Cited by 95Exercise and Physiological ResponsesPhysical Activity and HealthCardiovascular and exercise physiology

Effects of exercise on the immune system in the elderly population

Bruunsgaard, Helle, Pedersen, Bente Klarlund·2000·Immunology & Cell Biology

Abstract

Immunosenescence is characterized by impaired cellular immune function concomitant with increased inflammatory activity. Immune dysfunction is associated with increased mortality risk in elderly people. An important part of human ageing is characterized by a decline in the ability of individuals to adapt to environmental stress. Exercise has been suggested as a prototype for studying the effects of stress factors on the cellular immune system. Studies of interactions between an acute bout of exercise and immune function may be a useful and an ethically acceptable tool to investigate cell trafficking, immune mobilization/deficiency and the acute phase response during physical stress situations in relation to human ageing. Elderly humans have a preserved ability to recruit T lymphocytes and NK cells in response to an acute bout of exercise. Physical exercise training programs do not result in major restoration of the senescent immune system in humans. However, highly conditioned elderly humans seem to have a relatively better preserved immune system, although it is not possible to conclude if this is linked to training or other lifestyle‐related factors.

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Crossref · 10.1111/j.1440-1711.2000.t01-14-.x

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Authors
Bruunsgaard, H., & Pedersen, B. K.
Affiliations
  • Department of Infectious Diseases, Rigshospitalet, University of Copenhagen Copenhagen Denmark
  • University of Copenhagen (DK)
Venue
Immunology & Cell Biology
Publisher
Wiley
Published
2000-10
Volume
78
Issue
5
Pages
523-531
ISSN
  • 0004-945X (ISSN-L)
  • 0818-9641
  • 1440-1711
OpenAlex
W1979285258
Cited by
95
References
100
Citations by year
2026: 2 · 2025: 5 · 2024: 7 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 5 · 2018: 4 · 2017: 5 · 2016: 5 · 2015: 2 · 2014: 7 · 2013: 1 · 2012: 12
FWCI
1.19
Type
journal article
Language
en
Open access
closed
Locations
  • Immunology and Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Danmarks Grundforskningsfond
  • Velux Fonden
Topics
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Health Sciences › Medicine › Physiology › Physical Activity and Health
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords
physical activity, immunosenescence, older adults, cellular immune function, acute exercise, T cells, natural killer cells, acute phase response, physical stress, aging, exercise training
MeSH terms
Adolescent, Adult, Aged, Aging, Animals, Female, Free Radicals, Humans, Immune System, Lymphocytes, Male, Middle Aged, Physical Conditioning, Animal, Exercise

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