Cited by 114Neurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology ResearchNeural dynamics and brain function

Electrical activity controls area-specific expression of neuronal apoptosis in the mouse developing cerebral cortex

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Blanquie, Oriane, Yang, Jenq-Wei, Kilb, Werner, Sharopov, Salim, Sinning, Anne, Luhmann, Heiko J·2017·eLife

Abstract

Programmed cell death widely but heterogeneously affects the developing brain, causing the loss of up to 50% of neurons in rodents. However, whether this heterogeneity originates from neuronal identity and/or network-dependent processes is unknown. Here, we report that the primary motor cortex (M1) and primary somatosensory cortex (S1), two adjacent but functionally distinct areas, display striking differences in density of apoptotic neurons during the early postnatal period. These differences in rate of apoptosis negatively correlate with region-dependent levels of activity. Disrupting this activity either pharmacologically or by electrical stimulation alters the spatial pattern of apoptosis and sensory deprivation leads to exacerbated amounts of apoptotic neurons in the corresponding functional area of the neocortex. Thus, our data demonstrate that spontaneous and periphery-driven activity patterns are important for the structural and functional maturation of the neocortex by refining the final number of cortical neurons in a region-dependent manner.

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  • The rate of apoptosis in pyramidal cells varies among functionally different neocortical areas and across layers within the same area.

    “Indeed, the rate of apoptosis in pyramidal cells varies among functionally different neocortical areas and even across layers within the same cortical area (Blanquie et al., 2017).”

    From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Blanquie et al., 2017

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Authors
Blanquie, O., Yang, J.-W., Kilb, W., Sharopov, S., Sinning, A., & Luhmann, H. J.
Affiliations
University Medical Center of the Johannes Gutenberg University Mainz (DE)
Corresponding author
Luhmann, Heiko J
Venue
eLife
Published
2017-08-21
Volume
6
ISSN
2050-084X (ISSN-L)
OpenAlex
W2746129944
Cited by
114
References
88
Citations by year
2026: 7 · 2025: 12 · 2024: 11 · 2023: 11 · 2022: 22 · 2021: 13 · 2020: 12 · 2019: 12 · 2018: 11 · 2017: 2
FWCI
4.25
Type
journal article
Language
en
Open access
Locations
  • eLife (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Deutsche Forschungsgemeinschaft (Collaborative Research Center 1080)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
neuronal apoptosis, programmed cell death, cortical development, primary motor cortex, primary somatosensory cortex, spontaneous neuronal activity, sensory deprivation, neuronal loss, postnatal brain development
MeSH terms
Aging, Anesthesia, Animals, Animals, Newborn, Cell Count, Cerebral Cortex, Motor Cortex, Neurons, Somatosensory Cortex, Apoptosis, Mice, Caspase 3, Electrophysiological Phenomena

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