Hypothalamic innate immune reaction in obesity

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Alternative activation of macrophages

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Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo

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Protective and pathogenic functions of macrophage subsets

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Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

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Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

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Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

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Physiology of Microglia

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Signalling pathways of the TNF superfamily: a double-edged sword

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Analysis of Fractalkine Receptor CX₃CR1 Function by Targeted Deletion and Green Fluorescent Protein Reporter Gene Insertion

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Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor

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Mitofusin 2 tethers endoplasmic reticulum to mitochondria

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Integrating cell-signalling pathways with NF-κB and IKK function

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Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

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NF-κB, Inflammation, and Metabolic Disease

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Obesity is associated with hypothalamic injury in rodents and humans.

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Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action

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Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease

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Resting Microglia Directly Monitor the Functional State of Synapses <i>In Vivo</i> and Determine the Fate of Ischemic Terminals

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Control of microglial neurotoxicity by the fractalkine receptor

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Mechanisms of Pancreatic β-Cell Death in Type 1 and Type 2 Diabetes

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Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways

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Innate immune activation in neurodegenerative disease

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Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

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Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease

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Leptin regulates proinflammatory immune responses

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Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior

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Consumption of a Fat-Rich Diet Activates a Proinflammatory Response and Induces Insulin Resistance in the Hypothalamus

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Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity

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Debris clearance by microglia: an essential link between degeneration and regeneration

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Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions

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Mitochondria in neuroplasticity and neurological disorders

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Alzheimer's disease: strategies for disease modification

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Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6.

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Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration

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Hypothalamic insulin signaling is required for inhibition of glucose production

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Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain

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Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor

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Microglia derive from progenitors, originating from the yolk sac, and which proliferate in the brain

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The gut microbiota and obesity: from correlation to causality

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Experimental autoimmune encephalomyelitis repressed by microglial paralysis

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Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer’s disease

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Immunosurveillance by Hematopoietic Progenitor Cells Trafficking through Blood, Lymph, and Peripheral Tissues

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A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation

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Heterogeneity of CNS myeloid cells and their roles in neurodegeneration

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Formation of Projection Pathways from the Arcuate Nucleus of the Hypothalamus to Hypothalamic Regions Implicated in the Neural Control of Feeding Behavior in Mice

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Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation

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Reciprocal Regulation between Resting Microglial Dynamics and Neuronal Activity In Vivo

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Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance

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Glucose transporter proteins in brain

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MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity

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Functional Impairment of Microglia Coincides with Beta-Amyloid Deposition in Mice with Alzheimer-Like Pathology

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Regulation of the fructose transporter GLUT5 in health and disease

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The microglial "activation" continuum: from innate to adaptive responses

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Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity

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Immunological Goings-on in Visceral Adipose Tissue

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Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis

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High-Fat Diet Induces Apoptosis of Hypothalamic Neurons

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From neuroanatomy to behavior: central integration of peripheral signals regulating feeding behavior

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Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease–like pathology and cognitive decline

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Characterization of the microglial phenotype under specific pro-inflammatory and anti-inflammatory conditions: Effects of oligomeric and fibrillar amyloid-β

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Formation and maintenance of Alzheimer's disease β-amyloid plaques in the absence of microglia

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Selective targeting of perivascular macrophages for clearance of β-amyloid in cerebral amyloid angiopathy

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Slowing of neurodegeneration in Parkinson's disease and Huntington's disease: future therapeutic perspectives

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Mitochondrial Trafficking to Synapses in Cultured Primary Cortical Neurons

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Tanycytic VEGF-A Boosts Blood-Hypothalamus Barrier Plasticity and Access of Metabolic Signals to the Arcuate Nucleus in Response to Fasting

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Distinct and Non-Redundant Roles of Microglia and Myeloid Subsets in Mouse Models of Alzheimer's Disease

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Comparison of Lactate Transport in Astroglial Cells and Monocarboxylate Transporter 1 (MCT 1) Expressing Xenopus laevis Oocytes

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IKKβ/NF-κB disrupts adult hypothalamic neural stem cells to mediate a neurodegenerative mechanism of dietary obesity and pre-diabetes

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CNS-Derived Interleukin-4 Is Essential for the Regulation of Autoimmune Inflammation and Induces a State of Alternative Activation in Microglial Cells

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Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding

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Adipocyte/macrophage fatty acid–binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice

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Targeted estrogen delivery reverses the metabolic syndrome

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Rapid sensing of circulating ghrelin by hypothalamic appetite-modifying neurons

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Microglial activation by purines and pyrimidines

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Mitochondrial dynamics controlled by mitofusins regulate Agrp neuronal activity and diet-induced obesity

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GFAP Isoforms in Adult Mouse Brain with a Focus on Neurogenic Astrocytes and Reactive Astrogliosis in Mouse Models of Alzheimer Disease

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Astroglial heterogeneity closely reflects the neuronal-defined anatomy of the adult murine CNS

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Targeted Disruption of the Tumor Necrosis Factor-α Gene: Metabolic Consequences in Obese and Nonobese Mice

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Peroxisome proliferation–associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity

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Hormones and diet, but not body weight, control hypothalamic microglial activity

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