Differential cognitive effects of colloid cysts in the third ventricle that spare or compromise the fornix
Abstract
A series of twelve cases, all of whom had received surgery for the removal of a colloid cyst in the third ventricle, was examined on a series of memory tests. The only consistent predictor of poor memory performance that could be detected from MRIs was the presence of bilateral interruption of the fornix, which occurred in three of the subjects. Although these three cases were poor on tests of learning and recall, there was evidence that recognition was less impaired. The subjects were also tested on a set of recognition and concurrent discriminations that closely matched tests given to non-human primates. Clear parallels were found between the apparent effects of fornix damage in these clinical cases and those observed following more selective surgery in non-human primates. These findings not only indicate that fornix damage is sufficient to induce anterograde amnesia but also support the validity of recent animal tests that are thought to capture aspects of episodic memory.
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Damage to the fornix, as well as the anterior thalamus, causes anterograde amnesia in humans.
“Furthermore, damage to the fornix, as well as the anterior thalamus, causes anterograde amnesia in humans (Aggleton and Brown, 1999; Aggleton et al., 2000; Carlesimo et al., 2011; Gaffan and Gaffan, 1991).”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Aggleton et al., 2000
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- Authors
- Aggleton, J. P.
- Affiliations
- Cardiff University (GB)
- Corresponding author
- Aggleton, J. P.
- ORCID
- Aggleton, J. P.
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-04-01
- Volume
- 123
- Issue
- 4
- Pages
- 800-815
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- OpenAlex
- W2140405850
- Cited by
- 231
- References
- 55
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 8 · 2023: 5 · 2022: 12 · 2021: 3 · 2020: 7 · 2019: 4 · 2018: 11 · 2017: 9 · 2016: 8 · 2015: 10 · 2014: 7 · 2013: 11 · 2012: 2
- FWCI
- 3.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
- Keywords
- colloid cyst, third ventricle, anterograde amnesia, episodic memory, recognition memory, memory impairment, fornix lesions, nonhuman primate model
- MeSH terms
- Adult, Brain Diseases, Cerebral Ventricles, Cognition, Cysts, Discrimination, Psychological, Efferent Pathways, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Memory, Middle Aged, Neuropsychological Tests, Photic Stimulation, Psychometrics
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