Electrical activity controls area-specific expression of neuronal apoptosis in the mouse developing cerebral cortex
Open accessAbstract
Programmed cell death widely but heterogeneously affects the developing brain, causing the loss of up to 50% of neurons in rodents. However, whether this heterogeneity originates from neuronal identity and/or network-dependent processes is unknown. Here, we report that the primary motor cortex (M1) and primary somatosensory cortex (S1), two adjacent but functionally distinct areas, display striking differences in density of apoptotic neurons during the early postnatal period. These differences in rate of apoptosis negatively correlate with region-dependent levels of activity. Disrupting this activity either pharmacologically or by electrical stimulation alters the spatial pattern of apoptosis and sensory deprivation leads to exacerbated amounts of apoptotic neurons in the corresponding functional area of the neocortex. Thus, our data demonstrate that spontaneous and periphery-driven activity patterns are important for the structural and functional maturation of the neocortex by refining the final number of cortical neurons in a region-dependent manner.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The rate of apoptosis in pyramidal cells varies among functionally different neocortical areas and across layers within the same area.
“Indeed, the rate of apoptosis in pyramidal cells varies among functionally different neocortical areas and even across layers within the same cortical area (Blanquie et al., 2017).”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Blanquie et al., 2017
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.
Gavrieli, Y., Sherman, Y., & Ben-Sasson, S. A. (1992) · The Journal of cell biology · doi:10.1083/jcb.119.3.493 · Cited by 9,444 · see citing works
Shrestha, S., & Offer, S. M. (2016) · Medical Epigenetics · doi:10.1159/000444713 · Cited by 8,949 · see citing works
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
Datta, S. R., Dudek, H., Tao, X., Masters, S., Fu, H., Gotoh, Y., & Greenberg, M. E. (1997) · Cell · doi:10.1016/s0092-8674(00)80405-5 · Cited by 5,689 · see citing works
The Nerve Growth Factor 35 Years Later
Levi‐Montalcini, R. (1987) · Science · doi:10.1126/science.3306916 · Cited by 3,109 · see citing works
A simple method for organotypic cultures of nervous tissue
Stoppini, L., Buchs, P., & Muller, D. (1991) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(91)90128-m · Cited by 3,097 · see citing works
Cell death during development of the nervous system
Oppenheim, R. W. (1991) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.14.030191.002321 · Cited by 3,084 · see citing works
Blockade of NMDA Receptors and Apoptotic Neurodegeneration in the Developing Brain
Ikonomidou, C., Bosch, F., Miksa, M., Bittigau, P., Vöckler, J., Dikranian, K., Tenkova, T. I., Stefovska, V., Turski, L., & Olney, J. W. (1999) · Science · doi:10.1126/science.283.5398.70 · Cited by 2,055 · see citing works
Caspase-3 Is Required for DNA Fragmentation and Morphological Changes Associated with Apoptosis
Jänicke, R. U., Sprengart, M. L., Wati, M. R., & Porter, A. G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.16.9357 · Cited by 1,955 · see citing works
Trophic factors and neuronal survival
Barde, Y.-A. (1989) · Neuron · doi:10.1016/0896-6273(89)90040-8 · Cited by 1,625 · see citing works
Synaptic Assembly of the Brain in the Absence of Neurotransmitter Secretion
Verhage, M., Maia, A. S., Plomp, J. J., Brussaard, A. B., Heeroma, J. H., Vermeer, H., Toonen, R. F. G., Hammer, R. E., van den Berg, T. K., Berg, et al. (2000) · Science · doi:10.1126/science.287.5454.864 · Cited by 1,431 · see citing works
Tamamaki, N., Yanagawa, Y., Tomioka, R., Miyazaki, J., Obata, K., & Kaneko, T. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10905 · Cited by 1,277 · see citing works
Jones, K. R., Fariñas, I., Backus, C., & Reichardt, L. F. (1994) · Cell · doi:10.1016/0092-8674(94)90377-8 · Cited by 1,041 · see citing works
Neuron Number and Size in Prefrontal Cortex of Children With Autism
Courchesne, E., Mouton, P. R., Calhoun, M. E., Semendeferi, K., Ahrens-Barbeau, C., Hallet, M. J., Barnes, C. C., & Pierce, K. (2011) · JAMA · doi:10.1001/jama.2011.1638 · Cited by 779 · see citing works
Early motor activity drives spindle bursts in the developing somatosensory cortex
Khazipov, R., Sirota, A., Leinekugel, X., Holmes, G. L., Ben‐Ari, Y., & Buzsáki, G. (2004) · Nature · doi:10.1038/nature03132 · Cited by 634 · see citing works
Weissman, T. A., Riquelme, P. A., Ivic, L., Flint, A. C., & Kriegstein, A. R. (2004) · Neuron · doi:10.1016/j.neuron.2004.08.015 · Cited by 579 · see citing works
Blaschke, A. J., Staley, K., & Chun, J. J. M. (1996) · Development · doi:10.1242/dev.122.4.1165 · Cited by 532 · see citing works
Minicolumnar abnormalities in autism
Casanova, M. F., van Kooten, I. A. J., Switala, A. E., van Engeland, H., Heinsen, H., Steinbusch, H. W. M., Hof, P. R., Trippe, J., Stone, J., & Schmitz, C. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0085-5 · Cited by 499 · see citing works
Neuron Number and Size in Prefrontal Cortex of Children With Autism
Stockman, J. A. (2012) · Yearbook of Pediatrics · doi:10.1016/j.yped.2011.12.022 · Cited by 491 · see citing works
Early patterns of electrical activity in the developing cerebral cortex of humans and rodents
Khazipov, R., & Luhmann, H. J. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.05.007 · Cited by 482 · see citing works
Self-citationThalamocortical development: how are we going to get there?
López‐Bendito, G., & Molnár, Z. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1075 · Cited by 447 · see citing works
The subplate and early cortical circuits
Kanold, P. O., & Luhmann, H. J. (2010) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-060909-153244 · Cited by 440 · see citing works
Effects of seizures on developmental processes in the immature brain
Ben‐Ari, Y., & Holmes, G. L. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70626-3 · Cited by 374 · see citing works
Intrinsically determined cell death of developing cortical interneurons
Southwell, D. G., Paredes, M. F., Galvao, R. P., Jones, D. L., Froemke, R. C., Sebe, J. Y., Alfaro-Cervello, C., Tang, Y., Garcia-Verdugo, J. M., Rubenstein, J. L., et al. (2012) · Nature · doi:10.1038/nature11523 · Cited by 365 · see citing works
Apoptosis and Its Relation to the Cell Cycle in the Developing Cerebral Cortex
Thomaidou, D., Mione, M., Cavanagh, J. F. R., & Parnavelas, J. G. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-03-01075.1997 · Cited by 362 · see citing works
Rapid Cortical Oscillations and Early Motor Activity in Premature Human Neonate
Milh, M., Kamińska, A., Huon, C., Lapillonne, A., Ben‐Ari, Y., & Khazipov, R. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhl069 · Cited by 322 · see citing works
Development of neonatal EEG activity: From phenomenology to physiology
Vanhatalo, S., & Kaila, K. (2006) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2006.07.008 · Cited by 314 · see citing works
A structural view of mitochondria-mediated apoptosis.
Shi, Y. (2001) · Nature Structural Biology · doi:10.1038/87548 · Cited by 307 · see citing works
Antiepileptic Drugs and Apoptosis in the Developing Brain
Bittigau, P., Sifringer, M., & Ikonomidou, C. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb07517.x · Cited by 303 · see citing works
Neuronal activity is required for the development of specific cortical interneuron subtypes
De Marco García, N. V., Karayannis, T., & Fishell, G. (2011) · Nature · doi:10.1038/nature09865 · Cited by 294 · see citing works
Yang, C.-C., Barrós-Loscertales, A., Pinazo, D., Ventura-Campos, N., Borchardt, V., Bustamante, J.-C., Rodríguez-Pujadas, A., Fuentes-Claramonte, P., Balaguer, R., Ávila, C., et al. (2016) · Neural Plasticity · doi:10.1155/2016/9504642 · Cited by 284 · see citing works
Yang, J.-W., Hanganu-Opatz, I. L., Sun, J.-J., & Luhmann, H. J. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5646-08.2009 · Cited by 276 · see citing works
Self-citationLuhmann, H. J., Sinning, A., Yang, J., Reyes‐Puerta, V., Stüttgen, M. C., Kirischuk, S., & Kilb, W. (2016) · Frontiers in Neural Circuits · doi:10.3389/fncir.2016.00040 · Cited by 275 · see citing works
Self-citationThe Role of Cell Death in Regulating the Size and Shape of the Mammalian Forebrain
Haydar, T. F. (1999) · Cerebral Cortex · doi:10.1093/cercor/9.6.621 · Cited by 237 · see citing works
Minichiello, L., & Klein, R. (1996) · Genes & Development · doi:10.1101/gad.10.22.2849 · Cited by 232 · see citing works
Network Mechanisms of Spindle-Burst Oscillations in the Neonatal Rat Barrel Cortex In Vivo
Minlebaev, M., Ben‐Ari, Y., & Khazipov, R. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00759.2006 · Cited by 201 · see citing works
Sahara, S., Yanagawa, Y., O'Leary, D. D. M., & Stevens, C. F. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.6412-11.2012 · Cited by 198 · see citing works
Derer, P., & Derer, M. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90027-2 · Cited by 197 · see citing works
Death of developing neurons: New insights and implications for connectivity
Dekkers, M. P. J., Nikoletopoulou, V., & Barde, Y. (2013) · The Journal of Cell Biology · doi:10.1083/jcb.201306136 · Cited by 195 · see citing works
bax Deficiency Prevents the Increased Cell Death of Immature Neurons in bcl-x -Deficient Mice
Shindler, K. S., Latham, C. B., & Roth, K. A. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-09-03112.1997 · Cited by 177 · see citing works
Gamma abnormalities during perception of illusory figures in autism
Brown, C., Gruber, T., Boucher, J., Rippon, G., & Brock, J. (2005) · Cortex · doi:10.1016/s0010-9452(08)70273-9 · Cited by 166 · see citing works
Regulation of neuronal survival and death by extracellular signals during development
Davies, A. M. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg254 · Cited by 157 · see citing works
Mostafapour, S. P., Cochran, S. L., del Puerto, N. M., & Rubel, E. W. (2000) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20001030)426:4 · Cited by 156 · see citing works
Activity-Dependent Regulation of Neuronal Apoptosis in Neonatal Mouse Cerebral Cortex
Heck, N., Golbs, A., Riedemann, T., Sun, J., Leßmann, V., & Luhmann, H. J. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhm165 · Cited by 146 · see citing works
Self-citationSuppression of the Intrinsic Apoptosis Pathway by Synaptic Activity
Léveillé, F., Papadia, S., Fricker, M., Bell, K. F. S., Soriano, F. X., Martel, M., Puddifoot, C. A., Habel, M., Wyllie, D. J. A., Ikonomidou, C., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5115-09.2010 · Cited by 145 · see citing works
Atlas of the developing mouse brain at E 17.5, P0, and P6
Paxinos, G., Halliday, G. M., WATSON, C. R. R., Koutcherov, Y., & Wang, H. (2007) · Elsevier eBooks · Cited by 143 · see citing works
Activity-dependent neurotransmitter respecification
Spitzer, N. C. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3154 · Cited by 137 · see citing works
Molecular Diversity of Early-Born Subplate Neurons
Hoerder‐Suabedissen, A., & Molnár, Z. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhs137 · Cited by 137 · see citing works
Silos‐Santiago, I., Fagan, A. M., Garber, M., Fritzsch, B., & Barbacid, M. (1997) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1997.tb01372.x · Cited by 134 · see citing works
Differential survival of Cajal-Retzius cells in organotypic cultures of hippocampus and neocortex
Del Rı́o, J. A., Heimrich, B., Supèr, H., Borrell, V., Frotscher, M., & Soriano, E. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-21-06896.1996 · Cited by 133 · see citing works
Conti, F., Melone, M., Biasi, S. D., Minelli, A., Brecha, N. C., & Ducati, A. (1998) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19980622)396:1 · Cited by 130 · see citing works
Electrical activity patterns and the functional maturation of the neocortex
Kilb, W., Kirischuk, S., & Luhmann, H. J. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07878.x · Cited by 124 · see citing works
Self-citationNEURONAL DEATH IN THE DEVELOPMENT AND AGING OF THE CEREBRAL CORTEX OF THE MOUSE
Heumann, D., & Leuba, G. (1983) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1983.tb00116.x · Cited by 122 · see citing works
Is birth a critical period in the pathogenesis of autism spectrum disorders?
Ben-Ari, Y. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3956 · Cited by 117 · see citing works
Sensory inputs control the integration of neurogliaform interneurons into cortical circuits
De Marco García, N. V., Priya, R., Tuncdemir, S. N., Fishell, G., & Karayannis, T. (2015) · Nature Neuroscience · doi:10.1038/nn.3946 · Cited by 117 · see citing works
Programmed cell death during neuronal development: the sympathetic neuron model
Kristiansen, M., & Ham, J. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.47 · Cited by 115 · see citing works
Overproduction of Upper-Layer Neurons in the Neocortex Leads to Autism-like Features in Mice
Fang, W.-Q., Chen, W.-W., Jiang, L., Liu, K., Yung, W.-H., Fu, A. K. Y., & Ip, N. Y. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.11.003 · Cited by 114 · see citing works
Independent Controls for Neocortical Neuron Production and Histogenetic Cell Death
Verney, C., Takahashi, T., Bhide, P. G., Nowakowski, R. S., & Caviness, V. S. (2000) · Developmental Neuroscience · doi:10.1159/000017434 · Cited by 100 · see citing works
Sensory-Evoked and Spontaneous Gamma and Spindle Bursts in Neonatal Rat Motor Cortex
An, S., Kilb, W., & Luhmann, H. J. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4539-13.2014 · Cited by 94 · see citing works
Self-citationFerrer, I., Tortosa, A., Blanco, R. E., Martín, F., Serrano, T., Planas, A. M., & Macaya, A. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90210-0 · Cited by 94 · see citing works
Layer-Specific Refinement of Sensory Coding in Developing Mouse Barrel Cortex
van der Bourg, A., Yang, J., Reyes‐Puerta, V., Laurenczy, B., Wieckhorst, M., Stüttgen, M. C., Luhmann, H. J., & Helmchen, F. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw280 · Cited by 92 · see citing works
Self-citationRegulation of dendritic development by neuronal activity
Chen, Y., & Ghosh, A. (2005) · Journal of Neurobiology · doi:10.1002/neu.20150 · Cited by 87 · see citing works
Diessen, E. G. A. L. V., Senders, J. T., Jansen, F. E., Boersma, M., & Bruining, H. (2014) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-014-0527-3 · Cited by 84 · see citing works
Prenatal Neurogenesis in Autism Spectrum Disorders
Kaushik, G., & Zarbalis, K. S. (2016) · Frontiers in Chemistry · doi:10.3389/fchem.2016.00012 · Cited by 77 · see citing works
The Nature of the Sensory Input to the Neonatal Rat Barrel Cortex
Akhmetshina, D., Nasretdinov, A., Zakharov, A., Valeeva, G. R., & Khazipov, R. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.1781-16.2016 · Cited by 73 · see citing works
Cell death atlas of the postnatal mouse ventral forebrain and hypothalamus: Effects of age and sex
Ahern, T. H., Krug, S., Carr, A. V., Murray, E. K., Fitzpatrick, E. G., Bengston, L., McCutcheon, J., Vries, G. J. D., & Forger, N. G. (2013) · The Journal of Comparative Neurology · doi:10.1002/cne.23298 · Cited by 70 · see citing works
Nakamura, A., Swahari, V., Plestant, C., Smith, I. T., McCoy, E. S., Smith, S. L., Moy, S. S., Anton, E. S., & Deshmukh, M. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.4247-15.2016 · Cited by 67 · see citing works
Control of Programmed Cell Death by Distinct Electrical Activity Patterns
Golbs, A., Nimmervoll, B. V., Sun, J., Sava, I., & Luhmann, H. J. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhq200 · Cited by 64 · see citing works
Self-citationNeocortical Layer 6B as a Remnant of the Subplate - A Morphological Comparison
Marx, M., Qi, G., Hanganu‐Opatz, I. L., Kilb, W., Luhmann, H. J., & Feldmeyer, D. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhv279 · Cited by 63 · see citing works
Self-citationHigashi, S., Hioki, K., Kurotani, T., Kasim, N., & Molnár, Z. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4023-04.2005 · Cited by 62 · see citing works
Isoflurane suppresses early cortical activity
Ситдикова, Г. Ф., Zakharov, A., Janáčková, S., Gerasimova, E., Lebedeva, J., Inácio, A. R. L., Zaynutdinova, D., Minlebaev, M., Holmes, G. L., & Khazipov, R. (2013) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.16 · Cited by 61 · see citing works
Kilb, W., Dierkes, P. W., Syková, E., et al. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.20871 · Cited by 58 · see citing works
Self-citationNKCC1-Mediated GABAergic Signaling Promotes Postnatal Cell Death in Neocortical Cajal–Retzius Cells
Blanquie, O., Liebmann, L., Hübner, C. A., Luhmann, H. J., & Sinning, A. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw004 · Cited by 58 · see citing works
Self-citationHomeostatic interplay between electrical activity and neuronal apoptosis in the developing neocortex
Blanquie, O., Kilb, W., Sinning, A., & Luhmann, H. J. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.06.030 · Cited by 58 · see citing works
Self-citationPuskarjov, M., Ahmad, F., Khirug, S., Sivakumaran, S., Kaila, K., & Blaesse, P. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.09.005 · Cited by 57 · see citing works
Sullivan, R. M., Landers, M. S., Flemming, J., Vaught, C., Young, T. A., & Polan, H. J. (2003) · Somatosensory & Motor Research · doi:10.1080/0899022031000105190 · Cited by 56 · see citing works
Cortical area size dictates performance at modality-specific behaviors
Leingärtner, A., Thuret, S., Kroll, T. T., Chou, S., Leasure, J. L., Gage, F. H., & O’Leary, D. D. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611723104 · Cited by 55 · see citing works
Spindle Bursts in Neonatal Rat Cerebral Cortex
Yang, J., Reyes‐Puerta, V., Kilb, W., & Luhmann, H. J. (2016) · Neural Plasticity · doi:10.1155/2016/3467832 · Cited by 55 · see citing works
Self-citationHartung, H., Brockmann, M. D., Pöschel, B., Feo, V. D., & Hanganu‐Opatz, I. L. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3232-15.2016 · Cited by 53 · see citing works
Postnatal neuronal apoptosis in the cerebral cortex: Physiological and pathophysiological mechanisms
Nikolić, M., Gardner, H., & Tucker, K. L. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.09.035 · Cited by 49 · see citing works
Inhibition of Cortical Activity and Apoptosis Caused by Ethanol in Neonatal Rats In Vivo
Lebedeva, J., Zakharov, A., Ogievetsky, E., Minlebaeva, A., Kurbanov, R., Gerasimova, E., Ситдикова, Г. Ф., & Khazipov, R. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhv293 · Cited by 49 · see citing works
Ledonné, F., Orduz, D., Mercier, J., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.11.074 · Cited by 49 · see citing works
Conhaim, J. I., Easton, C. R., Becker, M. I., Barahimi, M., Cedarbaum, E. R., Moore, J. G., Mather, L. F., Dabagh, S., Minter, D. J., Moen, S. P., et al. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2010.202382 · Cited by 43 · see citing works
Patterns of cell death in the perinatal mouse forebrain
Mosley, M., Shah, C. R., Morse, K. A., Miloro, S. A., Holmes, M. M., Ahern, T. H., & Forger, N. G. (2016) · The Journal of Comparative Neurology · doi:10.1002/cne.24041 · Cited by 43 · see citing works
Murase, S., Owens, D. F., & McKay, R. D. G. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0202-11.2011 · Cited by 40 · see citing works
Soumiya, H., Godai, A., Araiso, H., Mori, S., Furukawa, S., & Fukumitsu, H. (2016) · PLoS ONE · doi:10.1371/journal.pone.0158583 · Cited by 39 · see citing works
Neocortical and Hippocampal Changes after Multiple Pilocarpine‐induced Status Epilepticus in Rats
da Silva, A. V., Regondi, M. C., Cipelletti, B., et al. (2005) · Epilepsia · doi:10.1111/j.1528-1167.2005.31604.x · Cited by 27 · see citing works
Activity‐dependent survival of developing neocortical neurons depends on PI3K signalling
Wagner-Golbs, A., & Luhmann, H. J. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07591.x · Cited by 18 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Development and Functional Diversification of Cortical Interneurons
Lim, L., Mi, D., Llorca, A., & Marín, O. (2018) · Neuron · doi:10.1016/j.neuron.2018.10.009 · Cited by 714 · see citing works
Transient cortical circuits match spontaneous and sensory-driven activity during development
Molnár, Z., Luhmann, H. J., & Kanold, P. O. (2020) · Science · doi:10.1126/science.abb2153 · Cited by 280 · see citing works
Self-citationPyramidal cell regulation of interneuron survival sculpts cortical networks
Wong, F. K., Bercsenyi, K., Sreenivasan, V., Portalés, A., Fernández-Otero, M., & Marín, O. (2018) · Nature · doi:10.1038/s41586-018-0139-6 · Cited by 286 · see citing works
Activity regulates cell death within cortical interneurons through a Calcineurin-dependent mechanism
Priya, R., Paredes, M. F., Karayannis, T., Yusuf, N., Liu, X., Jaglin, X., Graef, I., Alvarez-Buylla, A., & Fishell, G. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.01.007 · Cited by 127 · see citing works
Modulation of apoptosis controls inhibitory interneuron number in the cortex
Denaxa, M., Neves, G., Rabinowitz, A., Kemlo, S., Liodis, P., Burrone, J., & Pachnis, V. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.01.064 · Cited by 112 · see citing works
GABAergic Restriction of Network Dynamics Regulates Interneuron Survival in the Developing Cortex
Duan, Z. R. S., Che, A., Chu, P., Modol, L., Bollmann, Y., Babij, R., Fetcho, R. N., Otsuka, T., Fuccillo, M. V., Liston, C., et al. (2020) · Neuron · doi:10.1016/j.neuron.2019.10.008 · Cited by 102 · see citing works
Sleep, plasticity, and sensory neurodevelopment
Blumberg, M. S., Dooley, J. C., & Tiriac, A. (2022) · Neuron · doi:10.1016/j.neuron.2022.08.005 · Cited by 93 · see citing works
Large neutral amino acid levels tune perinatal neuronal excitability and survival
Knaus, L. S., Basilico, B., Malzl, D., Gerykova Bujalkova, M., Smogavec, M., Schwarz, L. A., Gorkiewicz, S., Amberg, N., Pauler, F. M., Knittl-Frank, C., et al. (2023) · Cell · doi:10.1016/j.cell.2023.02.037 · Cited by 70 · see citing works
Preterm Birth Changes Networks of Newborn Cortical Activity
Tokariev, A., Stjerna, S., Lano, A., Metsäranta, M., Palva, J. M., & Vanhatalo, S. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhy012 · Cited by 53 · see citing works
- Authors
- Blanquie, O., Yang, J.-W., Kilb, W., Sharopov, S., Sinning, A., & Luhmann, H. J.
- Affiliations
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- Corresponding author
- Luhmann, Heiko J
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2017-08-21
- Volume
- 6
- ISSN
- 2050-084X (ISSN-L)
- PMC
- PMC5582867
- OpenAlex
- W2746129944
- Cited by
- 114
- References
- 88
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 11 · 2023: 11 · 2022: 22 · 2021: 13 · 2020: 12 · 2019: 12 · 2018: 11 · 2017: 2
- FWCI
- 4.25
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- eLife (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Deutsche Forschungsgemeinschaft (Collaborative Research Center 1080)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- neuronal apoptosis, programmed cell death, cortical development, primary motor cortex, primary somatosensory cortex, spontaneous neuronal activity, sensory deprivation, neuronal loss, postnatal brain development
- MeSH terms
- Aging, Anesthesia, Animals, Animals, Newborn, Cell Count, Cerebral Cortex, Motor Cortex, Neurons, Somatosensory Cortex, Apoptosis, Mice, Caspase 3, Electrophysiological Phenomena
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review