Revenge of the “Sit”: How lifestyle impacts neuronal and cognitive health through molecular systems that interface energy metabolism with neuronal plasticity

Vaynman, Shoshanna; Gomez‐Pinilla, Fernando

doi:10.1002/jnr.20979

Cited by 299Nerve injury and regenerationNeurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology Research

Revenge of the “Sit”: How lifestyle impacts neuronal and cognitive health through molecular systems that interface energy metabolism with neuronal plasticity

Vaynman, Shoshanna, Gomez‐Pinilla, Fernando·2006·Journal of Neuroscience Research

DOI 10.1002/jnr.20979

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Abstract

Exercise, a behavior that is inherently associated with energy metabolism, impacts the molecular systems important for synaptic plasticity and learning and memory. This implies that a close association must exist between these systems to ensure proper neuronal function. This review emphasizes the ability of exercise and other lifestyle implementations that modulate energy metabolism, such as diet, to impact brain function. Mechanisms believed to interface metabolism and cognition seem to play a critical role with the brain derived neurotrophic factor (BDNF) system. Behaviors concerned with activity and metabolism may have developed simultaneously and interdependently during evolution to determine the influence of exercise and diet on cognition. Alook into our evolutionary past indicates that our genome remains unchanged from the times of our hunter‐gatherer ancestors, whose active lifestyle predominated throughout almost 100% of humankind's existence. Consequently, the sedentary lifestyle and eating behaviors enabled by the comforts of technologic progress may be reaping “revenge” on the health of both our bodies and brains. In the 21st century we are confronted by the ever‐increasing incidence of metabolic disorders in both the adult and child population. The ability of exercise and diet to impact systems that promote cell survival and plasticity may be applicable for combating the deleterious effects of disease and ageing on brain health and cognition. © 2006 Wiley‐Liss, Inc.

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Be smart, exercise your heart: Exercise effects on brain and cognition
Hillman, C. H., Erickson, K. I., & Kramer, A. F. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2298 · Cited by 3,563 · see citing works
Enrichment Effects on Adult Cognitive Development: Can the Functional Capacity of Older Adults Be Preserved and Enhanced?
Hertzog, C., Kramer, A. F., Wilson, R. S., & Lindenberger, U. (2008) · Psychological Science in the Public Interest · doi:10.1111/j.1539-6053.2009.01034.x · Cited by 1,495 · see citing works
Brain foods: The effects of nutrients on brain function.
Gómez-Pinilla, F. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2421 · Cited by 1,372 · see citing works
Effects of physical activity on children’s executive function: Contributions of experimental research on aerobic exercise
Best, J. R. (2010) · Developmental Review · doi:10.1016/j.dr.2010.08.001 · Cited by 1,078 · see citing works
Neuroplasticity – Exercise-Induced Response of Peripheral Brain-Derived Neurotrophic Factor: A Systematic Review of Experimental Studies in Human Subjects
Knaepen, K., Goekint, M., Heyman, E. M., & Meeusen, R. (2010) · Sports Medicine · doi:10.2165/11534530-000000000-00000 · Cited by 882 · see citing works
Exercise and Children’s Intelligence, Cognition, and Academic Achievement
Tomporowski, P. D., Davis, C. L., Miller, P. H., & Naglieri, J. A. (2008) · Educational Psychology Review · doi:10.1007/s10648-007-9057-0 · Cited by 874 · see citing works
Calcium and neurodegeneration
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Capitalizing on cortical plasticity: influence of physical activity on cognition and brain function
Kramer, A. F., & Erickson, K. I. (2007) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2007.06.009 · Cited by 741 · see citing works
Physical activity, fitness, and gray matter volume
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Exercise and Mental Health: Many Reasons to Move
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The Influence of Exercise on Cognitive Abilities
Gómez‐Pinilla, F., & Hillman, C. H. (2012) · Comprehensive physiology · doi:10.1002/cphy.c110063 · Cited by 683 · see citing works
Healthier Students Are Better Learners: A Missing Link in School Reforms to Close the Achievement Gap
Basch, C. E. (2011) · Journal of School Health · doi:10.1111/j.1746-1561.2011.00632.x · Cited by 521 · see citing works
Physical activity and memory functions: An interventional study
Ruscheweyh, R., Willemer, C., Krüger, K., Duning, T., Warnecke, T., Sommer, J., Völker, K., Ho, H. V., Mooren, F., Knecht, S., et al. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.08.001 · Cited by 499 · see citing works
Brain-Derived Neurotrophic Factor, Depression, and Physical Activity: Making the Neuroplastic Connection
Phillips, C. (2017) · Neural Plasticity · doi:10.1155/2017/7260130 · Cited by 456 · see citing works
What is the association between sedentary behaviour and cognitive function? A systematic review
Falck, R. S., Davis, J. C., & Liu-Ambrose, T. Y. L. (2016) · British Journal of Sports Medicine · doi:10.1136/bjsports-2015-095551 · Cited by 454 · see citing works
Exercise acts as a drug; the pharmacological benefits of exercise
Vina, J., Sanchis‐Gomar, F., Martinez‐Bello, V, & Gomez‐Cabrera, M. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.01970.x · Cited by 443 · see citing works
The neuropathology of sport
McKee, A. C., Daneshvar, D. H., Alvarez, V. E., & Stein, T. D. (2014) · Acta Neuropathologica · doi:10.1007/s00401-013-1230-6 · Cited by 422 · see citing works
Biological mechanisms underlying the role of physical fitness in health and resilience
Silverman, M. N., & Deuster, P. A. (2014) · Interface Focus · doi:10.1098/rsfs.2014.0040 · Cited by 416 · see citing works
A Review of the Relation of Aerobic Fitness and Physical Activity to Brain Structure and Function in Children
Chaddock, L., Pontifex, M. B., Hillman, C. H., & Kramer, A. F. (2011) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617711000567 · Cited by 369 · see citing works
Biological Mechanisms of Physical Activity in Preventing Cognitive Decline
Lista, I., & Sorrentino, G. (2009) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-009-9488-x · Cited by 367 · see citing works
Physical activity interventions and children's mental function: An introduction and overview
Tomporowski, P. D., Lambourne, K., & Okumura, M. S. (2011) · Preventive Medicine · doi:10.1016/j.ypmed.2011.01.028 · Cited by 358 · see citing works
Six months of dance intervention enhances postural, sensorimotor, and cognitive performance in elderly without affecting cardio-respiratory functions
Kattenstroth, J.-C., Kalisch, T., Holt, S., Tegenthoff, M., & Dinse, H. R. (2013) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2013.00005 · Cited by 351 · see citing works
Cardiorespiratory Fitness and the Flexible Modulation of Cognitive Control in Preadolescent Children
Pontifex, M. B., Raine, L. B., Johnson, C. R., Chaddock, L., Voss, M. W., Cohen, N. J., Kramer, A. F., & Hillman, C. H. (2011) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2010.21528 · Cited by 334 · see citing works
Current perspectives of the roles of the central norepinephrine system in anxiety and depression
Goddard, A. W., Ball, S. G., Martinez, J. M., Robinson, M. J., Yang, C. R., Russell, J. M., & Shekhar, A. (2009) · Depression and Anxiety · doi:10.1002/da.20642 · Cited by 316 · see citing works
Dose-response relationship between exercise and cognitive function in older adults with and without cognitive impairment: A systematic review and meta-analysis
Sanders, L. M. J., Hortobágyi, T., Gemert, S. L. B., van der Zee, E. A., & van Heuvelen, M. J. G. (2019) · PLoS ONE · doi:10.1371/journal.pone.0210036 · Cited by 319 · see citing works
The positive impact of physical activity on cognition during adulthood: a review of underlying mechanisms, evidence and recommendations
Ratey, J. J., & Loehr, J. E. (2011) · Reviews in the Neurosciences · doi:10.1515/rns.2011.017 · Cited by 308 · see citing works
Physical activity and memory functions: Are neurotrophins and cerebral gray matter volume the missing link?
Flöel, A., Ruscheweyh, R., Krüger, K., Willemer, C., Winter, B., Völker, K., Lohmann, H., Zitzmann, M., Mooren, F. C., Breitenstein, C., et al. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.10.043 · Cited by 243 · see citing works
High-intensity interval training evokes larger serum BDNF levels compared with intense continuous exercise
Marquez, C. M. S., Vanaudenaerde, B. M., Troosters, T., & Wenderoth, N. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00126.2015 · Cited by 243 · see citing works
Superior sensory, motor, and cognitive performance in elderly individuals with multi-year dancing activities
Kattenstroth (2010) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2010.00031 · Cited by 243 · see citing works
‘Adipaging’: ageing and obesity share biological hallmarks related to a dysfunctional adipose tissue
Pérez, L. M., Pareja‐Galeano, H., Sanchis‐Gomar, F., Emanuele, E., Lucia, A., & Gálvez, B. G. (2016) · The Journal of Physiology · doi:10.1113/jp271691 · Cited by 215 · see citing works
Differential effects of treadmill running and wheel running on spatial or aversive learning and memory: roles of amygdalar brain-derived neurotrophic factor and synaptotagmin I
Liu, Y., Chen, H., Wu, C., Kuo, Y., Yu, L., Huang, A., Wu, F., Chuang, J., & Jen, C. J. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.173088 · Cited by 199 · see citing works
High-Intensity Interval Exercise and Cerebrovascular Health: Curiosity, Cause, and Consequence
Lucas, S. J. E., Cotter, J. D., Brassard, P., & Bailey, D. M. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2015.49 · Cited by 194 · see citing works
How Does Exercise Reduce the Rate of Age-Associated Cognitive Decline? A Review of Potential Mechanisms
Kennedy, G., Hardman, R. J., Macpherson, H., Scholey, A. B., & Pipingas, A. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160665 · Cited by 187 · see citing works
Adherence to a Mediterranean-Style Diet and Effects on Cognition in Adults: A Qualitative Evaluation and Systematic Review of Longitudinal and Prospective Trials
Hardman, R. J., Kennedy, G., Macpherson, H., Scholey, A. B., & Pipingas, A. (2016) · Frontiers in Nutrition · doi:10.3389/fnut.2016.00022 · Cited by 179 · see citing works
Environment as ‘Brain Training’: A review of geographical and physical environmental influences on cognitive ageing
Cassarino, M., & Setti, A. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.06.003 · Cited by 180 · see citing works
Revenge of the “sit” II: does lifestyle impact neuronal and cognitive health through distinct mechanisms associated with sedentary behavior and physical activity?
Voss, M. W., Carr, L. J., Clark, R., & Weng, T. (2014) · Mental health and physical activity · doi:10.1016/j.mhpa.2014.01.001 · Cited by 164 · see citing works
Cognitive and behavioural effects of physical exercise in psychiatric patients
Knöchel, C., Oertel‐Knöchel, V., O’Dwyer, L., Prvulovic, D., Alves, G. S., Kollmann, B., & Hampel, H. J. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.11.007 · Cited by 164 · see citing works
Effect of age on exercise-induced alterations in cognitive executive function: Relationship to cerebral perfusion
Lucas, S. J. E., Ainslie, P. N., Murrell, C., Thomas, K. N., Franz, E. A., & Cotter, J. D. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2011.12.002 · Cited by 162 · see citing works
The Effects of Exercise Training in Addition to Energy Restriction on Functional Capacities and Body Composition in Obese Adults during Weight Loss: A Systematic Review
Miller, C. T., Fraser, S. F., Levinger, I., Straznicky, N. E., Dixon, J. B., Reynolds, J., & Selig, S. E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081692 · Cited by 160 · see citing works
Effects of low- and high-intensity physical exercise on physical and cognitive function in older persons with dementia: a randomized controlled trial
Sanders, L. M. J., Hortobágyi, T., Karssemeijer, E. G. A., Van der Zee, E. A., Scherder, E. J. A., & van Heuvelen, M. J. G. (2020) · Alzheimer's Research & Therapy · doi:10.1186/s13195-020-00597-3 · Cited by 154 · see citing works
Exercise Intervention in PTSD: A Narrative Review and Rationale for Implementation
Hegberg, N. J., Hayes, J. P., & Hayes, S. M. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00133 · Cited by 154 · see citing works
Alzheimer’s disease, cerebrovascular dysfunction and the benefits of exercise: From vessels to neurons
Lange‐Asschenfeldt, C., & Kojda, G. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.04.002 · Cited by 153 · see citing works
Can Taichi Reshape the Brain? A Brain Morphometry Study
Wei, G.-X., Xu, T., Fan, F.-M., Dong, H.-M., Jiang, L.-L., Li, H.-J., Yang, Z., Luo, J., & Zuo, X.-N. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061038 · Cited by 152 · see citing works
Physical activity and obesity mediate the association between childhood motor function and adolescents’ academic achievement
KANTOMAA, M. T., Stamatakis, E., Kankaanpää, A., Kaakinen, M., Rodriguez, A., Taanila, A. M., Ahonen, T. P. S., Järvelin, M., & Tammelin, T. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1214574110 · Cited by 150 · see citing works
Strength training does not influence serum brain-derived neurotrophic factor
Goekint, M., Pauw, K. D., Roelands, B., Njemini, R., Bautmans, I., Mets, T. F., & MEEUSEN, R. R. (2010) · European Journal of Applied Physiology · doi:10.1007/s00421-010-1461-3 · Cited by 150 · see citing works
The effect of cycling on cognitive function and well-being in older adults
Leyland, L., Spencer, B., Beale, N., Jones, T. J., & van Reekum, C. M. (2019) · PLoS ONE · doi:10.1371/journal.pone.0211779 · Cited by 146 · see citing works
The Effect of Physical Activity on Cognition - Physiological Mechanisms
Gligoroska, J. P., & Manchevska, S. (2012) · Materia Socio Medica · doi:10.5455/msm.2012.24.198-202 · Cited by 139 · see citing works
A Narrative Review of Physical Activity, Nutrition, and Obesity to Cognition and Scholastic Performance across the Human Lifespan
Burkhalter, T. M., & Hillman, C. H. (2011) · Advances in Nutrition · doi:10.3945/an.111.000331 · Cited by 137 · see citing works
Viewpoint: Mechanisms of Action and Therapeutic Potential of Neurohormetic Phytochemicals
Mattson, M. P., Son, T. G., & Camandola, S. (2007) · Dose-Response · doi:10.2203/dose-response.07-004.mattson · Cited by 137 · see citing works
Neuroimaging of Reading Intervention: A Systematic Review and Activation Likelihood Estimate Meta-Analysis
Barquero, L. A., Davis, N., & Cutting, L. E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0083668 · Cited by 138 · see citing works
Physical exercise as a possible strategy for brain protection: Evidence from mitochondrial-mediated mechanisms
Marques‐Aleixo, I., Oliveira, P. J., Moreira, P. I., Magalhães, J., & Ascensão, A. A. M. R. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.08.002 · Cited by 132 · see citing works
Reviews: Mechanisms Mediating Brain Plasticity: IGF1 and Adult Hippocampal Neurogenesis
Llorens-Martı́n, M., Torres‐Alemán, I., & Trejo, J. L. (2009) · The Neuroscientist · doi:10.1177/1073858408331371 · Cited by 130 · see citing works
No exercise-induced increase in serum BDNF after cycling near a major traffic road
Bos, I., Jacobs, L., Nawrot, T. S., de Geus, B., Torfs, R., Panis, L. I., Degraeuwe, B., & MEEUSEN, R. R. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.06.019 · Cited by 124 · see citing works
The Role of Aerobic Fitness in Cortical Thickness and Mathematics Achievement in Preadolescent Children
Chaddock‐Heyman, L., Erickson, K. I., Kienzler, C., King, M. A., Pontifex, M. B., Raine, L. B., Hillman, C. H., & Kramer, A. F. (2015) · PLoS ONE · doi:10.1371/journal.pone.0134115 · Cited by 122 · see citing works
Cross-Sectional Relationships of Physical Activity and Sedentary Behavior With Cognitive Function in Older Adults With Probable Mild Cognitive Impairment
Falck, R. S., Landry, G. J., Best, J. R., Davis, J. C., Chiu, B. K., & Liu-Ambrose, T. Y. L. (2017) · Physical Therapy · doi:10.1093/ptj/pzx074 · Cited by 120 · see citing works
Reduced alcohol consumption in mice with access to a running wheel
Ehringer, M. A., Hoft, N. R., & Zunhammer, M. (2009) · Alcohol · doi:10.1016/j.alcohol.2009.06.003 · Cited by 116 · see citing works
The interactive effects of physical fitness and acute aerobic exercise on electrophysiological coherence and cognitive performance in adolescents
Hogan, M., Kiefer, M., Kubesch, S., Collins, P., Kilmartin, L., & Brosnan, M. (2013) · Experimental Brain Research · doi:10.1007/s00221-013-3595-0 · Cited by 113 · see citing works
Physical exercise alleviates debilities of normal aging and Alzheimer’s disease
Archer, T. (2010) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2010.01412.x · Cited by 109 · see citing works
The effect of nature and physical activity on emotions and attention while engaging in green exercise
Han, K.-T. (2017) · Urban forestry & urban greening · doi:10.1016/j.ufug.2017.03.012 · Cited by 111 · see citing works
Non-exercise estimated cardiorespiratory fitness: Associations with brain structure, cognition, and memory complaints in older adults
McAuley, E., Szabo‐Reed, A. N., Mailey, E. L., Erickson, K. I., Voss, M. W., White, S. M., Wójcicki, T. R., Gothe, N. P., Olson, E. A., Mullen, S. P., et al. (2011) · Mental health and physical activity · doi:10.1016/j.mhpa.2011.01.001 · Cited by 102 · see citing works
Train the Vessel, Gain the Brain: Physical Activity and Vessel Function and the Impact on Stroke Prevention and Outcome in Cerebrovascular Disease
Schmidt, W. U., Endres, M., Dimeo, F., & Jungehulsing, G. J. (2013) · Cerebrovascular Diseases · doi:10.1159/000347061 · Cited by 104 · see citing works
Emerging Support for a Role of Exercise in Attention-Deficit/Hyperactivity Disorder Intervention Planning
Berwid, O. G., & Halperin, J. M. (2012) · Current Psychiatry Reports · doi:10.1007/s11920-012-0297-4 · Cited by 99 · see citing works
Upregulation of hippocampal TrkB and synaptotagmin is involved in treadmill exercise-enhanced aversive memory in mice
Liu, Y.-F., Chen, H.-I., Yu, L., Kuo, Y.-M., Wu, F.-S., Chuang, J.-I., Liao, P.-C., & Jen, C. J. (2008) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2008.02.005 · Cited by 98 · see citing works
The impact of voluntary exercise on mental health in rodents: A neuroplasticity perspective
Pietropaolo, S., Sun, Y., Li, R., Brana, C., Feldon, J., & Yee, B. K. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.03.014 · Cited by 99 · see citing works
The Long Run: Neuroprotective Effects of Physical Exercise on Adult Neurogenesis from Youth to Old Age
Saraulli, D., Costanzi, M., Mastrorilli, V., & Vecchioli, S. F. (2017) · Current Neuropharmacology · doi:10.2174/1570159x14666160412150223 · Cited by 96 · see citing works
Physical Activity Is Positively Associated with Episodic Memory in Aging
Hayes, S. M., Alosco, M. L., Hayes, J. P., Cadden, M. H., Peterson, K. M., Allsup, K., Forman, D. E., Sperling, R. A., & Verfaellie, M. H. (2015) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617715000910 · Cited by 97 · see citing works
The influence of exercise and physical fitness status on attention: a systematic review
de Sousa, A. F. M., Medeiros, A. R., Rosso, S. D., Stults‐Kolehmainen, M., & Boullosa, D. A. (2018) · International Review of Sport and Exercise Psychology · doi:10.1080/1750984x.2018.1455889 · Cited by 91 · see citing works
Exergaming in Youth
Best, J. R. (2013) · Zeitschrift für Psychologie · doi:10.1027/2151-2604/a000137 · Cited by 92 · see citing works
An Overview on the Associations between Health Behaviors and Brain Health in Children and Adolescents with Special Reference to Diet Quality
Naveed, S., Lakka, T. A., & Haapala, E. A. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17030953 · Cited by 101 · see citing works
A Review of Acute Physical Activity Effects on Brain and Cognition in Children
Hillman, C. H., Logan, N. E., & Shigeta, T. T. (2019) · Translational Journal of the American College of Sports Medicine · doi:10.1249/tjx.0000000000000101 · Cited by 92 · see citing works
The Influence of Exercise on Cognitive Abilities
Gómez‐Pinilla, F., & Hillman, C. H. (2013) · Comprehensive physiology · doi:10.1002/j.2040-4603.2013.tb00485.x · Cited by 86 · see citing works
Physical Activity and the Achievement Gap Among Urban Minority Youth
Basch, C. E. (2011) · Journal of School Health · doi:10.1111/j.1746-1561.2011.00637.x · Cited by 84 · see citing works
Can exercise shape your brain? A review of aerobic exercise effects on cognitive function and neuro-physiological underpinning mechanisms
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Review Revenge of the \\Sit": How Lifestyle Impacts Neuronal and Cognitive Health Through Molecular Systems That Interface Energy Metabolism With Neuronal Plasticity
Vaynman, S., & Gomez-pinilla, O. (2014)
Self-citation
The combined effects of exercise and foods in preventing neurological and cognitive disorders
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Self-citation
Molecular Mechanisms for the Ability of Exercise Supporting Cognitive Abilities and Counteracting Neurological Disorders
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Authors: Vaynman, S., & Gomez‐Pinilla, F.
Affiliations: University of California, Los Angeles (US)
Venue: Journal of Neuroscience Research
Publisher: Wiley
Published: 2006-07-21
Volume: 84
Issue: 4
Pages: 699-715
ISSN: 0360-4012 (ISSN-L)
1097-4547
DOI: 10.1002/jnr.20979
OpenAlex: W2106085375
Cited by: 299
References: 216
Citations by year: 2026: 3 · 2025: 6 · 2024: 20 · 2023: 7 · 2022: 16 · 2021: 20 · 2020: 12 · 2019: 12 · 2018: 15 · 2017: 19 · 2016: 12 · 2015: 23 · 2014: 20 · 2013: 16 · 2012: 21
FWCI: 1.37
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Neuroscience Research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: physical activity, lifestyle, energy metabolism, neuroplasticity, synaptic plasticity, learning and memory, brain-derived neurotrophic factor, diet, sedentary lifestyle, metabolic disorders, brain health, aging
MeSH terms: Aging, Animals, Brain, Cognition, Energy Metabolism, Humans, Learning, Life Style, Models, Biological, Neuronal Plasticity, Exercise, Brain-Derived Neurotrophic Factor

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Revenge of the “Sit”: How lifestyle impacts neuronal and cognitive health through molecular systems that interface energy metabolism with neuronal plasticity

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