Citations by year
- 2025: 1 · 2023: 2 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 3 · 2017: 1 · 2016: 1 · 2015: 5 · 2014: 2 · 2013: 1 · 2012: 2
- FWCI
- 1.90
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Archives of Clinical Neuropsychology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Developmental and Educational Neuropsychology
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- adult ADHD, methylphenidate, neuropsychological profile, cognitive impairment, processing speed, verbal memory, distractibility, motor performance, treatment response, yoked control
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