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Depression in Late Life: Review and Commentary

Blazer, D. G.·2003·The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

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Abstract

Depression is perhaps the most frequent cause of emotional suffering in later life and significantly decreases quality of life in older adults. In recent years, the literature on late-life depression has exploded. Many gaps in our understanding of the outcome of late-life depression have been filled. Intriguing findings have emerged regarding the etiology of late-onset depression. The number of studies documenting the evidence base for therapy has increased dramatically. Here, I first address case definition, and then I review the current community- and clinic-based epidemiological studies. Next I address the outcome of late-life depression, including morbidity and mortality studies. Then I present the extant evidence regarding the etiology of depression in late life from a biopsychosocial perspective. Finally, I present evidence for the current therapies prescribed for depressed elders, ranging from medications to group therapy.

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“Mini-mental state”
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Background
The role of corticotropin-releasing factor in depression and anxiety disorders
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Background
Metacognitive awareness and prevention of relapse in depression: Empirical evidence
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Efficacy of esketamine nasal spray for treatment-resistant depression: a meta-analysis of randomized controlled studies
Ouyang, Y., & Li, J. (2025) · Medicine · doi:10.1097/md.0000000000041495 · Cited by 10
Lifetime Abuse and Mental Health Among Older Persons: A European Study
Eslami, B., Macassa, G., Melchiorre, M. G., Barros, H., Viitasara, E., Lindert, J., Stankunas, M., Torres-Gonzalez, F., Ioannidi-Kapolou, E., & Soares, J. J. F. (2017) · Journal of Aggression, Maltreatment & Trauma · doi:10.1080/10926771.2017.1330295 · Cited by 10
Joint hypermobility is also associated with anxiety disorders in the elderly population
Bulbena‐Cabré, A., Rojo, C., Pailhez, G., Buron Maso, E., Martín‐Lopez, L. M., & Bulbena, A. (2018) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4733 · Cited by 10
Avoiding Aging? Social Psychology’s Treatment of Age
Barrett, A. E., Redmond, R., & von Rohr, C. (2012) · The American Sociologist · doi:10.1007/s12108-012-9157-2 · Cited by 9
Can support workers from AgeUK deliver an intervention to support older people with anxiety and depression? A qualitative evaluation
Kingstone, T., Bartlam, B., Burroughs, H., Bullock, P., Lovell, K., Ray, M., Bower, P., Waheed, W., Gilbody, S., Nicholls, E., et al. (2019) · BMC Family Practice · doi:10.1186/s12875-019-0903-1 · Cited by 8
BDNF promoter methylation and genetic variation in late-life depression
Januar, V, Ancelin, M.-L., Ritchie, K., Saffery, R., & Ryan, J. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.114 · Cited by 139

Authors: Blazer, D. G.
Venue: The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
Publisher: Oxford University Press (OUP)
Published: 2003-03-01
Volume: 58
Issue: 3
Pages: M249-M265
ISSN: 1079-5006 (ISSN-L)
1758-535X
DOI: 10.1093/gerona/58.3.m249
OpenAlex: W2106158410
Cited by: 2,344
References: 35
FWCI: 42.53
Type: journal article
Language: en
Open access: closed

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Depression in Late Life: Review and Commentary

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