The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Development of a vaccine against Staphylococcus aureus invasive infections: Evidence based on human immunity, genetics and bacterial evasion mechanisms
Open accessAbstract
Invasive Staphylococcus aureus infections are a leading cause of morbidity and mortality in both hospital and community settings, especially with the widespread emergence of virulent and multi-drug resistant methicillin-resistant S. aureus strains. There is an urgent and unmet clinical need for non-antibiotic immune-based approaches to treat these infections as the increasing antibiotic resistance is creating a serious threat to public health. However, all vaccination attempts aimed at preventing S. aureus invasive infections have failed in human trials, especially all vaccines aimed at generating high titers of opsonic antibodies against S. aureus surface antigens to facilitate antibody-mediated bacterial clearance. In this review, we summarize the data from humans regarding the immune responses that protect against invasive S. aureus infections as well as host genetic factors and bacterial evasion mechanisms, which are important to consider for the future development of effective and successful vaccines and immunotherapies against invasive S. aureus infections in humans. The evidence presented form the basis for a hypothesis that staphylococcal toxins (including superantigens and pore-forming toxins) are important virulence factors, and targeting the neutralization of these toxins are more likely to provide a therapeutic benefit in contrast to prior vaccine attempts to generate antibodies to facilitate opsonophagocytosis.
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“Additionally, antigenic redundancy (e.g., compensatory adhesins replacing ClfB/SasG) and the pathogen’s ability to skew immune responses toward non-protective antibody subtypes contribute to vaccine failures [55].”
From Staphylococcus aureus: A Review of the Pathogenesis and Virulence Mechanisms (2025) · cites this paper as [55]
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Cites
Cryopyrin activates the inflammasome in response to toxins and ATP
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β-Defensins: Linking Innate and Adaptive Immunity Through Dendritic and T Cell CCR6
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Impaired TH17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome
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Cited by
Antibiotic resistance: The challenges and some emerging strategies for tackling a global menace
Chinemerem Nwobodo, D., Ugwu, M. C., Oliseloke Anie, C., Al‐Ouqaili, M. T. S., Chinedu Ikem, J., Victor Chigozie, U., & Saki, M. (2022) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.24655 · Cited by 985
Skeletal infections: microbial pathogenesis, immunity and clinical management
Masters, E. A., Ricciardi, B. F., Bentley, K. L. D. M., Moriarty, T. F., Schwarz, E. M., & Muthukrishnan, G. (2022) · Nature Reviews Microbiology · doi:10.1038/s41579-022-00686-0 · Cited by 735
Staphylococcus aureus host interactions and adaptation
Howden, B. P., Giulieri, S. G., Wong Fok Lung, T., Baines, S. L., Sharkey, L. K., Lee, J. Y. H., Hachani, A., Monk, I. R., & Stinear, T. P. (2023) · Nature Reviews Microbiology · doi:10.1038/s41579-023-00852-y · Cited by 689
The Role of Macrophages in Staphylococcus aureus Infection
Pidwill, G. R., Gibson, J. F., Cole, J., Renshaw, S. A., & Foster, S. J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.620339 · Cited by 341
Staphylococcus aureus: A Review of the Pathogenesis and Virulence Mechanisms
Touaitia, R., Mairi, A., Ibrahim, N. A., Basher, N. S., Idres, T., & Touati, A. (2025) · Antibiotics · doi:10.3390/antibiotics14050470 · Cited by 273
Metadata
- Authors
- Miller, L. S., Fowler, V. G., Shukla, S. K., Rose, W. E., & Proctor, R. A.
- Venue
- FEMS Microbiology Reviews
- Publisher
- Oxford University Press (OUP)
- Published
- 2019-12-16
- Volume
- 44
- Issue
- 1
- Pages
- 123-153
- ISSN
- 0168-6445 (ISSN-L)
- 1574-6976
- OpenAlex
- W2995055934
- Cited by
- 240
- References
- 29
- FWCI
- 18.70
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Miller, L. S., Fowler, V. G., Shukla, S. K., Rose, W. E., & Proctor, R. A. (2020). Development of a vaccine against Staphylococcus aureus invasive infections: Evidence based on human immunity, genetics and bacterial evasion mechanisms. FEMS Microbiology Reviews. https://doi.org/10.1093/femsre/fuz030
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
