The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.
Non‐coding RNAs: the architects of eukaryotic complexity
Open accessAbstract
Around 98% of all transcriptional output in humans is non‐coding RNA. RNA‐mediated gene regulation is widespread in higher eukaryotes and complex genetic phenomena like RNA interference, co‐suppression, transgene silencing, imprinting, methylation, and possibly position‐effect variegation and transvection, all involve intersecting pathways based on or connected to RNA signaling. I suggest that the central dogma is incomplete, and that intronic and other non‐coding RNAs have evolved to comprise a second tier of gene expression in eukaryotes, which enables the integration and networking of complex suites of gene activity. Although proteins are the fundamental effectors of cellular function, the basis of eukaryotic complexity and phenotypic variation may lie primarily in a control architecture composed of a highly parallel system of trans ‐acting RNAs that relay state information required for the coordination and modulation of gene expression, via chromatin remodeling, RNA–DNA, RNA–RNA and RNA–protein interactions. This system has interesting and perhaps informative analogies with small world networks and dataflow computing.
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Cites
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The sequence of the human genome
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Error and attack tolerance of complex networks
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Error and attack tolerance of complex networksPreprint
Albert, R., Jeong, H., & Barabási, A.-Ĺ. (2000) · Cited by 6,467
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The Sequence of the Human Genome
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Cited by
The multilayered complexity of ceRNA crosstalk and competition
Tay, Y., Rinn, J., & Pandolfi, P. P. (2014) · Nature · doi:10.1038/nature12986 · Cited by 3,910
Khalil, A. M., Guttman, M., Huarte, M., Garber, M., Raj, A., Rivea Morales, D., Thomas, K., Presser, A., Bernstein, B. E., van Oudenaarden, A., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904715106 · Cited by 2,872
Multiscale entropy analysis of biological signals
Costa, M., Goldberger, A. L., & Peng, C.-K. (2005) · Physical Review E · doi:10.1103/physreve.71.021906 · Cited by 2,482
Kitano, H. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1471 · Cited by 2,278
The functional role of long non-coding RNA in human carcinomas
Gibb, E. A., Brown, C. J., & Lam, W. L. (2011) · Molecular Cancer · doi:10.1186/1476-4598-10-38 · Cited by 1,619
Metadata
- Authors
- Mattick, J. S.
- Venue
- EMBO reports
- Published
- 2001-11
- Volume
- 2
- Issue
- 11
- Pages
- 986-991
- ISSN
- 1469-221X (ISSN-L)
- 1469-3178
- OpenAlex
- W2102819831
- Cited by
- 848
- References
- 78
- FWCI
- 10.86
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
