Cited by 168Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchEpilepsy research and treatment

Senile plaques in temporal lobe epilepsy

Mackenzie, Ian R. A., Miller, Laurie A.·1994·Acta Neuropathologica

Abstract

Senile plaques (SP) are one of the characteristic pathological lesions of Alzheimer's disease (AD). They are also seen in the brains of some non-demented individuals as an age-related change. Identification of clinical conditions associated with these "incidental" SP could provide insight into AD pathogenesis. We have examined the presence of SP in lobectomy specimens (n = 101) removed in the surgical treatment of temporal lobe epilepsy (TLE). SP were present in 10 specimens from epileptic patients aged 36 to 61 years and the presence of SP correlated positively with patient age. No other significant AD-related pathology was identified and no patients showed any evidence of dementia on neuropsychological testing. When compared with temporal lobe tissue from non-demented, non-epileptic autopsy controls (n = 406), the density and distribution of SP was the same. The age-related incidence of SP however, was significantly greater in the epileptics. This suggests that some aspects of TLE has a positive influence on the formation of SP.

Integrity signals

Registry

Crossref · 10.1007/bf00294177

Cites

68 of 68 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Mackenzie, I. R. A., & Miller, L. A.
Affiliations
  • Western University (CA)
  • University Hospital (CA)
Corresponding author
Mackenzie, Ian R. A.
Venue
Acta Neuropathologica
Published
1994-05
Volume
87
Issue
5
Pages
504-510
ISSN
  • 0001-6322 (ISSN-L)
  • 1432-0533
OpenAlex
W2015490916
Cited by
168
References
68
Citations by year
2026: 3 · 2025: 5 · 2024: 7 · 2023: 5 · 2022: 8 · 2021: 7 · 2020: 8 · 2019: 6 · 2018: 9 · 2017: 9 · 2016: 7 · 2015: 11 · 2014: 8 · 2013: 5 · 2012: 11
FWCI
1.58
Type
journal article
Language
en
Open access
closed
Locations
  • Acta Neuropathologica (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
Keywords
amyloid plaques, temporal lobe epilepsy, Alzheimer's disease, incidental finding, brain aging, non-demented patients
MeSH terms
Adult, Aged, Aged, 80 and over, Aging, Brain, Epilepsy, Temporal Lobe, Humans, Middle Aged, Retrospective Studies, Neurofibrillary Tangles

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review