The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Intramyocellular Lipid and Impaired Myofiber Contraction in Normal Weight and Obese Older Adults
Open accessAbstract
BACKGROUND: Evidence implicates the amount and location of fat in aging-related loss of muscle function; however, whether intramyocellular lipids affect muscle contractile capacity is unknown. METHODS: We compared both in vivo knee extensor muscle strength, power, and quality and in vitro mechanical properties of vastus lateralis single-muscle fibers between normal weight (NW) and obese older adults and determined the relationship between muscle lipid content (both intramuscular adipose tissue and intramyocellular lipids) and in vivo and in vitro muscle function in NW and obese individuals. RESULTS: The obese group had a greater percentage of type-I fibers compared to the NW group. The cross-sectional area of type-I fibers was greater in obese compared to NW; however, maximal shortening velocity of type-I fibers in the obese was slower compared to NW. Type-I and type-IIa fibers from obese group produced lower specific force than that of type-I and type-IIa fibers from the NW group. Normalized power was also substantially lower (~50%) in type-I fibers from obese adults. The intramyocellular lipids data showed that total lipid droplet area, number of lipid droplets, and area fraction were about twofold greater in type-I fibers from the obese compared to the NW group. Interestingly, a significant inverse relationship between average number of lipid droplets and single-fiber unloaded shortening velocity, maximal velocity, and specific power was observed in obese participants. Additionally, muscle echointensity correlated with single-fiber specific force. CONCLUSIONS: These data indicate that greater intramyocellular lipids are associated with slower myofiber contraction, force, and power development in obese older adults.
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“Studies have reported that obese adults have about 20% higher thigh muscle mass than those with normal weight (85).”
From Long-Term Effects of a Novel Continuous Remote Care Intervention Including Nutritional Ketosis for the Management of Type 2 Diabetes: A 2-Year Non-randomized Clinical Trial (2019) · cites this paper as [85]
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“This could partly be explained by obesity being associated with lower muscle quality (myosteatosis and muscle fibre composition), as evidenced by decreased muscle strength”
From Changes in lean body mass with glucagon‐like peptide ‐1‐based therapies and mitigation strategies (2024) · cites this paper as [7]
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Cites
Visser, M., Goodpaster, B. H., Kritchevsky, S. B., Newman, A. B., Nevitt, M., Rubin, S. M., Simonsick, E. M., Harris, T. B., & Study, F. T. H. A. (2005) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/60.3.324 · Cited by 1,403
Attenuation of skeletal muscle and strength in the elderly: the Health ABC Study
Goodpaster, B. H., Carlson, C. L., Visser, M., Kelley, D. E., Scherzinger, A., Harris, T. B., Stamm, E., & Newman, A. B. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.90.6.2157 · Cited by 1,226
Goodpaster, B. H. (2001) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.12.5755 · Cited by 1,194
Dynapenia and aging: an update
Manini, T. M., & Clark, B. C. (2012) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glr010 · Cited by 875
Visser, M., Kritchevsky, S. B., Goodpaster, B. H., Newman, A. B., Nevitt, M., Stamm, E., & Harris, T. B. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50217.x · Cited by 845
Skeletal Muscle Ultrasound: Correlation Between Fibrous Tissue and Echo Intensity
Pillen, S., Tak, R. O., Zwarts, M. J., Lammens, M. M. Y., Verrijp, K. N., Arts, I. M. P., van der Laak, J. A. W. M., Hoogerbrugge, P. M., van Engelen, B. G. M., & Verrips, A. (2008) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2008.09.016 · Cited by 640
McGregor, R. A., Cameron-Smith, D., & Poppitt, S. D. (2014) · Longevity & Healthspan · doi:10.1186/2046-2395-3-9 · Cited by 532
Skeletal muscle fat infiltration: impact of age, inactivity, and exercise
Marcus, R. L., Addison, O., Kidde, J. P., Dibble, L. E., & Lastayo, P. C. (2010) · The Journal of nutrition, health and aging · doi:10.1007/s12603-010-0081-2 · Cited by 449
Zoico, E., Di Francesco, V, Guralnik, J. M., Mazzali, G., Bortolani, A., Guariento, S., Sergi, G., Bosello, O., & Zamboni, M. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802552 · Cited by 392 · cited 2×
“Both the absolute and relative amount of body fat increases with age (5), and greater fat mass is associated with lower muscle strength, power, and quality in older adults, even in those with a normal amount of muscle mass (6).”
BackgroundSkeletal muscle sonography: a correlative study of echogenicity and morphology
Reimers, K., Reimers, C. D., Wagner, S., Paetzke, I., & Pongratz, D. E. (1993) · Journal of Ultrasound in Medicine · doi:10.7863/jum.1993.12.2.73 · Cited by 385 · cited 1×
“Increased ultrasound echointensity has been attributed to increased intermuscular adipose tissue and intramuscular fat (30) and muscle fibrosis (31) though these data were derived from humans with muscular dystrophy and canines, respectively.”
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Preserving Healthy Muscle during Weight Loss
Cava, E., Yeat, N. C., & Mittendorfer, B. (2017) · Advances in Nutrition · doi:10.3945/an.116.014506 · Cited by 452
Changes in lean body mass with glucagon‐like peptide ‐1‐based therapies and mitigation strategies
Neeland, I. J., Linge, J., & Birkenfeld, A. L. (2024) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.15728 · Cited by 391
Hand grip strength as a proposed new vital sign of health: a narrative review of evidences
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Fatty infiltration of skeletal muscle: mechanisms and comparisons with bone marrow adiposity
Hamrick, M. W., McGee-Lawrence, M. E., & Frechette, D. M. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00069 · Cited by 372
Athinarayanan, S. J., Adams, R. N., Hallberg, S. J., McKenzie, A. L., Bhanpuri, N. H., Campbell, W. W., Volek, J. S., Phinney, S. D., & McCarter, J. P. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00348 · Cited by 324
Metadata
- Authors
- Choi, S. J., Files, D. C., Zhang, T., Wang, Z.-M., Messi, M. L., Gregory, H., Stone, J., Lyles, M. F., Dhar, S., Marsh, A. P., Nicklas, B. J., & Delbono, O.
- Affiliations
- Kyungsung University (KR)
- Wake Forest University Health Sciences (US)
- Wake Forest University (US)
- ORCID
- Venue
- The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-09-23
- Volume
- 71
- Issue
- 4
- Pages
- 557-564
- ISSN
- 1079-5006 (ISSN-L)
- 1758-535X
- PMC
- PMC5014190
- OpenAlex
- W2307246836
- Semantic Scholar
- 8fbd77bc5d0cd52c5ca154313787c9ad9b636842
- Cited by
- 171
- References
- 31
- Citations by year
- 2026: 6 · 2025: 20 · 2024: 13 · 2023: 13 · 2022: 20 · 2021: 18 · 2020: 28 · 2019: 18 · 2018: 16 · 2017: 13 · 2016: 6
- FWCI
- 5.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journals of Gerontology Series A (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (AG 15820, R01AG020583, AG-13934, R01AG015820, P30AG-21332, P30AG021332, R01AG013934)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Keywords
- intramyocellular lipid, obesity, aging, muscle strength, muscle power, lipid droplets, type I muscle fibers, vastus lateralis, muscle function, older adults
- MeSH terms
- Aged, Aged, 80 and over, Aging, Body Composition, Female, Humans, Lipids, Male, Muscle Contraction, Obesity, Muscle Fibers, Skeletal, Muscle Fibers, Fast-Twitch, Muscle Fibers, Slow-Twitch, Torque, Muscle Strength
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