Spectral and spatial shifts of post-ictal slow waves in temporal lobe seizures
Open accessAbstract
Temporal lobe seizures have a significant chance to induce impairment of normal brain functions. Even after the termination of ictal discharges, during the post-ictal period, loss of consciousness, decreased responsiveness or other cognitive dysfunctions can persist. Previous studies have found various anatomical and functional abnormalities accompanying temporal lobe seizures, including an abnormal elevation of cortical slow waves. Intracranial electroencephalography studies have shown a prominent increase of lower frequency components during and following seizures that impair (complex partial seizures) but not those that preserve (simple partial seizures) normal consciousness and responsiveness. However, due to the limited spatial coverage of intracranial electroencephalography, the investigation of cortical slow waves cannot be easily extended to the whole brain. In this study, we used scalp electroencephalography to study the spectral features and spatial distribution of post-ictal slow waves with comprehensive spatial coverage. We studied simple partial, complex partial and secondarily generalized seizures in 28 patients with temporal lobe seizures. We used dense-array electroencephalography and source imaging to reconstruct the post-ictal slow-wave distribution. In the studied cohort, we found that a 'global' spectral power shift to lower frequencies accompanied the increased severity of seizures. The delta spectral power relative to higher frequency bands was highest for secondarily generalized seizures, followed by complex partial seizures and lastly simple partial seizures. In addition to this 'global' spectral shift, we found a 'regional' spatial shift in slow-wave activity. Secondarily generalized seizures and complex partial seizures exhibited increased slow waves distributed to frontal areas with spread to contralateral temporal and parietal regions than in simple partial seizures. These results revealed that a widespread cortical network including temporal and fronto-parietal cortex is involved in abnormal slow-wave activity following temporal lobe seizures. The differential spectral and spatial shifts of post-ictal electroencephalography activity in simple partial, complex partial and secondarily generalized seizures suggest a possible connection between cortical slow waves and behavioural and cognitive changes in a human epilepsy model.
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The theta oscillation and its role in consciousness have been characterized with electrophysiological source imaging.
“The theta oscillation and its role in consciousness have also been characterized with ESI (85).”
From Electrophysiological source imaging: A noninvasive window to brain dynamics (2018) · cites this paper as [85]
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Electrophysiological source imaging: A noninvasive window to brain dynamics
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- Authors
- Yang, L., Worrell, G. A., Nelson, C., Brinkmann, B., & He, B.
- Affiliations
- University of Minnesota (US)
- Mayo Clinic (US)
- Corresponding author
- He, Bin
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-08-24
- Volume
- 135
- Issue
- 10
- Pages
- 3134-3143
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- PMC
- PMC3470709
- OpenAlex
- W2164085110
- Cited by
- 42
- References
- 49
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 1 · 2022: 7 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 7 · 2016: 4 · 2015: 3 · 2014: 1 · 2013: 1
- FWCI
- 1.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Brain (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (RO1 EB007920, RO1 EB006433, RO1 NS063039)
- National Science Foundation (CBET-0933067)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › EEG and Brain-Computer Interfaces
- Keywords
- temporal lobe epilepsy, complex partial seizures, simple partial seizures, secondary generalized seizures, frontal cortex, frontoparietal network, seizure severity
- MeSH terms
- Adult, Electroencephalography, Epilepsy, Temporal Lobe, Humans, Nerve Net, Neuropsychological Tests, Temporal Lobe, Time Factors, Brain Waves
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