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Cited by 341Gut microbiota and healthClostridium difficile and Clostridium perfringens researchProbiotics and Fermented Foods

The DOI matches its Crossref record; 206 of the 207 references it cites were found in a registry or an index.

Ruminococcus gnavus : friend or foe for human health

Open access
Crost, Emmanuelle H, Coletto, Erika, Bell, Andrew, Juge, Nathalie·2023·FEMS Microbiology Reviews
DOI 10.1093/femsre/fuad014PMC PMC10112845
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Abstract

Ruminococcus gnavus was first identified in 1974 as a strict anaerobe in the gut of healthy individuals, and for several decades, its study has been limited to specific enzymes or bacteriocins. With the advent of metagenomics, R. gnavus has been associated both positively and negatively with an increasing number of intestinal and extraintestinal diseases from inflammatory bowel diseases to neurological disorders. This prompted renewed interest in understanding the adaptation mechanisms of R. gnavus to the gut, and the molecular mediators affecting its association with health and disease. From ca. 250 publications citing R. gnavus since 1990, 94% were published in the last 10 years. In this review, we describe the biological characterization of R. gnavus, its occurrence in the infant and adult gut microbiota and the factors influencing its colonization of the gastrointestinal tract; we also discuss the current state of our knowledge on its role in host health and disease. We highlight gaps in knowledge and discuss the hypothesis that differential health outcomes associated with R. gnavus in the gut are strain and niche specific.

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Crossref · 10.1093/femsre/fuad014

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Figures

Figure 1. Scanning electron microscopy image of R. gnavus ATCC 35913 anaerobically grown in rich medium to stationary phase (courtesy of Catherine Booth).
Figure 1. Scanning electron microscopy image of R. gnavus ATCC 35913 anaerobically grown in rich medium to stationary phase (courtesy of Catherine Booth).CC BY · PubMed Central
Figure 2. Distribution of GHs across R. gnavus strains. A total of 7741 putative GHs has been identified by analysing 92 genomes of R. gnavus strains. These GHs are spread across 56 GH families. Some GH families are not widely spread amongst R. gnavus strains (i.e. GH35, GH38, GH53, GH65, GH79, GH84, GH91, GH101, GH120, GH125, and GH154) while other families are present in all the strains (i.e. GH1, GH2, GH3, GH13, GH18, GH25, GH29, GH31, GH32, GH36, GH73, GH77, GH78, GH95, GH112, and GH151). More than half of the sequences (4021/7741) belongs to seven GH families: GH1, GH2, GH3, GH13, GH23, GH32, and GH73. Combined, these families cover enzymes with a wide range of activities including (but not exclusively) α-amylase, isoamylase, pullulanase, β-glucosidase, β-galactosidase, β-mannosidase, β-glucuronidase, β-xylosidase, lysozyme, peptidoglycan hydrolase, invertase, inulinase, and endo-levanase.
Figure 2. Distribution of GHs across R. gnavus strains. A total of 7741 putative GHs has been identified by analysing 92 genomes of R. gnavus strains. These GHs are spread across 56 GH families. Some GH families are not widely spread amongst R. gnavus strains (i.e. GH35, GH38, GH53, GH65, GH79, GH84, GH91, GH101, GH120, GH125, and GH154) while other families are present in all the strains (i.e. GH1, GH2, GH3, GH13, GH18, GH25, GH29, GH31, GH32, GH36, GH73, GH77, GH78, GH95, GH112, and GH151). More than half of the sequences (4021/7741) belongs to seven GH families: GH1, GH2, GH3, GH13, GH23, GH32, and GH73. Combined, these families cover enzymes with a wide range of activities including (but not exclusively) α-amylase, isoamylase, pullulanase, β-glucosidase, β-galactosidase, β-mannosidase, β-glucuronidase, β-xylosidase, lysozyme, peptidoglycan hydrolase, invertase, inulinase, and endo-levanase.CC BY · PubMed Central
Figure 3. R. gnavus association in diseases and potential molecular mediators.
Figure 3. R. gnavus association in diseases and potential molecular mediators.CC BY · PubMed Central

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Metadata

Authors
Crost, E. H., Coletto, E., Bell, A., & Juge, N.
Affiliations
Quadram Institute (GB)
Corresponding author
Juge, Nathalie
ORCID
Venue
FEMS Microbiology Reviews
Publisher
Oxford University Press (OUP)
Published
2023-03
Volume
47
Issue
2
ISSN
  • 0168-6445 (ISSN-L)
  • 1574-6976
DOI
10.1093/femsre/fuad014
PMC
PMC10112845
OpenAlex
W4362525665
Cited by
335
References
207
Citations by year
2026: 90 · 2025: 128 · 2024: 98 · 2023: 19
FWCI
8.99
Type
journal article
Language
en
Open access
Licence
Locations
  • FEMS Microbiology Reviews (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
Biotechnology and Biological Sciences Research Council (BB/R012490/1)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords
Ruminococcus gnavus, gut microbiota, intestinal colonization, inflammatory bowel disease, neurological disorders, strain-specific effects, niche specificity, host-microbe interactions, anaerobic bacteria, metagenomics
MeSH terms
Eubacteriales, Gastrointestinal Microbiome, Adult, Humans, Gastrointestinal Tract, Ruminococcus

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