Cited by 860CRISPR and Genetic EngineeringDNA Repair MechanismsRNA regulation and disease

The DOI matches its Crossref record; 49 of the 50 references it cites were found in a registry or an index.

Targeted Chromosomal Cleavage and Mutagenesis in Drosophila Using Zinc-Finger Nucleases

Bibikova, Marina, Golic, Mary, Golic, Kent G, Carroll, Dana·2002·Genetics

Open this paper in CoChat — free account

Abstract

Zinc-finger nucleases (ZFNs) are hybrids between a nonspecific DNA-cleavage domain and a DNA-binding domain composed of Cys2His2 zinc fingers. Because zinc fingers can be manipulated to recognize a broad range of sequences, these enzymes have the potential to direct cleavage to arbitrarily chosen targets. We have tested this idea by designing a pair of ZFNs that recognize a unique site in the yellow (y) gene of Drosophila. When these nucleases were expressed in developing larvae, they led to somatic mutations specifically in the y gene. These somatic mosaics were observed in approximately one-half of the males expressing both nucleases. Germline y mutations were recovered from 5.7% of males, but from none of the females, tested. DNA sequences were determined and showed that all of the mutations were small deletions and/or insertions located precisely at the designed target. These are exactly the types of alterations expected from nonhomologous end joining (NHEJ) following double-strand cleavage of the target. This approach promises to permit generation of directed mutations in many types of cells and organisms.

Integrity signals

Registry

Crossref · 10.1093/genetics/161.3.1169

Cites

49 of 49 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The Genome Sequence of Drosophila melanogaster
Adams, M. D., Celniker, S., Holt, R. A., Evans, C. A., Gocayne, J. D., Amanatides, P. G., Scherer, S. E., Li, P. W., Hoskins, R. A., Galle, R. F., et al. (2000) · Science · doi:10.1126/science.287.5461.2185 · Cited by 5,902
[12] One-step gene disruption in yeast
Rothstein, R. J. (1983) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(83)01015-0 · Cited by 3,282
Zinc Finger-DNA Recognition: Crystal Structure of a Zif268-DNA Complex at 2.1 Å
Pavletich, N. P., & Pabo, C. O. (1991) · Science · doi:10.1126/science.2028256 · Cited by 2,081
Altering the Genome by Homologous Recombination
Capecchi, M. R. (1989) · Science · doi:10.1126/science.2660260 · Cited by 2,037
Hybrid restriction enzymes: zinc finger fusions to Fok I cleavage domain.
Kim, Y. G., Cha, J., & Chandrasegaran, S. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.3.1156 · Cited by 1,889
Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: A general strategy for targeting mutations to non-selectable genes
Mansour, S. L., Thomas, K. R., & Capecchi, M. R. (1988) · Nature · doi:10.1038/336348a0 · Cited by 1,683
Chromosomal stability and the DNA double-stranded break connection
van Gent, D. C., Hoeijmakers, J. H. J., & Kanaar, R. (2001) · Nature Reviews Genetics · doi:10.1038/35056049 · Cited by 1,219
Design and Selection of Novel Cys2His2 Zinc Finger Proteins
Pabo, C. O., Peisach, E., & Grant, R. A. (2001) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.70.1.313 · Cited by 715
Stimulation of Homologous Recombination through Targeted Cleavage by Chimeric Nucleases
Bibikova, M. V., Carroll, D., Segal, D. J., Trautman, J. K., Smith, J., Kim, Y., & Chandrasegaran, S. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.1.289-297.2001 · Cited by 614
Self-citation
Gene Targeting by Homologous Recombination in Drosophila
Rong, Y. S., & Golic, K. G. (2000) · Science · doi:10.1126/science.288.5473.2013 · Cited by 557
Self-citation

Show all 50 references

Sorted by citations

Items 601–700 of 858

Generation of Gene Edited Pigs
Navarro‐Serna, S., Piñeiro-Silva, C., Romar, R., Parrington, J., & Gadea, J. (2022) · Sustainable agriculture reviews · doi:10.1007/978-3-031-07496-7_3 · Cited by 7
Production of MSTN knockout porcine cells using adenine base-editing-mediated exon skipping
Yang, S.-P., Zhu, X., Qu, Z.-X., Chen, C.-Y., Wu, Y.-B., Wu, Y., Luo, Z.-D., Wang, X., He, C.-Y., Fang, J.-W., et al. (2023) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-023-00763-5 · Cited by 6
Nuclease-free precise genome editing corrects MECP2 mutations associated with Rett syndrome
Bijlani, S., Pang, K. M., Bugga, L., Rangasamy, S., Narayanan, V., & Chatterjee, S. (2024) · Frontiers in Genome Editing · doi:10.3389/fgeed.2024.1346781 · Cited by 6
A novel promoterless gene targeting vector to efficiently disrupt PRNP gene in cattle
Wang, S., Zhang, K., Ding, F., Zhao, R., Li, S., Li, R., Xu, L., Song, C., Dai, Y., & Li, N. (2012) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2012.10.018 · Cited by 6
CRISPR/CAS9 as a Powerful Tool for Crop Improvement
Song, J.-Y., Niño, M. C., Nogoy, F. M., Jung, Y., Kang, K.-K., & Cho, Y. (2017) · Journal of Plant Biotechnology · doi:10.5010/jpb.2017.44.2.107 · Cited by 6
CRISPR: The Revolutionary Gene Editing Tool with Far-Reaching Applications
Bhattacharyya, S., & Mukherjee, A. (2020) · Ecoproduction · doi:10.1007/978-3-030-36130-3_2 · Cited by 6
Gene Editing Profiles in 94 CRISPR-Cas9 Expressing T0 Transgenic Tobacco Lines Reveal High Frequencies of Chimeric Editing of the Target Gene
Song, G., Urban, G., Ryner, J. T., & Zhong, G. (2022) · Plants · doi:10.3390/plants11243494 · Cited by 6
Targeted Gene Disruption with Engineered Zinc-Finger Nucleases (ZFNs)
Young, J. J., & Harland, R. M. (2012) · Methods in molecular biology · doi:10.1007/978-1-61779-992-1_7 · Cited by 6
Conventional and molecular breeding systems in fig (Ficus caricaL.)
Flaishman, M. A., Peer, R., Freiman, Z. E., Izhaki, Y., & Yablowitz, Z. (2017) · Acta Horticulturae · doi:10.17660/actahortic.2017.1173.1 · Cited by 6
Establishment of Genome-edited Human Pluripotent Stem Cell Lines: From Targeting to Isolation
Blair, J. D., Bateup, H. S., & Hockemeyer, D. F. (2016) · Journal of Visualized Experiments · doi:10.3791/53583-v · Cited by 6
Delivery of genome editors with engineered virus-like particles
Lu, C., Li, Y., Cummings, J. R., & Banskota, S. (2025) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2025.01.007 · Cited by 8
Structure and Mechanism of Zinc-finger Nucleases-mediated Genome Editing in Plants
Chivukula, J., Ponnachan, B., Kumar, D., & Nagella, P. (2025) · CABI eBooks · doi:10.1079/9781800622517.0003 · Cited by 5
CRISPR/Cas9‐edited tumor‐associated immune cells in cancer immunotherapy
Ma, Y., Chen, J., Du, Y., Cao, Z., Ji, W., Niu, Y., & Yang, Z. (2025) · Open Research (University of Surrey) · doi:10.1002/viw.20250002 · Cited by 5
Treatment of Huntington’s disease with a pan-HTT-targeting CRISPR nuclease
Tan, K., Siller, D. D. B., Xiong, A. Y., Wang, A. X. A., McCallister, T. X., Mummadi, S., John, L. A. S., Lee, T. K., Carrillo, A., Renshaw, D. G., et al. (2026) · Molecular Therapy · doi:10.1016/j.ymthe.2026.04.038 · Cited by 6
Advancements in Genome Editing for Insect Control - A Comprehensive Review
Kumari, P., Verma, T., Yadav, M., Pawar, P., Mounika, J., & Singh, B. (2024) · Environment and Ecology · doi:10.60151/envec/dpbb8704 · Cited by 5
Microinjection of Western Corn Rootworm, Diabrotica virgifera virgifera, Embryos for Germline Transformation, or CRISPR/Cas9 Genome Editing
Chu, F., Wu, P.-S., Pinzi, S., Grubbs, N., & Lorenzen, M. D. (2018) · Journal of Visualized Experiments · doi:10.3791/57497 · Cited by 5
Role of CRISPR/Cas9 in Soybean (Glycine max L.) Quality Improvement
Siddique, S. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.102812 · Cited by 5
An Overview of Genome Editing in Cardiovascular and Metabolic Diseases
Musunuru, K. (2022) · Advances in experimental medicine and biology · doi:10.1007/978-981-19-5642-3_1 · Cited by 5
The applications of CRISPR/Cas-mediated genome editing in genetic hearing loss
Wu, J., Tao, Y., Deng, D., Meng, Z., & Zhao, Y. (2023) · Cell & Bioscience · doi:10.1186/s13578-023-01021-7 · Cited by 5
Evaluating CRISPR/Cas9's Progressive Role in Crop Enhancement and Sustainable Agriculture
Sathiyabalan, A., Amir, M., Sandhu, R., & Bhattacharya, S. (2024) · Journal of Advances in Biology & Biotechnology · doi:10.9734/jabb/2024/v27i6949 · Cited by 5
[Advances in genetic modification technologies].
Zhang, B., Sun, Q., & Li, H. (2015) · PubMed · Cited by 5
Therapeutic Gene Editing with CRISPR
Hahn, E., & Hiemenz, M. (2020) · Clinics in Laboratory Medicine · doi:10.1016/j.cll.2020.02.008 · Cited by 5
Advances in genetic engineering of domestic animals
Shaohua, W. A. N. G., ZHANG, K., & Yunping, D. A. I. (2016) · Frontiers of Agricultural Science and Engineering · doi:10.15302/j-fase-2016085 · Cited by 5
The Development and Use of Zinc-Finger Nucleases
Carroll, D. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-3509-3_2 · Cited by 5
Self-citation
Applications of genome editing in farm animals
Kumar, D., & Kues, W. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816352-8.00005-9 · Cited by 5
[Progress in gene knockout mice].
Wang, C., & Sun, H. (2019) · PubMed · doi:10.13345/j.cjb.180417 · Cited by 5
Targeting DNA 5mCpG sites with chimeric endonucleases
Fomenkov, A. I., Too, P. H.-M., Chan, S., Vaisvila, R., Cantin, B. A., Mazzola, L., Tam, V., & Xu, S.-Y. (2008) · Analytical Biochemistry · doi:10.1016/j.ab.2008.06.035 · Cited by 5
TRANSLATIONAL PERSPECTIVES — TRANSIENT EPIGENETIC GENE THERAPY: HAZARD-FREE CELL REPROGRAMMING APPROACH AND RISING ARM OF A UNIVERSAL STEM CELL GENE THERAPY PLATFORM
Bertolotti, R. (2009) · Gene Therapy and Regulation · doi:10.1142/s1568558609000102 · Cited by 5
Expression and Characterisation of Recombinant Molecules in Transgenic Soybean
da Cunha, N. B., Murad, A. M., Vianna, G. R., Coelho, C. M., & Rech, E. L. (2013) · Current Pharmaceutical Design · doi:10.2174/1381612811319310010 · Cited by 5
Selection-dependent and Independent Generation of CRISPR/Cas9-mediated Gene Knockouts in Mammalian Cells
Sternburg, E. L., Dias, K. C., & Karginov, F. V. (2017) · Journal of Visualized Experiments · doi:10.3791/55903 · Cited by 5
Genomics and Genome Engineering in Xenopus
Vouillot, L., Thélie, A., Scalvenzi, T., & Pollet, N. (2014) · Wiley eBooks · doi:10.1002/9781118492833.ch20 · Cited by 7
Gene Targeting by Homologous Recombination for Rice Functional Genomics
Iida, S., Johzuka‐Hisatomi, Y., & Terada, R. (2007) · Springer eBooks · doi:10.1007/0-387-48914-2_11 · Cited by 5
EDITORIAL: "AUTOLOGOUS STEM CELL GENE THERAPY: TOWARD A UNIVERSAL PLATFORM FOR PERSONALIZED THERAPY"
Bertolotti, R. (2006) · Gene Therapy and Regulation · doi:10.1142/s1568558607000022 · Cited by 5
Genome Editing for Improving Abiotic Stress Tolerance in Rice
Roy, S., Kushwaha, N. K., Ram, H., & Soni, P. (2021) · Wiley eBooks · doi:10.1002/9781119672425.ch18 · Cited by 6
Improved in vivo gene knockout with high specificity using multiplexed Cas12a sgRNAs
Port, F., Buhmann, M. A., Zhou, J., Stricker, M., Vaughan-Brown, A., Michalsen, A.-C., Rossmanith, E., Pöltl, A., Grosskurth, L., Huber, J., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-68434-z · Cited by 4
Potential Role of Genetic Engineering in Pest Management
Kwon, K., Kim, B. J., Yu, K., & Kwon, O. (2013) · Journal of Life Science · doi:10.5352/jls.2013.23.7.955 · Cited by 4
Gene Editing Tools for Engineering Beneficial Microorganism in Biofertilizer
Kavya, T. S., Kumari, H. K., Singh, G., Govindasamy, V., Vijaysri, D., Sushmitha, J., Varma, K. N., Sneha, G. R., Chethan, T., & Jadhav, S. E. (2024) · Springer eBooks · doi:10.1007/978-981-97-2910-4_5 · Cited by 4
A platform to deliver single and bi-specific Cas9/guide RNA to perturb genes in vitro and in vivo
Li, Y., Chien, S., Huang, R., Herrmann, A., Zhao, Q., Li, P.-C., Zhang, C., Martincuks, A., Santiago, N. L., Zong, K., et al. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2024.07.025 · Cited by 7
Reporter Mice for Gene Editing: A Key Tool for Advancing Gene Therapy of Rare Diseases
Li, S.-A., & Brakebusch, C. (2024) · Cells · doi:10.3390/cells13171508 · Cited by 4
Human health and genetic technology
Dederer, H. (2025) · Trends in biotechnology · doi:10.1016/j.tibtech.2024.12.006 · Cited by 4
Rescue the Failed Half-ZFN by a Sensitive Mammalian Cell-Based Luciferase Reporter System
Zhang, W., Guo, Y., Zhang, C., Ji, H., Meng, W., Wang, D., Li, X., Mao, Q., & Xia, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045169 · Cited by 4
The Application of CRISPR/Cas9 Technologies and Therapies in Stem Cells
Scholefield, J., & Weinberg, M. S. (2016) · Current Stem Cell Reports · doi:10.1007/s40778-016-0043-7 · Cited by 4
Application of CRISPR/Cas-Mediated Genome Editing Techniques in Leguminous Crops
Das, D., & Acharjee, S. (2023) · Springer eBooks · doi:10.1007/978-3-031-46150-7_15 · Cited by 4
Genetic Improvement in Leguminous Crops Through Genome Editing
Dervishi, A., Choudry, M. W., Riaz, R., & Bakhsh, A. (2023) · Springer eBooks · doi:10.1007/978-3-031-46150-7_16 · Cited by 4
Statistical Model for Predicting TALEN-DNA Binding Sites Based On Moving Average
Тетуев, Р. К., & Nazipova, N. N. (2023) · Mathematical Biology and Bioinformatics · doi:10.17537/2023.18.621 · Cited by 5
Genetically Modified Animals
Pritchett‐Corning, K. R., & Landel, C. P. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-409527-4.00032-8 · Cited by 4
Non-viral Gene Disruption by CRISPR/Cas9 Delivery Using Cell-permeable and Protein-stabilizing 30Kc19 Protein
Kim, Y. J., Lee, H., Cha, H., & Park, J. H. (2020) · Biotechnology and Bioprocess Engineering · doi:10.1007/s12257-020-0068-8 · Cited by 4
CRISPR-Cas Based Precision Breeding in Date Palm: Future Applications
Sattar, M. N., Iqbal, Z., & Al-Khayri, J. M. (2021) · Compendium of plant genomes · doi:10.1007/978-3-030-73750-4_9 · Cited by 5
Generation of a UsefulroX1Allele by Targeted Gene Conversion
Apte, M. S., Moran, V. A., Menon, D. U., Rattner, B. P., Barry, K. H., Zunder, R. M., Kelley, R., & Meller, V. H. (2013) · G3 Genes Genomes Genetics · doi:10.1534/g3.113.008508 · Cited by 4
ENGINEERING HOMING ENDONUCLEASES TO MODIFY COMPLEX GENOMES
Gimble, F. S. (2006) · Gene Therapy and Regulation · doi:10.1142/s1568558607000034 · Cited by 4
Genome Editing with Targetable Nucleases
Pelletier, S. W. (2016) · Springer eBooks · doi:10.1007/978-3-319-34148-4_1 · Cited by 4
Therapeutic Potential of Ribozymes
Balke, D., & Müller, S. (2019) · Royal Society of Chemistry eBooks · doi:10.1039/9781788015714-00434 · Cited by 4
Energetic costs of cellular and therapeutic control of stochastic mtDNA populationsPreprint
Hoitzing, H., Gammage, P. A., Minczuk, M. A., Johnston, I. G., & Jones, N. S. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/145292 · Cited by 4
Genetic Engineering and Genome Editing for Enhancing Nutritional Quality of Legumes
Chatterjee, A., Purkaystha, S., Bhattacharyya, S., & Sen, P. (2025) · Springer eBooks · doi:10.1007/978-3-031-75678-8_19 · Cited by 4
Structure and Mechanism of Transcription Activator-like Effector Nuclease-mediated Genome Editing in Plants
Khalid, S., Shahid, M. N., Nawaz, K., Naeem, M., & Jabeen, K. (2025) · CABI eBooks · doi:10.1079/9781800622517.0004 · Cited by 3
Forward Genetic Approaches for Gene Identification Controlling Nutrition in Staple Crops
Hina, A., Amin, R., Kabeer, T., Abbasi, A., Haq, I. U., Sarwar, M. F., Abdelsalam, N. R., & Ali, H. M. (2025) · Springer eBooks · doi:10.1007/978-981-96-4499-5_18 · Cited by 3
Gene therapy for inborn errors of immunity: past progress, current status and future directions
Torrance, R. W., Orf, K., & Fox, T. A. (2025) · Rare Disease and Orphan Drugs Journal · doi:10.20517/rdodj.2025.42 · Cited by 5
Gene transfer and genome editing of T cells for cancer immunotherapy: from allogeneic HSCT to TCR gene editing
Bonini, C. (2025) · Hematology · doi:10.1182/hematology.2025000681 · Cited by 3
Multiplex engineering and multifunction T cells for precise and effective immunotherapies
Jafarzadeh, L., Smaani, A., & Delisle, J. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1680410 · Cited by 3
Advances in Drosophila gene targeting and related techniques
Yu, Z., & Jiao, R. (2010) · Frontiers in Biology · doi:10.1007/s11515-010-0051-4 · Cited by 3
Crafting rat genomes with zinc fingers
Li, M. A., & Bradley, A. (2011) · Nature Biotechnology · doi:10.1038/nbt.1749 · Cited by 3
VirD2 of Agrobacterium tumefaciens : functional domains and biotechnological applications
van Kregten, M. (2011) · Cited by 3
Research: Biology's big hit
Corbyn, Z. (2015) · Nature · doi:10.1038/528s4a · Cited by 3
Insect Regulatory Genomics
Suryamohan, K., & Halfon, M. S. (2015) · Entomology in focus · doi:10.1007/978-3-319-24235-4_6 · Cited by 3
Current Status of Genome Editing in Cardiovascular Medicine
Termglinchan, V., Karakikes, I., Seeger, T., & Wu, J. C. (2016) · Springer eBooks · doi:10.1007/978-3-319-34148-4_7 · Cited by 3
Clustered regularly interspaced short palindromic repeats, a glimpse – impacts in molecular biology, trends and highlights
Selvaraj, D., Dawar, R., Kumar, S. P., & Devi, A. (2021) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2021-0062 · Cited by 3
Innovative Approaches to Genome Editing in Chickens
Barkova, O. Y., Ларкина, Т. А., Krutikova, A. A., Polteva, E. A., Shcherbakov, Y. S., Peglivanyan, G. K., & Pozovnikova, M. V. (2022) · Cytology and Genetics · doi:10.3103/s0095452722020037 · Cited by 3
Innovative Molecular Approaches for Pest Management
Aravintharaj, R., Asokan, R., Pavithra, B. S., & Sridhar, V. (2022) · Springer eBooks · doi:10.1007/978-981-19-0264-2_2 · Cited by 3
CRISPR/Cas9 Gene Disruption Studies in F0 Xenopus Tadpoles: Understanding Development and Disease in the Frog
Abu‐Daya, A., & Godwin, A. (2023) · Methods in molecular biology · doi:10.1007/978-1-0716-3004-4_10 · Cited by 3
Forward and Reverse Genetics in Crop Breeding
Choudhary, J. R., Bhavyasree, R. K., Sheoran, S., Choudhary, M., Chandra, S., Kaswan, V., & Wani, S. H. (2023) · Springer eBooks · doi:10.1007/978-3-031-28146-4_10 · Cited by 3
Opportunities for Gene Editing of Sweetpotato
Huang, D., Livengood, C., Yencho, G. C., & Liu, W. (2024) · Compendium of plant genomes · doi:10.1007/978-3-031-65003-1_10 · Cited by 3
Reframing Plant Stress Tolerance in the Era of Climate Change
Gökçe, Z. N. Ö., Akpınar, A., Algharib, A. M., Cagirici, H. B., Filiz, E., Hussain, B., Mahmoud, A. F., Muslu, T., Özdemir, B. S., Yüce, M., et al. (2025) · Springer eBooks · doi:10.1007/978-3-031-80610-0_1 · Cited by 3
Genetic Engineering of Plants Using Zn Fingers, TALENs, and CRISPRs
Bilichak, A., & Eudes, F. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803309-8.00012-4 · Cited by 3
Applications of genome editing in pet world
Sohal, J. S., Khan, A. A., Vats, D., Jain, M., Polavarapu, R., Aseri, G. K., & Sharma, D. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816352-8.00006-0 · Cited by 3
Tapping into the Unsung Potential of CRISPR/CAS Technology in Agriculture
Rehman, R. S., Ali, M., Zafar, S. A., Ahmad, M., Pasha, A. N., Bashir, H., Rashid, F., & Hussain, M. (2022) · Asian Journal of Biochemistry Genetics and Molecular Biology · doi:10.9734/ajbgmb/2022/v10i430249 · Cited by 3
Site-Specific Recombination for Gene Locus-Directed Transgene Integration and Modification
Ahmed, H. M. M., & Wimmer, E. A. (2022) · CABI eBooks · doi:10.1079/9781800621176.0005 · Cited by 3
Genetic Analysis of Synaptogenesis
Lu, C. S., & Vactor, D. V. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-397266-8.00104-6 · Cited by 3
[Advances in transcription activator-like effectors--a review].
Tang, Y., Li, L., & Lin, J. (2015) · PubMed · Cited by 3
Computational Phenotype Analysis in Human Medicine
Robinson, P. N. (2014) · CRC Press eBooks · doi:10.1201/b16437-3 · Cited by 3
Manufacturing and Delivering Genome-Editing Proteins
Liu, J., Liang, Y.-J., Ren, P.-L., & Gaj, T. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-8799-3_19 · Cited by 3
Considerations and practical implications of performing a phenotypic CRISPR/Cas survival screen
Ashoti, A., Limone, F., van Kranenburg, M., Alemany, A., Baak, M. L., Vivié, J., Piccioni, F., Dijkers, P. F., Creyghton, M. P., Eggan, K. C., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0263262 · Cited by 5
Construction of tgw6 Mutants in Rice Based on CRISPR/Cas9 Technology
Wang, J., ZHENG, C.-M., Liu, W., Luo, W., Wang, H., Chen, Z., & Guo, T. (2016) · ACTA AGRONOMICA SINICA · doi:10.3724/sp.j.1006.2016.01160 · Cited by 3
Gene targeting using zinc finger
Carroll, D. (2005) · Cited by 3
Self-citation
Site-Directed DNA Sequence Modification Using CRISPR/Cas 9
Concha, C., & Papa, R. (2022) · CABI eBooks · doi:10.1079/9781800621176.0007 · Cited by 2
Exploration of the potential of genomic editing in the treatment of congenital adrenal hyperplasia
Graves, L. E., Christina, S., Mullany, K., Alexander, I. E., & Falhammar, H. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1719376 · Cited by 2
Gene Editing and Transformation Strategies for Engineering Drought‐Tolerant Legumes
Fernandez-Gutierrez, A., Curtin, S. J., & Gutierrez-Gonzalez, J. J. (2026) · Legume Science · doi:10.1002/leg3.70080 · Cited by 4
Next-Generation Plant Gene-Editing Tools Empowered by Artificial Intelligence
Abd-Elsalam, K. A., Hassan, R. K., & Abdelkhalek, T. E. (2026) · Sustainability Sciences in Asia and Africa · doi:10.1007/978-981-95-6722-5_2 · Cited by 2
Genome Editing Technologies for Plant Improvement: Advances, Applications and Challenges
Kumar, R., Nizampatnam, N. R., Alam, M., Thakur, T. K., & Kumar, A. (2021) · Springer eBooks · doi:10.1007/978-981-16-0831-5_10 · Cited by 2
Application of CRISPR/Cas9 technology to improve the important traits in coffee
Santoso, T. J., Sisharmini, A., & Syafaruddin (2022) · IOP Conference Series Earth and Environmental Science · doi:10.1088/1755-1315/974/1/012082 · Cited by 2
Comprehensive transcriptomic analysis of myostatin-knockout pigs: insights into muscle growth and lipid metabolism
Khan, N., Li, Z., Ali, A., Quan, B., Kang, J., Ullah, M., Yin, X., & Shafiq, M. (2025) · Transgenic Research · doi:10.1007/s11248-025-00431-2 · Cited by 3
Knockout mouse production assisted by Blm knockdown
Fukuda, M., Inoue, M., MURAMATSU, D., Miyachi, H., & Shinkai, Y. (2015) · Journal of Reproduction and Development · doi:10.1262/jrd.2015-122 · Cited by 2
DNA Nucleases and their Use in Livestock Production
Petersen, B. (2018) · Springer eBooks · doi:10.1007/978-3-319-92348-2_7 · Cited by 2
Genetic Pest Management Technologies to Control Invasive Rodents.
Kanavy, D. (2018) · NCSU Libraries Repository (North Carolina State University Libraries) · Cited by 2
Genomic Region Analysis and Genome Editing for Grain Quality Improvement in Cereals
Jangra, S., Priti, P., Chaudhary, V., Mishra, A., Yadav, R. C., & Yadav, N. R. (2022) · Springer eBooks · doi:10.1007/978-3-030-96925-7_14 · Cited by 2
Adoption of Molecular Tools for Combatting the Arthropod Pests
Kariyanna, B., Ramkumar, G., Rana, D. K., Bheemanna, M., & Karthik, C. (2022) · Springer eBooks · doi:10.1007/978-981-19-0264-2_28 · Cited by 2
Zinc Finger Nuclease-Mediated Gene Targeting in Plants
Petolino, J. F., Sastry, L., & Samuel, J. P. (2015) · Springer eBooks · doi:10.1007/978-1-4939-2202-4_12 · Cited by 2
Defeating Randomness – Targeted Integration as a Boost for Biotechnology
Gama-Norton, L., Riemer, P., Sandhu, U., Nehlsen, K., Schucht, R., Häuser, H., & Wirth, D. (2009) · Cell engineering · doi:10.1007/978-90-481-2245-5_3 · Cited by 3
The mechanism and application of zinc finger nucleases
Zhong, Q., & Zhao, S. (2011) · Hereditas (Beijing) · doi:10.3724/sp.j.1005.2011.00123 · Cited by 2
Stem Cells for Modeling Human Disease
Martı́n, F., Sánchez‐Gilabert, A., Tristán‐Manzano, M., & Benabdellah, K. (2016) · InTech eBooks · doi:10.5772/63231 · Cited by 2
CRISPR/Cas9 Editing in Induced Pluripotent Stem Cells: A Way Forward for Treating Cystic Fibrosis?
Quiroz, E. J., & Ryan, A. L. (2019) · Springer eBooks · doi:10.1007/978-3-030-29403-8_9 · Cited by 2

Authors: Bibikova, M., Golic, M., Golic, K. G., & Carroll, D.
Affiliations: University of Utah (US)
Corresponding author: Carroll, Dana
ORCID: Golic, Kent G
Carroll, Dana
Venue: Genetics
Publisher: Oxford University Press (OUP)
Published: 2002-07-01
Volume: 161
Issue: 3
Pages: 1169-1175
ISSN: 0016-6731 (ISSN-L)
1943-2631
DOI: 10.1093/genetics/161.3.1169
OpenAlex: W1906155566
Cited by: 860
References: 50
Citations by year: 2026: 12 · 2025: 30 · 2024: 44 · 2023: 40 · 2022: 50 · 2021: 46 · 2020: 42 · 2019: 41 · 2018: 49 · 2017: 50 · 2016: 70 · 2015: 64 · 2014: 65 · 2013: 47 · 2012: 45
FWCI: 3.36
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: Genetics (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (7r01gm060700-12)
National Institute of General Medical Sciences (R01GM60700, R01 GM58504, R01GM058504)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › CRISPR and Genetic Engineering
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
Keywords: zinc finger nucleases, targeted mutagenesis, Drosophila, yellow gene, germline mutations, non-homologous end joining, double-strand DNA cleavage, C2H2 zinc finger, directed mutagenesis
MeSH terms: Amino Acid Sequence, Animals, Base Sequence, Crosses, Genetic, Deoxyribonucleases, DNA Transposable Elements, Drosophila, Female, Genetic Vectors, Male, Ribonucleases, Transformation, Genetic, Mutagenesis, Insertional, Zinc Fingers

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Targeted Chromosomal Cleavage and Mutagenesis in Drosophila Using Zinc-Finger Nucleases

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks