Striatal ups and downs: Their roles in vulnerability to addictions in humans

Leyton, Marco; Vezina, Paul

doi:10.1016/j.neubiorev.2013.01.018

Cited by 165Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesGambling Behavior and Treatments

Striatal ups and downs: Their roles in vulnerability to addictions in humans

Open access

Leyton, Marco, Vezina, Paul·2013·Neuroscience & Biobehavioral Reviews

DOI 10.1016/j.neubiorev.2013.01.018PMC PMC3743927

Open this paper in CoChat — free account

Abstract

Susceptibility to addictive behaviors has been related to both increases and decreases in striatal function. Both profiles have been reported in humans as well as in animal models. Yet, the mechanisms underlying these opposing effects and the manner in which they relate to the behavioral development and expression of addiction remain unclear. In the present review of human studies, we describe a number of factors that could influence whether striatal hyper- or hypo-function is observed and propose a model that integrates the influence of these opposite responses on the expression of addiction related behaviors. Central to this model is the role played by the presence versus absence of addiction related cues and their ability to regulate responding to abused drugs and other rewards. Striatal function and incentive motivational states are increased in the presence of these cues and decreased in their absence. Alternations between these states might account for the progressive narrowing of interests as addictions develop and point to relevant processes to target in treatment.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.neubiorev.2013.01.018

Cites

288 of 288 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Significant methodological differences across studies (sample size, subject characteristics, alcohol dose, route of administration, and degree of naturalism to usual contexts) hamper direct comparisons to discern the source of the discrepancy.
“Significant methodological differences across studies, i.e., sample size, subject characteristics, alcohol dose, route of administration, and degree of naturalism to usual contexts(16, 83), hamper direct comparisons to discern the source of this discrepancy.”
From A Prospective 5-Year Re-examination of Alcohol Response in Heavy Drinkers Progressing in Alcohol Use Disorder (2016) · cites this paper as [83]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

A neural substrate of prediction and reward
Schultz, W., Dayan, P., & Montague, P. R. (1997) · Science · doi:10.1126/science.275.5306.1593 · Cited by 9,388 · see citing works
The neural basis of drug craving: An incentive-sensitization theory of addiction
Robinson, T. (1993) · Brain Research Reviews · doi:10.1016/0165-0173(93)90013-p · Cited by 7,346 · see citing works
Autoradiographic localization of dopamine D1 and D2 receptors in rat nucleus accumbens: Resistance to differential rearing conditions
Bardo, M. T., & Hammer, R. P. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90226-e · Cited by 3,229 · see citing works
Handbook of Psychopharmacology
Iversen, L. L., Iversen, S. D., & Snyder, S. H. (1988) · Springer eBooks · doi:10.1007/978-1-4613-0933-8 · Cited by 2,755 · see citing works
Drug abuse: hedonic homeostatic dysregulation
Koob, G. F., & Moal, M. L. (1997) · Science · doi:10.1126/science.278.5335.52 · Cited by 2,535 · see citing works
Anticipation of Increasing Monetary Reward Selectively Recruits Nucleus Accumbens
Knutson, B., Adams, C. M., Fong, G. W., & Hommer, D. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-16-j0002.2001 · Cited by 2,244 · see citing works
Enduring changes in brain and behavior produced by chronic amphetamine administration: A review and evaluation of animal models of amphetamine psychosis
Robinson, T. G., & BECKER, J. (1986) · Brain Research · doi:10.1016/s0006-8993(86)80193-7 · Cited by 2,110 · see citing works
Dissociable Roles of Ventral and Dorsal Striatum in Instrumental Conditioning
O'Doherty, J., Dayan, P., Schultz, J., Deichmann, R., Friston, K., & Dolan, R. J. (2004) · Science · doi:10.1126/science.1094285 · Cited by 2,088 · see citing works
Discrete coding of reward probability and uncertainty by dopamine neurons
Fiorillo, C. D., Tobler, P. N., & Schultz, W. (2003) · Science · doi:10.1126/science.1077349 · Cited by 2,085 · see citing works
The Structure of Common Mental Disorders
Krueger, R. F. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.10.921 · Cited by 1,881 · see citing works
The structure of genetic and environmental risk factors for common psychiatric and substance use disorders in men and women
Kendler, K. S., Prescott, C. A., Myers, J., & Neale, M. C. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.9.929 · Cited by 1,868 · see citing works
Enduring changes in brain and behavior produced by chronic amphetamine administration: A review and evaluation of animal models of amphetamine psychosis
Robinson, T. E., & Becker, J. B. (1986) · Brain Research Reviews · doi:10.1016/0165-0173(86)90002-0 · Cited by 1,796 · see citing works
Meta‐analysis of cue‐reactivity in addiction research
Carter, B. L., & Tiffany, S. T. (1999) · Addiction · doi:10.1046/j.1360-0443.1999.9433273.x · Cited by 1,638 · cited 2× · see citing works
“In substance abusers, exposure to stimulant drug associated cues elicits a wide range of subjective, behavioral and physiological responses (Carter and Tiffany, 1999; Childress et al., 1988; O’Brien et al., 1990).”
A cognitive model of drug urges and drug-use behavior: role of automatic and nonautomatic processes
Tiffany, S. T. (1990) · Psychological Review · doi:10.1037/0033-295x.97.2.147 · Cited by 1,554 · see citing works
Addiction
Robinson, T. E., & Berridge, K. C. (2003) · Annual Review of Psychology · doi:10.1146/annurev.psych.54.101601.145237 · Cited by 1,509 · see citing works
The Neuroscience of Natural Rewards: Relevance to Addictive Drugs
Kelley, A. E., & Berridge, K. C. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03306.2002 · Cited by 1,465 · see citing works
Alterations in dopaminergic and glutamatergic transmission in the induction and expression of behavioral sensitization: a critical review of preclinical studies
Vanderschuren, L. J. M. J., & Kalivas, P. W. (2000) · Psychopharmacology · doi:10.1007/s002130000493 · Cited by 1,337 · see citing works
A Meta-Analytic Review of Psychosocial Interventions for Substance Use Disorders
Dutra, L., Stathopoulou, G., Basden, S. L., Leyro, T. M., Powers, M. B., & Otto, M. W. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.06111851 · Cited by 1,287 · see citing works
Earlier development of the accumbens relative to orbitofrontal cortex might underlie risk-taking behavior in adolescents.
Galvan, A., Hare, T. A., Parra, C. E., Penn, J., Voss, H., Glover, G., & Casey, B. J. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1062-06.2006 · Cited by 1,282 · see citing works
Evidence for striatal dopamine release during a video game
Koepp, M. J., Gunn, R. N., Lawrence, A. D., Cunningham, V. J., Dagher, A., Jones, T., Brooks, D. J., Bench, C. J., & Grasby, P. M. (1998) · Nature · doi:10.1038/30498 · Cited by 1,279 · see citing works
Changes in brain activity related to eating chocolate: From pleasure to aversion
Small, D. M. (2001) · Brain · doi:10.1093/brain/124.9.1720 · Cited by 1,179 · cited 2× · see citing works
“…addition to monetary reward, healthy human subjects have been reported to show striatal activations following exposure to cues associated with food (Small et al., 2001; Beaver et al., 2006; Hommer et al., 2012; Demos et al., 2012; Tang et al., 2012), sex (Hamann et al., 2004; Cloutier et al.,…”
Cocaine cues and dopamine in dorsal striatum: mechanism of craving in cocaine addiction
Volkow, N. D., Wang, G.-J., Telang, F., Fowler, J. S., Logan, J., Childress, A.-R., Jayne, M., Ma, Y., & Wong, C. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1544-06.2006 · Cited by 1,164 · see citing works
Role of unconditioned and conditioned drug effects in the self-administration of opiates and stimulants.
Stewart, J., de Wit, H., & Eikelboom, R. (1984) · Psychological Review · doi:10.1037//0033-295x.91.2.251 · Cited by 1,064 · see citing works
Role of unconditioned and conditioned drug effects in the self-administration of opiates and stimulants.
Stewart, J., de Wit, H., & Eikelboom, R. (1984) · Psychological Review · doi:10.1037/0033-295x.91.2.251 · Cited by 1,062 · see citing works
A selective role for dopamine in stimulus-reward learning
Flagel, S. B., Clark, J. J., Robinson, T. E., Mayo, L., Czuj, A., Willuhn, I., Akers, C. A., Clinton, S. M., Phillips, P. E. M., & Akil, H. (2011) · Nature · doi:10.1038/nature09588 · Cited by 1,026 · see citing works
A time of change: behavioral and neural correlates of adolescent sensitivity to appetitive and aversive environmental cues
Somerville, L. H., Jones, R. M., & Casey, B. J. (2010) · Brain and Cognition · doi:10.1016/j.bandc.2009.07.003 · Cited by 1,025 · see citing works
Neuropsychopharmacology: The Fifth Generation of Progress
Sagduyu, K. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.7.1251-a · Cited by 1,023 · see citing works
Incubation of cocaine craving after withdrawal
Grimm, J. W., Hope, B. T., Wise, R. A., & Shaham, Y. (2001) · Nature · doi:10.1038/35084134 · Cited by 1,003 · see citing works
Imaging Synaptic Neurotransmission with in Vivo Binding Competition Techniques: A Critical Review
Laruelle, M. (2000) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200003000-00001 · Cited by 944 · see citing works
Cue-induced cocaine craving: neuroanatomical specificity for drug users and drug stimuli
Garavan, H., Pankiewicz, J., Bloom, A., Cho, J.-K., Sperry, L., Ross, T. J., Salmeron, B. J., Risinger, R., Kelley, D., & Stein, E. A. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.11.1789 · Cited by 931 · see citing works
Reinstatement of cocaine-reinforced responding in the rat
de Wit, H., & Stewart, J. (1981) · Psychopharmacology · doi:10.1007/bf00432175 · Cited by 928 · see citing works
Decreased striatal dopaminergic responsiveness in detoxified cocaine-dependent subjects
Volkow, N. D., Wang, G.-J., Fowler, J. S., Logan, J., Gatley, S. J., Hitzemann, R., Chen, A. D., Dewey, S. L., & Pappas, N. (1997) · Nature · doi:10.1038/386830a0 · Cited by 854 · see citing works
A Randomized, Controlled Trial of Financial Incentives for Smoking Cessation
Volpp, K. G., Troxel, A. B., Pauly, M. V., Glick, H. A., Puig, A., Asch, D. A., Galvin, R., Zhu, J., Wan, F., DeGuzman, J., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmsa0806819 · Cited by 836 · see citing works
Familial Transmission of Substance Use Disorders
Merikangas, K. R., Stolar, M., Stevens, D. E., Goulet, J., Preisig, M. A., Fenton, B., Zhang, H., O'Malley, S. S., & Rounsaville, B. J. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.11.973 · Cited by 783 · see citing works
Functional magnetic resonance imaging of reward prediction
Knutson, B., & Cooper, J. C. (2005) · Current Opinion in Neurology · doi:10.1097/01.wco.0000173463.24758.f6 · Cited by 736 · see citing works
Pathological gambling is linked to reduced activation of the mesolimbic reward system
Reuter, J., Raedler, T., Rose, M., Hand, I., Gläscher, J., & Büchel, C. (2005) · Nature Neuroscience · doi:10.1038/nn1378 · Cited by 734 · see citing works
Co-occurrence of Abuse of Different Drugs in Men: The Role of Drug-Specific and Shared Vulnerabilities
Tsuang, M. T., Lyons, M. J., Meyer, J. M., Doyle, T., Eisen, S. A., Goldberg, J., True, W., Lin, N., Toomey, R., & Eaves, L. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.11.967 · Cited by 710 · see citing works
Unconscious affective reactions to masked happy versus angry faces influence consumption behavior and judgments of value.
Winkielman, P., Berridge, K. C., & Wilbarger, J. L. (2005) · Personality and Social Psychology Bulletin · doi:10.1177/0146167204271309 · Cited by 708 · see citing works
From prediction error to incentive salience: mesolimbic computation of reward motivation.
Berridge, K. C. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.07990.x · Cited by 700 · see citing works
Meta‐analysis of drug‐related deaths soon after release from prison
Merrall, E. L. C., Kariminia, A., Binswanger, I. A., HOBBS, M. S. T., Farrell, M., Marsden, J., Hutchinson, S. J., & Bird, S. M. (2010) · Addiction · doi:10.1111/j.1360-0443.2010.02990.x · Cited by 689 · see citing works
Conditioning factors in drug abuse: can they explain compulsion?
O’Brien, C. P., Childress, A. R., Ehrman, R. N., & Robbins, S. J. (1998) · Journal of Psychopharmacology · doi:10.1177/026988119801200103 · Cited by 680 · see citing works
Regulating the interpersonal self: Strategic self-regulation for coping with rejection sensitivity.
Ayduk, O., Mendoza-Denton, R., Mischel, W., Downey, G., Peake, P. K., & Rodriguez, M. (2000) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.79.5.776 · Cited by 669 · see citing works
Neurobehavioral disinhibition in childhood predicts early age at onset of substance use disorder
Tarter, R. E., Kirisci, L., Mezzich, A., Cornelius, J. R., Pajer, K., Vanyukov, M., Gardner, W., Blackson, T., & Clark, D. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.6.1078 · Cited by 655 · see citing works
Dynamics of Drug Dependence
Wikler, A. (1973) · Archives of General Psychiatry · doi:10.1001/archpsyc.1973.01750350005001 · Cited by 650 · see citing works
The neurocircuitry of impaired insight in drug addiction
Goldstein, R. Z., Craig, A. D. (., Bechara, A., Garavan, H., Childress, A. R., Paulus, M. P., & Volkow, N. D. (2009) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2009.06.004 · Cited by 641 · see citing works
Amygdala and nucleus accumbens in responses to receipt and omission of gains in adults and adolescents.
Ernst, M., Nelson, E. E., Jazbec, S., McClure, E. B., Monk, C. S., Leibenluft, E., Blair, J., & Pine, D. S. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2004.12.038 · Cited by 635 · see citing works
Feeding-induced dopamine release in dorsal striatum correlates with meal pleasantness ratings in healthy human volunteers
Small, D. M., Jones-Gotman, M., & Dagher, A. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00253-2 · Cited by 632 · see citing works
Men and women differ in amygdala response to visual sexual stimuli
Hamann, S., Herman, R. A., Nolan, C. L., & Wallen, K. (2004) · Nature Neuroscience · doi:10.1038/nn1208 · Cited by 603 · see citing works
A meta-analytic investigation of the relationship between attentional bias and subjective craving in substance abuse
Field, M., Munafò, M. R., & Franken, I. H. A. (2009) · Psychological Bulletin · doi:10.1037/a0015843 · Cited by 602 · see citing works
Dopaminergic Network Differences in Human Impulsivity
Buckholtz, J. W., Treadway, M. T., Cowan, R. L., Woodward, N. D., Li, R., Ansari, M. S., Baldwin, R. M., Schwartzman, A. N., Shelby, E. S., Smith, C. E., et al. (2010) · Science · doi:10.1126/science.1185778 · Cited by 600 · see citing works
Cue-induced activation of the striatum and medial prefrontal cortex is associated with subsequent relapse in abstinent alcoholics
Gr�sser, S. M., Wrase, J., Klein, S., Hermann, D., Smolka, M. N., Ruf, M., Weber-Fahr, W., Flor, H., Mann, K., Braus, D. F., et al. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1828-4 · Cited by 598 · see citing works
Individual Differences in Reward Drive Predict Neural Responses to Images of Food
Beaver, J. D., Lawrence, A. D., van Ditzhuijzen, J., Davis, M. H., Woods, A., & Calder, A. J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.0350-06.2006 · Cited by 594 · see citing works
Alcohol promotes dopamine release in the human nucleus accumbens
Boileau, I., Assaad, J., Pihl, R. O., Benkelfat, C., Leyton, M., Diksic, M., Tremblay, R. E., & Dagher, A. (2003) · Synapse · doi:10.1002/syn.10226 · Cited by 591 · see citing works
Self-citation
Incentive-elicited brain activation in adolescents: Similarities and differences from young adults
Bjork, J. M., Knutson, B., Fong, G. W., Caggiano, D. M., Bennett, S. M., & Hommer, D. W. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.4862-03.2004 · Cited by 567 · see citing works
Evidence that ‘food addiction’ is a valid phenotype of obesity
Davis, C. A., Curtis, C., Levitan, R. D., Carter, J. C., Kaplan, A. S., & Kennedy, J. L. (2011) · Appetite · doi:10.1016/j.appet.2011.08.017 · Cited by 539 · see citing works
Differential Brain Activity in Alcoholics and Social Drinkers to Alcohol Cues: Relationship to Craving
Myrick, H., Anton, R. F., Li, X., Henderson, S., Drobes, D., Voronin, K., & George, M. S. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300295 · Cited by 521 · see citing works
The Addiction-Stroop test: Theoretical considerations and procedural recommendations.
Cox, W. M., Fadardi, J. S., & Pothos, E. M. (2006) · Psychological Bulletin · doi:10.1037/0033-2909.132.3.443 · Cited by 517 · see citing works
Sensitization of midbrain dopamine neuron reactivity and the self-administration of psychomotor stimulant drugs
Vezina, P. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2003.11.001 · Cited by 515 · see citing works
Self-citation
Increased striatal dopamine release in Parkinsonian patients with pathological gambling: a [11C] raclopride PET study
Steeves, T. D. L., Miyasaki, J., Zurowski, M., Lang, A. E., Pellecchia, G., Van Eimeren, T., Rusjan, P., Houle, S., & Strafella, A. P. (2009) · Brain · doi:10.1093/brain/awp054 · Cited by 502 · see citing works
Mesolimbic dopamine reward system hypersensitivity in individuals with psychopathic traits
Buckholtz, J. W., Treadway, M. T., Cowan, R. L., Woodward, N. D., Benning, S. D., Li, R., Ansari, M. S., Baldwin, R. M., Schwartzman, A. N., Shelby, E. S., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2510 · Cited by 497 · see citing works
Mesolimbic Functional Magnetic Resonance Imaging Activations during Reward Anticipation Correlate with Reward-Related Ventral Striatal Dopamine Release
Schott, B. H., Minuzzi, L., Krebs, R. M., Elmenhorst, D., Lang, M., Winz, O. H., Seidenbecher, C. I., Coenen, H. H., Heinze, H.-J., Zilles, K., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2058-08.2008 · Cited by 496 · see citing works
Profound decreases in dopamine release in striatum in detoxified alcoholics: possible orbitofrontal involvement
Volkow, N. D., Wang, G.-J., Telang, F., Fowler, J. S., Logan, J., Jayne, M., Ma, Y., Pradhan, K., & Wong, C. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3371-07.2007 · Cited by 494 · see citing works
Dysfunction of reward processing correlates with alcohol craving in detoxified alcoholics
Wrase, J., Schlagenhauf, F., Kienast, T., Wüstenberg, T., Bermpohl, F., Kahnt, T., Beck, A., Ströhle, A., Juckel, G., Knutson, B. D., et al. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2006.11.043 · Cited by 480 · see citing works
The phenomenology of experimentally induced amphetamine psychosis--preliminary observations.
ANGRIST, B. M., & Gershon, S. (1970) · PubMed · Cited by 477 · see citing works
Amphetamine-induced increases in extracellular dopamine, drug wanting, and novelty seeking: a PET/[11C] raclopride study in healthy men
Leyton, M. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(02)00366-4 · Cited by 476 · see citing works
Self-citation
Compulsive drug use linked to sensitized ventral striatal dopamine transmission.
Evans, A. H., Pavese, N., Lawrence, A. D., Tai, Y. F., Appel, S., Doder, M., Brooks, D. J., Lees, A. J., & Piccini, P. (2006) · Annals of Neurology · doi:10.1002/ana.20822 · Cited by 473 · see citing works
Obesity and the brain: how convincing is the addiction model?
Ziauddeen, H., Farooqi, I. S., & Fletcher, P. C. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3212 · Cited by 462 · see citing works
Ventral striatal activation during reward anticipation correlates with impulsivity in alcoholics
Beck, A., Schlagenhauf, F., Wüstenberg, T., Hein, J., Kienast, T., Kahnt, T., Schmack, K., Hägele, C., Knutson, B., Heinz, A., et al. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.04.035 · Cited by 461 · see citing works
Food and drug cues activate similar brain regions: A meta-analysis of functional MRI studies
Tang, D., Fellows, L. K., Small, D. M., & Dagher, A. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2012.03.009 · Cited by 457 · see citing works
Time course of transient behavioral depression and persistent behavioral sensitization in relation to regional brain monoamine concentrations during amphetamine withdrawal in rats.
Paulson, P. E., Camp, D. M., & Robinson, T. E. (1991) · Psychopharmacology · doi:10.1007/bf02244248 · Cited by 455 · see citing works
“Nonhedonic” food motivation in humans involves dopamine in the dorsal striatum and methylphenidate amplifies this effect
Volkow, N. D., Wang, G., Fowler, J. S., Logan, J., Jayne, M., Franceschi, D., Wong, C., Gatley, S. J., Gifford, A. N., Ding, Y., et al. (2002) · Synapse · doi:10.1002/syn.10075 · Cited by 452 · see citing works
Similarities and differences between pathological gambling and substance use disorders: a focus on impulsivity and compulsivity
Leeman, R. F., & Potenza, M. N. (2012) · Psychopharmacology · doi:10.1007/s00213-011-2550-7 · Cited by 448 · see citing works
Alcohol dependence is associated with blunted dopamine transmission in the ventral striatum
Martinez, D., Gil, R., Slifstein, M., Hwang, D.-R., Huang, Y., Perez, A., Kegeles, L., Talbot, P., Evans, S., Krystal, J., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.04.044 · Cited by 445 · see citing works
Dissociation in Conditioned Dopamine Release in the Nucleus Accumbens Core and Shell in Response to Cocaine Cues and during Cocaine-Seeking Behavior in Rats
Ito, R., Dalley, J. W., Howes, S. R., Robbins, T. W., & Everitt, B. J. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-19-07489.2000 · Cited by 441 · see citing works
Control of cocaine-seeking behavior by drug-associated stimuli in rats: Effects on recovery of extinguished operant-responding and extracellular dopamine levels in amygdala and nucleus accumbens
Weiss, F., Maldonado-Vlaar, C. S., Parsons, L. H., Kerr, T. M., Smith, D. L., & Ben‐Shahar, O. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.8.4321 · Cited by 416 · see citing works
The familial aggregation of common psychiatric and substance use disorders in the national comorbidity survey: A family history study
Kendler, K. S., Davis, C. G., & Kessler, R. C. (1997) · British Journal of Psychiatry · doi:10.1192/bjp.170.6.541 · Cited by 412 · see citing works
Individual differences in nucleus accumbens activity to food and sexual images predict weight gain and sexual behavior
Demos, K. E., Heatherton, T. F., & Kelley, W. M. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.5958-11.2012 · Cited by 410 · see citing works
Immaturities in reward processing and its influence on inhibitory control in adolescence.
Geier, C. F., Terwilliger, R., Teslovich, T., Velanova, K., & Luna, B. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhp225 · Cited by 396 · see citing works
Prelude to Passion: Limbic Activation by “Unseen” Drug and Sexual Cues
Childress, A. R., Ehrman, R. N., Wang, Z., Li, Y., Sciortino, N., Hakun, J. G., Jens, W., Suh, J. J., Listerud, J., Marquez, K., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001506 · Cited by 395 · see citing works
RECENT PROGRESS IN RESEARCH ON THE NEUROPHYSIOLOGIC BASIS OF MORPHINE ADDICTION
Wikler, A. (1948) · American Journal of Psychiatry · doi:10.1176/ajp.105.5.329 · Cited by 394 · see citing works
Dopaminergic mechanisms of individual differences in human effort-based decision-making
Treadway, M. T., Buckholtz, J. W., Cowan, R. L., Woodward, N. D., Li, R., Ansari, M. S., Baldwin, R. M., Schwartzman, A. N., Kessler, R. M., & Zald, D. H. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.6459-11.2012 · Cited by 385 · see citing works
Activation of Prefrontal Cortex and Anterior Thalamus in Alcoholic Subjects on Exposure to Alcohol-Specific Cues
George, M. S., Anton, R. F., Bloomer, C., Tenebäck, C. C., Drobes, D. J., Lorberbaum, J. P., Nahas, Z. H., & Vincent, D. J. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.4.345 · Cited by 382 · see citing works
A learning model of binge eating: Cue reactivity and cue exposure
Jansen, A. T. M. (1998) · Behaviour Research and Therapy · doi:10.1016/s0005-7967(98)00055-2 · Cited by 377 · see citing works
Clinical effectiveness of attentional bias modification training in abstinent alcoholic patients
Schoenmakers, T. M., de Bruin, M., Lux, I. F. M., Goertz, A. G., Van Kerkhof, D. H. A. T., & Wiers, R. W. (2010) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2009.11.022 · Cited by 373 · see citing works
Cue Reactivity and Cue Reactivity Interventions in Drug Dependence
Childress, A. R., Hole, A. V., Ehrman, R. N., Robbins, S. J., McLellan, A. T., & O’Brien, C. P. (1993) · PsycEXTRA Dataset · doi:10.1037/e495912006-006 · Cited by 368 · see citing works
Sensitization in the Nervous System
Barnes, C. D. (2024) · CRC Press eBooks · doi:10.1201/9781003575955 · Cited by 361 · see citing works
Conditioning of drug-induced physiological responses.
Eikelboom, R., & Stewart, J. (1982) · Psychological Review · doi:10.1037/0033-295x.89.5.507 · Cited by 360 · see citing works
A developmental neurobiological model of motivated behavior: Anatomy, connectivity and ontogeny of the triadic nodes
Ernst, M., & Fudge, J. L. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.10.009 · Cited by 358 · see citing works
Initial, habitual and compulsive alcohol use is characterized by a shift of cue processing from ventral to dorsal striatum
Vollstädt‐Klein, S., Wichert, S., Rabinstein, J., Bühler, M., Klein, O., Ende, G., Hermann, D., & Mann, K. (2010) · Addiction · doi:10.1111/j.1360-0443.2010.03022.x · Cited by 357 · see citing works
Handbook of Functional Neuroimaging of Cognition
Bucks, R. S. (2002) · UWA Profiles and Research Repository (University of Western Australia) · Cited by 356 · see citing works
The Experimental Reproduction of Amphetamine Psychosis
Bell, D. S. (1973) · Archives of General Psychiatry · doi:10.1001/archpsyc.1973.04200010020003 · Cited by 355 · see citing works
Amphetamine-induced dopamine release: markedly blunted in cocaine dependence and predictive of the choice to self-administer cocaine
Martinez, D., Narendran, R., Foltin, R. W., Slifstein, M., Hwang, D.-R., Broft, A., Huang, Y., Cooper, T. B., Fischman, M. W., Kleber, H. D., et al. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.4.622 · Cited by 351 · see citing works
Effects of Expectation on Placebo-Induced Dopamine Release in Parkinson Disease
Lidstone, S. C., Schulzer, M., Dinelle, K., Mak, E., Sossi, V., Ruth, T. J., de la Fuente‐Fernández, R., Phillips, A. G., & Stoessl, A. J. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.88 · Cited by 325 · see citing works
The neural basis of drug stimulus processing and craving: an activation likelihood estimation meta-analysis
Chase, H. W., Eickhoff, S. B., Laird, A. R., & Hogarth, L. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.05.025 · Cited by 316 · see citing works
Enhanced Striatal Dopamine Release During Food Stimulation in Binge Eating Disorder
Wang, G., Geliebter, A., Volkow, N. D., Telang, F. W., Logan, J., Jayne, M. C., Galanti, K., Selig, P. A., Han, H., Zhu, W., et al. (2011) · Obesity · doi:10.1038/oby.2011.27 · Cited by 313 · see citing works
Response Perseveration and Ventral Prefrontal Sensitivity to Reward and Punishment in Male Problem Gamblers and Smokers
de Ruiter, M. B., Veltman, D. J., Goudriaan, A. E., Oosterlaan, J., Sjoerds, Z., & van den Brink, W. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.175 · Cited by 313 · see citing works
Increased Occupancy of Dopamine Receptors in Human Striatum during Cue-Elicited Cocaine Craving
Wong, D. F., Kuwabara, H., Schretlen, D. J., Bonson, K. R., Zhou, Y., Nandi, A., Brašić, J. R., Kimes, A. S., Maris, M. A., Kumar, A., et al. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301194 · Cited by 311 · see citing works
Modeling Sensitization to Stimulants in Humans: An [ 11 C]Raclopride/Positron Emission Tomography Study in Healthy Men
Boileau, I., Dagher, A., Leyton, M., Gunn, R. N., Baker, G. B., Diksic, M., & Benkelfat, C. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.12.1386 · Cited by 305 · see citing works
Self-citation
Diminished Frontostriatal Activity During Processing of Monetary Rewards and Losses in Pathological Gambling
Balodis, I. M., Kober, H., Worhunsky, P. D., Stevens, M. C., Pearlson, G. D., & Potenza, M. N. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.01.006 · Cited by 305 · see citing works
Sensitization to the psychomotor stimulant effects of amphetamine: Modulation by associative learning.
Anagnostaras, S., & Robinson, T. E. (1996) · Behavioral Neuroscience · doi:10.1037//0735-7044.110.6.1397 · Cited by 302 · see citing works
Sensitization to the psychomotor stimulant effects of amphetamine: modulation by associative learning
Anagnostaras, S. G., & Robinson, T. E. (1996) · Behavioral Neuroscience · doi:10.1037/0735-7044.110.6.1397 · Cited by 302 · see citing works
Real-Time Electronic Diary Reports of Cue Exposure and Mood in the Hours Before Cocaine and Heroin Craving and Use
Epstein, D. H., Willner‐Reid, J., Vahabzadeh, M., Mezghanni, M., Lin, J., & Preston, K. L. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2008.509 · Cited by 301 · see citing works
Cue-induced striatal dopamine release in Parkinson's disease-associated impulsive-compulsive behaviours
O'Sullivan, S. S., Wu, K., Politis, M., Lawrence, A. D., Evans, A. H., Bose, S. K., Djamshidian, A., Lees, A. J., & Piccini, P. (2011) · Brain · doi:10.1093/brain/awr003 · Cited by 297 · see citing works
Integrating systematic cue exposure with standard treatment in recovering drug dependent patients
O'Brien, C. P., Childress, A. R., McLellan, T. A., & Ehrman, R. N. (1990) · Addictive Behaviors · doi:10.1016/0306-4603(90)90045-y · Cited by 295 · see citing works
Rewards, aversions and affect in adolescence: emerging convergences across laboratory animal and human data
Spear, L. P. (2011) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2011.08.001 · Cited by 292 · see citing works
Neural Correlates of Stress-Induced and Cue-Induced Drug Craving: Influences of Sex and Cocaine Dependence
Potenza, M. N., Hong, K., Lacadie, C., Fulbright, R. K., Tuit, K. L., & Sinha, R. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.11020289 · Cited by 288 · see citing works
Classically Conditioned Responses in Opioid and Cocaine Dependence: A Role in Relapse?
Childress, A. R., McLellan, A. T., Ehrman, R. N., & O’Brien, C. P. (1988) · PsycEXTRA Dataset · doi:10.1037/e496602006-002 · Cited by 288 · see citing works
AMPHETAMINE PSYCHOSIS
ELLINWOOD, E. H. (1967) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-196704000-00005 · Cited by 286 · see citing works
Reversing the sequence: Reducing alcohol consumption by overcoming alcohol attentional bias
Fadardi, J. S., & Cox, W. M. (2009) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2008.11.015 · Cited by 282 · see citing works
Evidence That Methylphenidate Enhances the Saliency of a Mathematical Task by Increasing Dopamine in the Human Brain
Volkow, N. D., Wang, G.-J., Fowler, J. S., Telang, F., Maynard, L., Logan, J., Gatley, S. J., Pappas, N., Wong, C., Vaska, P., et al. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.7.1173 · Cited by 281 · see citing works
Amphetamine Psychosis
Bartosik, V. (2008) · Encyclopedia of Special Education · doi:10.1002/9780470373699.speced0124 · Cited by 280 · see citing works
Are Attractive People Rewarding? Sex Differences in the Neural Substrates of Facial Attractiveness
Cloutier, J., Heatherton, T. F., Whalen, P. J., & Kelley, W. M. (2008) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2008.20062 · Cited by 279 · see citing works
Time-Dependent Changes in Cocaine-Seeking Behavior and Extracellular Dopamine Levels in the Amygdala during Cocaine Withdrawal
Tran-Nguyen, L. T. L. (1998) · Neuropsychopharmacology · doi:10.1016/s0893-133x(97)00205-4 · Cited by 278 · see citing works
Priming effects with drugs and other reinforcers.
de Wit, H. (1996) · Experimental and Clinical Psychopharmacology · doi:10.1037/1064-1297.4.1.5 · Cited by 272 · see citing works
Binge Eating Disorder and Food Addiction
Gearhardt, A. N., White, M. A., & Potenza, M. N. (2011) · Current Drug Abuse Reviews · doi:10.2174/1874473711104030201 · Cited by 272 · see citing works
Dextroamphetamine
Griffith, J. D. (1972) · Archives of General Psychiatry · doi:10.1001/archpsyc.1972.01750200001001 · Cited by 270 · see citing works
Exposure to the Taste of Alcohol Elicits Activation of the Mesocorticolimbic Neurocircuitry
Filbey, F. M., Claus, E., Audette, A. R., Niculescu, M., Banich, M. T., Tanabe, J., Du, Y. P., & Hutchison, K. E. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301513 · Cited by 270 · see citing works
Amphetamine administered to the ventral tegmental area but not to the nucleus accumbens sensitizes rats to systemic morphine: lack of conditioned effects
Vezina, P., & Stewart, J. (1990) · Brain Research · doi:10.1016/0006-8993(90)90902-n · Cited by 253 · see citing works
Self-citation
Self-rating of alcohol intoxication by young men with and without family histories of alcoholism.
Schuckit, M. A. (1980) · Journal of Studies on Alcohol · doi:10.15288/jsa.1980.41.242 · Cited by 251 · see citing works
Identifying Neurobiological Phenotypes Associated with Alcohol Use Disorder Severity
Claus, E. D., Ewing, S. W. F., Filbey, F. M., Sabbineni, A., & Hutchison, K. E. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.99 · Cited by 249 · see citing works
The reinforcing and subjective effects of morphine in post-addicts: a dose-response study.
Lamb, R. J., Preston, K. L., Schindler, C. W., Meisch, R. A., Davis, F., Katz, J. L., Henningfield, J. E., & Goldberg, S. R. (1991) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)20504-3 · Cited by 245 · see citing works
Cytochrome P450 enzymes in the brain: emerging evidence of biological significance
Ferguson, C. S., & Tyndale, R. F. (2011) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2011.08.005 · Cited by 241 · see citing works
Dopamine Transmission in the Human Striatum during Monetary Reward Tasks
Zald, D. H., Boileau, I., El-Dearedy, W., Gunn, R., McGlone, F., Dichter, G. S., & Dagher, A. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.4643-03.2004 · Cited by 238 · see citing works
The cue-availability paradigm: The effects of cigarette availability on cue reactivity in smokers.
Carter, B. L., & Tiffany, S. T. (2001) · Experimental and Clinical Psychopharmacology · doi:10.1037//1064-1297.9.2.183 · Cited by 233 · see citing works
Altered Neural Reward Representations in Pathological Gamblers Revealed by Delay and Probability Discounting
Miedl, S. F. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.1552 · Cited by 229 · see citing works
Validation of a system of classifying female substance abusers on the basis of personality and motivational risk factors for substance abuse.
Conrod, P., Pihl, R. O., Stewart, S. H., & Dongier, M. (2000) · Psychology of Addictive Behaviors · doi:10.1037//0893-164x.14.3.243 · Cited by 226 · see citing works
Dopamine increases in striatum do not elicit craving in cocaine abusers unless they are coupled with cocaine cues
Volkow, N. D., Wang, G.-J., Telang, F., Fowler, J. S., Logan, J., Childress, A.-R., Jayne, M., Ma, Y., & Wong, C. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2007.09.059 · Cited by 224 · see citing works
Conditioned Dopamine Release in Humans: A Positron Emission Tomography [ 11 C]Raclopride Study with Amphetamine
Boileau, I., Dagher, A., Leyton, M., Welfeld, K., Booij, L., Diksic, M., & Benkelfat, C. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4370-06.2007 · Cited by 222 · see citing works
Self-citation
Relapse of Paranoid Psychotic State in Methamphetamine Model of Schizophrenia
Sato, M., Numachi, Y., & Hamamura, T. (1992) · Schizophrenia Bulletin · doi:10.1093/schbul/18.1.115 · Cited by 222 · see citing works
Lower Ventral Striatal Activation During Reward Anticipation in Adolescent Smokers
Peters, J., Bromberg, U., Schneider, S., Brassen, S., Menz, M., Banaschewski, T., Conrod, P. J., Flor, H., Gallinat, J., Garavan, H., et al. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.10071024 · Cited by 218 · see citing works
Attentional bias training and cue reactivity in cigarette smokers
Attwood, A. S., O’Sullivan, H. L., Leonards, U., Mackintosh, B., & Munafo, M. R. (2008) · Addiction · doi:10.1111/j.1360-0443.2008.02335.x · Cited by 215 · see citing works
Decreased dopamine activity predicts relapse in methamphetamine abusers
Wang, G. J., Smith, L., Volkow, N. D., Telang, F., Logan, J., Tomasi, D., Wong, C. T., Hoffman, W., Jayne, M., Alia-Klein, N., et al. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.86 · Cited by 214 · see citing works
Imaging dopamine transmission in cocaine dependence: link between neurochemistry and response to treatment
Martinez, D., Carpenter, K. M., Liu, F., Slifstein, M., Broft, A., Friedman, A. C., Kumar, D., Van Heertum, R., Kleber, H. D., & Nunes, E. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.10050748 · Cited by 212 · see citing works
Mesolimbic dopamine release is linked to symptom severity in pathological gambling
Joutsa, J., Johansson, J., Niemelä, S., Ollikainen, A., Hirvonen, M. M., Piepponen, P., Arponen, E., Alho, H., Voon, V., Rinne, J. O., et al. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.02.006 · Cited by 209 · see citing works
Sensitization of Midbrain Dopamine Neuron Reactivity Promotes the Pursuit of Amphetamine
Vezina, P., Lorrain, D. S., Arnold, G. M., Austin, J. D., & Suto, N. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-11-04654.2002 · Cited by 206 · see citing works
Self-citation
Haloperidol antagonism of cue-elicited cocaine craving
Berger, S. P., Reid, M. S., Delucchi, K., Hall, S. M., Hall, S. E., Berger, S. P., Mickalian, J. D., Reid, M. S., Delucchi, K., Hall, S. M., et al. (1996) · The Lancet · doi:10.1016/s0140-6736(96)91139-3 · Cited by 206 · see citing works
The role of withdrawal in heroin addiction: enhances reward or promotes avoidance?
Hutcheson, D. M., Everitt, B. J., Robbins, T. W., & Dickinson, A. (2001) · Nature Neuroscience · doi:10.1038/nn0901-943 · Cited by 205 · see citing works
Conditioned cues and the expression of stimulant sensitization in animals and humans
Vezina, P., & Leyton, M. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.06.070 · Cited by 201 · see citing works
Self-citation
The neural basis of video gaming
Kühn, S., Romanowski, A., Schilling, C., Lorenz, R., Mörsen, C., Seiferth, N., Banaschewski, T., Barbot, A., Barker, G. J., Büchel, C., et al. (2011) · Translational Psychiatry · doi:10.1038/tp.2011.53 · Cited by 201 · see citing works
Sex differences in neural responses to stress and alcohol context cues
Seo, D., Jia, Z., Lacadie, C., Tsou, K. A., Bergquist, K. L., & Sinha, R. (2010) · Human Brain Mapping · doi:10.1002/hbm.21165 · Cited by 199 · see citing works
The genetics of addiction—a translational perspective
Arpana Agrawal, A., Verweij, K. J. H., Gillespie, N. A., Heath, A. C., Lessov‐Schlaggar, C. N., Martin, N. G., Nelson, E. C., Slutske, W. S., Whitfield, J. B., & Lynskey, M. T. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.54 · Cited by 198 · see citing works
Alcohol-associated stimuli activate the ventral striatum in abstinent alcoholics
Braus, D. F., Wrase, J., Grüsser, S. M., Hermann, D., Ruf, M., Flor, H., Mann, K. F., & Heinz, A. (2001) · Journal of Neural Transmission · doi:10.1007/s007020170038 · Cited by 192 · see citing works
The cue-availability paradigm: The effects of cigarette availability on cue reactivity in smokers.
Carter, B. L., & Tiffany, S. T. (2001) · Experimental and Clinical Psychopharmacology · doi:10.1037/1064-1297.9.2.183 · Cited by 192 · see citing works
Shared brain vulnerabilities open the way for nonsubstance addictions: Carving addiction at a new joint?
Frascella, J., Potenza, M. N., Brown, L. L., & Childress, A. R. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05420.x · Cited by 191 · see citing works
Nicotine increases alcohol self-administration in non-dependent male smokers
Barrett, S. P., Tichauer, M. B., Leyton, M., & Pihl, R. O. (2005) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2005.06.009 · Cited by 187 · see citing works
Self-citation
Risk taking and the adolescent reward system: A potential common link to substance abuse
Schneider, S., Peters, J., Bromberg, U., Brassen, S., Miedl, S. F., Banaschewski, T., Barker, G. J., Conrod, P., Flor, H., Garavan, H., et al. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.11030489 · Cited by 186 · see citing works
The role of conditioning in drug tolerance and addiction.
Siegel, S. (1979) · Cited by 186 · see citing works
Effect of smoking cues and cigarette availability on craving and smoking behavior
Droungas, A., Ehrman, R. N., Childress, A. R., & O’Brien, C. P. (1995) · Addictive Behaviors · doi:10.1016/0306-4603(95)00029-c · Cited by 181 · see citing works
Individuals Family History Positive for Alcoholism Show Functional Magnetic Resonance Imaging Differences in Reward Sensitivity That Are Related to Impulsivity Factors
Andrews, M. M., Meda, S. A., Thomas, A. D., Potenza, M. N., Krystal, J. H., Worhunsky, P., Stevens, M. C., O'Malley, S., Book, G. A., Reynolds, B., et al. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.09.049 · Cited by 181 · see citing works
Recent advances in the genetic epidemiology and molecular genetics of substance use disorders
Kendler, K. S., Chen, X., Dick, D., Maes, H., Gillespie, N., Neale, M. C., & Riley, B. (2012) · Nature Neuroscience · doi:10.1038/nn.3018 · Cited by 179 · see citing works
Enhanced response to repeated d-amphetamine challenge: Evidence for behavioral sensitization in humans
Strakowski, S. M., Sax, K. W., Setters, M. J., & Keck, P. E. (1996) · Biological Psychiatry · doi:10.1016/0006-3223(95)00497-1 · Cited by 179 · see citing works
Pre-exposure of rats to amphetamine sensitizes self-administration of this drug under a progressive ratio schedule
Mendrek, A., Blaha, C. D., & Phillips, A. G. (1998) · Psychopharmacology · doi:10.1007/s002130050530 · Cited by 176 · see citing works
Do initial responses to drugs predict future use or abuse?
de Wit, H., & Phillips, T. J. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.04.005 · Cited by 172 · see citing works
Higher Binding of the Dopamine D 3 Receptor-Preferring Ligand [ 11 C]-(+)-Propyl-Hexahydro-Naphtho-Oxazin in Methamphetamine Polydrug Users: A Positron Emission Tomography Study
Boileau, I., Payer, D. E., Houle, S., Behzadi, A., Rusjan, P., Tong, J., Wilkins, D. G., Selby, P. L., George, T. P., Zack, M. H., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.4371-11.2012 · Cited by 169 · see citing works
Lower Level of Endogenous Dopamine in Patients With Cocaine Dependence: Findings From PET Imaging of D 2 /D 3 Receptors Following Acute Dopamine Depletion
Martínez, D., Greene, K. A., Broft, A. I., Kumar, D. J. S., Liu, F., Narendran, R., Slifstein, M., Heertum, R. V., & Kleber, H. D. (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.08121801 · Cited by 166 · see citing works
Transient alcohol craving suppression by rTMS of dorsal anterior cingulate: An fMRI and LORETA EEG study
Ridder, D. D., Vanneste, S., Kovacs, S., Sunaert, S. G., & Dom, G. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.03.074 · Cited by 165 · see citing works
Validation of a system of classifying female substance abusers on the basis of personality and motivational risk factors for substance abuse.
Conrod, P., Pihl, R. O., Stewart, S. H., et al. (2000) · Psychology of Addictive Behaviors · doi:10.1037/0893-164x.14.3.243 · Cited by 165 · see citing works
The Neural Basis of Intuitive Best Next-Move Generation in Board Game Experts
Wan, X., Nakatani, H., Ueno, K., Asamizuya, T., Cheng, K., & Tanaka, K. (2011) · Science · doi:10.1126/science.1194732 · Cited by 163 · see citing works
Progressive behavioral response to repeated d-amphetamine challenge: further evidence for sensitization in humans
Strakowski, S. M., & Sax, K. W. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00454-x · Cited by 160 · see citing works
The Motivation to Self-Administer is Increased After a History of Spiking Brain Levels of Cocaine
Zimmer, B. A., Oleson, E. B., & Roberts, D. C. S. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.37 · Cited by 160 · see citing works
A Lasting Vulnerability to Psychosis in Patients with Previous Methamphetamine Psychosis
Sato, M. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb25965.x · Cited by 158 · see citing works
Differentiating heavy from light drinkers by neural responses to visual alcohol cues and other motivational stimuli
Ihssen, N., Cox, W. M., Wiggett, A., Fadardi, J. S., & Linden, D. E. J. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhq220 · Cited by 157 · see citing works
Distorted expectancy coding in problem gambling: is the addictive in the anticipation?
van Holst, R. J., Veltman, D. J., Büchel, C., van den Brink, W., & Goudriaan, A. E. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.12.030 · Cited by 155 · see citing works
Striatal sensitivity to reward deliveries and omissions in substance dependent patients
Bjork, J. M., Smith, A. R., & Hommer, D. W. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.06.035 · Cited by 154 · see citing works
Deficits in dopamine D2 receptors and pre-synaptic dopamine in heroin dependence: commonalities and differences with other types of addiction
Martinez, D., Saccone, P., Liu, F., Slifstein, M., Orlowska, D., Grassetti, A., Cook, S., Broft, A., Heertum, R. V. V., & Comer, S. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.08.024 · Cited by 153 · see citing works
Exposure to nicotine and sensitization of nicotine-induced behaviors
Vezina, P., McGehee, D. S., & Green, W. N. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.08.038 · Cited by 151 · see citing works
Self-citation
Validating incentive salience with functional magnetic resonance imaging: association between mesolimbic cue reactivity and attentional bias in alcohol‐dependent patients
Vollstädt‐Klein, S., Loeber, S., Richter, A., Kirsch, M., Bach, P., von der Goltz, C., Hermann, D., Mann, K. F., & Kiefer, F. (2011) · Addiction Biology · doi:10.1111/j.1369-1600.2011.00352.x · Cited by 149 · see citing works
Reactivity to instructed smoking availability and environmental cues: Evidence with urge and reaction time.
Juliano, L. M., & Brandon, T. H. (1998) · Experimental and Clinical Psychopharmacology · doi:10.1037//1064-1297.6.1.45 · Cited by 148 · see citing works
Decreased ventral striatal activity with impulse control disorders in Parkinson's disease
Rao, H., Mamikonyan, E., Detre, J. A., Siderowf, A. D., Stern, M. B., Potenza, M. N., & Weintraub, D. A. (2010) · Movement Disorders · doi:10.1002/mds.23147 · Cited by 148 · see citing works
An Initial Study of Neural Responses to Monetary Incentives as Related to Treatment Outcome in Cocaine Dependence
Jia, Z., Worhunsky, P. D., Carroll, K. M., Rounsaville, B. J., Stevens, M. C., Pearlson, G. D., & Potenza, M. N. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.05.008 · Cited by 147 · see citing works
Electrophysiological indices of biased cognitive processing of substance-related cues: A meta-analysis
Littel, M., Euser, A. S., Munafo, M. R., & Franken, I. H. A. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.05.001 · Cited by 145 · see citing works
Neurobiological substrates of cue-elicited craving and anhedonia in recently abstinent opioid-dependent males
Zijlstra, F., Veltman, D. J., Booij, J., van den Brink, W., & Franken, I. H. A. (2008) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2008.07.012 · Cited by 143 · see citing works
Memory processes governing amphetamine-induced psychomotor sensitization
Anagnostaras, S. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00402-x · Cited by 143 · see citing works
Conditioned effects of environmental stimuli paired with smoked cocaine in humans
Foltin, R. W., & Haney, M. (2000) · Psychopharmacology · doi:10.1007/s002139900340 · Cited by 142 · see citing works
Family History as a Predictor of Alcohol Dependence
Dawson, D. A., Harford, T. C., & Grant, B. F. (1992) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1992.tb01419.x · Cited by 139 · see citing works
Incentive-elicited striatal activation in adolescent children of alcoholics
Bjork, J. M., Knutson, B., & Hommer, D. W. (2008) · Addiction · doi:10.1111/j.1360-0443.2008.02250.x · Cited by 139 · see citing works
Striatal Dopamine Responses to Intranasal Cocaine Self-Administration in Humans
Cox, S. M. L., Benkelfat, C., Dagher, A., Delaney, J. S., Durand, F., McKenzie, S. A., Kolivakis, T., Casey, K. F., & Leyton, M. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.01.021 · Cited by 138 · see citing works
Self-citation
Methamphetamine craving induced in an online virtual reality environment
Culbertson, C. S., Nicolas, S., Zaharovits, I., London, E. D., Garza, R. D. L., Brody, A. L., & Newton, T. F. (2010) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2010.07.005 · Cited by 136 · see citing works
Craving correlates with mesolimbic responses to heroin-related cues in short-term abstinence from heroin: an event-related fMRI study
Li, Q., Wang, Y., Zhang, Y., Li, W., Yang, W., Zhu, J., Wu, N., Chang, H., Zheng, Y., Qin, W., et al. (2012) · Brain Research · doi:10.1016/j.brainres.2012.06.024 · Cited by 133 · see citing works
Evaluating measures of family history of alcoholism: density versus dichotomy
Stoltenberg, S. F., Mudd, S. A., Blow, F. C., & Hill, E. M. (1998) · Addiction · doi:10.1046/j.1360-0443.1998.931015117.x · Cited by 131 · see citing works
Efficacy of Psychostimulant Drugs for Cocaine Dependence
Cervelló, X. C., Casas, M., Pérez‐Mañá, C., Roncero, C., Vidal, X., & Capellà, D. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007380.pub3 · Cited by 130 · see citing works
The influence of GABRA2, childhood trauma, and their interaction on alcohol, heroin, and cocaine dependence
Enoch, M.-A., Hodgkinson, C. A., Yuan, Q., Shen, P.-H., Goldman, D., & Roy, A. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.08.019 · Cited by 130 · see citing works
Dopamine release in ventral striatum of pathological gamblers losing money
Linnet, J., Peterson, E., Doudet, D. J., Gjedde, A., & Møller, A. (2010) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2010.01591.x · Cited by 127 · see citing works
Conditioned and sensitized responses to stimulant drugs in humans
Leyton, M. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.08.027 · Cited by 127 · see citing works
Self-citation
Amphetamine Activation of Hippocampal Drive of Mesolimbic Dopamine Neurons: A Mechanism of Behavioral Sensitization
Lodge, D. J., & Grace, A. A. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1582-08.2008 · Cited by 127 · see citing works
Amphetamine-Induced Place Preference in Humans
Childs, E., & de Wit, H. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.11.016 · Cited by 127 · see citing works
Nucleus Accumbens Response to Incentive Stimuli Anticipation in Children of Alcoholics: Relationships with Precursive Behavioral Risk and Lifetime Alcohol Use
Yau, W. W., Zubieta, J., Weiland, B. J., Samudra, P. G., Zucker, R. A., & Heitzeg, M. M. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1390-11.2012 · Cited by 123 · see citing works
Alcohol‐Related Olfactory Cues Activate the Nucleus Accumbens and Ventral Tegmental Area in High‐Risk Drinkers: Preliminary Findings
Kareken, D. A., Claus, E. D., Sabri, M., Džemidžić, M., Kosobud, A., Radnovich, A. J., Hector, D. H., Ramchandani, V. A., O’Connor, S., Lowe, M. J., et al. (2004) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000122764.60626.af · Cited by 122 · see citing works
Cocaine craving, euphoria, and self-administration: A preliminary study of the effect of catecholamine precursor depletion.
Leyton, M., Casey, K. F., Delaney, J. S., Kolivakis, T., & Benkelfat, C. (2005) · Behavioral Neuroscience · doi:10.1037/0735-7044.119.6.1619 · Cited by 120 · see citing works
Self-citation
Regional specificity in the real‐time development of phasic dopamine transmission patterns during acquisition of a cue–cocaine association in rats
Aragona, B. J., Day, J. J., Roitman, M. F., Cleaveland, N. A., Wightman, R. M., & Carelli, R. M. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.07027.x · Cited by 120 · see citing works
Extinction procedures abolish conditioned stimulus control but spare sensitized responding to amphetamine
Stewart, J., & Vezina, P. (1991) · Behavioural Pharmacology · doi:10.1097/00008877-199102000-00009 · Cited by 119 · see citing works
Self-citation
Gender Specific Associations Between Types of Childhood Maltreatment and the Onset, Escalation and Severity of Substance Use in Cocaine Dependent Adults
Hyman, S. M., García, M., & Sinha, R. (2006) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/10623320600919193 · Cited by 118 · see citing works
Stimuli associated with a single cocaine experience elicit long-lasting cocaine-seeking
Ciccocioppo, R., Martin‐Fardon, R., & Weiss, F. (2004) · Nature Neuroscience · doi:10.1038/nn1219 · Cited by 117 · see citing works
Unpredictable saccharin reinforcement enhances locomotor responding to amphetamine
Singer, B. F., Scott-Railton, J., & Vezina, P. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.09.003 · Cited by 117 · see citing works
Self-citation
Risperidone for the Treatment of Cocaine Dependence: Randomized, Double-Blind Trial
Grabowski, J. G., Rhoades, H. M., Silverman, P. B., Schmitz, J. M., Stotts, A. L., Creson, D., & Bailey, R. (2000) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-200006000-00003 · Cited by 116 · see citing works
Co-administration of either a selective D1 or D2 dopamine antagonist with methamphetamine prevents methamphetamine-induced behavioral sensitization and neurochemical change, studied by in vivo intracerebral dialysis
Hamamura, T., Akiyama, K., Akimoto, K., Kashihara, K., Okumura, K., Ujike, H., & Otsuki, S. (1991) · Brain Research · doi:10.1016/0006-8993(91)91156-u · Cited by 115 · see citing works
Attentional bias to drug cues is elevated before and during temptations to use heroin and cocaine
Waters, A. J., Marhe, R., & Franken, I. H. A. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2424-z · Cited by 115 · see citing works
Dopamine Release in Chronic Cannabis Users: A [11C]Raclopride Positron Emission Tomography Study
Urban, N., Slifstein, M., Thompson, J. L., Xu, X., Girgis, R. R., Raheja, S., Haney, M., & Abi‐Dargham, A. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.12.018 · Cited by 114 · see citing works
Previous Exposure to Psychostimulants Enhances the Reinstatement of Cocaine Seeking by Nucleus Accumbens AMPA
Suto, N., Tanabe, L. M., Austin, J. D., Creekmore, E., Pham, C. T., & Vezina, P. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300533 · Cited by 114 · see citing works
Self-citation
Amphetamine-Induced Changes in Dendritic Morphology in Rat Forebrain Correspond to Associative Drug Conditioning Rather than Nonassociative Drug Sensitization
Singer, B. F., Tanabe, L. M., Gorny, G., Jake-Matthews, C., Li, Y., Kolb, B. E., & Vezina, P. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.12.020 · Cited by 112 · see citing works
Self-citation

Flagged first, then by citations

Research works printed but not linked: 1

Toates F 1986 Motivational Systems Cambridge University Press Cambridge, UK

Sorted by citations

Pleasure Systems in the Brain
Berridge, K. C., & Kringelbach, M. L. (2015) · Neuron · doi:10.1016/j.neuron.2015.02.018 · Cited by 1,730 · see citing works
Liking, wanting, and the incentive-sensitization theory of addiction
Berridge, K. C., & Robinson, T. E. (2016) · American Psychologist · doi:10.1037/amp0000059 · Cited by 1,440 · see citing works
Disruption of Reward Processing in Addiction: An Image-Based Meta-analysis of Functional Magnetic Resonance Imaging Studies
Luijten, M., Schellekens, A. F., Kühn, S., Machielse, M. W. J., & Sescousse, G. (2017) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2016.3084 · Cited by 402 · see citing works
On the Motivational Properties of Reward Cues: Individual Differences
Robinson, T., Yager, L. M., Cogan, E. S., & Saunders, B. T. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.05.040 · Cited by 249 · see citing works
Is internet pornography causing sexual dysfunctions? A review with clinical reports
Park, B., Wilson, G., Berger, J., Christman, M., Reina, B., Bishop, F., Klam, W., & Doan, A. (2016) · Behavioral Sciences · doi:10.3390/bs6030017 · Cited by 187 · see citing works
Neural substrates of cue reactivity and craving in gambling disorder
Limbrick‐Oldfield, E. H., Mick, I., Cocks, R., McGonigle, J., Sharman, S., Goldstone, A. P., Stokes, P. R. A., Waldman, A. D., Erritzøe, D., Bowden‐Jones, H., et al. (2017) · Translational Psychiatry · doi:10.1038/tp.2016.256 · Cited by 186 · see citing works
Temporal Pattern of Cocaine Intake Determines Tolerance vs Sensitization of Cocaine Effects at the Dopamine Transporter
Calipari, E. S., Ferris, M. J., Zimmer, B. A., Roberts, D. C. S., & Jones, S. R. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.136 · Cited by 178 · see citing works
Reward Processing, Neuroeconomics, and Psychopathology
Zald, D. H., & Treadway, M. T. (2017) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-032816-044957 · Cited by 181 · see citing works
Individual variation in resisting temptation: Implications for addiction
Saunders, B. T., & Robinson, T. E. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.02.008 · Cited by 165 · see citing works
Measuring anhedonia: impaired ability to pursue, experience, and learn about reward
Thomsen, K. R. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.01409 · Cited by 156 · see citing works
Neural correlates of cognitive control in gambling disorder: a systematic review of fMRI studies
Moccia, L., Pettorruso, M., De Crescenzo, F., De Risio, L., di Nuzzo, L., Martinotti, G., Bifone, A., Janiri, L., & Di Nicola, M. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.04.025 · Cited by 158 · see citing works
Poverty and self-regulation: Connecting psychosocial processes, neurobiology, and the risk for psychopathology
Palacios‐Barrios, E. E., & Hanson, J. L. (2018) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2018.12.012 · Cited by 157 · see citing works
Neuroimaging of reward mechanisms in Gambling disorder: an integrative review
Clark, L., Boileau, I., & Zack, M. H. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0230-2 · Cited by 149 · see citing works
Mechanisms of Shared Vulnerability to Post-traumatic Stress Disorder and Substance Use Disorders
Maria-Rios, C. E., & Morrow, J. D. (2020) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.00006 · Cited by 141 · see citing works
A Prospective 5-Year Re-examination of Alcohol Response in Heavy Drinkers Progressing in Alcohol Use Disorder
King, A. C., Hasin, D., O’Connor, S. J., McNamara, P. J., & Cao, D. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.05.007 · Cited by 132 · see citing works
Role of basal ganglia neurocircuitry in the pathology of psychiatric disorders
Macpherson, T., & Hikida, T. (2019) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12830 · Cited by 131 · see citing works
Is Addiction a Brain Disease?
Berridge, K. C. (2016) · Neuroethics · doi:10.1007/s12152-016-9286-3 · Cited by 128 · see citing works
Dopamine ups and downs in vulnerability to addictions: a neurodevelopmental model
Leyton, M., & Vezina, P. (2014) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2014.04.002 · Cited by 127 · see citing works
Self-citation
Mapping the Development of the Basal Ganglia in Children With Attention-Deficit/Hyperactivity Disorder
Shaw, P., De Rossi, P., Watson, B., Wharton, A., Greenstein, D., Raznahan, A., Sharp, W., Lerch, J. P., & Chakravarty, M. M. (2014) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2014.05.003 · Cited by 126 · see citing works
Blunted ventral striatal responses to anticipated rewards foreshadow problematic drug use in novelty-seeking adolescents
Büchel, C., Peters, J., Banaschewski, T., Bokde, A. L. W., Bromberg, U., Conrod, P. J., Flor, H., Papadopoulos, D., Garavan, H., Gowland, P., et al. (2017) · Nature Communications · doi:10.1038/ncomms14140 · Cited by 118 · see citing works
Pathological choice: the neuroscience of gambling and gambling addiction
Clark, L., Averbeck, B., Payer, D., Sescousse, G., Winstanley, C. A., & Xue, G. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.3231-13.2013 · Cited by 116 · see citing works
Have we been ignoring the elephant in the room? Seven arguments for considering the cerebellum as part of addiction circuitry
Miquel, M., Vazquez-Sanroman, D. B., Carbo‐Gas, M., Gil‐Miravet, I., Sanchis‐Segura, C., Carulli, D., Manzo, J. G., & Coria‐Ávila, G. A. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.11.005 · Cited by 113 · see citing works
Altered neural correlates of reward and loss processing during simulated slot-machine fMRI in pathological gambling and cocaine dependence
Worhunsky, P. D., Malison, R. T., Rogers, R. D., & Potenza, M. N. (2014) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2014.09.013 · Cited by 112 · see citing works
Increased Striatal Dopamine Synthesis Capacity in Gambling Addiction
van Holst, R. J., Sescousse, G., Janssen, L. K., Janssen, M., Berry, A. S., Jagust, W. J., & Cools, R. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.06.010 · Cited by 111 · see citing works
Reward-based decision making in pathological gambling: The roles of risk and delay
Wiehler, A., & Peters, J. (2014) · Neuroscience Research · doi:10.1016/j.neures.2014.09.008 · Cited by 106 · see citing works
Applying incentive sensitization models to behavioral addiction
Thomsen, K. R., Fjorback, L. O., Møller, A., & Lou, H. C. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.07.009 · Cited by 96 · see citing works
Getting a grip on problem gambling: what can neuroscience tell us?
Goudriaan, A., Yücel, M., & van Holst, R. V. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00141 · Cited by 92 · see citing works
Cue-Induced Craving Increases Impulsivity via Changes in Striatal Value Signals in Problem Gamblers
Miedl, S. F., Büchel, C., & Peters, J. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.5020-13.2014 · Cited by 87 · see citing works
Is the Adolescent Brain at Greater Vulnerability to the Effects of Cannabis? A Narrative Review of the Evidence
Blest‐Hopley, G., Colizzi, M., Giampietro, V., & Bhattacharyya, S. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00859 · Cited by 85 · see citing works
A neurobehavioral approach to addiction: implications for the opioid epidemic and the psychology of addiction
Bechara, A., Berridge, K. C., Bickel, W. K., Morón, J. A., Williams, S. B., & Stein, J. S. (2019) · Psychological Science in the Public Interest · doi:10.1177/1529100619860513 · Cited by 82 · see citing works
Conceptual Framework of Harmful Gambling, Third Edition
Abbott, M., Binde, P., Clark, L., Hodgins, D., Johnson, M., Manitowabi, D., Quilty, L., Spångberg, J., Volberg, R., Walker, D. M., et al. (2018) · doi:10.33684/cfhg3.en · Cited by 22 · see citing works
Dopamine ‘ups and downs’ in addiction revisited
Samaha, A., Khoo, S. Y., Ferrario, C. R., & Robinson, T. E. (2021) · Trends in Neurosciences · doi:10.1016/j.tins.2021.03.003 · Cited by 77 · see citing works
Impulsivity relates to striatal gray matter volumes in humans: evidence from a delay discounting paradigm
Tschernegg, M., Pletzer, B. A., Schwartenbeck, P., Ludersdorfer, P., Hoffmann, U., & Kronbichler, M. (2015) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2015.00384 · Cited by 74 · see citing works
Is addiction a brain disease? A plea for agnosticism and heterogeneity
Pickard, H. (2021) · Psychopharmacology · doi:10.1007/s00213-021-06013-4 · Cited by 69 · see citing works
The Cambridge Handbook of Substance and Behavioral Addictions
Sussman, S. Y. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591 · Cited by 63 · see citing works
Individualized relapse prediction: Personality measures and striatal and insular activity during reward-processing robustly predict relapse
Gowin, J. L., Ball, T. M., Wittmann, M., Tapert, S. F., & Paulus, M. P. (2015) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2015.04.018 · Cited by 64 · see citing works
Amplified Striatal Responses to Near-Miss Outcomes in Pathological Gamblers
Sescousse, G., Janssen, L. K., Hashemi, M. M., Timmer, M. H. M., Geurts, D. E. M., ter Huurne, N. P., Clark, L., & Cools, R. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.43 · Cited by 62 · see citing works
Neurofeedback of visual food cue reactivity: a potential avenue to alter incentive sensitization and craving
Ihssen, N., Sokunbi, M. O., Lawrence, A. D., Lawrence, N., & Linden, D. E. J. (2016) · Brain Imaging and Behavior · doi:10.1007/s11682-016-9558-x · Cited by 53 · see citing works
Behavioral Economic Considerations of Novel Addictions and Nonaddictive Behavior: Research and Analytic Methods
Reed, D. D., Naudé, G. P., Gelino, B. W., & Amlung, M. T. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.011 · Cited by 48 · see citing works
Differential Striatal Dopamine Responses Following Oral Alcohol in Individuals at Varying Risk for Dependence
Setiawan, E., Pihl, R. O., Dagher, A., Schlagintweit, H. E., Casey, K. F., Benkelfat, C., & Leyton, M. (2013) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12218 · Cited by 47 · see citing works
Self-citation
The Prevention and Treatment of Gambling Disorders: Some Art, Some Science
Derevensky, J. L. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.024 · Cited by 45 · see citing works
Considering the Overlap and Nonoverlap of Compulsivity, Impulsivity, and Addiction
Blum, A. W., & Grant, J. E. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.038 · Cited by 44 · see citing works
Neurobiological Foundations of Behavioral Addictions
Vaccaro, A. G., & Potenza, M. N. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.016 · Cited by 45 · see citing works
Neurobiology of Substance Addictions
Christie, N. C., & Bechara, A. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.015 · Cited by 44 · see citing works
Sensitization of Incentive Salience and the Transition to Addiction
Warlow, S. M., Baumgartner, H. M., Freeland, C. M., Naffziger, E. E., Olney, J. J., Berridge, K. C., & Robinson, M. J. F. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.006 · Cited by 45 · see citing works
The Affective and Neural Correlates of Heroin versus Cocaine Use in Addiction Are Influenced by Environmental Setting But in Opposite Directions
Pirro, S. D., Galati, G., Pizzamiglio, L., & Badiani, A. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.0019-18.2018 · Cited by 45 · see citing works
Mindfulness-Based Interventions Applied to Addiction Treatments
Kechter, A., & Black, D. S. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.040 · Cited by 43 · see citing works
Multiple Memory Systems, Addiction, and Health Habits: New Routes for Translational Science
Stacy, A. W., Pike, J. R., & Lee, A. Y. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.017 · Cited by 43 · see citing works
Tanning as an Addiction: The State of the Research and Implications for Intervention
Miller, K. A., & Mays, D. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.037 · Cited by 43 · see citing works
Food versus Eating Addictions
Schulte, E. M., Schiestl, E. T., & Gearhardt, A. N. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.035 · Cited by 43 · see citing works
Behavioral Economics and Addictive Disorders
Jarmolowicz, D. P., & Schneider, T. D. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.005 · Cited by 42 · see citing works
Prevention and Treatment of Compulsive Buying Disorder
Galimov, A., & Black, D. W. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.027 · Cited by 42 · see citing works
Precision Behavioral Management (PBM): A Novel Genetically Guided Therapy to Combat Reward Deficiency Syndrome (RDS) Relevant to the Opiate Crisis
Blum, K., Roy, A. K., Podesta, A., Modestino, E. J., Steinberg, B., Gondré-Lewis, M. C., Baron, D. A., Thanos, P. K., Lott, L., Badgaiyan, S., et al. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.031 · Cited by 42 · see citing works
Prevention and Treatment of “Food Addiction”
Davis, C., & Mason, A. E. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.023 · Cited by 42 · see citing works
Human Neurobiological Approaches to Hedonically Motivated Behaviors
Burger, K. S., Shearrer, G. E., & Sadler, J. R. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.009 · Cited by 42 · see citing works
Feedback Models for Gambling Control: The Use and Efficacy of Online Responsible Gambling Tools
Griffiths, M. D. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.034 · Cited by 42 · see citing works
Reward pathway dysfunction in gambling disorder: A meta-analysis of functional magnetic resonance imaging studies
Meng, Y., Deng, W., Wang, H.-Y., Guo, W., Li, T., Lam, C., & Xia, L. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.08.057 · Cited by 42 · see citing works
The Effect of High-Frequency Repetitive Transcranial Magnetic Stimulation on Emotion Processing, Reappraisal, and Craving in Alcohol Use Disorder Patients and Healthy Controls: A Functional Magnetic Resonance Imaging Study
Jansen, J. M., van den Heuvel, O. A., van der Werf, Y. D., de Wit, S. J., Veltman, D. J., van den Brink, W., & Goudriaan, A. E. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00272 · Cited by 43 · see citing works
Common neurobiological and psychological underpinnings of gambling and substance-use disorders
Balodis, I. M., & Potenza, M. N. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.109847 · Cited by 37 · see citing works
The anticipatory dopamine response in addiction: A common neurobiological underpinning of gambling disorder and substance use disorder?
Linnet, J. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.109802 · Cited by 33 · see citing works
Elevated Functional Connectivity in a Striatal-Amygdala Circuit in Pathological Gamblers
Peters, J., Miedl, S. F., & Büchel, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074353 · Cited by 29 · see citing works
Skewed by Cues? The Motivational Role of Audiovisual Stimuli in Modelling Substance Use and Gambling Disorders
Barrus, M. M., Cherkasova, M. V., & Winstanley, C. A. (2015) · Current topics in behavioral neurosciences · doi:10.1007/7854_2015_393 · Cited by 30 · see citing works
Dopamine and Glutamate Interaction Mediates Reinstatement of Drug-Seeking Behavior by Stimulation of the Ventral Subiculum
Taepavarapruk, P., Butts, K. A., & Phillips, A. G. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu008 · Cited by 28 · see citing works
What’s deficient in reward deficiency?
Leyton, M. (2014) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.140204 · Cited by 28 · see citing works
Self-citation
Neural activation to monetary reward is associated with amphetamine reward sensitivity
Crane, N. A., Gorka, S. M., Weafer, J. J., Langenecker, S. A., de Wit, H., & Phan, K. L. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0042-8 · Cited by 26 · see citing works
Cue‐induced effects on decision‐making distinguish subjects with gambling disorder from healthy controls
Genauck, A., Andrejević, M., Brehm, K., Matthis, C., Heinz, A., Weinreich, A., Kathmann, N., & Romanczuk‐Seiferth, N. (2019) · Addiction Biology · doi:10.1111/adb.12841 · Cited by 24 · see citing works
A Systematic Review on Common and Distinct Neural Correlates of Risk-taking in Substance-related and Non-substance Related Addictions
Hüpen, P., Habel, U., Votinov, M., Kable, J. W., & Wagels, L. (2022) · Neuropsychology Review · doi:10.1007/s11065-022-09552-5 · Cited by 27 · see citing works
Examining Neural Reactivity to Gambling Cues in the Age of Online Betting
Brevers, D., Sescousse, G., Maurage, P., & Billieux, J. (2019) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-019-00177-2 · Cited by 26 · see citing works
Enhanced neural responses to monetary rewards in methamphetamine use disordered individuals compared to healthy controls
Wei, S., Zheng, Y., Li, Q., Dai, W., Sun, J., Wu, H., & Liu, X. (2018) · Physiology & Behavior · doi:10.1016/j.physbeh.2018.08.003 · Cited by 26 · see citing works
Neural reward circuit dysfunction as a risk factor for bipolar spectrum disorders and substance use disorders: A review and integration
Bart, C. P., Titone, M. K., Ng, T. H., Nusslock, R., & Alloy, L. B. (2021) · Clinical Psychology Review · doi:10.1016/j.cpr.2021.102035 · Cited by 25 · see citing works
The self-administration of rapidly delivered cocaine promotes increased motivation to take the drug: contributions of prior levels of operant responding and cocaine intake
Bouayad-Gervais, K., Minogianis, E.-A., Lévesque, D., & Samaha, A. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3576-4 · Cited by 21 · see citing works
Episodic Tags Enhance Striatal Valuation Signals during Temporal Discounting in pathological Gamblers
Wiehler, A., Petzschner, F. H., Stephan, K. E., & Peters, J. (2017) · eNeuro · doi:10.1523/eneuro.0159-17.2017 · Cited by 21 · see citing works
Opposite environmental gating of the experienced utility (‘liking’) and decision utility (‘wanting’) of heroin versus cocaine in animals and humans: implications for computational neuroscience
Badiani, A., Caprioli, D., & Pirro, S. D. (2019) · Psychopharmacology · doi:10.1007/s00213-019-05318-9 · Cited by 20 · see citing works
Effects of Cannabinoid Exposure during Adolescence on the Conditioned Rewarding Effects of WIN 55212-2 and Cocaine in Mice: Influence of the Novelty-Seeking Trait
Rodríguez‐Arias, M., Roger-Sánchez, C., Vilanova, I., Revert, N., Manzanedo, C., Miñarro, J., & Aguilar, M. A. (2015) · Neural Plasticity · doi:10.1155/2016/6481862 · Cited by 18 · see citing works
Reduced neural encoding of utility prediction errors in cocaine addiction
Konova, A. B., Ceceli, A. O., Horga, G., Moeller, S. J., Nelly Alia-klein, A., & Goldstein, R. Z. (2023) · Neuron · doi:10.1016/j.neuron.2023.09.015 · Cited by 19 · see citing works
Neural and neurocognitive markers of vulnerability to gambling disorder: a study of unaffected siblings
Limbrick‐Oldfield, E. H., Mick, I., Cocks, R., Flechais, R., Turton, S., Lingford-Hughes, A. R., Bowden‐Jones, H., & Clark, L. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0534-1 · Cited by 17 · see citing works
Neural correlates of cue‐induced changes in decision‐making distinguish subjects with gambling disorder from healthy controls
Genauck, A., Matthis, C., Andrejević, M., Ballon, L., Chiarello, F., Duecker, K., Heinz, A., Kathmann, N., & Romanczuk‐Seiferth, N. (2020) · Addiction Biology · doi:10.1111/adb.12951 · Cited by 15 · see citing works
Maladaptive consequences of repeated intermittent exposure to uncertainty
Mascia, P., Wang, Q., Brown, J., Nesbitt, K. M., Kennedy, R. T., & Vezina, P. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.109864 · Cited by 15 · see citing works
Self-citation
Sensitizing exposure to amphetamine increases AMPA receptor phosphorylation without increasing cell surface expression in the rat nucleus accumbens
Wang, Q., Li, D., Bubula, N., Campioni, M. R., McGehee, D. S., & Vezina, P. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.02.018 · Cited by 15 · see citing works
Self-citation
The role of attention in decision-making under risk in gambling disorder: An eye-tracking study
Hoven, M., Hirmas, A., Engelmann, J. B., & van Holst, R. J. (2022) · Addictive Behaviors · doi:10.1016/j.addbeh.2022.107550 · Cited by 14 · see citing works
Evidence for a long-term protection of wheel-running exercise against cocaine psychomotor sensitization in adolescent but not in adult mice
Lespine, L., & Tirelli, E. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.04.054 · Cited by 14 · see citing works
Drug-Paired Contextual Stimuli Increase Dendritic Spine Dynamics in Select Nucleus Accumbens Neurons
Singer, B. F., Bubula, N., Li, D., Przybycien–Szymanska, M. M., Bindokas, V. P., & Vezina, P. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.39 · Cited by 14 · see citing works
Self-citation
Decomposition of Reinforcement Learning Deficits in Disordered Gambling via Drift Diffusion Modeling and Functional Magnetic Resonance Imaging
Wiehler, A., & Peters, J. (2024) · Computational Psychiatry · doi:10.5334/cpsy.104 · Cited by 22 · see citing works
Conditioned inhibition of amphetamine sensitization
Guillory, A. M., Herrera, S., Baker, L. K., Bubula, N., Forneris, J., You, Z., Vezina, P., & Singer, B. F. (2022) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2022.107636 · Cited by 13 · see citing works
Self-citation
Brain responses to anticipating and receiving beer: Comparing light, at‐risk, and dependent alcohol users
Groefsema, M. M., Engels, R. C. M. E., Voon, V., Schellekens, A., Luijten, M., & Sescousse, G. (2019) · Addiction Biology · doi:10.1111/adb.12766 · Cited by 11 · see citing works
Biosensors and Biofeedback in Clinical Psychology
Mancuso, V., Stramba-Badiale, C., Cavedoni, S., & Cipresso, P. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818697-8.00002-9 · Cited by 13 · see citing works
Appetitive Needs and Addiction
Sussman, S. Y., & Pakdaman, S. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.004 · Cited by 12 · see citing works
Commentary on: Are we overpathologizing everyday life? A tenable blueprint for behavioral addiction research
Clark, L. (2015) · Journal of Behavioral Addictions · doi:10.1556/2006.4.2015.014 · Cited by 12 · see citing works
Season of birth, the dopamine D4 receptor gene and emotional eating in males and females. Evidence of a genetic plasticity factor?
van Strien, T., Levitan, R. D., Engels, R. C. M. E., & Homberg, J. R. (2015) · Appetite · doi:10.1016/j.appet.2015.02.024 · Cited by 11 · see citing works
Locomotor conditioning by amphetamine requires cyclin-dependent kinase 5 signaling in the nucleus accumbens
Singer, B. F., Neugebauer‎, N. M., Forneris, J., Rodvelt, K. R., Li, D., Bubula, N., & Vezina, P. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.05.033 · Cited by 11 · see citing works
Self-citation
Examining the link between reward and response inhibition in individuals with substance abuse tendencies
Byrne, K. A., & Worthy, D. A. (2018) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2018.11.014 · Cited by 10 · see citing works
Decomposition of reinforcement learning deficits in gambling disorder via drift diffusion modeling and functional magnetic resonance imagingPreprint
Wiehler, A., & Peters, J. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.06.03.131359 · Cited by 10 · see citing works
The influence of dopamine autoreceptors on temperament and addiction risk
Zald, D. H. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105456 · Cited by 9 · see citing works
Striatal ups or downs? Neural correlates of monetary reward anticipation, cue reactivity and their interaction in alcohol use disorder and gambling disorder
van Timmeren, T., van Holst, R. J., & Goudriaan, A. E. (2023) · Journal of Behavioral Addictions · doi:10.1556/2006.2023.00015 · Cited by 9 · see citing works
Ending the Chase: Experiences of Rural Individuals with Opioid Use Disorder
Scorsone, K. L., Haozous, E. A., Hayes, L., & Cox, K. J. (2021) · Substance Use & Misuse · doi:10.1080/10826084.2021.1914109 · Cited by 9 · see citing works
Wheel-running exercise before and during gestation against acute and sensitized cocaine psychomotor-activation in offspring
Lespine, L., Plenevaux, A., & Tirelli, E. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.01.049 · Cited by 9 · see citing works
Methylphenidate as a treatment option for substance use disorder: a transdiagnostic perspective
van Ruitenbeek, P., Franzen, L., Mason, N. L., Stiers, P. L. J., & Ramaekers, J. G. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1208120 · Cited by 8 · see citing works
The protective effects of free wheel-running against cocaine psychomotor sensitization persist after exercise cessation in C57BL/6J mice
Lespine, L., & Tirelli, E. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.10.009 · Cited by 8 · see citing works
Qualitative Approaches to the Study of Substance and Behavioral Addictions
Simpson, K. A., & Bluthenthal, R. N. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.013 · Cited by 8 · see citing works
Cocaine cue‐induced mesocorticolimbic activation in cocaine users: Effects of personality traits, lifetime drug use, and acute stimulant ingestion
Dâ€TMAmour-Horvat, V., Cox, S. M. L., Dagher, A., Kolivakis, T., Jaworska, N., & Leyton, M. (2021) · Addiction Biology · doi:10.1111/adb.13094 · Cited by 7 · see citing works
Self-citation

Striatal ups or downs? Neural correlates of monetary reward anticipation, cue reactivity and their interaction in gambling disorder and alcohol use disorder
Goudriaan, A. E. (2023) · European Psychiatry · doi:10.1192/j.eurpsy.2023.36
Cellular basis of the intrastriatal functional shifts that underlie the development of habits: relevance for drug addiction
Fouyssac, M., Everitt, B. J., & Belin, D. (2016) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2016.11.018 · Cited by 6 · see citing works
Striatal ups or downs? Neural correlates of monetary reward anticipation, cue reactivity and their interaction in alcohol use disorder and gambling disorder
van Timmeren, T., van Holst, R. J., & Goudriaan, A. E. (2023) · Journal of Behavioral Addictions · doi:10.1556/2006.2023.00015 · Cited by 9 · see citing works
A Translation from Goal-Directed to Habitual Control: the Striatum in Drug Addiction
Du, W., Liu, Y., Meng, Y., Yan, Y., Jin, L., Zhang, J., Liang, J., Li, Y.-H., & Shen, F. (2021) · Current Addiction Report · doi:10.1007/s40429-021-00392-6 · Cited by 5 · see citing works
From the ventral to the dorsal striatum: devolving views of their roles in drug addiction
Everitt, B. J., & Robbins, T. W. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.02.010 · Cited by 675 · see citing works

Authors: Leyton, M., & Vezina, P.
Affiliations: McGill University (CA)
University of Chicago (US)
Corresponding author: Leyton, Marco
Vezina, Paul
ORCID: Leyton, Marco
Venue: Neuroscience & Biobehavioral Reviews
Publisher: Elsevier BV
Published: 2013-11
Volume: 37
Issue: 9
Pages: 1999-2014
ISSN: 0149-7634 (ISSN-L)
DOI: 10.1016/j.neubiorev.2013.01.018
PMC: PMC3743927
OpenAlex: W1967611816
Cited by: 165
References: 284
Citations by year: 2026: 4 · 2025: 4 · 2024: 5 · 2023: 7 · 2022: 8 · 2021: 9 · 2020: 53 · 2019: 15 · 2018: 10 · 2017: 9 · 2016: 9 · 2015: 11 · 2014: 14 · 2013: 7
FWCI: 1.39
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience & Biobehavioral Reviews (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Canadian Institutes for Health Research (MOP-36429, MOP-64426)
National Institutes of Health (DA09397)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Social Sciences › Psychology › Clinical Psychology › Gambling Behavior and Treatments
Keywords: striatum, addiction vulnerability, incentive motivation, drug reward, addiction treatment
MeSH terms: Animals, Brain, Cues, Humans, Motivation, Reward, Illicit Drugs, Behavior, Addictive

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Striatal ups and downs: Their roles in vulnerability to addictions in humans

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks