The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
The prognostic value of brain MRI in clinically isolated syndromes of the CNS. A 10-year follow-up
Abstract
A definitive diagnosis of multiple sclerosis cannot be made at presentation on patients with a clinically isolated syndrome of the optic nerve, spinal cord or brainstem suggestive of demyelination, as dissemination in time is not established. To determine the long-term risk of abnormalities on brain MRI for the development of multiple sclerosis and disability we performed a 10-year follow-up on 81 such patients who had T2-weighted brain MRI at presentation. Initial brain MRI was abnormal in 54 (67%). Follow up of those patients with an abnormal MRI revealed progression to clinically definite multiple sclerosis in 45 out of 54 (83%), of whom 11 (20%) had relapsing/remitting disease (EDSS > 3), 13 (24%) secondary progressive and 21 (39%) benign (relapsing/remitting with EDSS < or = 3) disease. For those with a normal MRI progression to clinically definite multiple sclerosis occurred in only three out of 27 (11%), all benign. There was a significant relationship between the number of lesions at presentation and both EDSS (r = 0.45, P < 0.001) and the type of disease at follow-up (P < 0.0001). Brain MRI at presentation with a clinically isolated syndrome is predictive of the long-term risk of subsequent development of multiple sclerosis, the type of disease and extent of disability.
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Citations
Cites
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Cited by
Defining the clinical course of multiple sclerosis: The 2013 revisions
Lublin, F. D., Reingold, S. C., Cohen, J. A., Cutter, G. R., Sørensen, P. S., Thompson, A. J., Wolinsky, J. S., Balcer, L. J., Banwell, B., Barkhof, F., et al. (2014) · Neurology · doi:10.1212/wnl.0000000000000560 · Cited by 3,177
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Diagnostic criteria for multiple sclerosis
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A longitudinal study of abnormalities on MRI and disability from multiple sclerosis
Brex, P. A., Ciccarelli, O., O'Riordan, J. I., Sailer, M., Thompson, A. J., & Miller, D. H. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa011341 · Cited by 861
Self-citation
Metadata
- Authors
- O'Riordan, J.
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-03-01
- Volume
- 121
- Issue
- 3
- Pages
- 495-503
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- OpenAlex
- W2125422382
- Cited by
- 484
- References
- 40
- FWCI
- 20.88
- Type
- journal article
- Language
- en
- Open access
- closed
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- O'Riordan, J. (1998). The prognostic value of brain MRI in clinically isolated syndromes of the CNS. A 10-year follow-up. Brain. https://doi.org/10.1093/brain/121.3.495
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
