Neural bases of personal and extrapersonal neglect in humans
Abstract
Human awareness of left space may be disrupted by cerebral lesions to the right hemisphere (hemispatial neglect). Current knowledge on the anatomical bases of this complex syndrome is based on the results of group studies that investigated primarily the best known aspect of the syndrome, which is visual neglect for near extrapersonal (or peripersonal) space. However, another component-neglect for personal space-is more often associated with, than double-dissociated from, extrapersonal neglect, especially, in chronic patients. The present investigation aimed at exploring the anatomical substrate of both extrapersonal and personal neglect by using different advanced methodological approaches to lesion-function correlation. Fifty-two right ischaemic patients were submitted to neuropsychological assessment and in-depth MRI evaluation. The borders of each patient's lesion were delimited onto its own high-resolution anatomical image and then submitted to an automated spatial normalization algorithm. Besides conventional lesion density plots and subtraction analysis, region-based statistical analyses were performed on percentage values of the lesioned tissue also using a new parcellation of the white matter (WM). Data were finally submitted to voxelwise statistical analysis using a recently proposed method (voxel-based lesion-symptom mapping). Results converged in showing that awareness of extrapersonal space is based on the integrity of a circuit of right frontal (ventral premotor cortex and middle frontal gyrus) and superior temporal regions, whereas awareness of personal space is rooted in right inferior parietal regions (supramarginal gyrus, post-central gyrus and especially the WM medial to them). Common but less crucial regions for both neglect sub-types were located in the temporo-peri-Sylvian cortex. We suggest that extrapersonal space awareness critically involves a ventral circuit recently described for the exogenous allocation and reorienting of attention in space. Disruption of personal space awareness, instead, seems to be due to a functional disconnection between regions important for coding proprioceptive and somatosensory inputs, and regions coding more abstract egocentric representations of the body in space. In conclusion, present data strongly support a segregation of personal and extrapersonal spatial awareness in humans, both from a functional and an anatomical point of view.
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Patients with PPc lesions are strongly impaired when performing tasks requiring on-line coding of body posture, when attending to body parts on the left in the case of a right lesion, and when describing the spatial relations between body parts in the case of a left lesion.
“Patients with PPc lesions are strongly impaired when performing tasks requiring on-line coding of body posture (Schwoebel & Coslett, 2005), when attending to body parts on the left in the case of a right lesion (i.e.personal neglect; Committeri et al., 2007) and when describing the spatial relations between body parts in the case of a left lesion (i.e.autotopagnosia; Ogden, 1985).”
From Bodily ownership and self-location: Components of bodily self-consciousness (2013) · cites this paper as Committeri et al., 2007
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- Authors
- Committeri, G., Pitzalis, S., Galati, G., Patria, F., Pelle, G., Sabatini, U., Castriota-Scanderbeg, A., Piccardi, L., Guariglia, C., & Pizzamiglio, L.
- Affiliations
- University of Chieti-Pescara (IT)
- Fondazione Santa Lucia (IT)
- Sapienza University of Rome (IT)
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-02-01
- Volume
- 130
- Issue
- 2
- Pages
- 431-441
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- OpenAlex
- W2095173454
- Cited by
- 322
- References
- 66
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 12 · 2023: 10 · 2022: 18 · 2021: 16 · 2020: 16 · 2019: 12 · 2018: 9 · 2017: 19 · 2016: 18 · 2015: 22 · 2014: 14 · 2013: 30 · 2012: 26
- FWCI
- 5.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain (publishedVersion)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Archivio Istituzionale della Ricerca - Università degli Studi dell Aquila (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Spatial Neglect and Hemispheric Dysfunction
- Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Keywords
- hemispatial neglect, peripersonal space, right hemisphere damage, stroke, ventral premotor cortex, middle frontal gyrus, superior temporal cortex, inferior parietal cortex, supramarginal gyrus, white matter, voxel-based lesion-symptom mapping, spatial awareness, proprioception, somatosensory processing
- MeSH terms
- Adult, Aged, Awareness, Brain, Brain Mapping, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Perceptual Disorders, Personal Space, Space Perception, Stroke
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