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Cited by 222Hemispheric Asymmetry in NeuroscienceMedical and Biological SciencesAdvanced Neuroimaging Techniques and Applications

Hemispheric and Gender-related Differences in the Gross Morphology of the Anterior Cingulate/Paracingulate Cortex in Normal Volunteers: An MRI Morphometric Study

Yucel, M., Stuart, G. W., Maruff, P., Velakoulis, D., Crowe, S. F., Savage, G., Pantelis, C.·2001·Cerebral Cortex
DOI 10.1093/cercor/11.1.17
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Abstract

The sulci and gyri found within the anterior cingulate (AC), and across the cerebrum generally, have been found to vary in location and complexity from one individual to the next, making it difficult to analyze imaging data accurately and systematically. In this study, we examined the nature of morphometric variance in the AC of the left and right cerebral hemispheres using high-resolution structural magnetic resonance imaging (MRI) acquired from 176 healthy volunteers. Depending on the presence of a paracingulate sulcus (PCS) and its antero-posterior extent, three types of AC patterns were identified: 'prominent', 'present' and 'absent'. Hemispheric comparisons across the whole sample showed the PCS to be more commonly 'prominent' in the left hemisphere and more commonly 'absent' in the right hemisphere. There was a significant gender difference, such that males showed an asymmetric pattern characterized by increased fissurization of the left AC, while females showed greater symmetry, with less fissurization of the left AC. Overall cerebral morphology, namely hemispheric volume and hemispheric fissurization, were also measured and used as independent variables as well as covariates in the analyses in order to ascertain the specificity of the results regarding AC morphology. Results showed that cerebral volume for males was larger on the right than on the left while fissurization showed the reverse asymmetry of greater leftward fissurization. In contrast, females were symmetric in both respects. The findings regarding AC morphology could not be explained by differences in these overall cerebral measures or by differences in age and handedness within the population. The results suggest that in the normal male brain, there exist morphological asymmetries at both the global and local levels that are less apparent in the female brain. The findings have implications for future studies examining the organization, development and functional anatomy of the AC.

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Crossref · 10.1093/cercor/11.1.17

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  • Given the known variation in sulcal anatomy of this region in the human brain, it is reasonable to expect that some interindividual variation in cytoarchitectonic boundaries exists.

    “However, given the known variation in sulcal anatomy of this region in the human brain (Paus, Otaky, et al. 1996, Paus, Tomaiuolo, et al. 1996; Yucel et al. 2001; Fornito et al. 2004, 2006), it is reasonable to expect that some interindividual variation in cytoarchitectonic boundaries exists.”

    From Anatomical connectivity of the subgenual cingulate region targeted with deep brain stimulation for treatment-resistant depression (2008) · cites this paper as Yucel et al. 2001

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Authors
Yucel, M., Stuart, G. W., Maruff, P., Velakoulis, D., Crowe, S. F., Savage, G., & Pantelis, C.
Affiliations
  • Mental Health Research Institute (AU)
  • La Trobe University (AU)
  • The University of Melbourne (AU)
ORCID
Venue
Cerebral Cortex
Publisher
Oxford University Press (OUP)
Published
2001-01-01
Volume
11
Issue
1
Pages
17-25
ISSN
  • 1047-3211 (ISSN-L)
  • 1460-2199
DOI
10.1093/cercor/11.1.17
OpenAlex
W2161768943
Cited by
222
References
62
Citations by year
2026: 7 · 2025: 8 · 2024: 9 · 2023: 6 · 2022: 6 · 2021: 8 · 2020: 5 · 2019: 1 · 2018: 7 · 2017: 8 · 2016: 6 · 2015: 5 · 2014: 9 · 2013: 17 · 2012: 9
FWCI
5.77
Type
journal article
Language
en
Open access
closed
Locations
  • Cerebral Cortex (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Hemispheric Asymmetry in Neuroscience
  • Health Sciences › Medicine › Anatomy › Medical and Biological Sciences
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
Keywords
anterior cingulate cortex, paracingulate sulcus, hemispheric lateralization, sex differences, brain volume, sulcal morphology, brain structure
MeSH terms
Adolescent, Adult, Aged, Female, Gyrus Cinguli, Humans, Functional Laterality, Magnetic Resonance Imaging, Male, Middle Aged, Sex Factors

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