Cited by 1,410Adipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and AdiposityAdipose Tissue and Metabolism

The DOI matches its Crossref record; 137 of the 137 references it cites were found in a registry or an index.

Adipose tissue dysfunction in obesity, diabetes, and vascular diseases

Hajer, G. R., van Haeften, T. W., Visseren, F. L.J.·2008·European Heart Journal

DOI 10.1093/eurheartj/ehn387

Open this paper in CoChat — free account

Abstract

The classical perception of adipose tissue as a storage place of fatty acids has been replaced over the last years by the notion that adipose tissue has a central role in lipid and glucose metabolism and produces a large number of hormones and cytokines, e.g. tumour necrosis factor-alpha, interleukin-6, adiponectin, leptin, and plasminogen activator inhibitor-1. The increased prevalence of excessive visceral obesity and obesity-related cardiovascular risk factors is closely associated with the rising incidence of cardiovascular diseases and type 2 diabetes mellitus. This clustering of vascular risk factors in (visceral) obesity is often referred to as metabolic syndrome. The close relationship between an increased quantity of visceral fat, metabolic disturbances, including low-grade inflammation, and cardiovascular diseases and the unique anatomical relation to the hepatic portal circulation has led to an intense endeavour to unravel the specific endocrine functions of this visceral fat depot. The objective of this paper is to describe adipose tissue dysfunction, delineate the relation between adipose tissue dysfunction and obesity and to describe how adipose tissue dysfunction is involved in the development of diabetes mellitus type 2 and atherosclerotic vascular diseases. First, normal physiology of adipocytes and adipose tissue will be described.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1093/eurheartj/ehn387

Cites

137 of 137 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Summary of the second report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II)
Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944
Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
Expert Panel on Detection, E. (2001) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.285.19.2486 · Cited by 26,011
Atherosclerosis--an inflammatory disease
Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725
Central nervous system control of food intake
Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451
Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans
Considine, R. V., Sinha, M. K., Heiman, M. L., Kriauciunas, A., Stephens, T. W., Nyce, M. R., Ohannesian, J. P., Marco, C. C., McKee, L. J., Bauer, T. L., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199602013340503 · Cited by 6,326
Monocyte and macrophage heterogeneity
Gordon, S., & Taylor, P. R. (2005) · Nature Reviews Immunology · doi:10.1038/nri1733 · Cited by 5,190
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., et al. (2001) · Nature Medicine · doi:10.1038/90984 · Cited by 4,915
Cardiovascular Morbidity and Mortality Associated With the Metabolic Syndrome
Isomaa, B., Almgren, P., Tuomi, T., Forsén, B., Lahti, K., Nissén, M., Taskinen, M.-R., & Groop, L. (2001) · Diabetes Care · doi:10.2337/diacare.24.4.683 · Cited by 4,760
Obesity induces a phenotypic switch in adipose tissue macrophage polarization
Lumeng, C. N., Bodzin, J. L., & Saltiel, A. R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29881 · Cited by 4,664
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
Yamauchi, T., Kamon, J., Minokoshi, Y., Ito, Y., Waki, H., Uchida, S., Yamashita, S., Noda, M., Kita, S., Ueki, K., et al. (2002) · Nature Medicine · doi:10.1038/nm788 · Cited by 4,238

Show all 136 references

Research works printed but not linked: 6

Cheung, 1997, Endocrinology, 138, 4489, 10.1210/en.138.10.4489 · DOI · Paper page
2007, American heart journal, 154, 750
Tsigos, 1997, Journal of Clinical Endocrinology & Metabolism, 82, 4167, 10.1210/jc.82.12.4167 · DOI · Paper page
Ozata, 1999, Journal of Clinical Endocrinology & Metabolism, 84, 3686, 10.1210/jc.84.10.3686 · DOI · Paper page
1995, International journal of obesity, 19, S16
2004, Circulation Research, 94, e27

Sorted by citations

Items 401–500 of 999

Excess Early Postnatal Weight Gain Leads to Thicker and Stiffer Arteries in Young Children
Evelein, A. M. V., Visseren, F. L. J., van der Ent, C. K., Grobbee, D. E., & Uiterwaal, C. S. P. M. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-3208 · Cited by 43
Self-citation
The Oxidative Modification of Von Willebrand Factor Is Associated with Thrombotic Angiopathies in Diabetes Mellitus
Oggianu, L., Lancellotti, S., Pitocco, D., Zaccardi, F., Rizzo, P., Martini, F., Ghirlanda, G., & CRISTOFARO, R. D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055396 · Cited by 42
The source of the fat significantly affects the results of high-fat diet intervention
An, J., Wang, Q., Yi, S., Liu, X., Jin, H., Xu, J., Wen, G., Zhu, J., & Tuo, B. (2022) · Scientific Reports · doi:10.1038/s41598-022-08249-2 · Cited by 45
Abdominal obesity and low physical activity are associated with insulin resistance in overweight adolescents: a cross-sectional study
Velásquez, C., Velásquez-Villa, M., Gómez-Ocampo, L., & Bermúdez-Cardona, J. (2014) · BMC Pediatrics · doi:10.1186/1471-2431-14-258 · Cited by 42
Influencing factors on cardiac structure and function beyond glycemic control in patients with type 2 diabetes mellitus
Ichikawa, R., Daimon, M., Miyazaki, T., Kawata, T., Miyazaki, S., Maruyama, M., Chiang, S.-J., Suzuki, H., Ito, C., Sato, F., et al. (2013) · Cardiovascular Diabetology · doi:10.1186/1475-2840-12-38 · Cited by 43
Epicardial and Subcutaneous Adipose Tissue Fatty Acids Profiles in Diabetic and Non-Diabetic Patients Candidate for Coronary Artery Bypass Graft
Pezeshkian, M., & Mahtabipour, M.-R. (2013) · Europe PMC (PubMed Central) · doi:10.5681/bi.2013.004 · Cited by 42
Biomedical Consequences of Alcohol Use Disorders in the HIV-Infected Host
Molina, P. E., Bagby, G., & Nelson, S. (2014) · Current HIV Research · doi:10.2174/1570162x12666140721121849 · Cited by 43
Obesity-linked diabetes in the Arab world: a review
Abuyassin, B., & Laher, I. (2015) · Eastern Mediterranean Health Journal · doi:10.26719/2015.21.420 · Cited by 42
Obesity, Type 2 Diabetes, and the Metabolic Syndrome
Genser, L., Mariolo, J. R. C., Castagneto‐Gissey, L., Panagiotopoulos, S., & Rubino, F. (2016) · Surgical Clinics of North America · doi:10.1016/j.suc.2016.03.013 · Cited by 47
Edible Mushrooms: Novel Medicinal Agents to Combat Metabolic Syndrome and Associated Diseases
Tung, Y., Pan, C., Chien, Y., & Huang, H.-Y. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200831151316 · Cited by 42
Adipose Tissue Paracrine-, Autocrine-, and Matrix-Dependent Signaling during the Development and Progression of Obesity
Johnston, E. K., & Abbott, R. D. (2023) · Cells · doi:10.3390/cells12030407 · Cited by 44
Exercise Training Reverses Structural Microvascular Rarefaction and Improves Endothelium-Dependent Microvascular Reactivity in Rats with Diabetes
Machado, M. V. R., Martins, R. L., Borges, J. P., Antunes, B. R., Estato, V., Vieira, A. B., & Tibiriçá, E. V. (2016) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2015.0146 · Cited by 41
Anti-Obesity Effects of Soy Leaf via Regulation of Adipogenic Transcription Factors and Fat Oxidation in Diet-Induced Obese Mice and 3T3-L1 Adipocytes
Li, H., Kang, J., Han, J., Cho, M.-H., Chung, Y., Park, K. H., Shin, D., Park, H.-Y., Choi, M., & Jeong, T. (2015) · Journal of Medicinal Food · doi:10.1089/jmf.2014.3388 · Cited by 41
Advanced Oxidation Protein Products Induce Inflammatory Response and Insulin Resistance in Cultured Adipocytes via Induction of Endoplasmic Reticulum Stress
Zhou, Q. G., Zhou, M., Lou, A., Xie, D., & Hou, F. F. (2010) · Cellular Physiology and Biochemistry · doi:10.1159/000322345 · Cited by 41
The Effect of Exercise on Serum Levels of Interleukin-18 and Components of the Metabolic Syndrome
Trøseid, M., Lappegård, K. T., Mollnes, T. E., Arnesen, H., & Seljeflot, I. (2009) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2009.0003 · Cited by 41
NHG-Standaard Obesitas
van Binsbergen, J. J., Langens, F., Dapper, A. L. M., Halteren, M. M., Glijsteen, R., Cleyndert, G., Oei, S. N. M., & Avendonk, M. V. (2011) · Bohn Stafleu van Loghum eBooks · doi:10.1007/978-90-313-8279-8_72 · Cited by 41
Pharmacological myeloperoxidase (MPO) inhibition in an obese/hypertensive mouse model attenuates obesity and liver damage, but not cardiac remodeling
Piek, A., Koonen, D. P. Y., Schouten, E., Lindtstedt, E. L., Michaëlsson, E., de Boer, R. A., & Silljé, H. H. W. (2019) · Scientific Reports · doi:10.1038/s41598-019-55263-y · Cited by 41
Adlay Seed Extract ( Coix lachryma-jobi L.) Decreased Adipocyte Differentiation and Increased Glucose Uptake in 3T3-L1 Cells
Ha, D. T., Trung, T. N., Thu, N. B., On, T. V., Nam, N., Mến, C. V., Tran, P., & Bae, K. (2010) · Journal of Medicinal Food · doi:10.1089/jmf.2010.1155 · Cited by 41
Cardiovascular Disease Risk in Adult Women with Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency
Kim, M. S., & Merke, D. P. (2009) · Seminars in Reproductive Medicine · doi:10.1055/s-0029-1225259 · Cited by 41
Sleep Apnea–Hypopnea Syndrome and Type 2 Diabetes. A Reciprocal Relationship?
Martínez-Cerón, E., Mateos, R. C., & Rio, F. G. (2015) · Archivos de Bronconeumología · doi:10.1016/j.arbr.2014.12.007 · Cited by 41
Changes in body weight and composition, metabolic parameters, and quality of life in patients with type 2 diabetes treated with subcutaneous semaglutide in real-world clinical practice
Pantanetti, P., Cangelosi, G., Alberti, S., Marco, S. D., Michetti, G., Cerasoli, G., Giacinti, M. D., Coacci, S., Francucci, N., Petrelli, F., et al. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1394506 · Cited by 43
Metabolic Obesity, Adipocytokines, and Inflammatory Markers in Asian Indians—CURES-124
Indulekha, K., Surendar, J., Anjana, R., Geetha, L., Gokulakrishnan, K., Pradeepa, R., & Mohan, V. (2015) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2014.0202 · Cited by 46
Peripheral blood mononuclear cells as a source to detect markers of homeostatic alterations caused by the intake of diets with an unbalanced macronutrient composition
Díaz‐Rúa, R., Keijer, J., Caimari, A., van Schothorst, E. M., Palou, A., & Oliver, P. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2014.11.013 · Cited by 41
Non-invasive Quantitative Analysis of Specific Fat Accumulation in Subcutaneous Adipose Tissues using Raman Spectroscopy
Meksiarun, P., Andriana, B. B., Matsuyoshi, H., & Sato, H. (2016) · Scientific Reports · doi:10.1038/srep37068 · Cited by 42
Dynamic Interplay Between Metabolic Syndrome and Immunity
Paragh, G., Seres, I., Harangi, M., & Fülöp, P. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-07320-0_13 · Cited by 40
Alteration of local adipose tissue trace element homeostasis as a possible mechanism of obesity-related insulin resistance
Tinkov, A. A., Синицкий, А. И., Popova, E. V., Немерешина, О. Н., Gatiatulina, E. R., Геннадиевна, С. М., Skalny, A. V., & Nikonorov, A. А. (2015) · Medical Hypotheses · doi:10.1016/j.mehy.2015.06.005 · Cited by 40
Relationship between myocardial bridges and reduced coronary atherosclerosis in patients with angina pectoris
Verhagen, S. N., Rutten, A., Meijs, M. F. L., Išgum, I., Cramer, M. J., van der Graaf, Y., & Visseren, F. L. J. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.01.091 · Cited by 40
Self-citation
Fetuin-A and angiopoietins in obesity and type 2 diabetes mellitus
Rasul, S., Wagner, L., & Kautzky‐Willer, A. (2012) · Endocrine · doi:10.1007/s12020-012-9754-4 · Cited by 36
Perivascular adipose tissue of the descending thoracic aorta is associated with systemic lupus erythematosus and vascular calcification in women
Shields, K. J., Barinas‐Mitchell, E., Gingo, M. R., Tepper, P. G., Goodpaster, B. H., Kao, A. H., Manzi, S., & Sutton-Tyrrell, K. (2013) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.09.004 · Cited by 39
The Effect of Simvastatin–Ezetimibe Combination Therapy on Adipose Tissue Hormones and Systemic Inflammation in Patients with Isolated Hypercholesterolemia
Krysiak, R. G., Żmuda, W., & Okopień, B. (2013) · Cardiovascular Therapeutics · doi:10.1111/1755-5922.12057 · Cited by 39
Síndrome de apneas-hipopneas del sueño y diabetes tipo 2. ¿Una relación de ida y vuelta?
Martínez-Cerón, E., Mateos, R. C., & Rio, F. G. (2014) · Archivos de Bronconeumología · doi:10.1016/j.arbres.2014.06.017 · Cited by 41
Type 2 diabetes in children and adolescents
Amed, S., Daneman, D., Mahmud, F. H., & Hamilton, J. K. (2010) · Expert Review of Cardiovascular Therapy · doi:10.1586/erc.10.15 · Cited by 39
Role of Serum Adiponectin and Vitamin D in Prediabetes and Diabetes Mellitus
Banerjee, A., Khemka, V. K., Roy, D., Poddar, J., Roy, T. K. S., & Karnam, S. A. (2017) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2016.10.006 · Cited by 41
Causal Association of Overall Obesity and Abdominal Obesity with Type 2 Diabetes: A Mendelian Randomization Analysis
Wang, T., Zhang, R., Ma, X., Wang, S., He, Z., Huang, Y., Xu, B., Li, Y., Zhang, H., Jiang, F., et al. (2018) · Obesity · doi:10.1002/oby.22167 · Cited by 43
Bidirectional Communication Between the Brain and Other Organs: The Role of Extracellular Vesicles
Zhou, W., Zhao, L., Mao, Z., Wang, Z., Zhang, Z., & Li, M. (2023) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-023-01345-5 · Cited by 42
Adhesion molecule increases in sleep apnea: beneficial effect of positive airway pressure and moderation by obesity
Pak, V. M., Keenan, B. T., Jackson, N., Grandner, M. A., Maislin, G., Teff, K. L., Schwab, R. J., Arnardóttir, E. S., Júlíusson, S., Benediktsdottir, B., et al. (2014) · International Journal of Obesity · doi:10.1038/ijo.2014.123 · Cited by 38
Association Between Obesity, Abdominal Obesity, and Adiposity and the Prevalence of Atopic Dermatitis in Young Korean Adults: the Korea National Health and Nutrition Examination Survey 2008-2010
Lee, J. H., Han, K., Jung, H. M., Youn, Y. H., Lee, J. Y., Park, Y. G., Lee, S., & Park, Y. M. (2016) · Allergy Asthma and Immunology Research · doi:10.4168/aair.2016.8.2.107 · Cited by 38
Increased risk for development of coronary artery calcification in subjects with non-alcoholic fatty liver disease and systemic inflammation
Kim, J., Lee, W., Park, S. E., Park, C., Lee, W., Oh, K.-W., Park, S., & Rhee, E. (2017) · PLoS ONE · doi:10.1371/journal.pone.0180118 · Cited by 38
miR‐20b, miR‐296, and Let‐7f Expression in Human Adipose Tissue is Related to Obesity and Type 2 Diabetes
Gentile, A., Lhamyani, S., Coín‐Aragüez, L., Clemente‐Postigo, M., Oliva‐Olivera, W., Romero‐Zerbo, S., García‐Serrano, S., García‐Escobar, E., Zayed, H., Doblado, E., et al. (2018) · Obesity · doi:10.1002/oby.22363 · Cited by 39
Gut Microbiome, Inflammation, and Cerebrovascular Function: Link Between Obesity and Cognition
Olsthoorn, L., Vreeken, D., & Kiliaan, A. J. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.761456 · Cited by 39
Spatiotemporal Regulation of Early Lipolytic Signaling in Adipocytes
Martin, S., Okano, S., Kistler, C., Fernandez-Rojo, M. A., Hill, M. M. C., & Parton, R. G. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.002675 · Cited by 38
Serglycin is a novel adipocytokine highly expressed in epicardial adipose tissue
Imoto-Tsubakimoto, H., Takahashi, T., Ueyama, T., Ogata, T., Adachi, A., Nakanishi, N., Mizushima, K., Naito, Y., & Matsubara, H. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.01.078 · Cited by 38
Erythrocyte membrane phospholipid polyunsaturated fatty acids are related to plasma C-reactive protein and adiponectin in middle-aged German women and men
Enzenbach, C., Kröger, J., Zietemann, V., Jansen, E. H. J. M., Fritsche, A., Döring, F., Boeing, H., & Schulze, M. B. (2011) · European Journal of Nutrition · doi:10.1007/s00394-011-0169-4 · Cited by 37
BAFF knockout improves systemic inflammation via regulating adipose tissue distribution in high-fat diet-induced obesity
Kim, D.-H., & Do, M. (2015) · Experimental & Molecular Medicine · doi:10.1038/emm.2014.98 · Cited by 37
Abdominal Fat Mass Is Associated With Adaptive Immune Activation: The CODAM Study
Thewissen, M. M., Damoiseaux, J. G. M. C., Duijvestijn, A. M., van Greevenbroek, M. M. J., Kallen, C., Feskens, E. J. M., Blaak, E. E., Schalkwijk, C. G., Stehouwer, C. D. A., Tervaert, J. W. C., et al. (2011) · Obesity · doi:10.1038/oby.2010.337 · Cited by 39
Adiposity phenotypes are associated with type-2 diabetes: LAP index, body adiposity index, and neck circumference
Marcadenti, A., Fuchs, F. D., Moreira, L. B., Gus, M., & Fuchs, S. C. P. C. (2017) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2017.09.022 · Cited by 36
Association between increased visceral fat area and alterations in plasma fatty acid profile in overweight subjects: a cross-sectional study
Kang, M., Lee, A., Yoo, H. J., Kim, M., Kim, M., Shin, D. Y., & Lee, J. H. (2017) · Lipids in Health and Disease · doi:10.1186/s12944-017-0642-z · Cited by 37
Anaphylatoxin C5a induces inflammation and reduces insulin sensitivity by activating TLR4/NF-kB/PI3K signaling pathway in 3T3-L1 adipocytes
Zhang, X., Liu, Y., He, T., Yang, T., Wu, J., Cianflone, K., & Lü, H. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.04.057 · Cited by 37
Association between Triglyceride‐Glucose Index and Type 2 Diabetes Mellitus in the Japanese Population: A Secondary Analysis of a Retrospective Cohort Study
Liu, E.-Q., Weng, Y., Zhou, A., & Zeng, C. (2020) · BioMed Research International · doi:10.1155/2020/2947067 · Cited by 37
Transcriptional and DNA Methylation Signatures of Subcutaneous Adipose Tissue and Adipose-Derived Stem Cells in PCOS Women
Divoux, A., Erdős, E., Whytock, K. L., Osborne, T. F., & Smith, S. R. (2022) · Cells · doi:10.3390/cells11050848 · Cited by 40
Adiponectin in relation to insulin sensitivity and insulin secretion in the development of type 2 diabetes: a prospective study in 64-year-old women
Fagerberg, B., Kellis, D., Bergström, G. M. L., & Behre, C. J. (2010) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2010.02336.x · Cited by 38
Arterial hypertension in overweight and obese algerian adolescents: Role of abdominal adiposity
Benmohammed, K., Nguyen, M. T., Khensal, S., Valensi, P. E., & Lezzar, A. (2011) · Diabetes & Metabolism · doi:10.1016/j.diabet.2010.10.010 · Cited by 36
Protectin DX attenuates LPS-induced inflammation and insulin resistance in adipocytes via AMPK-mediated suppression of the NF-κB pathway
Jung, T. W., Chung, Y. H., Kim, H., El‐Aty, A. M. A., & Jeong, J. H. (2018) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00408.2017 · Cited by 37
Metabolically healthy general and abdominal obesity are associated with increased risk of hypertension
Zhao, Y., Qin, P., Sun, H., Liu, Y. S., Liu, D., Zhou, Q., Guo, C., Li, Q., Tian, G., Wu, X., et al. (2019) · British Journal Of Nutrition · doi:10.1017/s0007114519003143 · Cited by 36
Nutritional activities of luteolin in obesity and associated metabolic diseases: an eye on adipose tissues
Zhang, Z., Wang, J., Yan, L., Chen, J., Liu, J., & Zhang, X. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2138257 · Cited by 36
The reciprocal interaction between autophagic dysfunction and ER stress in adipose insulin resistance
Li, H., Zhou, B., Xu, L., Liu, J., Zang, W., Wu, S., & Sun, H. (2013) · Cell Cycle · doi:10.4161/cc.27406 · Cited by 37
Osteoprotective effects of Cimicifuga racemosa and its triterpene-saponins are responsible for reduction of bone marrow fat
Seidlová‐Wuttke, D., Stecher, G., Kammann, M., Haunschild, J., Eder, N., Stahnke, V., Wessels, J. T., & Wuttke, W. (2012) · Phytomedicine · doi:10.1016/j.phymed.2012.05.002 · Cited by 36
Obesity-Associated Hepatosteatosis and Impairment of Glucose Homeostasis Are Attenuated by Haptoglobin Deficiency
Lisi, S., Gamucci, O., Vottari, T., Scabia, G., Funicello, M., Marchi, M., Galli, G., Arisi, I., Brandi, R., D’Onofrio, M., et al. (2011) · Diabetes · doi:10.2337/db10-1536 · Cited by 37
Modulatory Role of Omentin-1 in Inflammation: Cytokines and Dietary Intake
Zabetian‐Targhi, F., Mirzaei, K., Keshavarz, S. A., & Hossein‐Nezhad, A. (2016) · Journal of the American College of Nutrition · doi:10.1080/07315724.2015.1126207 · Cited by 36
Influence of gestational diabetes mellitus on subclinical myocardial dysfunction during pregnancy: A systematic review and meta-analysis
Sonaglioni, A., Bordoni, T., Naselli, A., Nicolosi, G. L., Grasso, E., Bianchi, S., Ferrulli, A., Lombardo, M., & Ambrosio, G. (2023) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2023.11.007 · Cited by 36
Rictor in Perivascular Adipose Tissue Controls Vascular Function by Regulating Inflammatory Molecule Expression
Bhattacharya, I., Drägert, K., Albert, V., Contassot, E., Damjanović, M., Hagiwara, A., Zimmerli, L., Humar, R., Hall, M. N., Battegay, E., et al. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.301001 · Cited by 34
Anti-obesity effect ofSolidago virgaureavar.giganteaextract through regulation of adipogenesis and lipogenesis pathways in high-fat diet-induced obese mice (C57BL/6N)
Wang, Z., Kim, J. H., Jang, Y. S., Kim, C. H., Lee, J., & Lim, S. S. (2017) · Food & Nutrition Research · doi:10.1080/16546628.2016.1273479 · Cited by 35
Cytometric analysis of adipose tissue reveals increments of adipocyte progenitor cells after weight loss induced by bariatric surgery
García-Rubio, J., León, J., Redruello-Romero, A., Pavón, E. J., Cozar, A., Tamayo, F., Molina, M. C., Salmerón, J., & Carazo, Á. (2018) · Scientific Reports · doi:10.1038/s41598-018-33488-7 · Cited by 35
Inhibition of Serine Protease Activity Protects Against High Fat Diet-Induced Inflammation and Insulin Resistance
Kuo, C., Chen, J.-S., Lin, L., Schmid-Schönbein, G. W., Chien, S., Huang, P., Chen, J., & Lin, S. (2020) · Scientific Reports · doi:10.1038/s41598-020-58361-4 · Cited by 35
Fish oil reverses metabolic syndrome, adipocyte dysfunction, and altered adipokines secretion triggered by high‐fat diet‐induced obesity
de Sá, R. D. C. C., Cruz, M. M., Farias, T. M., da Silva, V. S., Simão, J. D. J., Telles, M. M., & Alonso‐Vale, M. I. C. (2020) · Physiological Reports · doi:10.14814/phy2.14380 · Cited by 37
A system biological approach to investigate the genetic profiling and comorbidities of type 2 diabetes
Podder, N. K., Rana, H. K., Azam, M. S., Rana, M. S., Akhtar, M. R., Rahman, M. R., Rahman, M. H., & Moni, M. A. (2020) · Gene Reports · doi:10.1016/j.genrep.2020.100830 · Cited by 35
Serum Ferritin Is Inversely Correlated with Serum Adiponectin Level: Population-Based Cross-Sectional Study
Ku, B. J., Kim, S.-Y., Lee, T., & Park, K. S. (2009) · Disease Markers · doi:10.1155/2009/931082 · Cited by 34
Antithrombotic therapy in obesity
Vera, R. H., Padró, T., Vilahur, G., & Badimón, L. (2013) · Thrombosis and Haemostasis · doi:10.1160/th12-12-0928 · Cited by 33
Utility of Body Mass Index in Identifying Excess Adiposity in Youth Across the Obesity Spectrum
Ryder, J. R., Kaizer, A. M., Rudser, K. D., Daniels, S. R., & Kelly, A. S. (2016) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2016.06.059 · Cited by 37
Fundamentals of Skin Bioimpedances
Presti, A. L., Montoya, N. A., Criscuolo, V., Khan, G., Khan, U., Vecchione, R., & Falconi, C. (2023) · Advanced Materials · doi:10.1002/adma.202302127 · Cited by 34
Contributions of elevated CRP, hyperglycaemia, and type 2 diabetes to cardiovascular risk in the general population: observational and Mendelian randomization studies
Rolver, M. G., Emanuelsson, F., Nordestgaard, B. G., & Benn, M. (2024) · Cardiovascular Diabetology · doi:10.1186/s12933-024-02207-0 · Cited by 37
MicroRNA-23a regulates 3T3-L1 adipocyte differentiation
Shen, L., Zhang, Y., Du, J., Chen, L., Luo, J., Li, X., Li, M., Tang, G., Zhang, S., & Zhu, L. (2015) · Gene · doi:10.1016/j.gene.2015.09.060 · Cited by 34
Regulation of adipose tissue energy availability through blood flow control in the metabolic syndrome
Alemany, M. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.03.003 · Cited by 36
Adipose Tissue Dysfunction: Clinical Relevance and Diagnostic Possibilities
Schrover, I. M., Spiering, W., Leiner, T., & Visseren, F. L. J. (2016) · Hormone and Metabolic Research · doi:10.1055/s-0042-103243 · Cited by 34
Self-citation
Fast eating and the risk of type 2 diabetes mellitus: A case-control study
Radzevičienė, L., & Ostrauskas, R. (2012) · Clinical Nutrition · doi:10.1016/j.clnu.2012.06.013 · Cited by 34
Identification of a Subpopulation of Marrow MSC-Derived Medullary Adipocytes That Express Osteoclast-Regulating Molecules: Marrow Adipocytes Express Osteoclast Mediators
Holt, V., Caplan, A. I., & Haynesworth, S. E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108920 · Cited by 33
Acetylshikonin from Zicao Prevents Obesity in Rats on a High-Fat Diet by Inhibiting Lipid Accumulation and Inducing Lipolysis
Su, M., Huang, W., & Zhu, B. (2016) · PLoS ONE · doi:10.1371/journal.pone.0146884 · Cited by 34
Pharmaceutical efficacy of novel human-origin Faecalibacterium prausnitzii strains on high-fat-diet-induced obesity and associated metabolic disorders in mice
Yang, M., Wang, J., Shin, J., Lee, D., Lee, S., Seo, J., Shin, J., Nam, Y., Kim, H., & Sun, X. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1220044 · Cited by 37
Anti-inflammatory Profile of FTO Gene Expression in Adipose Tissues From Morbidly Obese Women
Terra, X., Auguet, T., Porras, J. A., Quintero, Y., Aguilar, C., Luna, A. M., Hernández, M., Sabench, F., Castillo, D. D., & Richart, C. (2010) · Cellular Physiology and Biochemistry · doi:10.1159/000323979 · Cited by 34
Vitamin D receptor Cdx-2-dependent response of central obesity to vitamin D intake in the subjects with type 2 diabetes: a randomised clinical trial
Shab‐Bidar, S., Neyestani, T. R., & Djazayery, A. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515003049 · Cited by 33
Biological activity of Bauhinia racemosa against Diabetes and Interlinked Disorders like Obesity and Hyperlipidemia
Kumar, V., Rathore, K., Jain, P., & Ahmed, Z. (2017) · Clinical Phytoscience · doi:10.1186/s40816-017-0044-9 · Cited by 33
Metabolic and Endocrine Role of Adipose Tissue During Lactation
McNamara, J. P., & Huber, K. (2017) · Annual Review of Animal Biosciences · doi:10.1146/annurev-animal-030117-014720 · Cited by 35
Butyrate Reduces HFD-Induced Adipocyte Hypertrophy and Metabolic Risk Factors in Obese LDLr-/-.Leiden Mice
Pelgrim, C. E., Franx, B. A. A., Snabel, J. M., Kleemann, R., Arnoldussen, I. A. C., & Kiliaan, A. J. (2017) · Nutrients · doi:10.3390/nu9070714 · Cited by 34
Cerebrovascular Disease: Consequences of Obesity-Induced Endothelial Dysfunction
Letra, L., & Sena, C. M. (2017) · Advances in neurobiology · doi:10.1007/978-3-319-63260-5_7 · Cited by 33
Triterpenoids from Hibiscus sabdariffa L. with PPARδ/γ Dual Agonist Action: In Vivo, In Vitro and In Silico Studies
Giacoman‐Martínez, A., Alarcón-Aguilar, F. J., Zamilpa, A., Hidalgo‐Figueroa, S., Navarrete‐Vázquez, G., García-Macedo, R., Román‐Ramos, R., & Almanza-Pérez, J. C. (2019) · Planta Medica · doi:10.1055/a-0824-1316 · Cited by 33
Association of Body Mass Index and Extreme Obesity With Long‐Term Outcomes Following Percutaneous Coronary Intervention
Biswas, S., Andrianopoulos, N., Dinh, D. T., Duffy, S. J., Lefkovits, J., Brennan, A., Noaman, S. Q., Ajani, A. E., Clark, D. J., Freeman, M., et al. (2019) · Journal of the American Heart Association · doi:10.1161/jaha.119.012860 · Cited by 33
Overexpression of TNF-α converting enzyme promotes adipose tissue inflammation and fibrosis induced by high fat diet
Matsui, Y., Tomaru, U., Miyoshi, A., Ito, T., Fukaya, S., Miyoshi, H., Atsumi, T., & Ishizu, A. (2014) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2014.09.017 · Cited by 33
Meal-Related Increases in Microvascular Vasomotion Are Impaired in Obese Individuals
Jonk, A. M., Houben, A. J. H. M., Schaper, N. C., de Leeuw, P. W., Serné, E. H., Smulders, Y. M., & Stehouwer, C. D. A. (2011) · Diabetes Care · doi:10.2337/dc11-s240 · Cited by 33
Association of Vaspin with Metabolic Syndrome: The Pivotal Role of Insulin Resistance
Esteghamati, A., Noshad, S., Mousavizadeh, M., Zandieh, A., & Nakhjavani, M. (2014) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2014.38.2.143 · Cited by 33
Postnatal high-fat diet enhances ectopic fat deposition in pigs with intrauterine growth retardation
Yan, H., Zheng, P., Yu, B., Yu, J., Mao, X., He, J., Huang, Z., & Chen, D. (2015) · European Journal of Nutrition · doi:10.1007/s00394-015-1093-9 · Cited by 33
Are Thyroid Autoimmune Diseases Associated with Cardiometabolic Risks in a Population with Normal Thyroid-Stimulating Hormone?
Chen, Y., Zhu, C., Chen, Y., Wang, N., Li, Q., Han, B., Zhao, L., Chen, C., Zhai, H., Zhang, L., et al. (2018) · Mediators of Inflammation · doi:10.1155/2018/1856137 · Cited by 33
Adipose tissue chromium and vanadium disbalance in high-fat fed Wistar rats
Tinkov, A. A., Popova, E. V., Polyakova, V. S., Kvan, O. V., Skalny, A. V., & Nikonorov, A. А. (2014) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2014.07.006 · Cited by 33
Coprinus comatus Cap Inhibits Adipocyte Differentiation via Regulation of PPARγ and Akt Signaling Pathway
Park, H. J., Yun, J., Jang, S.-H., Kang, S. N., Jeon, B., Ko, Y., Kim, H.-D., Won, C., Kim, G. S., & Cho, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105809 · Cited by 32
Cardiovascular Metabolic Syndrome: Mediators Involved in the Pathophysiology from Obesity to Coronary Heart Disease
Roos, C. J., Quax, P. H. A., & Jukema, J. W. (2012) · Biomarkers in Medicine · doi:10.2217/bmm.11.105 · Cited by 30
Adaptation of human adipose tissue to hypocaloric diet
Rossmeislová, L., Mališová, L., Kračmerová, J., & Štich, V. (2012) · International Journal of Obesity · doi:10.1038/ijo.2012.80 · Cited by 32
Impact of Bariatric Surgery on Carotid Artery Inflammation and the Metabolic Activity in Different Adipose Tissues
Bucerius, J. A., Vijgen, G. H. E. J., Brans, B. T., Bouvy, N. D., Bauwens, M., Rudd, J. H. F., Havekes, B., Fayad, Z. A., Lichtenbelt, W. D. V. M., & Mottaghy, F. M. (2015) · Medicine · doi:10.1097/md.0000000000000725 · Cited by 32
Effect of food intake and ambient air pollution exposure on ankylosing spondylitis disease activity
Soleimanifar, N., Nicknam, M. H., Bidad, K., Jamshidi, A., Mahmoudi, M., Mostafaei, S., Hosseini‐khah, Z., & Nikbin, B. (2019) · Revista Brasileira de Reumatologia · doi:10.1186/s42358-019-0051-2 · Cited by 32
Exploring the Mediators that Promote Carotid Body Dysfunction in Type 2 Diabetes and Obesity Related Syndromes
Sacramento, J. F., Andrzejewski, K., Melo, B. F., Ribeiro, M. J., Obeso, A., & Conde, S. V. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155545 · Cited by 35
Changes in serum aldosterone are associated with changes in obesity-related factors in normotensive overweight and obese young adults
Cooper, J. N., Fried, L. F., Tepper, P. G., Barinas‐Mitchell, E., Conroy, M. B., Evans, R. G., Brooks, M. M., Woodard, G. A., & Sutton‐Tyrrell, K. (2013) · Hypertension Research · doi:10.1038/hr.2013.45 · Cited by 33
Intrauterine Growth Restriction Increases TNFα and Activates the Unfolded Protein Response in Male Rat Pups
Riddle, E., Campbell, M. S., Lang, B. Y., Bierer, R., Wang, Y., Bagley, H. N., & Joss-Moore, L. (2014) · Journal of Obesity · doi:10.1155/2014/829862 · Cited by 32

Authors: Hajer, G. R., van Haeften, T. W., & Visseren, F. L. J.
Affiliations: University Medical Center Utrecht (NL)
Corresponding author: Visseren, F. L.J.
ORCID: Visseren, F. L.J.
Venue: European Heart Journal
Publisher: Oxford University Press (OUP)
Published: 2008-09-05
Volume: 29
Issue: 24
Pages: 2959-2971
ISSN: 0195-668X (ISSN-L)
1522-9645
DOI: 10.1093/eurheartj/ehn387
OpenAlex: W2100784798
Semantic Scholar: a5a791d646daf7a9ba3a727d27f953ec6ca43ec5
Cited by: 1,410
References: 136
Citations by year: 2026: 23 · 2025: 54 · 2024: 45 · 2023: 55 · 2022: 58 · 2021: 68 · 2020: 83 · 2019: 69 · 2018: 85 · 2017: 88 · 2016: 98 · 2015: 100 · 2014: 134 · 2013: 130 · 2012: 103
FWCI: 7.72
Type: journal article
Language: en
Open access: closed
Locations: European Heart Journal (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: adipose tissue dysfunction, visceral obesity, type 2 diabetes, metabolic syndrome, cardiovascular disease, atherosclerosis, adipokines, adiponectin, leptin, TNF-α, interleukin-6, plasminogen activator inhibitor-1, low-grade inflammation, portal circulation, cardiovascular risk factors
MeSH terms: Adipose Tissue, Diabetes Mellitus, Type 2, Diabetic Angiopathies, Energy Metabolism, Female, Humans, Male, Obesity, Transcription Factors, Adipocytes, Leptin, Metabolic Syndrome, Risk Reduction Behavior, Intra-Abdominal Fat, Atherosclerosis, Subcutaneous Fat, Abdominal

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Adipose tissue dysfunction in obesity, diabetes, and vascular diseases

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks