Cited by 71Olfactory and Sensory Function StudiesAdvanced Chemical Sensor TechnologiesComputational Drug Discovery Methods

Machine Learning in Human Olfactory Research

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Lötsch, Jörn, Kringel, Dario, Hummel, Thomas·2019·Chemical Senses

Abstract

The complexity of the human sense of smell is increasingly reflected in complex and high-dimensional data, which opens opportunities for data-driven approaches that complement hypothesis-driven research. Contemporary developments in computational and data science, with its currently most popular implementation as machine learning, facilitate complex data-driven research approaches. The use of machine learning in human olfactory research included major approaches comprising 1) the study of the physiology of pattern-based odor detection and recognition processes, 2) pattern recognition in olfactory phenotypes, 3) the development of complex disease biomarkers including olfactory features, 4) odor prediction from physico-chemical properties of volatile molecules, and 5) knowledge discovery in publicly available big databases. A limited set of unsupervised and supervised machine-learned methods has been used in these projects, however, the increasing use of contemporary methods of computational science is reflected in a growing number of reports employing machine learning for human olfactory research. This review provides key concepts of machine learning and summarizes current applications on human olfactory data.

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Authors
Lötsch, J., Kringel, D., & Hummel, T.
Affiliations
  • Goethe University Frankfurt (DE)
  • Klinik und Poliklinik für Hals-, Nasen- und Ohrenheilkunde (DE)
Corresponding author
Lötsch, Jörn
Venue
Chemical Senses
Published
2018-10-27
Volume
44
Issue
1
Pages
11-22
ISSN
  • 0379-864X (ISSN-L)
  • 1464-3553
OpenAlex
W2898511110
Cited by
71
References
138
Citations by year
2026: 5 · 2025: 11 · 2024: 11 · 2023: 9 · 2022: 9 · 2021: 11 · 2020: 9 · 2019: 6
FWCI
1.21
Type
journal article
Language
en
Open access
Locations
  • Chemical Senses (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • Publikationsdatenbank der Fraunhofer-Gesellschaft (Fraunhofer-Gesellschaft) (submittedVersion, other-oa)
  • Fraunhofer-Publica (Fraunhofer-Gesellschaft) (submittedVersion)
Funders
  • Landesoffensive zur Entwicklung wissenschaftlich-ökonomischer Exzellenz
  • LOEWE-Zentrum für Translationale Medizin und Pharmakologie
  • Deutsche Forschungsgemeinschaft (DFG HU 441/18-1, DFG Lo 612/10–1)
  • European Union Seventh Framework Programme (FP7/2007 - 2013, 602919)
Topics
  • Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
  • Physical Sciences › Engineering › Biomedical Engineering › Advanced Chemical Sensor Technologies
  • Physical Sciences › Computer Science › Computational Theory and Mathematics › Computational Drug Discovery Methods
Keywords
machine learning, human olfaction, odor detection, odor recognition, olfactory biomarkers, odor prediction, volatile compounds, physicochemical properties, pattern recognition
MeSH terms
Machine Learning, Humans, Odorants, Smell, Biomarkers, Databases, Factual, Volatile Organic Compounds, Electronic Nose

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