Functional connectivity of the insula in the resting brain
Open accessAbstract
The human insula is hidden in the depth of the cerebral hemisphere by the overlying frontal and temporal opercula, and consists of three cytoarchitectonically distinct regions: the anterior agranular area, posterior granular area, and the transitional dysgranular zone; each has distinct histochemical staining patterns and specific connectivity. Even though there are several studies reporting the functional connectivity of the insula with the cingulated cortex, its relationships with other brain areas remain elusive in humans. Therefore, we decided to use resting state functional connectivity to elucidate in details its connectivity, in terms of cortical and subcortical areas, and also of lateralization. We investigated correlations in BOLD fluctuations between specific regions of interest of the insula and other brain areas of right-handed healthy volunteers, on both sides of the brain. Our findings document two major complementary networks involving the ventral-anterior and dorsal-posterior insula: one network links the anterior insula to the middle and inferior temporal cortex and anterior cingulate cortex, and is primarily related to limbic regions which play a role in emotional aspects; the second links the middle-posterior insula to premotor, sensorimotor, supplementary motor and middle-posterior cingulate cortices, indicating a role for the insula in sensorimotor integration. The clear bipartition of the insula was confirmed by negative correlation analysis. Correlation maps are partially lateralized: the salience network, related to the ventral anterior insula, displays stronger connections with the anterior cingulate cortex on the right side, and with the frontal cortex on the left side; the posterior network has stronger connections with the superior temporal cortex and the occipital cortex on the right side. These results are in agreement with connectivity studies in primates, and support the use of resting state functional analysis to investigate connectivity in the living human brain.
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“…demonstrated that AIC and ACC are coactivated in various experimental paradigms (Critchley, 2004; Dosenbach et al., 2006; Craig, 2009; Medford and Critchley, 2010; Fan et al., 2011) as well as in resting states (Seeley et al., 2007; Britz et al., 2010; Cauda et al., 2011; Fan et al., 2012).”
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“Approaches investigating cortical sub-specialization capitalized on this type of inter-regional connectivity, such as for the successful parcellation of the premotor cortex (Kim et al., 2010), insular cortex (Cauda et al., 2011), and thalamus (Zhang et al., 2008).”
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Insular and hippocampal gray matter volume reductions in patients with major depressive disorder
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“Prior investigations of the insular cortex functional connectivity among healthy populations demonstrated that both the anterior insular cortex (including both ventral and dorsal anterior insula) were connected with cognitive control regions, including dorsal ACC and lateral PFC (Taylor et al., 2009; Cauda et al., 201…”
BackgroundStructural basis of empathy and the domain general region in the anterior insular cortex
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- Authors
- Cauda, F., D'Agata, F., Sacco, K., Duca, S., Geminiani, G., & Vercelli, A.
- Affiliations
- Ospedale Koelliker (IT)
- Corresponding author
- Cauda, Franco
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2011-03
- Volume
- 55
- Issue
- 1
- Pages
- 8-23
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W2028365182
- Semantic Scholar
- d771b8e432d85a5e8c1ba0104a7e3154ae59c570
- Cited by
- 793
- References
- 118
- Citations by year
- 2026: 25 · 2025: 27 · 2024: 67 · 2023: 39 · 2022: 42 · 2021: 59 · 2020: 59 · 2019: 65 · 2018: 56 · 2017: 61 · 2016: 59 · 2015: 63 · 2014: 61 · 2013: 45 · 2012: 44
- FWCI
- 21.14
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion, other-oa)
- Funders
- Regione Piemonte (4/2006)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- insula, resting-state functional connectivity, anterior insula, posterior insula, salience network, sensorimotor integration, anterior cingulate cortex, inferior temporal cortex, superior temporal cortex, hemispheric lateralization, limbic system
- MeSH terms
- Brain Mapping, Cerebral Cortex, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Net, Neural Pathways, Rest
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