Preterm Birth Changes Networks of Newborn Cortical Activity
Open accessAbstract
Preterm birth is the greatest risk factor for lifelong neurocognitive deficits, globally. The effect of prematurity on early cortical network function has, however, remained poorly understood. Here, we developed a novel methodology that allows reliable assessment of functional connectivity in neonatal brain activity at millisecond and multisecond scales in terms of cortical phase and amplitude correlations, respectively. We measured scalp electroencephalography at term-equivalent age in infants exposed to very early prematurity as well as in healthy controls. We found that newborn cortical activity organizes into multiplex networks that differ significantly between vigilance states. As compared with healthy control infants, prematurity was found to cause frequency-specific patterns of dysconnectivity in cortical network, changes that were distinct for networks of phase and amplitude correlations. Neuroanatomically, the most prominent markers of prematurity were found in connections involving the frontal regions. Phase synchrony in frontally connected networks was correlated with newborn neurological performance, suggesting the first measure of cortical functional coupling that correlates with neurological performance in human infant.
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Disruptions in PFC network activity often further aggravate the already compromised neurocognitive development in preterm children.
“Disruptions in PFC network activity often further aggravates the already compromised neurocognitive development in these children [365, 366].”
From Development of prefrontal cortex (2022) · cites this paper as [365]
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Development of prefrontal cortex
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- Authors
- Tokariev, A., Stjerna, S., Lano, A., Metsäranta, M., Palva, J. M., & Vanhatalo, S.
- Affiliations
- University of Helsinki (FI)
- Corresponding author
- Tokariev, Anton
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-02-23
- Volume
- 29
- Issue
- 2
- Pages
- 814-826
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- OpenAlex
- W2792641772
- Cited by
- 53
- References
- 71
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 4 · 2023: 7 · 2022: 10 · 2021: 9 · 2020: 5 · 2019: 5 · 2018: 2 · 2012: 1
- FWCI
- 5.80
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Cerebral Cortex (publishedVersion)
- PubMed (publishedVersion)
- Työväentutkimus Vuosikirja (submittedVersion, other-oa)
- Funders
- Academy of Finland
- Sigrid Jusélius Foundation, Finnish Cultural Foundation
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Development and Preterm Care
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- preterm birth, multiplex networks, phase synchronization, amplitude correlation, dysconnectivity, frontal cortex, sleep-wake states, term-equivalent age, neurodevelopmental outcomes
- MeSH terms
- Cerebral Cortex, Electroencephalography, Female, Humans, Infant, Newborn, Infant, Premature, Magnetic Resonance Imaging, Male, Nerve Net
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