Cited by 1,410Adipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and AdiposityAdipose Tissue and Metabolism

The DOI matches its Crossref record; 137 of the 137 references it cites were found in a registry or an index.

Adipose tissue dysfunction in obesity, diabetes, and vascular diseases

Hajer, G. R., van Haeften, T. W., Visseren, F. L.J.·2008·European Heart Journal

DOI 10.1093/eurheartj/ehn387

Open this paper in CoChat — free account

Abstract

The classical perception of adipose tissue as a storage place of fatty acids has been replaced over the last years by the notion that adipose tissue has a central role in lipid and glucose metabolism and produces a large number of hormones and cytokines, e.g. tumour necrosis factor-alpha, interleukin-6, adiponectin, leptin, and plasminogen activator inhibitor-1. The increased prevalence of excessive visceral obesity and obesity-related cardiovascular risk factors is closely associated with the rising incidence of cardiovascular diseases and type 2 diabetes mellitus. This clustering of vascular risk factors in (visceral) obesity is often referred to as metabolic syndrome. The close relationship between an increased quantity of visceral fat, metabolic disturbances, including low-grade inflammation, and cardiovascular diseases and the unique anatomical relation to the hepatic portal circulation has led to an intense endeavour to unravel the specific endocrine functions of this visceral fat depot. The objective of this paper is to describe adipose tissue dysfunction, delineate the relation between adipose tissue dysfunction and obesity and to describe how adipose tissue dysfunction is involved in the development of diabetes mellitus type 2 and atherosclerotic vascular diseases. First, normal physiology of adipocytes and adipose tissue will be described.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1093/eurheartj/ehn387

Cites

137 of 137 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Summary of the second report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II)
Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944
Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
Expert Panel on Detection, E. (2001) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.285.19.2486 · Cited by 26,011
Atherosclerosis--an inflammatory disease
Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725
Central nervous system control of food intake
Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451
Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans
Considine, R. V., Sinha, M. K., Heiman, M. L., Kriauciunas, A., Stephens, T. W., Nyce, M. R., Ohannesian, J. P., Marco, C. C., McKee, L. J., Bauer, T. L., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199602013340503 · Cited by 6,326
Monocyte and macrophage heterogeneity
Gordon, S., & Taylor, P. R. (2005) · Nature Reviews Immunology · doi:10.1038/nri1733 · Cited by 5,190
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., et al. (2001) · Nature Medicine · doi:10.1038/90984 · Cited by 4,915
Cardiovascular Morbidity and Mortality Associated With the Metabolic Syndrome
Isomaa, B., Almgren, P., Tuomi, T., Forsén, B., Lahti, K., Nissén, M., Taskinen, M.-R., & Groop, L. (2001) · Diabetes Care · doi:10.2337/diacare.24.4.683 · Cited by 4,760
Obesity induces a phenotypic switch in adipose tissue macrophage polarization
Lumeng, C. N., Bodzin, J. L., & Saltiel, A. R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29881 · Cited by 4,664
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
Yamauchi, T., Kamon, J., Minokoshi, Y., Ito, Y., Waki, H., Uchida, S., Yamashita, S., Noda, M., Kita, S., Ueki, K., et al. (2002) · Nature Medicine · doi:10.1038/nm788 · Cited by 4,238

Show all 136 references

Research works printed but not linked: 6

Cheung, 1997, Endocrinology, 138, 4489, 10.1210/en.138.10.4489 · DOI · Paper page
2007, American heart journal, 154, 750
Tsigos, 1997, Journal of Clinical Endocrinology & Metabolism, 82, 4167, 10.1210/jc.82.12.4167 · DOI · Paper page
Ozata, 1999, Journal of Clinical Endocrinology & Metabolism, 84, 3686, 10.1210/jc.84.10.3686 · DOI · Paper page
1995, International journal of obesity, 19, S16
2004, Circulation Research, 94, e27

Sorted by citations

Items 101–200 of 999

Mediterranean Diet and Cardiodiabesity: A Review
García-Fernández, E., Rico-Cabanas, L., Rosgaard, N., Estruch, R., & Bach-Faig, A. (2014) · Nutrients · doi:10.3390/nu6093474 · Cited by 141
Associations of Physical Activity With Inflammatory Factors, Adipocytokines, and Metabolic Syndrome in Middle-Aged and Older Chinese People
Yu, Z., Ye, X., Wang, J., Qi, Q., Franco, O. H., Rennie, K. L., Pan, A., Li, H., Liu, Y., Hu, F. B., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.833574 · Cited by 130
Endothelial Function and Dysfunction: Impact of Metformin
Nafisa, A., Gray, S. G., Cao, Y., Wang, T., Xu, S., Wattoo, F. H., Barras, M., Cohen, N., Kamato, D., & Little, P. J. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.07.007 · Cited by 128
Inter‐relationships of the chronobiotic, melatonin, with leptin and adiponectin: implications for obesity
Szewczyk‐Golec, K., Woźniak, A., & Reiter, R. J. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12257 · Cited by 153
Cardiac Fibrosis and Arrhythmogenesis
Nguyen, M., Kiriazis, H., Gao, X., & Du, X. (2017) · Comprehensive physiology · doi:10.1002/cphy.c160046 · Cited by 153
Adverse Fetal and Neonatal Outcomes Associated with a Life-Long High Fat Diet: Role of Altered Development of the Placental Vasculature
Hayes, E. K., Lechowicz, A., Petrik, J., Storozhuk, Y., Paez-Parent, S., Dai, Q., Samjoo, I. A., Mansell, M., Gruslin, A., Holloway, A. C., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033370 · Cited by 124
The Interaction of Obstructive Sleep Apnea and Obesity on the Inflammatory Markers C-Reactive Protein and Interleukin-6: The Icelandic Sleep Apnea Cohort
Arnardóttir, E. S., Maislin, G., Schwab, R. J., Staley, B. A., Benediktsdóttir, B., Ólafsson, Í., Júlíusson, S., Romer, M. A., Gíslason, Þ., & Pack, A. I. (2012) · SLEEP · doi:10.5665/sleep.1952 · Cited by 125
Propionic acid and butyric acid inhibit lipolysis and de novo lipogenesis and increase insulin-stimulated glucose uptake in primary rat adipocytes
Heimann, E., NYMAN, M. E., & Degerman, E. (2014) · Adipocyte · doi:10.4161/21623945.2014.960694 · Cited by 133
Adipose-Derived Stems Cells and Their Role in Human Cancer Development, Growth, Progression, and Metastasis: A Systematic Review
Freese, K. E., Kokai, L. E., Edwards, R. P., Philips, B. J., Sheikh, M. A., Kelley, J. L., Comerci, J. T., Marra, K. G., Rubin, J. P., & Linkov, F. Y. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-2744 · Cited by 128
ABO blood group and incidence of epithelial ovarian cancer
Gates, M. A., Wolpin, B. M., Cramer, D. W., Hankinson, S. E., & Tworoger, S. S. (2010) · International Journal of Cancer · doi:10.1002/ijc.25339 · Cited by 123
Anthocyanin increases adiponectin secretion and protects against diabetes-related endothelial dysfunction
Liu, Y., Li, D., Zhang, Y., Sun, R., & Xia, M. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00699.2013 · Cited by 125
Association of visceral and subcutaneous fat with glucose intolerance, insulin resistance, adipocytokines and inflammatory markers in Asian Indians (CURES-113)
Indulekha, K., Anjana, R. M., Surendar, J., & Mohan, V. (2011) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2010.12.015 · Cited by 125
Gluten-free diet reduces adiposity, inflammation and insulin resistance associated with the induction of PPAR-alpha and PPAR-gamma expression
Soares, F. L. P., Matoso, R. D. O., Teixeira, L. G., Garcia, Z. M., Pereira, S. S., Alves, A. C., Batista, N. V., Faria, A. M. C., Cara, D. C., Ferreira, A. V. M., et al. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.08.009 · Cited by 120
Obstructive sleep apnea as a risk factor for type 2 diabetes mellitus
Greenberg, H. E., & Rajan, P. (2015) · Nature and Science of Sleep · doi:10.2147/nss.s90835 · Cited by 125
Diabetes and obesity during pregnancy alter insulin signalling and glucose transporter expression in maternal skeletal muscle and subcutaneous adipose tissue
Magee, M., Permezel, M., & Lappas, M. (2009) · Journal of Molecular Endocrinology · doi:10.1677/jme-09-0091 · Cited by 119
Long-term Changes in Leptin, Chemerin and Ghrelin Levels Following Different Bariatric Surgery Procedures: Roux-en-Y Gastric Bypass and Sleeve Gastrectomy
Terra, X., Auguet, T., Guiu‐Jurado, E., Berlanga, A., Orellana‐Gavaldà, J. M., Hernández, M., Sabench, F., Porras, J. A., Llutart, J., Martínez, S., et al. (2013) · Obesity Surgery · doi:10.1007/s11695-013-1033-9 · Cited by 118
Decreased Serum Level of miR-146a as Sign of Chronic Inflammation in Type 2 Diabetic Patients
Baldeón, L., Weigelt, K., de Wit, H., Özcan, B., van Oudenaren, A., Sempértegui, F., Sijbrands, E. J. G., Grosse, L., Freire, W. B., Drexhage, H. A., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0115209 · Cited by 123
Interleukin-15 contributes to the regulation of murine adipose tissue and human adipocytes
Barra, N. G., Reid, S., MacKenzie, R., Werstuck, G., Trigatti, B. L., Richards, C., Holloway, A. C., & Ashkar, A. A. (2010) · Obesity · doi:10.1038/oby.2009.445 · Cited by 116
Obesity but not high-fat diet impairs lymphatic function
Nores, G. D. G., Cuzzone, D. A., Albano, N. J., Hespe, G. E., Kataru, R. P., Torrisi, J. S., Gardenier, J. C., Savetsky, I. L., Aschen, S. Z., Nitti, M. D., et al. (2016) · International Journal of Obesity · doi:10.1038/ijo.2016.96 · Cited by 117
The Relationship of Body Mass Index to Percutaneous Coronary Intervention Outcomes
Holroyd, E. W., Sirker, A., Kwok, C. S., Kontopantelis, E., Ludman, P., de Belder, M., Butler, R., Cotton, J. M., Zaman, A., & Mamas, M. A. (2017) · JACC: Cardiovascular Interventions · doi:10.1016/j.jcin.2017.03.013 · Cited by 118
Adiponectin Is Required for PPARγ-Mediated Improvement of Endothelial Function in Diabetic Mice
Wong, W. T., Tian, X. Y., Xu, A., Yu, J. Q., Lau, C. W., Hoo, R. L. C., Wang, Y., Lee, V. W. Y., Lam, K. S. L., Vanhoutte, P. M., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.05.009 · Cited by 115
Statins Reduce Epicardial Adipose Tissue Attenuation Independent of Lipid Lowering: A Potential Pleiotropic Effect
Raggi, P., Gadiyaram, V., Zhang, C., Chen, Z., Lopaschuk, G., & Stillman, A. E. (2019) · Journal of the American Heart Association · doi:10.1161/jaha.119.013104 · Cited by 113
Impact of Maternal Obesity on Fetal Health
Tenenbaum-Gavish, K., & Hod, M. (2013) · Fetal Diagnosis and Therapy · doi:10.1159/000350170 · Cited by 111
Evidence for Osteocalcin Production by Adipose Tissue and Its Role in Human Metabolism
Foresta, C., Strapazzon, G., Toni, L. D., Gianesello, L., Calcagno, A., Pilon, C., Plebani, M., & Vettor, R. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2557 · Cited by 111
Effect of diet on adiponectin levels in blood
Silva, F. M., de Almeida, J. C., & Feóli, A. M. P. (2011) · Nutrition Reviews · doi:10.1111/j.1753-4887.2011.00414.x · Cited by 113
Adipose tissue estrogen production and metabolism in premenopausal women
Hetemäki, N., Mikkola, T. S., Tikkanen, M. J., Wang, F., Hämäläinen, E., Turpeinen, U., Haanpää, M., Vihma, V., & Savolainen-Peltonen, H. (2021) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2021.105849 · Cited by 118
Time-restricted eating with or without low-carbohydrate diet reduces visceral fat and improves metabolic syndrome: A randomized trial
He, M., Wang, J., Liang, Q., Li, M., Guo, H., Wang, Y., Deji, C., Sui, J., Wang, Y.-W., Liu, Y., et al. (2022) · Cell Reports Medicine · doi:10.1016/j.xcrm.2022.100777 · Cited by 111
Sphingolipids in Obesity, Type 2 Diabetes, and Metabolic Disease
Russo, S. B., Ross, J. S., & Cowart, L. A. (2013) · Handbook of experimental pharmacology · doi:10.1007/978-3-7091-1511-4_19 · Cited by 113
Síndrome metabólico en España: prevalencia y riesgo coronario asociado a la definición armonizada y a la propuesta por la OMS. Estudio DARIOS
Fernandez-Berges, D. J., de León, A. C., Sanz, H., Elosúa, R., Guembe, M. J., Alzamora, M. T., Vega-Alonso, T., Félix-Redondo, F. J., Ortiz-Marrón, H., Rigo, F., et al. (2012) · Revista Española de Cardiología · doi:10.1016/j.recesp.2011.10.015 · Cited by 125
High fat diet consumption differentially affects adipose tissue inflammation and adipocyte size in obesity-prone and obesity-resistant rats
Poret, J. M., Souza‐Smith, F. M., Marcell, S. J., Gaudet, D. A., Tzeng, T. H., Braymer, H. D., Harrison‐Bernard, L. M., & Primeaux, S. D. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.280 · Cited by 112
Mechanisms of obesity-induced metabolic and vascular dysfunctions
Caldwell, R. W. (2019) · Frontiers in bioscience · doi:10.2741/4758 · Cited by 112
The role of adiponectin in human vascular physiology
Vaiopoulos, G., Marinou, K., Christodoulides, C., & Koutsilieris, M. (2011) · International Journal of Cardiology · doi:10.1016/j.ijcard.2011.07.047 · Cited by 108
Elevated C-reactive protein, interleukin 6, tumor necrosis factor alpha and glycemic load associated with type 2 diabetes mellitus in rural Thais: a cross-sectional study
Phosat, C., Phienluphon, P. P., Chumpathat, N., Prangthip, P., Chantratita, N., Soonthornworasiri, N., Puduang, S., & Kwanbunjan, K. (2017) · BMC Endocrine Disorders · doi:10.1186/s12902-017-0189-z · Cited by 107
Molecular aspects of diabetes mellitus: Resistin, microRNA, and exosome
Borujeni, M. J. S., Esfandiary, E., Taheripak, G., Codoñer‐Franch, P., Alonso‐Iglesias, E., & Mirzaei, H. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26271 · Cited by 105
Components of the interleukin-6 transsignalling system are associated with the metabolic syndrome, endothelial dysfunction and arterial stiffness.
Weiss, T., Arnesen, H., & Seljeflot, I. (2013) · Metabolism: Clinical and Experimental · doi:10.1016/j.metabol.2013.01.019 · Cited by 109
Epicardial Fat: Physiological, Pathological, and Therapeutic Implications
Salazar, J. J., Luzardo, E., Mejías, J. C., Rojas, J., Ferreira, A. M., Rivas-Ríos, J. R., & Bermúdez, V. (2016) · Cardiology Research and Practice · doi:10.1155/2016/1291537 · Cited by 115
Higher omega-3 index is associated with increased insulin sensitivity and more favourable metabolic profile in middle-aged overweight men
Albert, B. B., Derraik, J. G. B., Brennan, C. M., Biggs, J. B., Smith, G. C., Garg, M. L., Cameron-Smith, D., Hofman, P. L., & Cutfield, W. S. (2014) · Scientific Reports · doi:10.1038/srep06697 · Cited by 105
Effects of aerobic training on serum omentin-1 and cardiometabolic risk factors in overweight and obese men
Saremi, A., Asghari, M., & Ghorbani, A. (2010) · Journal of Sports Sciences · doi:10.1080/02640414.2010.484070 · Cited by 103
Metabolic syndrome, insulin resistance, fibrinogen, homocysteine, leptin, and C-reactive protein in obese patients with obstructive sleep apnea syndrome
Basoglu, Ö. K., Saraç, F., Sarac, S., Uluer, H., & Yılmaz, C. (2011) · Annals of Thoracic Medicine · doi:10.4103/1817-1737.82440 · Cited by 103
Possible hypoglycemic effect of Aloe vera L. high molecular weight fractions on type 2 diabetic patients
Yagi, A., Hegazy, S. K., Kabbash, A. M., & Wahab, E. A.-E. (2009) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2009.08.007 · Cited by 103
Venous thromboembolism has the same risk factors as atherosclerosis
Mi, Y., Yan, S., Lu, Y., Liang, Y., & Li, C. (2016) · Medicine · doi:10.1097/md.0000000000004495 · Cited by 102
The role of arsenic in obesity and diabetes
Farkhondeh, T., Samarghandian, S., & Azimi–Nezhad, M. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28112 · Cited by 103
Clinical Practice Guidelines for Healthy Eating for the Prevention and Treatment of Metabolic and Endocrine Diseases in Adults: Cosponsored by the American Association of Clinical Endocrinologists/The American College of Endocrinology and the Obesity Society Executive Summary
González-Campoy, J. M., Jeor, S. T. S., CASTORINO, K. N., Ebrahim, A., Hurley, D., Jovanovič, L., Mechanick, J. I., Petak, S. M., Yu, Y., Harris, K. A., et al. (2013) · Endocrine Practice · doi:10.4158/ep13155.esgl · Cited by 102
Circulating IL-8 levels are increased in patients with type 2 diabetes and associated with worse inflammatory and cardiometabolic profile
Cimini, F. A., Barchetta, I., Porzia, A., Mainiero, F., Costantino, C., Bertoccini, L., Ceccarelli, V., Morini, S., Baroni, M. G., Lenzi, A., et al. (2017) · Acta Diabetologica · doi:10.1007/s00592-017-1039-1 · Cited by 106
Clinical Practice Guidelines for Healthy Eating for the Prevention and Treatment of Metabolic and Endocrine Diseases in Adults: Cosponsored by the American Association of Clinical Endocrinologists/The American College of Endocrinology and the Obesity Society
González-Campoy, J. M., CASTORINO, K. N., Ebrahim, A., Hurley, D., Jovanovič, L., Mechanick, J. I., Petak, S. M., Yu, Y., Jeor, S. T. S., Harris, K. A., et al. (2013) · Endocrine Practice · doi:10.4158/ep13155.gl · Cited by 107
Resident tissue macrophages: Key coordinators of tissue homeostasis beyond immunity
Zhao, J., Andreev, I., & Silva, H. M. (2024) · Science Immunology · doi:10.1126/sciimmunol.add1967 · Cited by 109
Adipocyte SIRT1 controls systemic insulin sensitivity by modulating macrophages in adipose tissue
Hui, X. H., Zhang, M., Gu, P., Li, K., Gao, Y. Z., Wu, D., Wang, Y., & Xu, A. (2017) · EMBO Reports · doi:10.15252/embr.201643184 · Cited by 99
Should Adipokines be Considered in the Choice of the Treatment of Obesity-Related Health Problems?
Athyros, V. G., Τζιόμαλος, Κ., Karagiannis, A. I., Anagnostis, P. G., Mikhailidis, D. P., Fiorino, G., Rovida, S., Correale, C., Malesci, A., & Danese, S. (2009) · Current Drug Targets · doi:10.2174/138945010790030992 · Cited by 102
Human Mesenteric Adipose Tissue Plays Unique Role Versus Subcutaneous and Omental Fat in Obesity Related Diabetes
Yang, Y., Chen, M., Clements, R. H., Abrams, G. A., Aprahamian, C. J., & Harmon, C. M. (2008) · Cellular Physiology and Biochemistry · doi:10.1159/000185527 · Cited by 100
Efficacy of omega-3 polyunsaturated fatty acids supplementation in managing overweight and obesity: A meta-analysis of randomized clinical trials
Zhang, Y. Y., Liu, W., Zhao, T. Y., & Tian, H. M. (2017) · The Journal of nutrition, health and aging · doi:10.1007/s12603-016-0755-5 · Cited by 101
Age- and sex-specific differences in blood-borne microvesicles from apparently healthy humans
Gustafson, C. M., Shepherd, A. J., Miller, V. M., & Jayachandran, M. (2015) · Biology of Sex Differences · doi:10.1186/s13293-015-0028-8 · Cited by 98
Diet, Obesity, and Asthma
Wood, L. G. (2017) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201702-124aw · Cited by 99
Kynurenine Pathway in Diabetes Mellitus—Novel Pharmacological Target?
Kozieł, K., & Urbańska, E. M. (2023) · Cells · doi:10.3390/cells12030460 · Cited by 104
The Macrophage‐Specific Serum Marker, Soluble CD163, Is Increased in Obesity and Reduced After Dietary‐Induced Weight Loss
Fjeldborg, K., Christiansen, T., Bennetzen, M., Møller, H. J., Pedersen, S. B., & Richelsen, B. (2013) · Obesity · doi:10.1002/oby.20376 · Cited by 96
Flavan‐3‐ols, anthocyanins, and inflammation
Mena, P. R., Domínguez‐Perles, R., Gironés‐Vilaplana, A., Baenas, N., García‐Viguera, C., & Villaño, D. (2014) · IUBMB Life · doi:10.1002/iub.1332 · Cited by 96
Neck circumference as an effective measure for identifying cardio-metabolic syndrome: a comparison with waist circumference
Luo, Y., Ma, X., Shen, Y., Xu, Y., Xiong, Q., Zhang, X., Xiao, Y., Bao, Y., & Jia, W. (2016) · Endocrine · doi:10.1007/s12020-016-1151-y · Cited by 96
Molecular and Biochemical Pathways of Catalpol in Alleviating Diabetes Mellitus and Its Complications
Bhattamisra, S. K., Koh, H. M., Lim, S. Y., Choudhury, H., & Pandey, M. (2021) · Biomolecules · doi:10.3390/biom11020323 · Cited by 96
Metabolic Syndrome in Spain: Prevalence and Coronary Risk Associated With Harmonized Definition and WHO Proposal. DARIOS Study
Fernandez-Berges, D. J., de León, A. C., Sanz, H., Elosúa, R., Guembe, M. J., Alzamora, M. T., Vega-Alonso, T., Félix-Redondo, F. J., Ortiz-Marrón, H., Rigo, F., et al. (2012) · Revista Española de Cardiología (English Edition) · doi:10.1016/j.rec.2011.10.017 · Cited by 95
Cardiac computed tomography-derived epicardial fat volume and attenuation independently distinguish patients with and without myocardial infarction
Mahabadi, A. A., Balcer, B., Dykun, I., Forsting, M., Schlosser, T. W., Heusch, G., & Rassaf, T. (2017) · PLoS ONE · doi:10.1371/journal.pone.0183514 · Cited by 94
Circulating levels of adipokines and IGF-1 are associated with skeletal muscle strength of young and old healthy subjects
Bucci, L., Yani, S. L., Fabbri, C., Bijlsma, A. Y., Maier, A. B., Meskers, C. G. M., Narici, M. V., Jones, D. A., McPhee, J. S., Seppet, E. K., et al. (2013) · Biogerontology · doi:10.1007/s10522-013-9428-5 · Cited by 93
Psoriasis Comorbidities: Results from the National Psoriasis Foundation Surveys 2003 to 2011
Armstrong, A. W., Schupp, C. W., & Bebo, B. F. (2012) · Dermatology · doi:10.1159/000342180 · Cited by 92
Single-Locus and Multi-Locus Genome-Wide Association Studies for Intramuscular Fat in Duroc Pigs
Ding, R., Yang, M. J., Quan, J., Li, S., Zhuang, Z., Zhou, S., Zheng, E., Hong, L., Li, Z., Cai, G., et al. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00619 · Cited by 92
Regulatory microRNAs in Brown, Brite and White Adipose Tissue
Gharanei, S., Shabir, K., Brown, J. E. P., Weickert, M. O., Barber, T. M., Kyrou, I., & Randeva, H. S. (2020) · Cells · doi:10.3390/cells9112489 · Cited by 100
Oxidative stress and protein carbonylation in adipose tissue — Implications for insulin resistance and diabetes mellitus
Ruskovska, T., & Bernlohr, D. (2013) · Journal of Proteomics · doi:10.1016/j.jprot.2013.04.002 · Cited by 92
Hypoglycemic and hypolipidemic effects of neohesperidin derived from Citrus aurantium L. in diabetic KK-A y mice
Jia, S., Hu, Y., Zhang, W., Zhao, X., Chen, Y., Sun, C., Li, X., & Chen, K. (2015) · Food & Function · doi:10.1039/c4fo00993b · Cited by 92
Stress Augments Insulin Resistance and Prothrombotic State
Uchida, Y., Takeshita, K., Yamamoto, K., Kikuchi, R., Nakayama, T., Nomura, M., Cheng, X. W., Egashira, K., Matsushita, T., Nakamura, H., et al. (2012) · Diabetes · doi:10.2337/db11-0828 · Cited by 90
Inflammatory characteristics of distinct abdominal adipose tissue depots relate differently to metabolic risk factors for cardiovascular disease
Kranendonk, M. E. G., van Herwaarden, J. A., Stupkova, T., Jager, W. D., Vink, A., Moll, F. L., Kalkhoven, E., & Visseren, F. L. J. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.01.035 · Cited by 91
Self-citation
Melatonin Supplementation Lowers Oxidative Stress and Regulates Adipokines in Obese Patients on a Calorie‐Restricted Diet
Szewczyk-Golec, K., Rajewski, P., Gackowski, M., Mila-Kierzenkowska, C., Wesołowski, R., Sutkowy, P., Pawłowska, M., & Woźniak, A. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/8494107 · Cited by 92
Leucine in Obesity: Therapeutic Prospects
Yao, K., Duan, Y., Li, F., Tan, B., Hou, Y., Wu, G., & Yin, Y. (2016) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2016.05.004 · Cited by 90
Perivascular adipose tissue as a regulator of vascular disease pathogenesis: identifying novel therapeutic targets
Akoumianakis, I., Tarun, A., & Antoniades, C. A. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13666 · Cited by 91
Saturated fatty acids and insulin resistance
Funaki, M. (2009) · The Journal of Medical Investigation · doi:10.2152/jmi.56.88 · Cited by 90
Association of Tumor Necrosis Factor Alpha, Interleukin 6, and C-Reactive Protein with the Risk of Developing Type 2 Diabetes: A Retrospective Cohort Study of Rural Thais
Lainampetch, J., Phienluphon, P. P., Phosat, C., Chumpathat, N., Prangthip, P., Soonthornworasiri, N., Puduang, S., Wechjakwen, N., & Kwanbunjan, K. (2019) · Journal of Diabetes Research · doi:10.1155/2019/9051929 · Cited by 98
WAT-on-a-chip integrating human mature white adipocytes for mechanistic research and pharmaceutical applications
Rogal, J., Binder, C., Kromidas, E., Roosz, J., Probst, C., Schneider, S., Schenke‐Layland, K., & Loskill, P. (2020) · Scientific Reports · doi:10.1038/s41598-020-63710-4 · Cited by 93
Relation between cardiovascular disease risk factors and epicardial adipose tissue density on cardiac computed tomography in patients at high risk of cardiovascular events
Franssens, B. T., Nathoe, H. M., Leiner, T., van der Graaf, Y., & Visseren, F. L. J. (2016) · European Journal of Preventive Cardiology · doi:10.1177/2047487316679524 · Cited by 91
Self-citation
Metabolic consequences of modern immunosuppressive agents in solid organ transplantation
Bamgbola, O. (2016) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/2042018816641580 · Cited by 85
Rice Bran Protein Hydrolysates Improve Insulin Resistance and Decrease Pro-inflammatory Cytokine Gene Expression in Rats Fed a High Carbohydrate-High Fat Diet
Boonloh, K., Kukongviriyapan, V., Kongyingyoes, B., Kukongviriyapan, U., Thawornchinsombut, S., & Pannangpetch, P. (2015) · Nutrients · doi:10.3390/nu7085292 · Cited by 89
Position paper of the European Society of Cardiology–working group of coronary pathophysiology and microcirculation: obesity and heart disease
Badimón, L., Bugiardini, R., Cenko, E., Cubedo, J., Dorobanţu, M., Duncker, D. J., Estruch, R., Miličić, D., Tousoulis, D., Vasiljević, Z., et al. (2017) · European Heart Journal · doi:10.1093/eurheartj/ehx181 · Cited by 89
Neck circumference as a measure of neck fat and abdominal visceral fat in Chinese adults
Li, H., Zhang, F., Zhao, D., Zhong, X., Guo, S., Wang, S., Zhang, J.-J., Wang, J., Li, Y., Yang, G.-R., et al. (2014) · BMC Public Health · doi:10.1186/1471-2458-14-311 · Cited by 88
Ameliorative effect of myricetin on insulin resistance in mice fed a high-fat, high-sucrose diet
Choi, H., Kang, M., Lee, S., & Kim, J.-I. (2014) · Nutrition Research and Practice · doi:10.4162/nrp.2014.8.5.544 · Cited by 90
Management of Obesity in Cardiovascular Practice
Després, J.-P., Carpentier, A. C., Tchernof, A., Neeland, I. J., & Poirier, P. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.05.035 · Cited by 87
Association of Visceral Fat Area with Chronic Kidney Disease and Metabolic Syndrome Risk in the General Population: Analysis Using Multi-Frequency Bioimpedance
Kang, S. H., Cho, K. H., Park, J. W., Yoon, K. W., & Do, J. Y. (2015) · Kidney and Blood Pressure Research · doi:10.1159/000368498 · Cited by 72
3D Adipose Tissue Culture Links the Organotypic Microenvironment to Improved Adipogenesis
Shen, J. X., Couchet, M., Dufau, J., Barbosa, T. D. C., Ulbrich, M. H., Helmstädter, M., Kemas, A. M., Shafagh, R. Z., Marqués, M.-A., Hansen, J. B., et al. (2021) · Advanced Science · doi:10.1002/advs.202100106 · Cited by 94
The Impact of Weight Gain on Motivation, Compliance, and Metabolic Control in Patients with Type 2 Diabetes Mellitus
Pi-Sunyer, X. (2009) · Postgraduate Medicine · doi:10.3810/pgm.2009.09.2056 · Cited by 88
Lack of TRPV2 impairs thermogenesis in mouse brown adipose tissue
Sun, W., Uchida, K., Suzuki, Y., Zhou, Y., Kim, M., Takayama, Y., Takahashi, N., Goto, T., Wakabayashi, S., Kawada, T., et al. (2016) · EMBO Reports · doi:10.15252/embr.201540819 · Cited by 84
The physiological and pathophysiological roles of taurine in adipose tissue in relation to obesity
Murakami, S. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.08.008 · Cited by 86
Life in the fat lane: seasonal regulation of insulin sensitivity, food intake, and adipose biology in brown bears
Rigano, K. S., Gehring, J. L., Hutzenbiler, B. D. E., Chen, A. V., Nelson, O. L., Vella, C. A., Robbins, C. T., & Jansen, H. T. (2016) · Journal of Comparative Physiology B · doi:10.1007/s00360-016-1050-9 · Cited by 87
Renal sinus fat and renal hemodynamics: a cross-sectional analysis
Spit, K. A., Muskiet, M. H. A., Tonneijck, L., Smits, M. M., Kramer, M. H. H., Joles, J. A., de Boer, A., & van Raalte, D. H. (2019) · Magnetic Resonance Materials in Physics Biology and Medicine · doi:10.1007/s10334-019-00773-z · Cited by 86
Preadipocytes of type 2 diabetes subjects display an intrinsic gene expression profile of decreased differentiation capacity
van Tienen, F. H. J., Kallen, C., Lindsey, P. J., Wanders, R. J. A., van Greevenbroek, M. M. J., & Smeets, H. J. M. (2011) · International Journal of Obesity · doi:10.1038/ijo.2010.275 · Cited by 83
MicroRNAs miR-27a and miR-143 Regulate Porcine Adipocyte Lipid Metabolism
Wang, T., Li, M., Guan, J., Li, P., Wang, H., Guo, Y., Shuai, S., & Li, X. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms12117950 · Cited by 82
The effects of exercise modalities on adiposity in obese rats
Speretta, G. F. F., Rosante, M. C., Duarte, F. O., Leite, R. D., Lino, A. D. D. S., Andre, R. A., Silvestre, J. G., Selistre-de-Araújo, H. S., & Duarte, A. C. G. D. O. (2012) · Clinics · doi:10.6061/clinics/2012(12)19 · Cited by 83
Level of serum IL-12 and its correlation with endothelial dysfunction, insulin resistance, proinflammatory cytokines and lipid profile in newly diagnosed type 2 diabetes
Mishra, M., Kumar, H., Bajpai, S., Singh, R. K., & Tripathi, K. (2011) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2011.07.037 · Cited by 81
Associations among Metabolic Syndrome, Ischemia, Inflammatory, Oxidatives, and Lipids Biomarkers
Gottlieb, M. G. V., da Cruz, I. B. M., Duarte, M. M. M. F., Moresco, R. N., Wiehe, M., Schwanke, C. H. A., & Bodanese, L. C. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1592 · Cited by 82
Association Between Visceral Adipose Tissue Area and Coronary Plaque Morphology Assessed by CT Angiography
Ohashi, N., Yamamoto, H., Horiguchi, J., Kitagawa, T., Kunita, E., Utsunomiya, H., Oka, T., Kohno, N., & Kihara, Y. (2010) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2010.06.014 · Cited by 84
Role of adiponectin and some other factors linking type 2 diabetes mellitus and obesity
Chakraborti, C. K. (2015) · World Journal of Diabetes · doi:10.4239/wjd.v6.i15.1296 · Cited by 81
Altered Adipose Tissue DNA Methylation Status in Metabolic Syndrome: Relationships Between Global DNA Methylation and Specific Methylation at Adipogenic, Lipid Metabolism and Inflammatory Candidate Genes and Metabolic Variables
Castellano‐Castillo, D., Moreno‐Indias, I., Sánchez‐Alcoholado, L., Ramos‐Molina, B., Alcaide‐Torres, J., Morcillo, S., Ocaña-Wilhelmi, L., Tinahones, F. J., Queipo‐Ortuño, M. I., & Cardona, F. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8010087 · Cited by 82
Phycocyanin prevents hypertension and low serum adiponectin level in a rat model of metabolic syndrome
Ichimura‐Shimizu, M., Kato, S., Tsuneyama, K., Matsutake, S., Kamogawa, M., Hirao, E., Miyata, A., Mori, S., Yamaguchi, N., Suruga, K., et al. (2013) · Nutrition Research · doi:10.1016/j.nutres.2013.03.006 · Cited by 82
Natural history and physiological determinants of changes in glucose tolerance in a non-diabetic population: the RISC Study
on behalf of the RISC Investigators, Ferrannini, E., Natali, A., Muscelli, E., Nilsson, P. M., Golay, A., Laakso, M., Beck-Nielsen, H., & Mari, A. (2011) · Diabetologia · doi:10.1007/s00125-011-2112-x · Cited by 80
Effects of resveratrol on obesity-related inflammation markers in adipose tissue of genetically obese rats
Gómez-Zorita, S., Fernández-Quintela, A., Lasa, A., Hijona, E., Bujanda, L., & Portillo, M. P. (2013) · Nutrition · doi:10.1016/j.nut.2013.04.014 · Cited by 79
Impact of Maternal Obesity on Fetal Programming of Cardiovascular Disease
Roberts, V. H. J., Frias, A. E., & Grove, K. L. (2015) · Physiology · doi:10.1152/physiol.00021.2014 · Cited by 79
Serum levels of fibroblast growth factor‐21 are increased in chronic and acute renal dysfunction
Hindricks, J., Ebert, T., Bachmann, A., Kralisch, S., Lössner, U., Kratzsch, J., Stolzenburg, J., Dietel, A., Beige, J., Anders, M. S., et al. (2013) · Clinical Endocrinology · doi:10.1111/cen.12380 · Cited by 80

Authors: Hajer, G. R., van Haeften, T. W., & Visseren, F. L. J.
Affiliations: University Medical Center Utrecht (NL)
Corresponding author: Visseren, F. L.J.
ORCID: Visseren, F. L.J.
Venue: European Heart Journal
Publisher: Oxford University Press (OUP)
Published: 2008-09-05
Volume: 29
Issue: 24
Pages: 2959-2971
ISSN: 0195-668X (ISSN-L)
1522-9645
DOI: 10.1093/eurheartj/ehn387
OpenAlex: W2100784798
Semantic Scholar: a5a791d646daf7a9ba3a727d27f953ec6ca43ec5
Cited by: 1,410
References: 136
Citations by year: 2026: 23 · 2025: 54 · 2024: 45 · 2023: 55 · 2022: 58 · 2021: 68 · 2020: 83 · 2019: 69 · 2018: 85 · 2017: 88 · 2016: 98 · 2015: 100 · 2014: 134 · 2013: 130 · 2012: 103
FWCI: 7.72
Type: journal article
Language: en
Open access: closed
Locations: European Heart Journal (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: adipose tissue dysfunction, visceral obesity, type 2 diabetes, metabolic syndrome, cardiovascular disease, atherosclerosis, adipokines, adiponectin, leptin, TNF-α, interleukin-6, plasminogen activator inhibitor-1, low-grade inflammation, portal circulation, cardiovascular risk factors
MeSH terms: Adipose Tissue, Diabetes Mellitus, Type 2, Diabetic Angiopathies, Energy Metabolism, Female, Humans, Male, Obesity, Transcription Factors, Adipocytes, Leptin, Metabolic Syndrome, Risk Reduction Behavior, Intra-Abdominal Fat, Atherosclerosis, Subcutaneous Fat, Abdominal

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Adipose tissue dysfunction in obesity, diabetes, and vascular diseases

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks