The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Appearances can be deceiving: phenotypes of knockout mice
Open accessAbstract
In the field of mammalian functional genomics, one of the main aims in the post-genomic era is to elucidate the function of all genes in the genome. The powerful technology of gene targeting in embryonic stem cells has enabled the simple generation of mice lacking a specific gene. However, it is evident that in a proportion of such knockout mice no deviation in phenotype could be detected. Advancements in the field of mouse phenotyping and use of extensive phenotyping tests on each knockout showed that abnormal phenotypes were sometimes detected in physiological areas where they were not initially anticipated, or only manifested under certain conditions, emphasizing the need for careful phenotypic investigation. Nevertheless, the effect of some genes became evident only upon inactivation of another gene, pointing to the phenomenon of biological robustness. Unlike in yeast, this phenomenon has not yet been analysed systematically in the mouse. In this review, we present examples of mouse knockouts that lend support to the concept of robustness, discuss the mechanisms by which it may have evolved, as well as speculate on the reasons for its evolution.
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Cites
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Cited by
Nizri, E., Irony-Tur-Sinai, M., Lory, O., Orr-Urtreger, A., Lavi, E., & Brenner, T. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0902212 · Cited by 304
Protein Homeostasis and the Phenotypic Manifestation of Genetic Diversity: Principles and Mechanisms
Jarosz, D. F., Taipale, M., & Lindquist, S. (2010) · Annual Review of Genetics · doi:10.1146/annurev.genet.40.110405.090412 · Cited by 179
The myostatin gene: an overview of mechanisms of action and its relevance to livestock animals
Aiello, D., Patel, K., & Lasagna, E. (2018) · Animal Genetics · doi:10.1111/age.12696 · Cited by 162
Fan, J., Campioli, E., Midzak, A., Culty, M., & Papadopoulos, V. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1502670112 · Cited by 133
Altered immune response in mice deficient for the G protein-coupled receptor GPR34
Liebscher, I., Müller, U., Teupser, D., Engemaier, E., Engel, K. M. Y., Ritscher, L., Thor, D., Sangkuhl, K., Ricken, A., Wurm, A., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.196659 · Cited by 106
Metadata
- Authors
- Barbaric, I., Miller, G., & Dear, T. N.
- Venue
- Briefings in Functional Genomics and Proteomics
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-09-03
- Volume
- 6
- Issue
- 2
- Pages
- 91-103
- ISSN
- 1473-9550 (ISSN-L)
- 1477-4062
- OpenAlex
- W2124850941
- Cited by
- 195
- References
- 9
- FWCI
- 3.23
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Barbaric, I., Miller, G., & Dear, T. N. (2007). Appearances can be deceiving: phenotypes of knockout mice. Briefings in Functional Genomics and Proteomics. https://doi.org/10.1093/bfgp/elm008
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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