CoChat
Sign Up
Cited by 219Parkinson's Disease Mechanisms and TreatmentsNeurological disorders and treatmentsTreatment of Major Depression

Depression in Parkinson's Disease: A Positron Emission Study

Open access
Ring, H. A., Bench, C. J., Trimble, M. R., Brooks, D. J., Frackowiak, R. S. J., Dolan, R. J.·1994·British Journal of Psychiatry
DOI 10.1192/bjp.165.3.333
Open this paper in CoChat — free account

Abstract

Background: This study investigated biological correlates of depression in patients with idiopathic Parkinson's disease (PD). We tested the hypothesis that in patients with PD and depression, there was regional dysfunction involving brain areas previously implicated in functional imaging studies of patients with primary depression. Method: Using positron emission tomographic measurements of regional cerebral blood flow (rCBF), patterns of resting rCBF were measured in ten patiens with PD and major depression, and ten patients with PD alone. The results were compared with findings from ten patients with primary depression and ten normal controls, scanned using identical methods as part of an earlier study. Groups were matched for age, sex and symptom severity. Results: Bilateral decreases in rCBF were observed in anteromedial regions of the medial frontal cortex and the cingulate cortex (Brodmann's areas (BA) 9 and 32) in the depressed PD group, compared with those with PD alone and compared with normal controls. This regional disturbance overlapped that observed in patients with primary depression. Conclusions: The findings indicate that the medial prefrontal cortex is a common area of neural dysfunction in the manifestation of both primary depression and depression in PD.

Integrity signals

Registry

Crossref · 10.1192/bjp.165.3.333

Cites

26 of 26 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Parkinson's disease patients with depression show altered metabolism or blood flow in orbital and medial frontal cortex compared with non-depressed Parkinson's patients or healthy controls.

    “Patients with Parkinson’s disease who manifest depression show altered metabolism or blood flow in the orbital and medial frontal cortex compared to non-depressed Parkinson’s patients or healthy controls (42, 43).”

    From Localization of Dysfunction in Major Depressive Disorder: Prefrontal Cortex and Amygdala (2011) · cites this paper as [43]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Ring, H. A., Bench, C. J., Trimble, M. R., Brooks, D. J., Frackowiak, R. S. J., & Dolan, R. J.
Affiliations
  • UCL Queen Square Institute of Neurology (GB)
  • The Royal Free Hospital (GB)
Corresponding author
Ring, H. A.
ORCID
Venue
British Journal of Psychiatry
Publisher
Royal College of Psychiatrists
Published
1994-09
Volume
165
Issue
3
Pages
333-339
ISSN
  • 0007-1250 (ISSN-L)
  • 1472-1465
DOI
10.1192/bjp.165.3.333
OpenAlex
W1969926186
Cited by
219
References
26
Citations by year
2025: 1 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 3 · 2018: 1 · 2017: 2 · 2016: 6 · 2015: 6 · 2014: 7 · 2013: 11 · 2012: 1
FWCI
6.95
Type
journal article
Language
en
Open access
Licence
Locations
  • The British Journal of Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
  • Max Planck Digital Library (submittedVersion, other-oa)
  • MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
Funders
Wellcome Trust
Topics
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Neurology › Neurological disorders and treatments
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords
Parkinson's disease, depression, regional cerebral blood flow, medial prefrontal cortex, cingulate cortex, primary depression, neuroimaging of depression
MeSH terms
Aged, Brain, Brain Mapping, Depressive Disorder, Dominance, Cerebral, Female, Frontal Lobe, Gyrus Cinguli, Humans, Image Processing, Computer-Assisted, Male, Mental Status Schedule, Middle Aged, Parkinson Disease, Regional Blood Flow, Tomography, Emission-Computed, Geriatric Assessment, Prefrontal Cortex

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review