Cited by 341Gut microbiota and healthClostridium difficile and Clostridium perfringens researchProbiotics and Fermented Foods

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Ruminococcus gnavus : friend or foe for human health

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Crost, Emmanuelle H, Coletto, Erika, Bell, Andrew, Juge, Nathalie·2023·FEMS Microbiology Reviews

DOI 10.1093/femsre/fuad014PMC PMC10112845

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Abstract

Ruminococcus gnavus was first identified in 1974 as a strict anaerobe in the gut of healthy individuals, and for several decades, its study has been limited to specific enzymes or bacteriocins. With the advent of metagenomics, R. gnavus has been associated both positively and negatively with an increasing number of intestinal and extraintestinal diseases from inflammatory bowel diseases to neurological disorders. This prompted renewed interest in understanding the adaptation mechanisms of R. gnavus to the gut, and the molecular mediators affecting its association with health and disease. From ca. 250 publications citing R. gnavus since 1990, 94% were published in the last 10 years. In this review, we describe the biological characterization of R. gnavus, its occurrence in the infant and adult gut microbiota and the factors influencing its colonization of the gastrointestinal tract; we also discuss the current state of our knowledge on its role in host health and disease. We highlight gaps in knowledge and discuss the hypothesis that differential health outcomes associated with R. gnavus in the gut are strain and niche specific.

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Figure 1. Scanning electron microscopy image of R. gnavus ATCC 35913 anaerobically grown in rich medium to stationary phase (courtesy of Catherine Booth).CC BY · PubMed Central

Figure 2. Distribution of GHs across R. gnavus strains. A total of 7741 putative GHs has been identified by analysing 92 genomes of R. gnavus strains. These GHs are spread across 56 GH families. Some GH families are not widely spread amongst R. gnavus strains (i.e. GH35, GH38, GH53, GH65, GH79, GH84, GH91, GH101, GH120, GH125, and GH154) while other families are present in all the strains (i.e. GH1, GH2, GH3, GH13, GH18, GH25, GH29, GH31, GH32, GH36, GH73, GH77, GH78, GH95, GH112, and GH151). More than half of the sequences (4021/7741) belongs to seven GH families: GH1, GH2, GH3, GH13, GH23, GH32, and GH73. Combined, these families cover enzymes with a wide range of activities including (but not exclusively) α-amylase, isoamylase, pullulanase, β-glucosidase, β-galactosidase, β-mannosidase, β-glucuronidase, β-xylosidase, lysozyme, peptidoglycan hydrolase, invertase, inulinase, and endo-levanase.CC BY · PubMed Central

Figure 3. R. gnavus association in diseases and potential molecular mediators.CC BY · PubMed Central

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Retracted
A human gut microbial gene catalogue established by metagenomic sequencing
MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624
Human gut microbiome viewed across age and geography
Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815
Gut microbiota in human metabolic health and disease
Fan, Y., & Pedersen, O. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-020-0433-9 · Cited by 4,724
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Rooks, M. G., & Garrett, W. S. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.42 · Cited by 3,409
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Roager, H. M., & Licht, T. R. (2018) · Nature Communications · doi:10.1038/s41467-018-05470-4 · Cited by 2,236
Gut microbiota-derived metabolites as key actors in inflammatory bowel disease
Lavelle, A., & Sokol, H. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0258-z · Cited by 2,015
Gut microbiome structure and metabolic activity in inflammatory bowel disease
Franzosa, E. A., Sirota-Madi, A., Avila-Pacheco, J., Fornelos, N., Haiser, H. J., Reinker, S., Vatanen, T., Hall, A. B., Mallick, H., McIver, L. J., et al. (2018) · Nature Microbiology · doi:10.1038/s41564-018-0306-4 · Cited by 1,995
The abundance and variety of carbohydrate-active enzymes in the human gut microbiota
Kaoutari, A. E., Armougom, F., Gordon, J. I., Raoult, D., & Henrissat, B. (2013) · Nature Reviews Microbiology · doi:10.1038/nrmicro3050 · Cited by 1,683
The composition of the gut microbiota throughout life, with an emphasis on early life
Rodríguez, J. M., Murphy, K., Stanton, C., Ross, R. P., Kober, O. I., Juge, N., Avershina, E., Rudi, K., Narbad, A., Jenmalm, M. C., et al. (2015) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v26.26050 · Cited by 1,414
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Bong, H., Min, J., Kim, S., Lım, W., Lim, D., Eom, H., Her, Y., & Jeon, M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.14.664646
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Additional file 8 of Causal relationship between gut microbiota and gastrointestinal diseases: a mendelian randomization study
Wu, K., Luo, Q., Liu, Y., Li, A., Xia, D., & Sun, X. (2024) · Figshare · doi:10.6084/m9.figshare.26671287
Additional file 3 of Causal relationship between gut microbiota and gastrointestinal diseases: a mendelian randomization study
Wu, K., Luo, Q., Liu, Y., Li, A., Xia, D., & Sun, X. (2024) · Figshare · doi:10.6084/m9.figshare.26671272
Additional file 6 of Causal relationship between gut microbiota and gastrointestinal diseases: a mendelian randomization study
Wu, K., Luo, Q., Liu, Y., Li, A., Xia, D., & Sun, X. (2024) · Figshare · doi:10.6084/m9.figshare.26671281
Additional file 4 of Causal relationship between gut microbiota and gastrointestinal diseases: a mendelian randomization study
Wu, K., Luo, Q., Liu, Y., Li, A., Xia, D., & Sun, X. (2024) · Figshare · doi:10.6084/m9.figshare.26671275
Additional file 5 of Causal relationship between gut microbiota and gastrointestinal diseases: a mendelian randomization study
Wu, K., Luo, Q., Liu, Y., Li, A., Xia, D., & Sun, X. (2024) · Figshare · doi:10.6084/m9.figshare.26671278
Additional file 2 of Causal relationship between gut microbiota and gastrointestinal diseases: a mendelian randomization study
Wu, K., Luo, Q., Liu, Y., Li, A., Xia, D., & Sun, X. (2024) · Figshare · doi:10.6084/m9.figshare.26671269
Additional file 7 of Causal relationship between gut microbiota and gastrointestinal diseases: a mendelian randomization study
Wu, K., Luo, Q., Liu, Y., Li, A., Xia, D., & Sun, X. (2024) · Figshare · doi:10.6084/m9.figshare.26671284
Additional file 1 of Causal relationship between gut microbiota and gastrointestinal diseases: a mendelian randomization study
Wu, K., Luo, Q., Liu, Y., Li, A., Xia, D., & Sun, X. (2024) · Figshare · doi:10.6084/m9.figshare.26671266
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Mihai, C., Dranga, M., Nedelciuc, O., & Prelipcean, C. C. (2025) · Springer eBooks · doi:10.1007/978-3-032-11445-7_7
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Liu, Y., Peng, P., Hung, W.-C., Wu, P., Lu, C.-C., Lin, Y.-H., Wu, C.-D., Kuo, C., & Chen, S. (2026) · Air Quality Atmosphere & Health · doi:10.1007/s11869-026-01932-7
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Zafeiropoulou, K., Hageman, I., Mu, T., Davids, M., Yim, A. Y. F. L., Joustra, V., Hakvoort, T. B. M., Satsangi, J., Chronas, K., Koelink, P. J., et al. (2026) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2026.1741002
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Cheng, Z., Xiang, W., Chen, X., Xu, X., Hou, W., Gao, J., & Zhou, J. (2026) · Fitoterapia · doi:10.1016/j.fitote.2026.107239
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Beaufrère, M. (2024) · theses.fr (ABES) · doi:10.70675/e2ad4bb8zc461z4159z99eaz2d8e71144ddf
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Elhani, I. (2024) · theses.fr (ABES) · doi:10.70675/3d60157fz88efz4edazb51ezd427f44ecb7f
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Liu, M., Yang, Z., Liu, B., Cheng, H., Qin, J., Zhang, P., Tang, T., Peng, F., Yang, J., Wei, P., et al. (2026) · Food & Function · doi:10.1039/d6fo00282j
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Wang, P. Y., Wang, M., Shen, Y., Yao, Y., Yan, K., Wang, S., Li, Z., Dong, Y., Li, B., & Li, J. (2026) · Microbiology Spectrum · doi:10.1128/spectrum.03294-25
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Ding, M., de Farias, F. M., O’Connor, P. M., Huang, X., Ross, F. C., Kennedy, E. C., Hawkes, C. P., Hill, C., Stanton, C., & Ross, R. P. (2026) · MicrobiologyOpen · doi:10.1002/mbo3.70315

Authors: Crost, E. H., Coletto, E., Bell, A., & Juge, N.
Affiliations: Quadram Institute (GB)
Corresponding author: Juge, Nathalie
ORCID: Crost, Emmanuelle H
Coletto, Erika
Bell, Andrew
Juge, Nathalie
Venue: FEMS Microbiology Reviews
Publisher: Oxford University Press (OUP)
Published: 2023-03
Volume: 47
Issue: 2
ISSN: 0168-6445 (ISSN-L)
1574-6976
DOI: 10.1093/femsre/fuad014
PMC: PMC10112845
OpenAlex: W4362525665
Cited by: 335
References: 207
Citations by year: 2026: 90 · 2025: 128 · 2024: 98 · 2023: 19
FWCI: 8.99
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor, 35 d)
Locations: FEMS Microbiology Reviews (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: Biotechnology and Biological Sciences Research Council (BB/R012490/1)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords: Ruminococcus gnavus, gut microbiota, intestinal colonization, inflammatory bowel disease, neurological disorders, strain-specific effects, niche specificity, host-microbe interactions, anaerobic bacteria, metagenomics
MeSH terms: Eubacteriales, Gastrointestinal Microbiome, Adult, Humans, Gastrointestinal Tract, Ruminococcus

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Ruminococcus gnavus : friend or foe for human health

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