Senile plaques in temporal lobe epilepsy
Abstract
Senile plaques (SP) are one of the characteristic pathological lesions of Alzheimer's disease (AD). They are also seen in the brains of some non-demented individuals as an age-related change. Identification of clinical conditions associated with these "incidental" SP could provide insight into AD pathogenesis. We have examined the presence of SP in lobectomy specimens (n = 101) removed in the surgical treatment of temporal lobe epilepsy (TLE). SP were present in 10 specimens from epileptic patients aged 36 to 61 years and the presence of SP correlated positively with patient age. No other significant AD-related pathology was identified and no patients showed any evidence of dementia on neuropsychological testing. When compared with temporal lobe tissue from non-demented, non-epileptic autopsy controls (n = 406), the density and distribution of SP was the same. The age-related incidence of SP however, was significantly greater in the epileptics. This suggests that some aspects of TLE has a positive influence on the formation of SP.
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Epilepsy promotes plaque pathology.
“Hyperexcitability is present in AD brain [142] and epilepsy was shown to promote plaque pathology [110].”
From Intraneuronal β-amyloid accumulation and synapse pathology in Alzheimer’s disease (2010) · cites this paper as [110]
Cites
Glutamate neurotoxicity and diseases of the nervous system
Choi, D. W. (1988) · Neuron · doi:10.1016/0896-6273(88)90162-6 · Cited by 8,152 · see citing works
Glenner, G. G., & Wong, C. W. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(84)80190-4 · Cited by 5,404 · see citing works
Goate, A., Chartier-Harlin, M.-C., Mullan, M., Brown, J., Crawford, F., Fidani, L., Giuffra, L., Haynes, A., Irving, N., James, L., et al. (1991) · Nature · doi:10.1038/349704a0 · Cited by 4,659 · see citing works
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
Kang, J., Lemaire, H.-G., Unterbeck, A., Salbaum, J. M., Masters, C. L., Grzeschik, K.-H., Multhaup, G., Beyreuther, K., & Müller-Hill, B. (1987) · Nature · doi:10.1038/325733a0 · Cited by 4,619 · see citing works
Amyloid plaque core protein in Alzheimer disease and Down syndrome.
Masters, C. L., Simms, G., Weinman, N. A., Multhaup, G., McDonald, B. L., & Beyreuther, K. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.12.4245 · Cited by 4,431 · see citing works
The molecular pathology of Alzheimer's disease
Selkoe, D. J. (1991) · Neuron · doi:10.1016/0896-6273(91)90052-2 · Cited by 2,708 · see citing works
Observations on the brains of demented old people
Tomlinson, B. E., Blessed, G., & Roth, M. (1970) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(70)90063-8 · Cited by 2,084 · see citing works
Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides
Yankner, B. A., Duffy, L. K., & Kirschner, D. A. (1990) · Science · doi:10.1126/science.2218531 · Cited by 1,975 · see citing works
Excitatory amino acid neurotoxicity and neurodegenerative disease
Meldrum, B. S., & Garthwaite, J. (1990) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(90)90184-a · Cited by 1,774 · see citing works
Ben-Ari, Y. (1985) · Neuroscience · doi:10.1016/0306-4522(85)90299-4 · Cited by 1,753 · see citing works
Mattson, M. P., Cheng, B., Davis, D. G., Bryant, K., Lieberburg, I. M., & Rydel, R. E. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-02-00376.1992 · Cited by 1,627 · see citing works
Amyloid β Protein Gene: cDNA, mRNA Distribution, and Genetic Linkage Near the Alzheimer Locus
Tanzi, R. E., Gusella, J. F., Watkins, P. C., Bruns, G. A. P., St George-Hyslop, P., Van Keuren, M. L., Patterson, D., Pagan, S., Kurnit, D. M., & Neve, R. L. (1987) · Science · doi:10.1126/science.2949367 · Cited by 1,611 · see citing works
Cleavage of Amyloid β Peptide During Constitutive Processing of Its Precursor
Esch, F. S., Keim, P. S., Beattie, E. C., Blacher, R. W., Culwell, A. R., Oltersdorf, T., McClure, D., & Ward, P. J. (1990) · Science · doi:10.1126/science.2111583 · Cited by 1,403 · see citing works
Goldgaber, D., Lerman, M. I., McBride, O. W., Saffiotti, U., & Gajdusek, D. C. (1987) · Science · doi:10.1126/science.3810169 · Cited by 1,333 · see citing works
EPILEPSY AND THE TEMPORAL LOBES
Margerison, J. H., & Corsellis, J. (1966) · Brain · doi:10.1093/brain/89.3.499 · Cited by 1,260 · see citing works
Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity
Kitaguchi, N., Takahashi, Y., Tokushima, Y., Shiojiri, S., & Ito, H. (1988) · Nature · doi:10.1038/331530a0 · Cited by 1,083 · see citing works
Release of Excess Amyloid β Protein from a Mutant Amyloid β Protein Precursor
Cai, X.-D., Golde, T. E., & Younkin, S. G. (1993) · Science · doi:10.1126/science.8424174 · Cited by 913 · see citing works
Evidence that β-Amyloid Protein in Alzheimer's Disease Is Not Derived by Normal Processing
Sisodia, S. S., Koo, E. H., Beyreuther, K. T., Unterbeck, A., & Price, D. L. (1990) · Science · doi:10.1126/science.1691865 · Cited by 894 · see citing works
Price, J. L., Davis, P. B., Morris, J. C., & White, D. L. (1991) · Neurobiology of Aging · doi:10.1016/0197-4580(91)90006-6 · Cited by 818 · see citing works
Observations on the brains of non-demented old people
Tomlinson, B. E., Blessed, G., & Roth, M. (1968) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(68)90154-8 · Cited by 681 · see citing works
Amyloid A4 Protein and Its Precursor in Down's Syndrome and Alzheimer's Disease
Rumble, B. A., Retallack, R. W., Hilbich, C., Simms, G., Multhaup, G., Martins, R. N., Hockey, A., Montgomery, P., Beyreuther, K. T., & Masters, C. L. (1989) · New England Journal of Medicine · doi:10.1056/nejm198906013202203 · Cited by 652 · see citing works
Arriagada, P. V., Marzloff, K., & Hyman, B. T. (1992) · Neurology · doi:10.1212/wnl.42.9.1681 · Cited by 638 · see citing works
β-Amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage
Koh, J., Yang, L. L., & Cotman, C. W. (1990) · Brain Research · doi:10.1016/0006-8993(90)91355-k · Cited by 617 · see citing works
Robakis, N. K. R. K., Ramakrishna, N., Wolfe, G. C., & Wisniewski, H. M. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.12.4190 · Cited by 603 · see citing works
An in vivo model for the neurodegenerative effects of beta amyloid and protection by substance P.
Kowall, N. W., Beal, M. F., Busciglio, J. A., Duffy, L. K., & Yankner, B. A. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.16.7247 · Cited by 525 · see citing works
Excitatory amino acids and Alzheimer's disease
Greenamyre, J. T., & Young, A. B. (1989) · Neurobiology of Aging · doi:10.1016/0197-4580(89)90143-7 · Cited by 482 · see citing works
Mann, D. M. A., & Esiri, M. M. (1989) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(89)90019-1 · Cited by 471 · see citing works
A case‐control study of Alzheimer's disease in Australia
Broe, G. A., Henderson, A. S., Creasey, H. M., McCusker, E. A., Korten, A. E., Jorm, A. F., Longley, W. A., & Anthony, J. C. (1990) · Neurology · doi:10.1212/wnl.40.11.1698 · Cited by 446 · see citing works
Shivers, B. D., Hilbich, C., Multhaup, G., Salbaum, M., Beyreuther, K. T., & SEEBURG, P. H. (1988) · The EMBO Journal · doi:10.1002/j.1460-2075.1988.tb02952.x · Cited by 442 · see citing works
Golde, T. E., Estus, S., Usiak, M., Younkin, L. H., & Younkin, S. G. (1990) · Neuron · doi:10.1016/0896-6273(90)90100-t · Cited by 431 · see citing works
Potentially Amyloidogenic, Carboxyl-Terminal Derivatives of the Amyloid Protein Precursor
Estus, S., Golde, T. E., Kunishita, T., Blades, D. A., Lowery, D. E., Eisen, M., Usiak, M., QU, X., Tabira, T., Greenberg, B., et al. (1992) · Science · doi:10.1126/science.1738846 · Cited by 431 · see citing works
A4 amyloid protein deposition and the diagnosis of Alzheimer's disease
Davies, L., Wolska, B., Hilbich, C., Multhaup, G., Martins, R. N., Simms, G., Beyreuther, K. T., & Masters, C. L. (1988) · Neurology · doi:10.1212/wnl.38.11.1688 · Cited by 369 · see citing works
The pathological association between down syndrome and Alzheimer disease
Mann, D. M. A. (1988) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(88)90041-3 · Cited by 346 · see citing works
Down's Syndrome and Alzheimer's disease: a review
Oliver, C., & Holland, A. J. (1986) · Psychological Medicine · doi:10.1017/s0033291700009120 · Cited by 316 · see citing works
Naruse, S., Igarashi, S., Aoki, K., Kaneko, K., Iihara, K., Miyatake, T., Kobayashi, H., Inuzuka, T., Shimizu, T., Kojima, T., et al. (1991) · The Lancet · doi:10.1016/0140-6736(91)91612-x · Cited by 282 · see citing works
Cortical senile plaques in coronary artery disease, aging and Alzheimer's disease
Sparks, D. L., Hunsaker, J. C., Scheff, S. W., Kryscio, R. J., Henson, J. L., & Markesbery, W. R. (1990) · Neurobiology of Aging · doi:10.1016/0197-4580(90)90024-t · Cited by 271 · see citing works
Diffuse type of senile plaques in the brains of Alzheimer-type dementia
Yamaguchi, H., Hirai, S., Morimatsu, M., Shoji, M., & Harigaya, Y. (1988) · Acta Neuropathologica · doi:10.1007/bf00687420 · Cited by 235 · see citing works
Goedert, M. (1987) · The EMBO Journal · doi:10.1002/j.1460-2075.1987.tb02694.x · Cited by 222 · see citing works
ULRICH, J. (1985) · Annals of Neurology · doi:10.1002/ana.410170309 · Cited by 211 · see citing works
Abe, K., Tanzi, R. E., & Kogure, K. (1991) · Neuroscience Letters · doi:10.1016/0304-3940(91)90020-t · Cited by 205 · see citing works
Delaère, P., Duyckaerts, C., Masters, C., Beyreuther, K., Piette, F., & Hauw, J.-J. (1990) · Neuroscience Letters · doi:10.1016/0304-3940(90)90391-l · Cited by 186 · see citing works
Risk factors for Alzheimer's disease
Shalat, S. L., Seltzer, B., Pidcock, C., & Baker, E. L. (1987) · Neurology · doi:10.1212/wnl.37.10.1630 · Cited by 184 · see citing works
The Seminal Role of β-Amyloid in the Pathogenesis of Alzheimer Disease
Joachim, C. L., & Selkoe, D. J. (1992) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199205000-00003 · Cited by 181 · see citing works
Clinical risk factors for Alzheimer's disease
Kokmen, E., Beard, C. M., Chandra, V., OFFORD, K. P., Schoenberg, B. S., & Ballard, D. (1991) · Neurology · doi:10.1212/wnl.41.9.1393 · Cited by 170 · see citing works
Neuropathology of status epilepticus in humans.
Corsellis, J., & Cj, B. (1983) · PubMed · Cited by 156 · see citing works
Card, J. P., Meade, R. P., & Davis, L. G. (1988) · Neuron · doi:10.1016/0896-6273(88)90131-6 · Cited by 155 · see citing works
Tamaoka, A., Kalaria, R. N., Lieberburg, I. M., & Selkoe, D. J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.4.1345 · Cited by 143 · see citing works
Amyloid precursor protein gene mutation in early-onset Alzheimer's disease
Duijn, C. V., Hendriks, L., Cruts, M., Hardy, J., Albert Hofman, D., & Broeckhoven, C. V. (1991) · The Lancet · doi:10.1016/0140-6736(91)91611-w · Cited by 134 · see citing works
Motte, J., & Williams, R. S. (1989) · Acta Neuropathologica · doi:10.1007/bf00687256 · Cited by 126 · see citing works
van Duijn, C. M., & Stijnen, T. (1991) · International Journal of Epidemiology · doi:10.1093/ije/20.supplement_2.s4 · Cited by 124 · see citing works
Albert Hofman, D., Schulte, W., Tanja, T. A., van Duijn, C. M., Haaxma, R., Lameris, A. J., Otten, V. M., & Saan, R. J. (1989) · Neurology · doi:10.1212/wnl.39.12.1589 · Cited by 117 · see citing works
Nordstedt, C., Gandy, S., Alafuzoff, I. I., Caporaso, G. L., Iverfeldt, K., Grebb, J. A., Winblad, B. G., & Greengard, P. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.20.8910 · Cited by 105 · see citing works
Lin, T. H. (1971) · Journal of The Royal Naval Medical Service · doi:10.1136/jrnms-57-55b · Cited by 91 · see citing works
Robakis, N. K., Ramakrishna, N., Wolfe, G. C., & Wisniewski, H. M. (1988) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-198802020-00014 · Cited by 90 · see citing works
Yamaguchi, H., Haga, C., Hirai, S., Nakazato, Y., & Kosaka, K. (1990) · Acta Neuropathologica · doi:10.1007/bf00296119 · Cited by 86 · see citing works
The Dementia of Down's Syndrome and its Relevance to Aetiological Studies of Alzheimer's Disease
Whalley, L. J. (1982) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1982.tb26842.x · Cited by 86 · see citing works
MANN, D. M. A., TUCKER, C. M., & YATES, P. O. (1987) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1987.tb00176.x · Cited by 80 · see citing works
Zimmermann, K., Herget, T., Salbaum, J. M., SCHUBERT, W. J., Hilbich, C., Cramer, M., Masters, C. L., Multhaup, G., Kang, J., & Lemaire, H.-G. (1988) · The EMBO Journal · doi:10.1002/j.1460-2075.1988.tb02822.x · Cited by 77 · see citing works
Widespread expression of amyloid beta-protein precursor gene in rat brain.
Mita, S., Schon, E. A., & Herbert, J. (1989) · PubMed Central · Cited by 77 · see citing works
Induction of amyloid precursor protein mRNA after heat shock in cultured human lymphoblastoid cells
Abe, K., George‐Hyslop, P. S., Tanzi, R. E., & Kogure, K. (1991) · Neuroscience Letters · doi:10.1016/0304-3940(91)90019-p · Cited by 77 · see citing works
Effect of pre- and postmortem variables on specific mRNA levels in human brain
Burke, W. J., O’Malley, K. L., Chung, H. D., Harmon, S., Miller, J. P., & van den Berg, L. H. (1991) · Molecular Brain Research · doi:10.1016/0169-328x(91)90018-s · Cited by 71 · see citing works
Wakita, H., Tomimoto, H., Akiguchi, I., Ohnishi, K., Nakamura, S., & Kimura, J. (1992) · Neuroscience Letters · doi:10.1016/0304-3940(92)90061-b · Cited by 54 · see citing works
Mann, D. M. A., Jones, D., South, P. W., Snowden, J. S., & Neary, D. (1992) · Acta Neuropathologica · doi:10.1007/bf00713534 · Cited by 44 · see citing works
The neuropathology of temporal lobe epilepsy.
Corsellis, J. A. (1970) · PubMed · Cited by 27 · see citing works
βA4 deposition in the temporal cortex of adults with Down's syndrome
Spargo, E., Luthert, P. J., Janota, I., & Lantos, P. L. (1992) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(92)90108-w · Cited by 20 · see citing works
AMYLOID (A4) PROTEIN DEPOSITION IN BRAIN IN PROGRESSIVE SUPRANUCLEAR PALSY (PSP)
Tan, N., Mastaglia, F. L., Masters, C. L., Beyreuther, K. T., & Kakulas, B. A. (1988) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-198802030-00113 · Cited by 16 · see citing works
DEPOSITION OF AMYLOID (A4) PROTEIN IN THE CEREBRAL CORTEX IN PARKINSON??S DISEASE (PD)
Mastaglia, F. L., Masters, C. L., Beyreuther, K. T., & Kakulas, B. A. (1988) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-198802030-00094 · Cited by 7 · see citing works
FAMILIAL AND SPORADIC CEREBRAL AMYLOID ANGIOPATHY
Frangione, B. (1988) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-198802030-00103 · Cited by 3 · see citing works
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Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks
Palop, J. J., & Mucke, L. (2010) · Nature Neuroscience · doi:10.1038/nn.2583 · Cited by 1,651 · see citing works
Synaptic Activity Regulates Interstitial Fluid Amyloid-β Levels In Vivo
Cirrito, J. R., Yamada, K. A., Finn, M. B., Sloviter, R. S., Bales, K. R., May, P. C., Schoepp, D. D., Paul, S. M., Mennerick, S., & Holtzman, D. M. (2005) · Neuron · doi:10.1016/j.neuron.2005.10.028 · Cited by 1,265 · see citing works
Trafficking and Proteolytic Processing of APP
Haass, C., Kaether, C., Thinakaran, G., & Sisodia, S. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006270 · Cited by 1,075 · see citing works
Griffin, W. S. T., Sheng, J. G., Royston, M. C., Gentleman, S., McKenzie, J. E., Graham, D. I., Roberts, G. W., & Mrak, R. E. (1998) · Brain Pathology · doi:10.1111/j.1750-3639.1998.tb00136.x · Cited by 708 · see citing works
Endocytosis Is Required for Synaptic Activity-Dependent Release of Amyloid-β In Vivo
Cirrito, J. R., Kang, J.-E., Lee, J., Stewart, F. R., Verges, D. K., Silverio, L. M., Bu, G., Mennerick, S., & Holtzman, D. M. (2008) · Neuron · doi:10.1016/j.neuron.2008.02.003 · Cited by 635 · see citing works
Glia and their cytokines in progression of neurodegeneration
Mrak, R. E., & Griffin, W. S. T. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.05.010 · Cited by 592 · see citing works
Epileptic activity in Alzheimer’s disease: Causes and clinical relevance
Vossel, K. A., Tartaglia, M. C., Nygaard, H. B., Zeman, A. Z., & Miller, B. L. (2017) · The Lancet Neurology · doi:10.1016/s1474-4422(17)30044-3 · Cited by 590 · see citing works
O’Connor, T., Sadleir, K. R., Maus, E., Velliquette, R. A., Zhao, J., Cole, S. L., Eimer, W. A., Hitt, B. D., Bembinster, L. A., Lammich, S., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.047 · Cited by 422 · see citing works
Intraneuronal β-amyloid accumulation and synapse pathology in Alzheimer’s disease
Gouras, G. K., Tampellini, D., Takahashi, R. H., & Capetillo-Zarate, E. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0679-9 · Cited by 372 · see citing works
Interleukin-1, neuroinflammation, and Alzheimer's disease
Mrak, R. E. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00287-1 · Cited by 356 · see citing works
Jokeit, H., & Ebner, A.-S. (1999) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.67.1.44 · Cited by 314 · see citing works
Tai, X. Y., Koepp, M., Duncan, J. S., Fox, N., Thompson, P., Baxendale, S., Liu, J. Y. W., Reeves, C., Michalak, Z., & Thom, M. (2016) · Brain · doi:10.1093/brain/aww187 · Cited by 291 · see citing works
Cognition and dementia in older patients with epilepsy
Sen, A., Capelli, V., & Husain, M. (2018) · Brain · doi:10.1093/brain/awy022 · Cited by 280 · see citing works
Interleukin-1 mediates Alzheimer and Lewy body pathologies
Griffin, W. S. T., Liu, L., Li, Y., Mrak, R. E., & Barger, S. W. (2006) · Journal of Neuroinflammation · doi:10.1186/1742-2094-3-5 · Cited by 262 · see citing works
Griffin, W. S. T., & Mrak, R. E. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.72.2.233 · Cited by 248 · see citing works
Chronic Optogenetic Activation Augments Aβ Pathology in a Mouse Model of Alzheimer Disease
Yamamoto, K., Tanei, Z., Hashimoto, T., Wakabayashi, T., Okuno, H., Naka, Y., Yizhar, O., Fenno, L. E., Fukayama, M., Bito, H., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.04.017 · Cited by 225 · see citing works
Prevalence of Alzheimer plaques in AIDS
Esiri, M. M., Biddolph, S. C., & Morris, C. S. (1998) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.65.1.29 · Cited by 224 · see citing works
Zilberter, Y., & Zilberter, M. Y. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.24064 · Cited by 213 · see citing works
Palop, J. J., & Mucke, L. (2009) · NeuroMolecular Medicine · doi:10.1007/s12017-009-8097-7 · Cited by 177 · see citing works
Effects of chronic epilepsy on intellectual functions
Jokeit, H., & Ebner, A. (2002) · Progress in brain research · doi:10.1016/s0079-6123(02)35042-8 · Cited by 169 · see citing works
Thom, M., Liu, J. Y. W., Thompson, P., Phadke, R., Narkiewicz, M., Martinian, L., Marsdon, D., Koepp, M., Caboclo, L., Catarino, C. B., et al. (2011) · Brain · doi:10.1093/brain/awr209 · Cited by 167 · see citing works
Association Between Midlife Risk Factors and Late-Onset Epilepsy
Johnson, E. L., Krauss, G. L., Lee, A. K., Schneider, A. L. C., Dearborn, J. L., Kucharska‐Newton, A., Huang, J., Alonso, Á., & Gottesman, R. F. (2018) · JAMA Neurology · doi:10.1001/jamaneurol.2018.1935 · Cited by 166 · see citing works
Sleep Interacts with Aβ to Modulate Intrinsic Neuronal Excitability
Tabuchi, M., Lone, S. R., Liu, S., Liu, Q., Zhang, J., Spira, A. P., & Wu, M. N. (2015) · Current Biology · doi:10.1016/j.cub.2015.01.016 · Cited by 165 · see citing works
Tampellini, D., Capetillo‐Zarate, E., Dumont, M., Huang, Z., Yu, F., Lin, M. T. S., & Gouras, G. K. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3383-10.2010 · Cited by 161 · see citing works
Gourmaud, S., Shou, H., Irwin, D. J., Sansalone, K., Jacobs, L. M., Lucas, T. H., Marsh, E. D., Davis, K. A., Jensen, F. E., & Talos, D. M. (2020) · Brain · doi:10.1093/brain/awz381 · Cited by 155 · see citing works
Neurobehavioural comorbidities of epilepsy: towards a network-based precision taxonomy
Hermann, B. P., Struck, A. F., Busch, R. M., Reyes, A., Kaestner, E. J., & McDonald, C. R. (2021) · Nature Reviews Neurology · doi:10.1038/s41582-021-00555-z · Cited by 153 · see citing works
Is aging part of Alzheimer's disease, or is Alzheimer's disease part of aging?
Swerdlow, R. H. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.06.021 · Cited by 144 · see citing works
Tai, X. Y., Bernhardt, B. C., Thom, M., Thompson, P. J., Baxendale, S., Koepp, M. J., & Bernasconi, N. (2017) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12458 · Cited by 143 · see citing works
Biomarkers for Alzheimer's disease therapeutic trials
Hampel, H. J., Wilcock, G. K., Andrieu, S., Aisen, P. S. S., Blennow, K., Broich, K., Carrillo, M. C., Fox, N. C., Frisoni, G. B., Isaac, M., et al. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.11.005 · Cited by 137 · see citing works
Causes of Alzheimer's disease.
Muñoz, D. G., & Feldman, H. (2000) · PubMed Central · Cited by 136 · see citing works
Alzheimer's disease and late-onset epilepsy of unknown origin: two faces of beta amyloid pathology
Costa, C., Romoli, M., Liguori, C., Farotti, L., Eusebi, P., Bedetti, C., Siliquini, S., Cesarini, E. N., Romigi, A., Mercuri, N. B., et al. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.09.006 · Cited by 124 · see citing works
The galvanization of β-amyloid in Alzheimer's disease
Bush, A. I., & Tanzi, R. E. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122249699 · Cited by 122 · see citing works
Interleukin-1 and the Immunogenetics of Alzheimer Disease
Mrak, R. E., & Griffin, W. S. T. (2000) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/59.6.471 · Cited by 119 · see citing works
Herpes simplex virus type 1 and Alzheimer's disease: possible mechanisms and signposts
Itzhaki, R. F. (2017) · The FASEB Journal · doi:10.1096/fj.201700360 · Cited by 118 · see citing works
Copper, Zinc, and the Metallobiology of Alzheimer Disease
Bush, A. I. (2003) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-200307000-00005 · Cited by 117 · see citing works
In vivo characterization of the early states of the amyloid-beta network
Sepulcre, J., Sabuncu, M. R., Becker, A., Sperling, R., & Johnson, K. A. (2013) · Brain · doi:10.1093/brain/awt146 · Cited by 117 · see citing works
The lower hippocampus global connectivity, the higher its local metabolism in Alzheimer disease
Tahmasian, M., Pasquini, L., Scherr, M., Meng, C., Förster, S., Bratec, S. M., Shi, K., Yakushev, I. Y., Schwaiger, M., Grimmer, T., et al. (2015) · Neurology · doi:10.1212/wnl.0000000000001575 · Cited by 111 · see citing works
Regulation of astrocyte glutamine synthetase in epilepsy
Eid, T., Tu, N., Lee, T.-S. W., & Lai, J. C. K. (2013) · Neurochemistry International · doi:10.1016/j.neuint.2013.06.008 · Cited by 109 · see citing works
Stargardt, A., Swaab, D. F., & Bossers, K. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.08.014 · Cited by 109 · see citing works
Synaptic Dysfunction in Alzheimer’s Disease
Marcello, E. E., Epis, R., Saraceno, C., & Luca, M. D. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-3-7091-0932-8_25 · Cited by 107 · see citing works
Epileptic Seizures in Alzheimer Disease
Horvath, A. A., Szűcs, A., Barcs, G., Noebels, J. L., & Kamondi, A. (2016) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0000000000000134 · Cited by 107 · see citing works
Biomarkers in Sporadic and Familial Alzheimer’s Disease
Lista, S., O’Bryant, S. E., Blennow, K., Dubois, B., Hugon, J., Zetterberg, H., & Hampel, H. (2015) · Journal of Alzheimer's Disease · doi:10.3233/jad-143006 · Cited by 106 · see citing works
Genetic Landscape of Common Epilepsies: Advancing towards Precision in Treatment
Thakran, S., Guin, D., Singh, P., Singh, P., Kukal, S., Rawat, C., Yadav, S., Kushwaha, S. S., Srivastava, A. K., Hasija, Y., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207784 · Cited by 103 · see citing works
Neurochemical and morphological changes associated with human epilepsy
Glass, M., & Dragunow, M. (1995) · Brain Research Reviews · doi:10.1016/0165-0173(95)00005-n · Cited by 98 · see citing works
Circadian rhythms, aging and memory
Antoniadis, E. A., Ko, C. H., Ralph, M. R., & McDonald, R. J. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00290-4 · Cited by 99 · see citing works
Microtubule Dynamics in Neuronal Development, Plasticity, and Neurodegeneration
Penazzi, L., Bakota, L., & Brandt, R. (2015) · International review of cytology · doi:10.1016/bs.ircmb.2015.09.004 · Cited by 94 · see citing works
Hunsberger, H. C., Weitzner, D. S., Rudy, C. C., Hickman, J. E., Libell, E. M., Speer, R. R., Gerhardt, G. A., & Reed, M. N. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13230 · Cited by 87 · see citing works
Locus coeruleus, norepinephrine and Aβ peptides in Alzheimer's disease
Ross, J. A., McGonigle, P., & Bockstaele, E. J. V. (2015) · Neurobiology of Stress · doi:10.1016/j.ynstr.2015.09.002 · Cited by 85 · see citing works
Increased apolipoprotein E ϵ4 in epilepsy with senile plaques
Gouras, G. K., Relkin, N. R., Sweeney, D. A., Muñoz, D. G., Mackenzie, I. R., & Gandy, S. (1997) · Annals of Neurology · doi:10.1002/ana.410410317 · Cited by 85 · see citing works
Self-citationKeret, O., Hoang, T. D. M., Xia, F., Rosen, H. J., & Yaffe, K. S. (2020) · JAMA Neurology · doi:10.1001/jamaneurol.2020.0187 · Cited by 82 · see citing works
Sheng, J. G., Mrak, R. E., Bales, K. R., Cordell, B., Paul, S. M., Jones, R. A., Woodward, S., Zhou, X. Q., McGinness, J. M., & Griffin, W. S. T. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0740295.x · Cited by 82 · see citing works
Epilepsy and Alzheimer’s Disease: Potential mechanisms for an association
Giorgi, F. S., Saccaro, L. F., Busceti, C. L., Biagioni, F., & Fornai, F. (2020) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2020.04.009 · Cited by 76 · see citing works
Hermann, B. P., Seidenberg, M., Sager, M. A., Carlsson, C. M., Gidal, B. E., Sheth, R. D., Rutecki, P. A., & Asthana, S. (2007) · Epilepsia · doi:10.1111/j.1528-1167.2007.01435.x · Cited by 76 · see citing works
Association Between Childhood-Onset Epilepsy and Amyloid Burden 5 Decades Later
Joutsa, J., Rinne, J. O., Hermann, B. P., Karrasch, M., Anttinen, A., Shinnar, S., & Sillanpää, M. L. (2017) · JAMA Neurology · doi:10.1001/jamaneurol.2016.6091 · Cited by 75 · see citing works
Pitkänen, A., Laakso, M. P., Kälviäinen, R. K., Partanen, K. P. L., Vainio, P. A., Lehtovirta, M., Riekkinen, P. J., & Soininen, H. S. (1996) · Neurology · doi:10.1212/wnl.46.6.1724 · Cited by 73 · see citing works
Synapses, NMDA receptor activity and neuronal Aβ production in Alzheimer’s disease
Bordji, K., Becerril-Ortega, J., & Buisson, A. (2011) · Reviews in the Neurosciences · doi:10.1515/rns.2011.029 · Cited by 72 · see citing works
Paradigm Shifts in the Neuropsychology of Epilepsy
Hermann, B. P., Loring, D. W., & Wilson, S. J. (2017) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617717000650 · Cited by 69 · see citing works
Neuropathology and the Neuroinflammation Idea
Mrak, R. E. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1158 · Cited by 66 · see citing works
Osorio, R. S., Ducca, E. L., Wohlleber, M. E., Tanzi, E. B., Gumb, T., Twumasi, A., Tweardy, S., Lewis, C., Fischer, E., Koushyk, V., et al. (2016) · SLEEP · doi:10.5665/sleep.5846 · Cited by 64 · see citing works
Westmark, C. J. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.122 · Cited by 63 · see citing works
Yan, X.-X., Cai, Y., Shelton, J., Deng, S.-H., Luo, X.-G., Oddo, S., LaFerla, F. M., Cai, H., Rose, G. M., & Patrylo, P. R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048782 · Cited by 64 · see citing works
Marcello, E. E., Epis, R., & Luca, M. D. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.11.083 · Cited by 61 · see citing works
Alzheimer‘s Disease and Epilepsy: Insight From Animal Models
Scharfman, H. E. (2012) · Future Neurology · doi:10.2217/fnl.12.8 · Cited by 60 · see citing works
Neuronal Cyclin Expression in the Hippocampus in Temporal Lobe Epilepsy
Nagy, Z., & Esiri, M. M. (1998) · Experimental Neurology · doi:10.1006/exnr.1997.6753 · Cited by 60 · see citing works
ApoE Epsilon4 Allele and Disease Duration Affect Verbal Learning in Mild Temporal Lobe Epilepsy
Gambardella, A., Aguglia, U., Chifari, R., Labate, A., Manna, I., Serra, P., Romeo, N., Sibilia, G., Piane, E. L., Russa, A. L., et al. (2005) · Epilepsia · doi:10.1111/j.0013-9580.2005.15804.x · Cited by 60 · see citing works
Microglia in Alzheimer Brain: A Neuropathological Perspective
Mrak, R. E. (2012) · International Journal of Alzheimer s Disease · doi:10.1155/2012/165021 · Cited by 58 · see citing works
Alterations in hippocampal activity and Alzheimer’s disease.
Setti, S. E., Hunsberger, H. C., & Reed, M. N. (2017) · Translational Issues in Psychological Science · doi:10.1037/tps0000124 · Cited by 57 · see citing works
Tumor-associated epilepsy and glioma: Are there common genetic pathways?
Berntsson, S. G., Malmer, B., Bondy, M. L., Qu, M., & Smits, A. (2009) · Acta Oncologica · doi:10.1080/02841860903104145 · Cited by 56 · see citing works
Seizure in Alzheimer’s Disease: An Underestimated Phenomenon
Asadollahi, M., Atazadeh, M., & Noroozıan, M. (2018) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317518813551 · Cited by 54 · see citing works
Synapses, synaptic activity and intraneuronal Aβ in Alzheimer’s disease
Tampellini, D. (2010) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2010.00013 · Cited by 54 · see citing works
The role of mTORC1 activation in seizure-induced exacerbation of Alzheimer's disease
Gourmaud, S., Stewart, D. A., Irwin, D. J., Roberts, N., Barbour, A. J., Eberwine, G., O’Brien, W. T., Vassar, R. J., Talos, D. M., & Jensen, F. E. (2021) · Brain · doi:10.1093/brain/awab268 · Cited by 48 · see citing works
Circadian rhythms, aging and memory
Antoniadis, E. A., Ko, C. H., Ralph, M. R., & McDonald, R. J. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00145-5 · Cited by 51 · see citing works
The role of synaptic activity in the regulation of amyloid beta levels in Alzheimer's disease
Cheng, X., Wu, J., Geng, M., & Xiong, J. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.11.021 · Cited by 48 · see citing works
Hasegawa, H., Liu, L., Tooyama, I., Murayama, S., & Nishimura, M. (2014) · Nature Communications · doi:10.1038/ncomms4917 · Cited by 47 · see citing works
Rush, T., & Buisson, A. (2014) · Cell and Tissue Research · doi:10.1007/s00441-013-1789-1 · Cited by 47 · see citing works
The clinical correlation between Alzheimer's disease and epilepsy
Zhang, D., Chen, S., Xu, S., Wu, J., Zhuang, Y., Cao, W., Chen, X., & Li, X. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.922535 · Cited by 46 · see citing works
Diagnosing cognitive disorders in older adults with epilepsy
Reyes, A., Kaestner, E. J., Edmonds, E. C., Macari, A. C., Wang, Z. I., Drane, D. L., Punia, V., Busch, R. M., Hermann, B. P., McDonald, C. R., et al. (2020) · Epilepsia · doi:10.1111/epi.16780 · Cited by 43 · see citing works
Apolipoprotein E Polymorphisms and the Risk of Nonlesional Temporal Lobe Epilepsy
Gambardella, A., Aguglia, U., Cittadella, R., Romeo, N., Sibilia, G., Piane, E. L., Messina, D., Manna, I., Oliveri, R. L., Zappia, M., et al. (1999) · Epilepsia · doi:10.1111/j.1528-1157.1999.tb01602.x · Cited by 38 · see citing works
Hickman, L. B., Stern, J. M., Silverman, D. H. S., Salamon, N., & Vossel, K. A. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1241638 · Cited by 36 · see citing works
Association between APOE polymorphisms and mesial temporal lobe epilepsy with hippocampal sclerosis
Yenı, S. N., Özkara, Ç., Buyru, N., Baykara, O., Hanoğlu, L., Karaağaç, N., Özyurt, E., & Uzan, M. (2005) · European Journal of Neurology · doi:10.1111/j.1468-1331.2004.00956.x · Cited by 36 · see citing works
Similar brain proteomic signatures in Alzheimer’s disease and epilepsy
Leitner, D., Pires, G., Kavanagh, T., Kanshin, E., Askenazi, M., Ueberheide, B. M., Devinsky, O., Wısnıewskı, T., & Drummond, E. (2024) · Acta Neuropathologica · doi:10.1007/s00401-024-02683-4 · Cited by 35 · see citing works
APOE genetic associations with seizure development after severe traumatic brain injury
Miller, M. A., Conley, Y. P., Scanlon, J. M., Ren, D., Kamboh, M. I., Niyonkuru, C., & Wagner, A. K. (2010) · Brain Injury · doi:10.3109/02699052.2010.520299 · Cited by 35 · see citing works
Epilepsy: neuroinflammation, neurodegeneration, and APOE genotype
Aboud, O., Mrak, R. E., Boop, F. A., & Griffin, W. S. T. (2013) · Acta Neuropathologica Communications · doi:10.1186/2051-5960-1-41 · Cited by 37 · see citing works
Neuronal expression of ILEI/FAM3C and its reduction in Alzheimer’s disease
Liu, L., Watanabe, N., Akatsu, H., & Nishimura, M. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.05.050 · Cited by 34 · see citing works
Apolipoprotein E expression is elevated by interleukin 1 and other interleukin 1-induced factors
Liu, L., Aboud, O., Jones, R. A., Mrak, R. E., Griffin, W. S. T., & Barger, S. W. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-175 · Cited by 33 · see citing works
Carroll, C. M., & Macauley, S. L. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00258 · Cited by 32 · see citing works
Apolipoprotein epsilon 3 alleles are associated with indicators of neuronal resilience
Aboud, O., Mrak, R. E., Boop, F. A., & Griffin, S. T. (2012) · BMC Medicine · doi:10.1186/1741-7015-10-35 · Cited by 34 · see citing works
Risk Profiles of Alzheimer Disease
Bilbul, M., & Schipper, H. (2011) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100012129 · Cited by 33 · see citing works
Prospective neuropsychological assessment of nondemented patients with biopsy proven senile plaques
Mackenzie, I. R., McLachlan, R. S., Kubu, C. S., & Miller, L. A. (1996) · Neurology · doi:10.1212/wnl.46.2.425 · Cited by 32 · see citing works
Self-citationTen year cumulative incidence of dementia after late onset epilepsy of unknown etiology
Keret, O., Brauner, R., Benninger, F., & Glik, A. (2021) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2021.01.030 · Cited by 32 · see citing works
Nagappan-Chettiar, S., Johnson‐Venkatesh, E., & Umemori, H. (2016) · Neuroscience Research · doi:10.1016/j.neures.2016.12.003 · Cited by 31 · see citing works
Hyperphosphorylated Tau in Mesial Temporal Lobe Epilepsy: a Neuropathological and Cognitive Study
Toscano, E. C. D. B., Vieira, É. L. M., Grinberg, L. T., Rocha, N. P., Brant, J. A. S., Paradela, R. S., Giannetti, A. V., Suemoto, C. K., Leite, R. E. P., Nitríni, R., et al. (2023) · Molecular Neurobiology · doi:10.1007/s12035-022-03190-x · Cited by 31 · see citing works
BACE1 elevation is associated with aberrant limbic axonal sprouting in epileptic CD1 mice
Yan, X.-X., Cai, Y., Zhang, X.-M., Luo, X.-G., Cai, H., Rose, G. M., & Patrylo, P. R. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.01.003 · Cited by 29 · see citing works
Low prevalence of amyloid and tau pathology in drug-resistant temporal lobe epilepsy.
Silva, J. C., Vivash, L., Malpas, C. B., Hao, Y., McLean, C., Chen, Z., O'Brien, T. J., Jones, N. C., & Kwan, P. (2021) · Epilepsia · doi:10.1111/epi.17086 · Cited by 28 · see citing works
Kodam, A., Ourdev, D., Maulik, M., Hariharakrishnan, J., Banerjee, M., Yu⁃xiang, W. A. N. G., & Kar, S. (2018) · Brain Pathology · doi:10.1111/bpa.12617 · Cited by 27 · see citing works
Recent Insights on Glutamatergic Dysfunction in Alzheimer’s Disease and Therapeutic Implications
Pinky, P. D., Pfitzer, J. C., Senfeld, J. I., Hong, H., Bhattacharya, S., Suppiramaniam, V. D., Qureshi, I., & Reed, M. N. (2022) · The Neuroscientist · doi:10.1177/10738584211069897 · Cited by 26 · see citing works
Mrak, R. E., & Griffin, W. S. T. (1997) · Journal of NeuroVirology · doi:10.3109/13550289709029465 · Cited by 25 · see citing works
Alcantara‐Gonzalez, D., Villasana‐Salazar, B., & Peña‐Ortega, F. (2019) · Hippocampus · doi:10.1002/hipo.23129 · Cited by 23 · see citing works
Kotloski, R. J., Dowding, J., Hermann, B. P., & Sutula, T. P. (2019) · Handbook of clinical neurology · doi:10.1016/b978-0-12-804766-8.00025-x · Cited by 23 · see citing works
Aboud, O., Parcon, P. A., DeWall, K. M., Liu, L., Mrak, R. E., & Griffin, W. S. T. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00103 · Cited by 22 · see citing works
- Authors
- Mackenzie, I. R. A., & Miller, L. A.
- Affiliations
- Western University (CA)
- University Hospital (CA)
- Corresponding author
- Mackenzie, Ian R. A.
- Venue
- Acta Neuropathologica
- Published
- 1994-05
- Volume
- 87
- Issue
- 5
- Pages
- 504-510
- ISSN
- 0001-6322 (ISSN-L)
- 1432-0533
- OpenAlex
- W2015490916
- Cited by
- 168
- References
- 68
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 7 · 2023: 5 · 2022: 8 · 2021: 7 · 2020: 8 · 2019: 6 · 2018: 9 · 2017: 9 · 2016: 7 · 2015: 11 · 2014: 8 · 2013: 5 · 2012: 11
- FWCI
- 1.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Acta Neuropathologica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Keywords
- amyloid plaques, temporal lobe epilepsy, Alzheimer's disease, incidental finding, brain aging, non-demented patients
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aging, Brain, Epilepsy, Temporal Lobe, Humans, Middle Aged, Retrospective Studies, Neurofibrillary Tangles
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