The DOI matches its Crossref record; 84 of the 84 references it cites were found in a registry or an index.
Representation of Pain and Somatic Sensation in the Human Insula: a Study of Responses to Direct Electrical Cortical Stimulation
Abstract
We studied painful and non-painful somaesthetic sensations elicited by direct electrical stimulations of the insular cortex performed in 43 patients with drug refractory temporal lobe epilepsy, using stereotactically implanted depth electrodes. Painful sensations were evoked in the upper posterior part of the insular cortex in 14 patients, mostly in the right hemisphere. Non-painful sensations were elicited in the posterior part of the insular cortex in 16 patients, in both hemispheres. Thus, painful and non-painful somaesthetic representations in the human insula overlap. Both types of responses showed a trend toward a somatotopic organization. These results agree with previous anatomical and unit recording studies in monkeys indicating a participation of the posterior part of the insular cortex in processing both noxious and innocuous somaesthetic stimuli. In humans, both a posterior and an anterior pain-related cortical area have been described within the insular cortex using functional imaging. Our results help to define the respective functional roles of these two insular areas. Finally, lateralization in the right hemisphere of sites where painful sensations were evoked is coherent with the hypothesis of a preponderant role of this hemisphere in species survival.
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Cites
Talairach, J., Tournoux, P., & Rayport, M. (1988) · Thieme eBooks · Cited by 5,058
PENFIELD, W., & BOLDREY, E. (1937) · Brain · doi:10.1093/brain/60.4.389 · Cited by 4,188
EPILEPSY AND THE FUNCTIONAL ANATOMY OF THE HUMAN BRAIN
Penfield, W., & Jasper, H. (1954) · Southern Medical Journal · doi:10.1097/00007611-195407000-00024 · Cited by 4,092
Pain Affect Encoded in Human Anterior Cingulate But Not Somatosensory Cortex
Rainville, P., Duncan, G. H., Price, D. D., Carrier, B., & Bushnell, M. C. (1997) · Science · doi:10.1126/science.277.5328.968 · Cited by 2,687
A cortical network for directed attention and unilateral neglect
Mesulam, M. ‐. (1981) · Annals of Neurology · doi:10.1002/ana.410100402 · Cited by 2,498 · cited 1×
“Furthermore, studies on cerebral lateralization have emphasized the fact that the right hemisphere is more involved in spatial as well as in attentional process and many aspects of emotion (Mesulam, 1981; Silberman and Weingartner, 1986; Gainotti, 1996).”
BackgroundFunctional imaging of brain responses to pain. A review and meta-analysis (2000)
Peyron, R., Laurent, B., & García-Larrea, L. (2000) · Neurophysiologie Clinique/Clinical Neurophysiology · doi:10.1016/s0987-7053(00)00227-6 · Cited by 2,171
Geschwind, N. (1985) · Archives of Neurology · doi:10.1001/archneur.1985.04060060019009 · Cited by 1,714
Cardiovascular effects of human insular cortex stimulation
Oppenheimer, S. M., Gelb, A., Girvin, J. P., & Hachinski, V. C. (1992) · Neurology · doi:10.1212/wnl.42.9.1727 · Cited by 1,272
Dissociating pain from its anticipation in the human brain
Ploghaus, A., Tracey, I., Gati, J. S., Clare, S., Menon, R. S., Matthews, P. M., & Rawlins, J. N. P. (1999) · Science · doi:10.1126/science.284.5422.1979 · Cited by 1,151
Thermosensory activation of insular cortex
Craig, A. D., Chen, K., Bandy, D., & Reiman, E. M. (2000) · Nature Neuroscience · doi:10.1038/72131 · Cited by 1,004
Cited by
Cognitive and emotional control of pain and its disruption in chronic pain
Bushnell, M. C., Čeko, M., & Low, L. A. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3516 · Cited by 2,076
The Neural Substrate of Human Empathy: Effects of Perspective-taking and Cognitive Appraisal
Lamm, C., Batson, C. D., & Decety, J. (2007) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2007.19.1.42 · Cited by 1,464
Kurth, F., Zilles, K., Fox, P. T., Laird, A. R., & Eickhoff, S. B. (2010) · Brain Structure and Function · doi:10.1007/s00429-010-0255-z · Cited by 1,293
Human empathy through the lens of social neuroscience.
Decety, J., & Lamm, C. (2006) · The Scientific World JOURNAL · doi:10.1100/tsw.2006.221 · Cited by 1,051
“This pattern of activation is also consistent with data collected using direct nonpainful and painful electrical stimulation of the insular cortex in neurological patients[29].”
ResultFunctional connectivity of the insula in the resting brain
Cauda, F., D'Agata, F., Sacco, K., Duca, S., Geminiani, G., & Vercelli, A. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2010.11.049 · Cited by 793
Metadata
- Authors
- Ostrowsky, K.
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-04-01
- Volume
- 12
- Issue
- 4
- Pages
- 376-385
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- OpenAlex
- W2126758870
- Cited by
- 573
- References
- 84
- FWCI
- 11.57
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ostrowsky, K. (2002). Representation of Pain and Somatic Sensation in the Human Insula: a Study of Responses to Direct Electrical Cortical Stimulation. Cerebral Cortex. https://doi.org/10.1093/cercor/12.4.376
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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