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Cited by 79Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsAdvanced Neuroimaging Techniques and Applications

Memory binding and white matter integrity in familial Alzheimer’s disease

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Parra, Mario A., Saarimäki, Heini, Bastin, Mark E., Londoño, Ana C., Pettit, Lewis, Lopera, Francisco, Della Sala, Sergio, Abrahams, Sharon·2015·Brain
DOI 10.1093/brain/awv048PMC PMC5963407
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Abstract

Binding information in short-term and long-term memory are functions sensitive to Alzheimer's disease. They have been found to be affected in patients who meet criteria for familial Alzheimer's disease due to the mutation E280A of the PSEN1 gene. However, only short-term memory binding has been found to be affected in asymptomatic carriers of this mutation. The neural correlates of this dissociation are poorly understood. The present study used diffusion tensor magnetic resonance imaging to investigate whether the integrity of white matter structures could offer an account. A sample of 19 patients with familial Alzheimer's disease, 18 asymptomatic carriers and 21 non-carrier controls underwent diffusion tensor magnetic resonance imaging, neuropsychological and memory binding assessment. The short-term memory binding task required participants to detect changes across two consecutive screens displaying arrays of shapes, colours, or shape-colour bindings. The long-term memory binding task was a Paired Associates Learning Test. Performance on these tasks were entered into regression models. Relative to controls, patients with familial Alzheimer's disease performed poorly on both memory binding tasks. Asymptomatic carriers differed from controls only in the short-term memory binding task. White matter integrity explained poor memory binding performance only in patients with familial Alzheimer's disease. White matter water diffusion metrics from the frontal lobe accounted for poor performance on both memory binding tasks. Dissociations were found in the genu of corpus callosum which accounted for short-term memory binding impairments and in the hippocampal part of cingulum bundle which accounted for long-term memory binding deficits. The results indicate that white matter structures in the frontal and temporal lobes are vulnerable to the early stages of familial Alzheimer's disease and their damage is associated with impairments in two memory binding functions known to be markers for Alzheimer's disease.

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  • Previous DTI studies in autosomal-dominant Alzheimer's disease lacked sufficient statistical power, considering relatively low sample sizes (n = 8 to 18 asymptomatic carriers), to detect the subtle pre-symptomatic phase.

    “However, these studies either lacked sufficient statistical power considering the relatively low sample sizes (n = 8 to 18 of asymptomatic carriers) to detect subtle pre-symptomatic phase”

    From White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer’s disease (2018) · cites this paper as Parra et al., 2015

    The Discussion (page unavailable) says previous DT-MRI studies consistently reported white-matter differences in presymptomatic familial Alzheimer’s disease—the opposite of the claim that they lacked power to detect them. It raises genetic heterogeneity and age as possible reasons its own study did not replicate those findings. Its limited-power caveat concerns associations in its own asymptomatic-carrier sample, not the previous studies. (LLM, conf=0.85)

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  • Previous DTI studies in autosomal-dominant Alzheimer's disease did not estimate years from symptom onset (EYO), which reduced the sensitivity to detect DTI changes that occur in close proximity to the onset of dementia symptoms.

    “or did not estimate years from symptom onset (EYO) (Ringman et al., 2007; Ryan et al., 2013; Parra et al., 2015), which reduced the sensitivity to detect DTI changes that occur in close proximity to the onset of dementia symptoms.”

    From White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer’s disease (2018) · cites this paper as Parra et al., 2015

    The Participants and Statistical analyses sections describe grouping carriers by clinical status and analyzing DT-MRI measures by group; they do not describe estimating years from symptom onset. The Discussion treats age as relevant to time to clinical expression, but does not say that omitting EYO reduced sensitivity to detect DTI changes near symptom onset. Page numbers are not available in our copy. (LLM, conf=0.78)

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  • A few DTI studies on white matter alterations in autosomal-dominant Alzheimer's disease have been previously conducted.

    “A few DTI studies on white matter alterations in autosomal-dominant Alzheimer’s disease have been previously conducted (Ringman et al., 2007; Ryan et al., 2013; Parra et al., 2015; Sanchez-Valle et al., 2016).”

    From White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer’s disease (2018) · cites this paper as Parra et al., 2015

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Research works printed but not linked: 1

  1. Sumerall SW, Timmons PL, James AL, Ewing MJ, Oehlert ME. Expanded norms for the Controlled Oral Word Association Test. J Clin Psychol 1997; 53: 517-21.

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Authors
Parra, M. A., Saarimäki, H., Bastin, M. E., Londoño, A. C., Pettit, L., Lopera, F., Della Sala, S., & Abrahams, S.
Affiliations
  • National Health Service Scotland (GB)
  • University of Edinburgh (GB)
  • Universidad de Antioquia (CO)
ORCID
Venue
Brain
Publisher
Oxford University Press (OUP)
Published
2015-03-11
Volume
138
Issue
5
Pages
1355-1369
ISSN
  • 0006-8950 (ISSN-L)
  • 1460-2156
DOI
10.1093/brain/awv048
PMC
PMC5963407
OpenAlex
W2121091792
Cited by
79
References
118
Citations by year
2026: 5 · 2025: 5 · 2024: 3 · 2023: 9 · 2022: 3 · 2021: 9 · 2020: 11 · 2019: 7 · 2018: 9 · 2017: 5 · 2016: 12 · 2015: 1
FWCI
7.30
Type
journal article
Language
en
Open access
Locations
  • Brain (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Institutional Repository University of Antioquia (University of Antioquia) (publishedVersion, cc-by-nc)
  • Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
Funders
  • Departamento Administrativo de Ciencia, Tecnología e Innovación (COLCIENCIAS) (1115-408-20512, 1115-343-19127)
  • Alzheimer's Society (AS-R42303)
  • University of Edinburgh
  • Universidad de Antioquia
  • Centre for Cognitive Ageing and Cognitive Epidemiology
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
Keywords
memory binding, familial Alzheimer's disease, PSEN1 E280A mutation, white matter integrity, asymptomatic mutation carriers, short-term memory, long-term memory, paired-associate learning, corpus callosum, cingulum, frontal lobe, hippocampus, diffusion tensor imaging
MeSH terms
Adult, Aged, Alzheimer Disease, Brain Mapping, Female, Humans, Image Processing, Computer-Assisted, Male, Memory, Memory Disorders, Middle Aged, Mutation, Neuropsychological Tests, Diffusion Magnetic Resonance Imaging, White Matter

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