The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Activation of the Human Orbitofrontal Cortex to a Liquid Food Stimulus is Correlated with its Subjective Pleasantness
Abstract
Single-neuron recording studies in non-human primates indicate that orbitofrontal cortex neurons represent the reward value of the sight, smell and taste of food, and even changes in the relative reward value, but provide no direct evidence on brain activity that is correlated with subjective reports of the pleasantness of food. In this fMRI investigation we report a significant correlation between the activation of a region of the human orbitofrontal cortex and the decrease in subjective pleasantness when a liquid food is eaten to satiety. Moreover, a cluster of voxels in the orbitofrontal cortex showed a decrease in its activation that was specific to the particular liquid food consumed in a meal, providing a neural correlate of sensory-specific satiety to a liquid whole food in humans. This sensory-specific reduction in activation of the orbitofrontal cortex correlating with subjective pleasantness is consistent with an important role for the orbitofrontal cortex in human emotion and motivation, and associated subjective states.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Watson and colleagues [334] outlined a framework delineating linkages between AN and reward-processing deficits. Their model stressed the highly social nature of eating, the overlapping reward circuitry of gustatory and social stimuli [335,336], and the tendency of individuals with AN to deprive themselves of pleasure.”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [335]
In the citing paper
“Similarly, subjective pleasantness in humans was coded by neural activity in the medial orbitofrontal cortex as measured by functional MRI (fMRI) and was subject to sensory-specific satiety, a form of reinforcer devaluation”
From Food reward, hyperphagia, and obesity (2011) · cites this paper as [100]
In the citing paper
“Diminished activity in the OFC has been found after a specific food item has been eaten to satiety, thereby decreasing its hedonic value and subjective pleasantness [25,26].”
From Social “wanting” dysfunction in autism: neurobiological underpinnings and treatment implications (2012) · cites this paper as [25]
Citations
Cites
A global optimisation method for robust affine registration of brain images
Jenkinson, M., & Smith, S. M. (2001) · Medical Image Analysis · doi:10.1016/s1361-8415(01)00036-6 · Cited by 7,018
Ongur, D. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.206 · Cited by 2,627
Abstract reward and punishment representations in the human orbitofrontal cortex
O'Doherty, J., Kringelbach, M. L., Rolls, E. T., Hornak, J., & Andrews, C. (2001) · Nature Neuroscience · doi:10.1038/82959 · Cited by 2,003
Self-citationThe Orbitofrontal Cortex and Reward
Rolls, E. T. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.284 · Cited by 1,595
Relative reward preference in primate orbitofrontal cortex
Tremblay, L., & Schultz, W. (1999) · Nature · doi:10.1038/19525 · Cited by 1,314
Rolls, E. T. (1998) · doi:10.1093/oso/9780198524649.001.0001 · Cited by 1,314
Changes in brain activity related to eating chocolate: From pleasure to aversion
Small, D. M. (2001) · Brain · doi:10.1093/brain/124.9.1720 · Cited by 1,179
Blood, A. J., Zatorre, R. J., Bermudez, P., & Evans, A. C. (1999) · Nature Neuroscience · doi:10.1038/7299 · Cited by 1,097
Reward processing in primate orbitofrontal cortex and basal ganglia
Schultz, W. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.272 · Cited by 942
Sensory specific satiety in man☆
Rolls, B. J., Rolls, E. T., Rowe, E. A., & Sweeney, K. F. (1981) · Physiology & Behavior · doi:10.1016/0031-9384(81)90310-3 · Cited by 884
Zald, D. H., & Pardo, J. V. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.8.4119 · Cited by 863
Representation of Pleasant and Aversive Taste in the Human Brain
O’Doherty, J. P., Rolls, E. T., Francis, S., Bowtell, R. W., & McGlone, F. P. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.85.3.1315 · Cited by 688
Functional localization and lateralization of human olfactory cortex
Zatorre, R. J., Jones‐Gotman, M., Evans, A. C., & Meyer, E. (1992) · Nature · doi:10.1038/360339a0 · Cited by 682
Variety in a meal enhances food intake in man.
Rolls, B., Rowe, E. A., Rolls, E., Kingston, B., Megson, A., & Gunary, R. (1981) · Physiology and Behavior · doi:10.1016/0031-9384(81)90014-7 · Cited by 621
Different representations of pleasant and unpleasant odours in the human brain
Rolls, E. T., Kringelbach, M. L., & de Araújo, I. E. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02779.x · Cited by 605
Self-citationBrain processing of visual sexual stimuli in human males
Redout�, J., Stol�ru, S., Gr�goire, M.-C., Costes, N., Cinotti, L., Lavenne, F., Bars, D. L., Forest, M. G., & Pujol, J. F. (2000) · Human Brain Mapping · doi:10.1002/1097-0193(200011)11:3 · Cited by 522
Sensory-specific satiety-related olfactory activation of the human orbitofrontal cortex
OʼDoherty, J., Rolls, E. T., Francis, S., Bowtell, R., McGlone, F., Kobal, G., Renner, B., & Ahne, G. (2000) · NeuroReport · doi:10.1097/00001756-200002070-00035 · Cited by 482
Critchley, H., & Rolls, E. T. (1996) · Journal of Neurophysiology · doi:10.1152/jn.1996.75.4.1673 · Cited by 467
Rolls, E. T., Sienkiewicz, Z. J., & Yaxley, S. (1989) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1989.tb00774.x · Cited by 466
Human cortical gustatory areas: A review of functional neuroimaging data
Small, D. M., Zald, D. H., Jones-Gotman, M., Zatorre, R. J., Pardo, J. V., Frey, S., & Petrides, M. (1999) · NeuroReport · doi:10.1097/00001756-199901180-00002 · Cited by 431
Francis, S., Rolls, E. T., Bowtell, R. W., McGlone, F. P., O’Doherty, J. P., Browning, A., Clare, S., & Smith, E. (1999) · Neuroreport · doi:10.1097/00001756-199902250-00003 · Cited by 421
How sensory properties of foods affect human feeding behavior
Rolls, B. J., Rowe, E. A., & Rolls, E. T. (1982) · Physiology & Behavior · doi:10.1016/0031-9384(82)90259-1 · Cited by 419
Aversive gustatory stimulation activates limbic circuits in humans
Zald, D. H. (1998) · Brain · doi:10.1093/brain/121.6.1143 · Cited by 385
Projections of thalamic gustatory and lingual areas in the monkey, Macaca fascicularis
Pritchard, T. C., Hamilton, R. B., Morse, J. R., & Norgren, R. (1986) · The Journal of Comparative Neurology · doi:10.1002/cne.902440208 · Cited by 292
The temporal response of the brain after eating revealed by functional MRI
Liu, Y., Gao, J., Liu, H., & Fox, P. T. (2000) · Nature · doi:10.1038/35016590 · Cited by 291
Olfactory Sensory-Specific Satiety in Humans
Rolls, E. T., & ROLLS, J. (1997) · Physiology & Behavior · doi:10.1016/s0031-9384(96)00464-7 · Cited by 284
Gustatory responses of single neurons in the caudolateral orbitofrontal cortex of the macaque monkey
Rolls, E. T., Yaxley, S., & Sienkiewicz, Z. J. (1990) · Journal of Neurophysiology · doi:10.1152/jn.1990.64.4.1055 · Cited by 282
Responses to the Sensory Properties of Fat of Neurons in the Primate Orbitofrontal Cortex
Rolls, E. T., Critchley, H. D., Browning, A. S., Hernadi, I., & Lenard, L. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-04-01532.1999 · Cited by 278
Activation of the human brain by monetary reward
Thut, G., Schultz, W., Roelcke, U., Nienhusmeier, M., Missimer, J. H., Maguire, R. P., & Leenders, K. L. (1997) · Neuroreport · doi:10.1097/00001756-199703240-00033 · Cited by 273
Burton, M. J., Rolls, E. T., & Mora, F. (1976) · Experimental Neurology · doi:10.1016/0014-4886(76)90189-8 · Cited by 252
Sensory-specific and motivation-specific satiety for the sight and taste of food and water in man
Rolls, E. T., Rolls, B. J., & Rowe, E. A. (1983) · Physiology & Behavior · doi:10.1016/0031-9384(83)90003-3 · Cited by 249
Gustatory responses in the frontal opercular cortex of the alert cynomolgus monkey
Scott, T. R., Yaxley, S., Sienkiewicz, Z. J., & Rolls, E. T. (1986) · Journal of Neurophysiology · doi:10.1152/jn.1986.56.3.876 · Cited by 227
Afferent connections of the caudolateral orbitofrontal cortex taste area of the primate
Baylis, L. L., Rolls, E. T., & Baylis, G. C. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00449-f · Cited by 217
Yaxley, S., Rolls, E. T., & Sienkiewicz, Z. J. (1988) · Physiology & Behavior · doi:10.1016/0031-9384(88)90074-1 · Cited by 206
Role of the hypothalamus in the regulation of food and water intake.
Grossman, S. P. (1975) · Psychology Review · doi:10.1037/0033-295x.82.3.200 · Cited by 193
Differential neural response to positive and negative feedback in planning and guessing tasks
Elliott, R., Frith, C., & Dolan, R. J. (1997) · Neuropsychologia · doi:10.1016/s0028-3932(97)00055-9 · Cited by 192
Rolls, E. T., Murzi, E., Yaxley, S., Thorpe, S. J., & Simpson, S. J. (1986) · Brain Research · doi:10.1016/0006-8993(86)91044-9 · Cited by 180
Coding and Monitoring of Motivational Context in the Primate Prefrontal Cortex
Watanabe, M., Hikosaka, K., Sakagami, M., & Shirakawa, S. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-06-02391.2002 · Cited by 159
Fast, Fully Automated Global and Local Magnetic Field Optimization for fMRI of the Human Brain
WILSON, J. L., Jenkinson, M., de Araújo, I., Kringelbach, M. L., Rolls, E. T., & Jezzard, P. (2002) · NeuroImage · doi:10.1006/nimg.2002.1172 · Cited by 144
Self-citationUnit study of exteroceptive inputs to claustrocortex in awake, sitting, squirrel monkey
Судаков, К. В., MacLean, P. D., Reeves, A. G., & Marino, R. (1971) · Brain Research · doi:10.1016/0006-8993(71)90521-x · Cited by 125
Central Taste Anatomy and Neurophysiology
Rolls, E. T., & Scott, T. R. (2003) · CRC Press eBooks · doi:10.1201/9780203911457-38 · Cited by 115
Clark, J. M., Clark, A. J. M., Bartle, A., & Winn, P. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90276-t · Cited by 30
Central Taste Anatomy and Neurophysiology
Scott, T. R., & Rolls, E. T. (2003) · CRC Press eBooks · doi:10.1201/9780203911457.ch33 · Cited by 17
Fast, Fully Automated Global and Local Magnetic Field Optimization for fMRI of the Human Brain
Wilson, J. (2002) · NeuroImage · doi:10.1016/s1053-8119(02)91172-9 · Cited by 16
Rempel-Clower, N. L., & Barbas, H. (1998) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19980831)398:3
Worsley (1996) · doi:10.1002/(sici)1097-0193(1996)4:1
Flagged first, then by citations
Cited by
Sorted by citations
Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications
Goldstein, R. Z., & Volkow, N. D. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3119 · Cited by 2,749
Central nervous system control of food intake and body weight
Morton, G. J., Cummings, D. E., Baskin, D. G., Barsh, G. S., & Schwartz, M. W. (2006) · Nature · doi:10.1038/nature05026 · Cited by 2,503
A framework for studying the neurobiology of value-based decision making
Rangel, A., Camerer, C., & Montague, P. R. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2357 · Cited by 2,184
The human orbitofrontal cortex: linking reward to hedonic experience
Kringelbach, M. L. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1747 · Cited by 2,180
Self-citationKRINGELBACH, M. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.03.006 · Cited by 1,977
Self-citation
Metadata
- Authors
- Kringelbach, M. L.
- Affiliations
- University of Oxford (GB)
- Corresponding author
- Kringelbach, M.L.
- ORCID
- Kringelbach, M.L.
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-10-01
- Volume
- 13
- Issue
- 10
- Pages
- 1064-1071
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- OpenAlex
- W1998712051
- Cited by
- 824
- References
- 46
- Citations by year
- 2026: 9 · 2025: 14 · 2024: 20 · 2023: 33 · 2022: 25 · 2021: 33 · 2020: 26 · 2019: 35 · 2018: 27 · 2017: 36 · 2016: 46 · 2015: 51 · 2014: 44 · 2013: 46 · 2012: 57
- FWCI
- 12.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cerebral Cortex (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- orbitofrontal cortex, sensory-specific satiety, food pleasantness, liquid foods, satiety, reward value, emotion and motivation
- MeSH terms
- Adult, Analysis of Variance, Brain Mapping, Feeding Behavior, Frontal Lobe, Humans, Male, Satiation, Smell, Taste, Visual Cortex
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review