CoChat
Sign Up
Cited by 303

The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.

Hippocampal T cell infiltration promotes neuroinflammation and cognitive decline in a mouse model of tauopathy

Laurent, Cyril, Dorothée, Guillaume, Hunot, Stéphane, Martin, Elodie, Monnet, Yann, Duchamp, Marie, Dong, Yuan, Légeron, François-Pierre, Leboucher, Antoine, Burnouf, Sylvie, Faivre, Emilie, Carvalho, Kévin, Caillierez, Raphaëlle, Zommer, Nadège, Demeyer, Dominique, Jouy, Nathalie, Sazdovitch, Veronique, Schraen-Maschke, Susanna, Delarasse, Cécile, Buée, Luc, Blum, David·2017·Brain
DOI 10.1093/brain/aww270PMC PMC5382942
Open this paper in CoChat — free account

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1093/brain/aww270

Cites

15 of 15 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Exhausted activation of microglia is crucial to promoting T cell infiltration into the brain, which exacerbates neuroinflammation and neurodegeneration and impairs cognition, in two different mouse models of tauopathy (THY-tau22 and PS19 mice).

    “Recent reports in two different mouse models of tauopathy (THY-tau22 and PS19 mice) suggest that exhausted activation of microglia is crucial to promoting the T cell infiltration into the brain, which exacerbates neuroinflammation and neurodegeneration and impairs cognition (Laurent et al., 2017; Chen et al., 2023).”

    From Cholesterol 25-hydroxylase mediates neuroinflammation and neurodegeneration in a mouse model of tauopathy (2024) · cites this paper as Laurent et al., 2017

    The Discussion (page unavailable) reports microglial CCL3 production before T-cell infiltration in THY-Tau22 mice, but says it *could* contribute to recruitment; it does not establish that exhausted microglial activation is crucial. The Results, “T cell depletion restrains cognitive deficits in THY-Tau22 mice” (page unavailable), support a role for infiltrating T cells in neuroinflammation and cognitive decline. This paper studies THY-Tau22, not PS19, and its Discussion describes T-cell recruitment in the absence of neuronal death rather than showing that infiltration exacerbates neurodegeneration. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 55

  1. Ahmed, 2015, Rescue of impaired late-phase long-term depression in a tau transgenic mouse model, Neurobiol Aging, 36, 730, 10.1016/j.neurobiolaging.2014.09.015 · DOI
  2. 10.1038/nn.4132 · DOI · Paper page
  3. 10.1016/j.nbd.2011.04.022 · DOI
  4. 10.1016/S0002-9440(10)63421-9 · DOI
  5. 10.1159/000322228 · DOI
  6. 10.1186/s40478-015-0186-2 · DOI · Paper page
  7. 10.1097/NEN.0b013e318232a379 · DOI · Paper page
  8. 10.4049/jimmunol.1200947 · DOI
  9. 10.1093/hmg/ddv268 · DOI · Paper page
  10. 10.2174/156720512800492468 · DOI
  11. 10.1111/acel.12018 · DOI
  12. 10.1016/S0165-0270(96)00121-5 · DOI
  13. 10.1016/j.nbd.2008.12.015 · DOI
  14. 10.1093/brain/awv408 · DOI
  15. 10.1212/WNL.52.6.1158 · DOI · Paper page
  16. 10.1016/S0197-4580(97)80306-5 · DOI · Paper page
  17. 10.1016/j.nbd.2006.03.008 · DOI
  18. 10.4049/jimmunol.178.8.4865 · DOI
  19. 10.1084/jem.20070064 · DOI
  20. 10.3389/fpsyt.2010.00136 · DOI · Paper page
  21. 10.1016/S0197-4580(99)00063-9 · DOI
  22. 10.1007/s00441-012-1427-3 · DOI
  23. Jones, 2015, How dependent is synaptic plasticity on microglial phenotype?, Neuropharmacology, 96, 3, 10.1016/j.neuropharm.2014.08.012 · DOI
  24. 10.1007/s12026-012-8327-1 · DOI
  25. Lambert, 2010, Implication of the immune system in Alzheimer's disease: evidence from genome-wide pathway analysis, J Alzheimers Dis, 20, 1107, 10.3233/JAD-2010-100018 · DOI · Paper page
  26. 10.1016/j.neurobiolaging.2014.03.027 · DOI
  27. Laurent, 2016, A2A adenosine receptor deletion is protective in a mouse model of Tauopathy, Mol Psychiatry, 21, 97, 10.1038/mp.2014.151 · DOI
  28. 10.2337/db12-0866 · DOI
  29. 10.1016/j.tins.2013.01.008 · DOI
  30. 10.1016/j.neurobiolaging.2014.08.008 · DOI
  31. 10.1016/j.neurobiolaging.2006.02.013 · DOI
  32. Marciniak, 2015, The Chemokine MIP-1α/CCL3 impairs mouse hippocampal synaptic transmission, plasticity and memory, Sci Rep, 5, 15862, 10.1038/srep15862 · DOI · Paper page
  33. 10.1073/pnas.82.12.4245 · DOI · Paper page
  34. Minatohara, 2016, Role of immediate-early genes in synaptic plasticity and neuronal ensembles underlying the memory trace, Front Mol Neurosci, 8, 78, 10.3389/fnmol.2015.00078 · DOI
  35. 10.1172/JCI200318104 · DOI · Paper page
  36. 10.1073/pnas.0506209103 · DOI
  37. Papegaey, 2016, Reduced Tau protein expression is associated with frontotemporal degeneration with progranulin mutation, Acta Neuropathol Comm, 4, 74, 10.1186/s40478-016-0345-0 · DOI
  38. 10.1016/j.neuropharm.2014.12.020 · DOI
  39. 10.1016/j.mcn.2011.09.004 · DOI
  40. 10.1523/JNEUROSCI.4393-13.2014 · DOI
  41. 10.1016/S0197-4580(88)80079-4 · DOI · Paper page
  42. Rosset, 2015, Vaccine-induced Aβ-specific CD8+ T cells do not trigger autoimmune neuroinflammation in a murine model of Alzheimer's disease, J Neuroinflamm, 12, 95, 10.1186/s12974-015-0317-5 · DOI
  43. 10.1016/j.brainres.2008.02.084 · DOI
  44. Sauer, 2013, Axons are injured by antigen-specific CD8(+) T cells through a MHC class I- and granzyme B-dependent mechanism, Neurobiol Dis, 59, 194, 10.1016/j.nbd.2013.07.010 · DOI
  45. 10.2353/ajpath.2006.060002 · DOI
  46. 10.1586/14789450.5.2.207 · DOI · Paper page
  47. 10.1016/j.immuni.2013.02.012 · DOI · Paper page
  48. 10.1523/JNEUROSCI.2545-05.2005 · DOI
  49. 10.1016/S0165-5728(01)00496-9 · DOI · Paper page
  50. 10.1128/JVI.77.7.4004-4014.2003 · DOI
  51. 10.1016/j.nlm.2010.12.005 · DOI
  52. Van der Jeugd, 2013, Progressive age-related cognitive decline in tau mice, J Alzheimers Dis, 37, 777, 10.3233/JAD-130110 · DOI
  53. Vidal, 1990, Tissue-specific control elements of the Thy-1 gene, EMBO J, 9, 833, 10.1002/j.1460-2075.1990.tb08180.x · DOI
  54. 10.1172/JCI41911 · DOI
  55. 10.1093/brain/awt210 · DOI · Paper page

Cited by

Sorted by citations

Metadata

Authors
Laurent, C., Dorothée, G., Hunot, S., Martin, E., Monnet, Y., Duchamp, M., Dong, Y., Légeron, F.-P., Leboucher, A., Burnouf, S., Faivre, E., Carvalho, K., Caillierez, R., Zommer, N., Demeyer, D., Jouy, N., Sazdovitch, V., Schraen-Maschke, S., Delarasse, C., Buée, L., & Blum, D.
Venue
Brain
Publisher
Oxford University Press (OUP)
Published
2016-11-05
Volume
140
Issue
1
Pages
184-200
ISSN
  • 0006-8950
  • 1460-2156
DOI
10.1093/brain/aww270
PMC
PMC5382942
Cited by
303
References
15
Language
en

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review