The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Depression in Parkinson's disease: loss of dopamine and noradrenaline innervation in the limbic system
Abstract
The reason for the high frequency of depression and anxiety in Parkinson's disease is poorly understood. Degeneration of neurotransmitter systems other than dopamine might play a specific role in the occurrence of these affective disorders. We used [11C]RTI-32 PET, an in vivo marker of both dopamine and noradrenaline transporter binding, to localize differences between depressed and non-depressed patients. We studied eight and 12 Parkinson's disease patients with and without a history of depression matched for age, disease duration and doses of antiparkinsonian medication. The depressed Parkinson's disease cohort had lower [11C]RTI-32 binding than non-depressed Parkinson's disease cases in the locus coeruleus and in several regions of the limbic system including the anterior cingulate cortex, the thalamus, the amygdala and the ventral striatum. Exploratory analyses revealed that the severity of anxiety in the Parkinson's disease patients was inversely correlated with the [11C]RTI-32 binding in most of these regions and apathy was inversely correlated with [11C]RTI-32 binding in the ventral striatum. These results suggest that depression and anxiety in Parkinson's disease might be associated with a specific loss of dopamine and noradrenaline innervation in the limbic system.
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Cites
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“In addition, the CingA receives a strong dopaminergic and noradrenergic innervation (Williams and Goldman-Rakic, 1993).”
BackgroundLower dopamine transporter binding potential in striatum during depression
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Depression in Parkinson's Disease: A Positron Emission Study
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Cited by
Non-motor symptoms of Parkinson's disease: diagnosis and management
Chaudhuri, K. R., Healy, D. G., & Schapira, A. H. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70373-8 · Cited by 2,807
Non-motor features of Parkinson disease
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Obeso, J. A., Stamelou, M., Goetz, C. G., Poewe, W., Lang, A. E., Weintraub, D., Burn, D., Halliday, G. M., Bezard, E., Przedborski, S., et al. (2017) · Movement Disorders · doi:10.1002/mds.27115 · Cited by 859
Self-citationThe pros and cons of phytoestrogens
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Metadata
- Authors
- Remy, P., Doder, M., Lees, A., Turjanski, N., & Brooks, D.
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-02-16
- Volume
- 128
- Issue
- 6
- Pages
- 1314-1322
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- OpenAlex
- W2168132298
- Cited by
- 1,040
- References
- 10
- FWCI
- 20.57
- Type
- journal article
- Language
- en
- Open access
- closed
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