Cited by 399Skin Protection and AgingTea Polyphenols and EffectsPhytochemicals and Antioxidant Activities

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Green tea polyphenol (-)-epigallocatechin-3-gallate treatment of human skin inhibits ultraviolet radiation-induced oxidative stress

Katiyar, S. K., Afaq, F., Perez, A., Mukhtar, H.·2001·Carcinogenesis

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Abstract

The use of naturally occurring botanicals with substantial antioxidant activity to afford protection to human skin against UV damage is receiving increasing attention. The green tea constituent (-)-epigallocatechin-3-gallate (EGCG) is a potent antioxidant and has shown remarkable preventive effects against photocarcinogenesis and phototoxicity in mouse models. In this study we have investigated the effects of topical application of EGCG, the major polyphenol present in green tea, to human skin before UV irradiation on UV-induced markers of oxidative stress and antioxidant enzymes. Using immunohistochemistry and analytical enzyme assays, we found that application of EGCG (mg/cm(2) skin) before a single UV exposure of 4x minimal erythema dose (MED) markedly decreases UV-induced production of hydrogen peroxide (68-90%, P < 0.025-0.005) and nitric oxide (30-100%, P < 0.025-0.005) in both epidermis and dermis in a time-dependent manner. EGCG pretreatment also inhibits UV-induced infiltration of inflammatory leukocytes, particularly CD11b(+) cells (a surface marker of monocytes/macrophages and neutrophils), into the skin, which are considered to be the major producers of reactive oxygen species. EGCG treatment was also found to inhibit UV-induced epidermal lipid peroxidation at each time point studied (41-84%, P < 0.05). A single UV exposure of 4x MED to human skin was found to increase catalase activity (109-145%) and decrease glutathione peroxidase (GPx) activity (36-54%) and total glutathione (GSH) level (13-36%) at different time points studied. Pretreatment with EGCG was found to restore the UV-induced decrease in GSH level and afforded protection to the antioxidant enzyme GPx. Further studies are warranted to study the preventive effects of EGCG against multiple exposures to UV light of human skin.

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Authors: Katiyar, S. K., Afaq, F., Perez, A., & Mukhtar, H.
Affiliations: University of Alabama at Birmingham (US)
ORCID: Katiyar, S. K.
Afaq, F.
Mukhtar, H.
Venue: Carcinogenesis
Publisher: Oxford University Press (OUP)
Published: 2001-02-01
Volume: 22
Issue: 2
Pages: 287-294
ISSN: 0143-3334 (ISSN-L)
1460-2180
DOI: 10.1093/carcin/22.2.287
OpenAlex: W2012908941
Cited by: 399
References: 53
Citations by year: 2026: 2 · 2025: 11 · 2024: 7 · 2023: 7 · 2022: 13 · 2021: 11 · 2020: 15 · 2019: 11 · 2018: 17 · 2017: 12 · 2016: 21 · 2015: 12 · 2014: 17 · 2013: 22 · 2012: 21
FWCI: 17.81
Type: journal article
Language: en
Open access: closed
Locations: Carcinogenesis (publishedVersion)
PubMed (publishedVersion)
Funders: Ohio Cancer Research Associates
U.S. Public Health Service
National Cancer Institute (R01CA 78809, R01CA078809)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (P30AR039750, P30 AR39750)
Topics: Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Life Sciences › Agricultural and Biological Sciences › Food Science › Tea Polyphenols and Effects
Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Keywords: epigallocatechin gallate, green tea polyphenols, ultraviolet radiation, skin photoprotection, oxidative stress, hydrogen peroxide, nitric oxide, lipid peroxidation, antioxidant enzymes, catalase, glutathione peroxidase, glutathione, topical application, phototoxicity
MeSH terms: Adult, Catalase, Catechin, Female, Glutathione, Glutathione Peroxidase, Humans, Hydrogen Peroxide, Immunoenzyme Techniques, Leukocytes, Male, Middle Aged, Nitric Oxide, Radiodermatitis, Skin, Tea, Time Factors, Ultraviolet Rays, Lipid Peroxidation, Free Radical Scavengers, Oxidative Stress

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Green tea polyphenol (-)-epigallocatechin-3-gallate treatment of human skin inhibits ultraviolet radiation-induced oxidative stress

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