Cited by 1,410Adipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and AdiposityAdipose Tissue and Metabolism

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Adipose tissue dysfunction in obesity, diabetes, and vascular diseases

Hajer, G. R., van Haeften, T. W., Visseren, F. L.J.·2008·European Heart Journal

DOI 10.1093/eurheartj/ehn387

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Abstract

The classical perception of adipose tissue as a storage place of fatty acids has been replaced over the last years by the notion that adipose tissue has a central role in lipid and glucose metabolism and produces a large number of hormones and cytokines, e.g. tumour necrosis factor-alpha, interleukin-6, adiponectin, leptin, and plasminogen activator inhibitor-1. The increased prevalence of excessive visceral obesity and obesity-related cardiovascular risk factors is closely associated with the rising incidence of cardiovascular diseases and type 2 diabetes mellitus. This clustering of vascular risk factors in (visceral) obesity is often referred to as metabolic syndrome. The close relationship between an increased quantity of visceral fat, metabolic disturbances, including low-grade inflammation, and cardiovascular diseases and the unique anatomical relation to the hepatic portal circulation has led to an intense endeavour to unravel the specific endocrine functions of this visceral fat depot. The objective of this paper is to describe adipose tissue dysfunction, delineate the relation between adipose tissue dysfunction and obesity and to describe how adipose tissue dysfunction is involved in the development of diabetes mellitus type 2 and atherosclerotic vascular diseases. First, normal physiology of adipocytes and adipose tissue will be described.

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Authors: Hajer, G. R., van Haeften, T. W., & Visseren, F. L. J.
Affiliations: University Medical Center Utrecht (NL)
Corresponding author: Visseren, F. L.J.
ORCID: Visseren, F. L.J.
Venue: European Heart Journal
Publisher: Oxford University Press (OUP)
Published: 2008-09-05
Volume: 29
Issue: 24
Pages: 2959-2971
ISSN: 0195-668X (ISSN-L)
1522-9645
DOI: 10.1093/eurheartj/ehn387
OpenAlex: W2100784798
Semantic Scholar: a5a791d646daf7a9ba3a727d27f953ec6ca43ec5
Cited by: 1,410
References: 136
Citations by year: 2026: 23 · 2025: 54 · 2024: 45 · 2023: 55 · 2022: 58 · 2021: 68 · 2020: 83 · 2019: 69 · 2018: 85 · 2017: 88 · 2016: 98 · 2015: 100 · 2014: 134 · 2013: 130 · 2012: 103
FWCI: 7.72
Type: journal article
Language: en
Open access: closed
Locations: European Heart Journal (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: adipose tissue dysfunction, visceral obesity, type 2 diabetes, metabolic syndrome, cardiovascular disease, atherosclerosis, adipokines, adiponectin, leptin, TNF-α, interleukin-6, plasminogen activator inhibitor-1, low-grade inflammation, portal circulation, cardiovascular risk factors
MeSH terms: Adipose Tissue, Diabetes Mellitus, Type 2, Diabetic Angiopathies, Energy Metabolism, Female, Humans, Male, Obesity, Transcription Factors, Adipocytes, Leptin, Metabolic Syndrome, Risk Reduction Behavior, Intra-Abdominal Fat, Atherosclerosis, Subcutaneous Fat, Abdominal

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Adipose tissue dysfunction in obesity, diabetes, and vascular diseases

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