The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Substrate modification combined with pulmonary vein isolation improves outcome of catheter ablation in patients with persistent atrial fibrillation: a prospective randomized comparison
Abstract
AIMS: To investigate the effectiveness of additional substrate modification (SM) by left atrial (LA) linear lesions as compared with pulmonary vein isolation (PVI) alone in patients with persistent atrial fibrillation (AF) in a prospective randomized study. Percutaneous PVI has evolved as an accepted treatment for paroxysmal AF but seemed to be less effective in patients with persistent AF. The benefit of PVI alone and additional linear lesions has not been validated in a randomized study so far. METHODS AND RESULTS: Sixty-two patients with persistent AF (median duration 7, range 1-18 months) were randomly assigned to either PVI alone (n = 30) or additional SM (n =32) consisting of a roof line connecting both left superior and right superior PV and LA isthmus ablation between left inferior PV and mitral annulus. Procedures including SM were performed using a three-dimensional mapping system (EnSite NavX, St Jude Medical, St Paul, MN, USA). Anti-arrhythmic drugs were discontinued within 8 weeks after ablation in both groups. Follow-up included daily trans-telephonic ECG transmitted irrespective of the patient's symptoms. PVI was successful in 98% of all targeted veins in both groups. Additional SM did not increase fluoroscopy time (72.1+/-18.7 vs. 72.9+/-17.3 min, P=0.92) because of the use of three-dimensional navigation in the PVI+SM group. AF recurrences within the first 4 weeks following ablation were more common after PVI alone (77%) than additional SM (44%, P=0.002). After a follow-up time of 487 (429-570) days, only 20% of patients undergoing stand alone PVI remained in sinus rhythm when compared with 69% following PVI combined with SM (P=0.0001). Two patients assigned to PVI+SM experienced procedure-related complications (cardiac tamponade and minor stroke) which resolved without sequelae. CONCLUSION: PVI alone is insufficient in the treatment of persistent AF. However, additional left linear lesions increase the success rate significantly. Early AF-relapses are associated with a negative outcome after PVI alone but not following additional SM.
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Citations
Cites
Spontaneous Initiation of Atrial Fibrillation by Ectopic Beats Originating in the Pulmonary Veins
Haïssaguerre, M., Jaïs, P., Shah, D. C., Takahashi, A., Hocini, M., Quiniou, G., Garrigue, S., Le Mouroux, A., Le Métayer, P., & Clémenty, J. (1998) · New England Journal of Medicine · doi:10.1056/nejm199809033391003 · Cited by 7,975
Chen, S.-A., Hsieh, M.-H., Tai, C.-T., Tsai, C.-F., Prakash, V. S., Yu, W.-C., Hsu, T.-L., Ding, Y.-A., & Chang, M.-S. (1999) · Circulation · doi:10.1161/01.cir.100.18.1879 · Cited by 1,446
Pulmonary Vein Isolation for Paroxysmal and Persistent Atrial Fibrillation
Oral, H., Knight, B. P., Tada, H., Özaydın, M., Chugh, A., Hassan, S., Scharf, C., Lai, S. W. K., Greenstein, R., Pelosi, F., et al. (2002) · Circulation · doi:10.1161/hc0902.104712 · Cited by 1,112
Pappone, C., Santinelli, V., Manguso, F., Vicedomini, G., Gugliotta, F., Augello, G., Mazzone, P., Tortoriello, V., Landoni, G., Zangrillo, A., et al. (2004) · Circulation · doi:10.1161/01.cir.0000112641.16340.c7 · Cited by 1,018
Electrophysiological Breakthroughs From the Left Atrium to the Pulmonary Veins
Haïssaguerre, M., Shah, D. C., Jaïs, P., Hocini, M., Yamane, T., Deisenhofer, I., Chauvin, M., Garrigue, S., & Clémenty, J. (2000) · Circulation · doi:10.1161/01.cir.102.20.2463 · Cited by 952
Haïssaguerre, M., Jaïs, P., Shah, D. C., Garrigue, S., Takahashi, A., Lavergne, T., Hocini, M., Peng, J. T., Roudaut, R., & Clémenty, J. (2000) · Circulation · doi:10.1161/01.cir.101.12.1409 · Cited by 922
Catheter Ablation for Atrial Fibrillation in Congestive Heart Failure
Hsu, L.-F., Jaïs, P., Sanders, P., Garrigue, S., Hocini, M., Sacher, F., Takahashi, Y., Rotter, M., Pasquié, J.-L., Scavée, C., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa041018 · Cited by 892
Pappone, C., Oreto, G., Rosanio, S., Vicedomini, G., Tocchi, M., Gugliotta, F., Salvati, A., Dicandia, C., Calabrò, M. P., Mazzone, P., et al. (2001) · Circulation · doi:10.1161/hc4601.098517 · Cited by 863
Technique and Results of Linear Ablation at the Mitral Isthmus
Jaïs, P., Hocini, M., Hsu, L.-F., Sanders, P., Scavee, C., Weerasooriya, R., Macle, L., Raybaud, F., Garrigue, S., Shah, D. C., et al. (2004) · Circulation · doi:10.1161/01.cir.0000146917.75041.58 · Cited by 751
Anatomy of the Left Atrium: Implications for Radiofrequency Ablation of Atrial Fibrillation
YEN HO, S., SANCHEZ‐QUINTANA, D., CABRERA, J. A., & ANDERSON, R. H. (1999) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.1999.tb00211.x · Cited by 691
Cited by
Approaches to catheter ablation for persistent atrial fibrillation
Verma, A., Jiang, C.-Y., Betts, T. R., Chen, J., Deisenhofer, I., Mantovan, R., Macle, L., Morillo, C. A., Haverkamp, W., Weerasooriya, R., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1408288 · Cited by 2,339
Calkins, H., Brugada, J., Packer, D. L., Cappato, R., Chen, S.-A., Crijns, H. J. G., Damiano, R. J., Davies, D. W., Haines, D. E., Haissaguerre, M., et al. (2007) · Europace · doi:10.1093/europace/eum120 · Cited by 1,290
Catheter Ablation Versus Antiarrhythmic Drugs for Atrial Fibrillation: The A4 Study
Jaïs, P., Cauchemez, B., Macle, L., Daoud, E., Khairy, P., Subbiah, R., Hocini, M., Extramiana, F., Sacher, F., Bordachar, P., et al. (2008) · Circulation · doi:10.1161/circulationaha.108.772582 · Cited by 891
Venice Chart International Consensus Document on Atrial Fibrillation Ablation
NATALE, A., RAVIELE, A., ARENTZ, T., CALKINS, H., CHEN, S., HAÏSSAGUERRE, M., HINDRICKS, G., HO, Y., KUCK, K. H., MARCHLINSKI, F., et al. (2007) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2007.00816.x · Cited by 406
Pulmonary Vein Isolation Versus Defragmentation
Vogler, J., Willems, S., Sultan, A., Schreiber, D., Lüker, J., Servatius, H., Schäffer, B., Moser, J., Hoffmann, B. A., & Steven, D. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.09.088 · Cited by 349
Self-citation
Metadata
- Authors
- Willems, S., Klemm, H., Rostock, T., Brandstrup, B., Ventura, R., Steven, D., Risius, T., Lutomsky, B., & Meinertz, T.
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-11-13
- Volume
- 27
- Issue
- 23
- Pages
- 2871-2878
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- OpenAlex
- W2098977037
- Cited by
- 332
- References
- 34
- FWCI
- 12.90
- Type
- journal article
- Language
- en
- Open access
- closed
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- Willems, S., Klemm, H., Rostock, T., Brandstrup, B., Ventura, R., Steven, D., Risius, T., Lutomsky, B., & Meinertz, T. (2006). Substrate modification combined with pulmonary vein isolation improves outcome of catheter ablation in patients with persistent atrial fibrillation: a prospective randomized comparison. European Heart Journal. https://doi.org/10.1093/eurheartj/ehl093
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