Functional Outcomes for Clinical Trials in Frail Older Persons: Time To Be Moving: Working Group on Functional Outcome Measures for Clinical Trials

Frailty in Older Adults: Evidence for a Phenotype

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A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission

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Lower-extremity function in persons over the age of 70 years as a predictor of subsequent disability

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Lower extremity function and subsequent disability: consistency across studies, predictive models, and value of gait speed alone compared with the short physical performance battery

Guralnik, J. M., Ferrucci, L., Pieper, C. F., Leveille, S. G., Markides, K. S., Ostir, G. V., Studenski, S., Berkman, L. F., & Wallace, R. B. (2000) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/55.4.m221 · Cited by 2,898 · see citing works

Meaningful change and responsiveness in common physical performance measures in older adults.

Perera, S., Mody, S. H., Woodman, R. C., & Studenski, S. A. (2006) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2006.00701.x · Cited by 2,513 · see citing works

The healthcare costs of sarcopenia in the United States

Janssen, I., Shepard, D. S., Katzmarzyk, P. T., & Roubenoff, R. (2004) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2004.52014.x · Cited by 1,546 · see citing works

Physical performance measures in the clinical setting

Studenski, S., Perera, S., Wallace, D., Chandler, J. M., Duncan, P. W., Rooney, E., Fox, M., & Guralnik, J. M. (2003) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2003.51104.x · Cited by 1,218 · see citing works

Designing Randomized, Controlled Trials Aimed at Preventing or Delaying Functional Decline and Disability in Frail, Older Persons: A Consensus Report

Ferrucci, L., Guralnik, J. M., Studenski, S., Fried, L. P., Cutler, G. B., Walston, J. D., & The Interventions on Frailty Working Group (2004) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2004.52174.x · Cited by 1,027 · cited 1× · see citing works

Leg extensor power and functional performance in very old men and women.

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Frailty and Activation of the Inflammation and Coagulation Systems With and Without Clinical Comorbidities<subtitle>Results From the Cardiovascular Health Study</subtitle>

Walston, J. (2002) · Archives of Internal Medicine · doi:10.1001/archinte.162.20.2333 · Cited by 940 · see citing works

Association of Long-Distance Corridor Walk Performance With Mortality, Cardiovascular Disease, Mobility Limitation, and Disability

Newman, A. B., Simonsick, E. M., Naydeck, B. L., Boudreau, R. M., Kritchevsky, S. B., Nevitt, M. C., Pahor, M., Satterfield, S., Brach, J. S., Studenski, S. A., et al. (2006) · JAMA · doi:10.1001/jama.295.17.2018 · Cited by 934 · see citing works

Prediction of Mortality and Morbidity With a 6-Minute Walk Test in Patients With Left Ventricular Dysfunction

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Inflammatory Markers and Physical Performance in Older Persons: The InCHIANTI Study

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A Randomized Trial of Care in a Hospital Medical Unit Especially Designed to Improve the Functional Outcomes of Acutely Ill Older Patients

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Gait velocity as a single predictor of adverse events in healthy seniors aged 75 years and older

Montero-Odasso, M., Schapira, M., Soriano, E. R., Varela, M., Kaplan, R., Camera, L. A., & Mayorga, L. M. (2005) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/60.10.1304 · Cited by 746 · see citing works

What Is Sarcopenia?

Evans, W. J. (1995) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/50a.special_issue.5 · Cited by 606 · see citing works

The relationship between leg power and physical performance in mobility-limited older people

Md, J. F. B., Kiely, D. K., Herman, S., Leveille, S. G., Mizer, K., Frontera, W. R., & Fielding, R. A. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50111.x · Cited by 605 · see citing works

Anemia Is Associated with Disability and Decreased Physical Performance and Muscle Strength in the Elderly

Penninx, B. W. J. H., Pahor, M., Cesari, M., Corsi, A. M., Woodman, R. C., Bandinelli, S., Guralnik, J. M., & Ferrucci, L. (2004) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2004.52208.x · Cited by 567 · see citing works

Older Men Are as Responsive as Young Men to the Anabolic Effects of Graded Doses of Testosterone on the Skeletal Muscle

Bhasin, S., Woodhouse, L., Casaburi, R., Singh, A. B., Mac, R. P., Lee, M., Yarasheski, K. E., Sinha-Hikim, I., Dzekov, C., Dzekov, J., et al. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1184 · Cited by 544 · see citing works

Measuring Higher Level Physical Function in Well-Functioning Older Adults: Expanding Familiar Approaches in the Health ABC Study

Simonsick, E. M., Newman, A. B., Nevitt, M. C., Kritchevsky, S. B., Ferrucci, L., Guralnik, J. M., Harris, T. B., & for the Health ABC Study Group (2001) · The Journals of Gerontology Series A · doi:10.1093/gerona/56.10.m644 · Cited by 478 · see citing works

Six-Minute-Walk Distance Predicts Waiting List Survival in Idiopathic Pulmonary Fibrosis

Lederer, D. J., Arcasoy, S. M., Wilt, J. S., D’Ovidio, F., Sonett, J. R., & Kawut, S. M. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200604-520oc · Cited by 399 · see citing works

Association between 25-hydroxy vitamin D levels, physical activity, muscle strength and fractures in the prospective population-based OPRA Study of Elderly Women

Gerdhem, P., Ringsberg, K., Obrant, K. J., & Åkesson, K. (2005) · Osteoporosis International · doi:10.1007/s00198-005-1860-1 · Cited by 383 · see citing works

Frailty syndrome and skeletal muscle: results from the Invecchiare in Chianti study

Cesari, M., Leeuwenburgh, C., Lauretani, F., Onder, G., Bandinelli, S., Maraldi, C., Guralnik, J. M., Pahor, M., & Ferrucci, L. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.5.1142 · Cited by 365 · see citing works

Muscle power of the ankle flexors predicts functional performance in community-dwelling older women.

Suzuki, T., Bean, J. F., & Fielding, R. A. (2001) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2001.49232.x · Cited by 343 · see citing works

Reliability and sensitivity to change assessed for a summary measure of lower body function

Ostir, G. V., Volpato, S., Fried, L. P., Chaves, P. H. M., & Guralnik, J. M. (2002) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(02)00436-5 · Cited by 323 · see citing works

Minimal Clinically Important Differences in the Six-Minute Walk Test and the Incremental Shuttle Walking Test

Wise, R. A., & Brown, C. D. (2005) · COPD Journal of Chronic Obstructive Pulmonary Disease · doi:10.1081/copd-200050527 · Cited by 309 · see citing works

Physical Performance Measures as Predictors of Mortality in a Cohort of Community-dwelling Older French Women

Rolland, Y., Lauwers‐Cancès, V., Cesari, M., Vellas, B. J., Pahor, M., & Grandjean, H. (2006) · European Journal of Epidemiology · doi:10.1007/s10654-005-5458-x · Cited by 262 · see citing works

Validation of the Late‐Life Function and Disability Instrument

Sayers, S. P., Jette, A. M., Haley, S. M., Heeren, T., Guralnik, J. M., & Fielding, R. A. (2004) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2004.52422.x · Cited by 230 · see citing works

Changes in depression and physical decline in older adults: a longitudinal perspective

Penninx, B. W. J. H., Deeg, D. J. H., van Eijk, J. T. M., Beekman, A. T. F., & Guralnik, J. M. (2000) · Journal of Affective Disorders · doi:10.1016/s0165-0327(00)00152-x · Cited by 230 · see citing works

Subclinical Brain Magnetic Resonance Imaging Abnormalities Predict Physical Functional Decline in High‐Functioning Older Adults

Rosano, C., Kuller, L. H., Chung, H., Arnold, A. M., Longstreth, W. T., Jr., & Newman, A. B. (2005) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2005.53214.x · Cited by 206 · see citing works

White matter abnormalities in mobility-impaired older persons

Guttmann, C. R. G., Benson, R. R., Warfield, S. K., Wei, X., Anderson, M. C., Hall, C. B., Abu‐Hasaballah, K., Mugler, J. P., & WOLFSON, L. I. (2000) · Neurology · doi:10.1212/wnl.54.6.1277 · Cited by 169 · see citing works

Comparison of the WOMAC (Western Ontario and McMaster Universities) osteoarthritis index and a self-report format of the self-administered Lequesne–Algofunctional index in patients with knee and hip osteoarthritis

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Characteristics of Nondisabled Older Persons Who Perform Poorly in Objective Tests of Lower Extremity Function

Ferrucci, L., Penninx, B. W. J. H., Leveille, S. G., Corti, M., Pahor, M., Wallace, R. B., Harris, T. B., Havlik, R. J., & Guralnik, J. M. (2000) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2000.tb04787.x · Cited by 163 · see citing works

Medical and Long-Term Care Costs When Older Persons Become More Dependent

Guralnik, J. M., Alecxih, L. M. B., Branch, L. G., & Wiener, J. M. (2002) · American Journal of Public Health · doi:10.2105/ajph.92.8.1244 · Cited by 132 · see citing works

Editorial: Exercise Strategies Should Be Designed to Increase Muscle Power

Evans, W. J. (2000) · The Journals of Gerontology Series A · doi:10.1093/gerona/55.6.m309 · Cited by 126 · see citing works

Simple versus complex assessment of white matter hyperintensities in relation to physical performance and cognition: the LADIS study

Gouw, A. A., van der Flier, W. M., van Straaten, E. C. W., Barkhof, F., Ferro, J. M., Bäezner, H., Pantoni, L., Inzitari, D., Erkinjuntti, T., Wahlund, L., et al. (2006) · Journal of Neurology · doi:10.1007/s00415-006-0193-5 · Cited by 120 · see citing works

Reliability, Validity, and Responsiveness of a 2-Min Walk Test To Assess Exercise Capacity of COPD Patients

Leung, A. S. Y., Chan, K. K., Sykes, K., & Chan, K. S. (2006) · CHEST Journal · doi:10.1378/chest.130.1.119 · Cited by 114 · see citing works

Six-minute walk distance as parameter of functional outcome after pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension

Reesink, H. J., van der Plas, M. N., Verhey, N. E., van Steenwijk, R. P., Kloek, J. J., & Bresser, P. (2007) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2006.10.020 · Cited by 101 · see citing works

Lifetime occupation and physical function: a prospective cohort study on persons aged 80 years and older living in a community

Russo, A., Onder, G., Cesari, M., Zamboni, V., Barillaro, C., Capoluongo, E., Pahor, M., Bernabei, R., & Landi, F. (2006) · Occupational and Environmental Medicine · doi:10.1136/oem.2005.023549 · Cited by 91 · see citing works

Incidence of Loss of Ability to Walk 400 Meters in a Functionally Limited Older Population

Chang, M., Cohen‐Mansfield, J., Ferrucci, L., Leveille, S. G., Volpato, S., de Rekeneire, N., & Guralnik, J. M. (2004) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2004.52570.x · Cited by 86 · see citing works

Body mass index, free insulin-like growth factor I, and physical function among older adults: results from the ilSIRENTE study

Onder, G., Liperoti, R., Russo, A., Soldato, M., Capoluongo, E., Volpato, S., Cesari, M., Ameglio, F., Bernabei, R., & Landi, F. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00138.2006 · Cited by 70 · see citing works

D‐Dimer and Inflammatory Markers as Predictors of Functional Decline in Men and Women with and without Peripheral Arterial Disease

McDermott, M. M., Ferrucci, L., Liu, K., Criqui, M. H., Greenland, P., Green, D., Guralnik, J. M., Ridker, P. M., Taylor, L. M., Rifai, N., et al. (2005) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2005.53510.x · Cited by 52 · see citing works

Lower limb function as predictor of falls and loss of mobility with social repercussions one year after discharge among elderly inpatients

Quadri, P., Tettamanti, M., Bernasconi, S., Trento, F., & Loew, F. (2005) · Aging Clinical and Experimental Research · doi:10.1007/bf03324578 · Cited by 47 · see citing works

Experimental designs for multicomponent interventions among persons with multifactorial geriatric syndromes

Allore, H. G., Tinettia, M. E., Gill, T. M., & Peduzzi, P. N. (2005) · Clinical Trials · doi:10.1191/1740774505cn067oa · Cited by 41 · see citing works

Randomized Controlled Drug Trials on Very Elderly Subjects: Descriptive and Methodological Analysis of Trials Published Between 1990 and 2002 and Comparison With Trials on Adults

Quintrec, J.-L. L., Bussy, C., Golmard, J., Hervé, C., Baulon, A., & Piette, F. (2005) · The Journals of Gerontology Series A · doi:10.1093/gerona/60.3.340 · Cited by 37 · see citing works

Sarcopenia: European consensus on definition and diagnosis

Cruz-Jentoft, A. J., Baeyens, J. P., Bauer, J. M., Boirie, Y., Cederholm, T., Landi, F., Martin, F. C., Michel, J.-P., Rolland, Y., Schneider, S. M., et al. (2010) · Age and Ageing · doi:10.1093/ageing/afq034 · Cited by 11,601 · see citing works

Sarcopenia in Asia: Consensus Report of the Asian Working Group for Sarcopenia

Chen, L.-K., Liu, L.-K., Woo, J., Assantachai, P., Auyeung, T.-W., Bahyah, K. S., Chou, M.-Y., Chen, L.-Y., Hsu, P.-S., Krairit, O., et al. (2014) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2013.11.025 · Cited by 4,051 · see citing works

Evidence-Based Recommendations for Optimal Dietary Protein Intake in Older People: A Position Paper From the PROT-AGE Study Group

Bauer, J., Biolo, G., Cederholm, T., Cesari, M., Cruz-Jentoft, A. J., Morley, J. E., Phillips, S., Sieber, C., Stehle, P., Teta, D., et al. (2013) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2013.05.021 · Cited by 2,553 · see citing works

Gait speed at usual pace as a predictor of adverse outcomes in community-dwelling older people an International Academy on Nutrition and Aging (IANA) Task Force

Abellan Van Kan, G., Rolland, Y., Andrieu, S., Bauer, J., Beauchet, O., Bonnefoy, M., Cesari, M., Donini, L. M., Gillette-Guyonnet, S., Inzitari, M., et al. (2009) · The Journal of nutrition, health and aging · doi:10.1007/s12603-009-0246-z · Cited by 2,003 · see citing works

Assessment of Muscle Function and Physical Performance in Daily Clinical Practice: A position paper endorsed by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO)

Beaudart, C., Rolland, Y., Cruz-Jentoft, A. J., Bauer, J. M., Sieber, C., Cooper, C., Al-Daghri, N., Araujo de Carvalho, I., Bautmans, I., Bernabei, R., et al. (2019) · Calcified Tissue International · doi:10.1007/s00223-019-00545-w · Cited by 528 · see citing works

Sarcopenia: An overview

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Quality of Life in Sarcopenia and Frailty

Rizzoli, R., Reginster, J.-Y., Arnal, J.-F., Bautmans, I., Beaudart, C., Bischoff-Ferrari, H., Biver, E., Boonen, S., Brandi, M.-L., Chines, A., et al. (2013) · Calcified Tissue International · doi:10.1007/s00223-013-9758-y · Cited by 425 · see citing works

The Effects of Polypharmacy in Older Adults

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Neuroimaging of Mobility in Aging: A Targeted Review

Holtzer, R., Epstein, N. E., Mahoney, J. R., İzzetoğlu, M., & Blumen, H. M. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu052 · Cited by 303 · see citing works

Prevention of falls in older people living in the community

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Performance of SARC-F in Regard to Sarcopenia Definitions, Muscle Mass and Functional Measures

Bahat, G., Yilmaz, O., Kiliç, C., Oren, M. M., & Karan, M. A. (2018) · The Journal of nutrition, health and aging · doi:10.1007/s12603-018-1067-8 · Cited by 263 · see citing works

Frailty and Chronic Diseases in Older Adults

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Slower gait, slower information processing and smaller prefrontal area in older adults

Rosano, C., Studenski, S. A., Aizenstein, H. J., Boudreau, R. M., Longstreth, W. T., & Newman, A. B. (2011) · Age and Ageing · doi:10.1093/ageing/afr113 · Cited by 209 · see citing works

The Epidemiology of Sarcopenia

Janssen, I. (2011) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2011.03.004 · Cited by 191 · see citing works

Prevalence of Sarcopenia and Associated Outcomes in the Clinical Setting

Peterson, S. J., & Braunschweig, C. A. (2015) · Nutrition in Clinical Practice · doi:10.1177/0884533615622537 · Cited by 187 · see citing works

Reliability and validity of 4-metre gait speed in COPD

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Sarcopenia in the elderly: basic and clinical issues

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Dietary protein intake is associated with better physical function and muscle strength among elderly women

Isanejad, M., Mursu, J., Sirola, J., Kröger, H., Rikkonen, T., Tuppurainen, M., & Erkkila, A. (2016) · British Journal of Nutrition · doi:10.1017/s000711451600012x · Cited by 171 · see citing works

High-speed circuit training vs hypertrophy training to improve physical function in sarcopenic obese adults: A randomized controlled trial

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Gait speed has comparable prognostic capability to six-minute walk distance in older patients with cardiovascular disease

Kamiya, K., Hamazaki, N., Matsue, Y., Mezzani, A., Corrà, U., Matsuzawa, R., Nozaki, K., Tanaka, S., Maekawa, E., Noda, C., et al. (2017) · European Journal of Preventive Cardiology · doi:10.1177/2047487317735715 · Cited by 148 · see citing works

Effect of Sarcopenia on Postoperative Morbidity and Mortality After Thoracolumbar Spine Surgery

Bokshan, S. L., Han, A., DePasse, J. M., Eltorai, A. E. M., Marcaccio, S. E., Palumbo, M. A., & Daniels, A. H. (2016) · Orthopedics · doi:10.3928/01477447-20160811-02 · Cited by 144 · see citing works

Identifying a standard set of outcome parameters for the evaluation of orthogeriatric co-management for hip fractures

Liem, I. S. L., Kammerlander, C., Suhm, N., Blauth, M., Roth, T., Gosch, M., Hoang‐Kim, A., Mendelson, D. A., Zuckerman, J. D., Leung, F. K. L., et al. (2013) · Injury · doi:10.1016/j.injury.2013.06.018 · Cited by 138 · see citing works

Medication Use and Functional Status Decline in Older Adults: A Narrative Review

Peron, E. P., Gray, S. L., & Hanlon, J. T. (2011) · The American Journal of Geriatric Pharmacotherapy · doi:10.1016/j.amjopharm.2011.10.002 · Cited by 136 · see citing works

Variability in measuring (instrumental) activities of daily living functioning and functional decline in hospitalized older medical patients: a systematic review

Buurman, B. M., Munster, B. C. V., Korevaar, J. C., de Haan, R. J., & de Rooij, S. E. (2010) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2010.07.005 · Cited by 134 · see citing works

The 4-metre gait speed in COPD: responsiveness and minimal clinically important difference

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Gait speed and readmission following hospitalisation for acute exacerbations of COPD: a prospective study

Kon, S. S. C., Jones, S. E., Schofield, S. J., BANYA, W. A. S., Dickson, M. J., Canavan, J. L., Nolan, C. M., Haselden, B. M., Polkey, M. I., Cullinan, P., et al. (2015) · Thorax · doi:10.1136/thoraxjnl-2015-207046 · Cited by 103 · see citing works

Effects of a progressive resistance exercise program with high-speed component on the physical function of older women with sarcopenic obesity: a randomized controlled trial

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Utility of SARC-F for Assessing Physical Function in Elderly Patients With Cardiovascular Disease

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Impact of physical function impairment and multimorbidity on mortality among community-living older persons with sarcopaenia: results from the ilSIRENTE prospective cohort study

Landi, F., Calvani, R., Tosato, M., Martone, A. M., Bernabei, R., Onder, G., & Marzetti, E. (2016) · BMJ Open · doi:10.1136/bmjopen-2015-008281 · Cited by 96 · see citing works

Whole-body vibration in addition to strength and balance exercise for falls-related functional mobility of frail older adults: a single-blind randomized controlled trial

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Deterioration of Limb Muscle Function during Acute Exacerbation of Chronic Obstructive Pulmonary Disease

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Percutaneous coronary intervention in the elderly

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