Rapamycin Increases Mortality in db/db Mice, a Mouse Model of Type 2 Diabetes
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We examined the effect of rapamycin on the life span of a mouse model of type 2 diabetes, db/db mice. At 4 months of age, male and female C57BLKSJ-lepr (db/db) mice (db/db) were placed on either a control diet, lacking rapamycin or a diet containing rapamycin and maintained on these diets over their life span. Rapamycin was found to reduce the life span of the db/db mice. The median survival of male db/db mice fed the control and rapamycin diets was 349 and 302 days, respectively, and the median survival of female db/db mice fed the control and rapamycin diets was 487 and 411 days, respectively. Adjusting for gender differences, rapamycin increased the mortality risk 1.7-fold in both male and female db/db mice. End-of-life pathological data showed that suppurative inflammation was the main cause of death in the db/db mice, which is enhanced slightly by rapamycin treatment.
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Rapamycin reduces lifespan in obese db/db mice.
“a recent paper indicate that rapamycin reduces lifespan in the obese db/db mice (Sataranatarajan et al., 2016).”
From Mitochondrial Activity and Dynamics Changes Regarding Metabolism in Ageing and Obesity (2017) · cites this paper as Sataranatarajan et al., 2016
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- Authors
- Sataranatarajan, K., Ikeno, Y., Bokov, A., Feliers, D., Yalamanchili, H., Lee, H. J., Mariappan, M. M., Tabatabai-Mir, H., Diaz, V., Prasad, S., Javors, M. A., Ghosh Choudhury, G., Hubbard, G. B., Barnes, J. L., Richardson, A., & Kasinath, B. S.
- Affiliations
- The University of Texas at San Antonio Health Science Center (US)
- Oklahoma City VA Medical Center (US)
- ORCID
- Venue
- The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-10-05
- Volume
- 71
- Issue
- 7
- Pages
- 850-857
- ISSN
- 1079-5006 (ISSN-L)
- 1758-535X
- PMC
- PMC4906320
- OpenAlex
- W2343560494
- Cited by
- 65
- References
- 57
- Citations by year
- 2026: 1 · 2025: 7 · 2023: 11 · 2022: 5 · 2021: 5 · 2020: 8 · 2019: 7 · 2018: 7 · 2017: 2 · 2016: 12
- FWCI
- 2.80
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journals of Gerontology Series A (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- National Institutes of Health (RC2AG036613, DK077295, DK050190)
- Juvenile Diabetes Research Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- rapamycin, db/db mice, type 2 diabetes, lifespan, mortality, mTOR inhibition, suppurative inflammation, sex differences
- MeSH terms
- Animals, Cause of Death, Diabetes Mellitus, Experimental, Diabetes Mellitus, Type 2, Female, Immunosuppressive Agents, Inflammation, Longevity, Male, Mice, Inbred C57BL, Mortality, Sex Factors, Treatment Outcome, Sirolimus, Mice
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