Cited by 315Genomics and Chromatin DynamicsNuclear Structure and FunctionChromosomal and Genetic Variations

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The heterochromatin-associated protein HP-1 is an essential protein in Drosophila with dosage-dependent effects on position-effect variegation.

Eissenberg, J C, Morris, G D, Reuter, G, Hartnett, T·1992·Genetics

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Abstract

Chromosome rearrangements which place euchromatic genes adjacent to a heterochromatic breakpoint frequently result in gene repression (position-effect variegation). This repression is thought to reflect the spreading of a heterochromatic structure into neighboring euchromatin. Two allelic dominant suppressors of position-effect variegation were found to contain mutations within the gene encoding the heterochromatin-specific chromosomal protein HP-1. The site of mutation for each allele is given: one converts Lys169 into a nonsense (ochre) codon, while the other is a frameshift after Ser10. In flies heterozygous for one of the mutant alleles (Su(var)2-504), a truncated HP-1 protein was detectable by Western blot analysis. An HP-1 minigene, consisting of HP-1 cDNA under the control of an Hsp70 heat-inducible promoter, was transduced into flies by P element-mediated germ line transformation. Heat-shock driven expression of this minigene results in elevated HP-1 protein level and enhancement of position-effect variegation. Levels of variegating gene expression thus appear to depend upon the level of expression of a heterochromatin-specific protein. The implications of these observations for mechanism of heterochromatic position effects and heterochromatin function are discussed.

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Authors: Eissenberg, J. C., Morris, G. D., Reuter, G., & Hartnett, T.
Affiliations: Saint Louis University (US)
ORCID: Reuter, G
Venue: Genetics
Publisher: Oxford University Press (OUP)
Published: 1992-06-01
Volume: 131
Issue: 2
Pages: 345-352
ISSN: 0016-6731 (ISSN-L)
1943-2631
DOI: 10.1093/genetics/131.2.345
OpenAlex: W1856601345
Cited by: 315
References: 39
Citations by year: 2026: 4 · 2025: 5 · 2024: 12 · 2023: 4 · 2022: 5 · 2021: 6 · 2020: 6 · 2019: 3 · 2018: 10 · 2017: 1 · 2016: 6 · 2015: 7 · 2014: 7 · 2013: 7 · 2012: 6
FWCI: 3.84
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: Genetics (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01gm040732-02)
National Institute of General Medical Sciences (GM40732)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
Keywords: heterochromatin, position effect variegation, dose-dependent effects, heterochromatin spreading, gene repression, Drosophila
MeSH terms: Chromobox Protein Homolog 5, Alleles, Animals, Chromosomal Proteins, Non-Histone, DNA, Drosophila melanogaster, Epistasis, Genetic, Gene Expression Regulation, Genes, Lethal, Heterochromatin, Mutation, Recombinant Fusion Proteins, Genes, Suppressor

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The heterochromatin-associated protein HP-1 is an essential protein in Drosophila with dosage-dependent effects on position-effect variegation.

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