Modern fertility awareness methods: wrist wearables capture the changes in temperature associated with the menstrual cycle
Open accessAbstract
Core and peripheral body temperatures are affected by changes in reproductive hormones during the menstrual cycle. Women worldwide use the basal body temperature (BBT) method to aid and prevent conception. However, prior research suggests that taking one’s daily temperature can prove inconvenient and subject to environmental factors. We investigate whether a more automatic, non-invasive temperature measurement system can detect changes in temperature across the menstrual cycle. We examined how wrist skin temperature (WST), measured with wearable sensors, correlates with urinary tests of ovulation and may serve as a new method of fertility tracking. One hundred and thirty-six eumenorrheic, non-pregnant women participated in an observational study. Participants wore WST biosensors during sleep and reported their daily activities. An at-home luteinizing hormone (LH) test was used to confirm ovulation. WST was recorded across 437 cycles (mean cycles/participant = 3.21, S.D. = 2.25). We tested the relationship between the fertile window and WST temperature shifts, using the BBT three-over-six rule. A sustained 3-day temperature shift was observed in 357/437 cycles (82%), with the lowest cycle temperature occurring in the fertile window 41% of the time. Most temporal shifts (307/357, 86%) occurred on ovulation day (OV) or later. The average early-luteal phase temperature was 0.33°C higher than in the fertile window. Menstrual cycle changes in WST were impervious to lifestyle factors, like having sex, alcohol, or eating prior to bed, that, in prior work, have been shown to obfuscate BBT readings. Although currently costlier than BBT, the present study suggests that WST could be a promising, convenient parameter for future multiparameter fertility awareness methods.
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Basal body temperature based apps detect the BBT rise.
“basal body temperature (BBT; defined as lowest resting body temperature) based apps that detect the BBT rise,20–22”
From Real-world menstrual cycle characteristics of more than 600,000 menstrual cycles (2019) · cites this paper as [21]
A pre-ovulatory temperature nadir was detected in only 41% of cycles in one study investigating wrist skin temperature, suggesting prospective determination of ovulation with this method was not robust.
“One study that investigated the possibility of detecting a decrease in skin temperature (measured at the wrist) before ovulation revealed that a pre-ovulatory temperature nadir was detected in only 41% of cycles, suggesting that prospective determination of ovulation with this method was not robust [177].”
From Temperature regulation in women: Effects of the menstrual cycle (2020) · cites this paper as [177]
The Ava bracelet detected a temperature nadir in a 5-day period pre-ovulation in only 41% of cycles.
“- In only 41% of cycles, a T nadir (lowest T in a given cycle) was detected in a 5-day period pre-ovulation.”
From Temperature regulation in women: Effects of the menstrual cycle (2020) · cites this paper as [177]
The Ava bracelet showed an upward shift in wrist skin temperature in 82% of cycles, with higher average skin temperature in the luteal phase than the early follicular phase.
“- Showed an upward shift in wrist skin T in 82% of cycles, with higher average skin T in LP than early FP.”
From Temperature regulation in women: Effects of the menstrual cycle (2020) · cites this paper as [177]
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Cites
Mixed-effects modeling with crossed random effects for subjects and items
Baayen, R. H., Davidson, D. J., & Bates, D. M. (2008) · Journal of Memory and Language · doi:10.1016/j.jml.2007.12.005 · Cited by 8,540 · see citing works
Biodiversity on the Rocks: Macrofauna Inhabiting Authigenic Carbonate at Costa Rica Methane Seeps
Levin, L. A., Mendoza, G., Grupe, B., Gonzalez, J. P., Jellison, B. M., Rouse, G. W., Thurber, A. R., & Warén, A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0131080 · Cited by 2,166 · see citing works
Wilcox, A. J., Weinberg, C. R., & Baird, D. D. (1995) · New England Journal of Medicine · doi:10.1056/nejm199512073332301 · Cited by 1,071 · see citing works
The circadian rhythm of body temperature
Refinetti, R., & Menaker, M. (1992) · Physiology & Behavior · doi:10.1016/0031-9384(92)90188-8 · Cited by 735 · see citing works
Wilcox, A. J. (2000) · BMJ · doi:10.1136/bmj.321.7271.1259 · Cited by 452 · see citing works
Evaluation of wireless determination of skin temperature using iButtons
VANMARKENLICHTENBELT, W., DAANEN, H., WOUTERS, L., FRONCZEK, R., RAYMANN, R., SEVERENS, N., & VANSOMEREN, E. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.04.026 · Cited by 392 · see citing works
The dependence of onset and duration of sleep on the circadian rhythm of rectal temperature
Zulley, J., Wever, R., & Aschoff, J. (1981) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00581514 · Cited by 377 · see citing works
Behre, H. M., Kuhlage, J., Gaβner, C., Sonntag, B., Schem, C., Schneider, H. P. G., & Nieschlag, E. (2000) · Human Reproduction · doi:10.1093/humrep/15.12.2478 · Cited by 238 · see citing works
Dunson, D. B., Baird, D. D., Wilcox, A. J., & Weinberg, C. R. (1999) · Human Reproduction · doi:10.1093/humrep/14.7.1835 · Cited by 235 · see citing works
Circadian rhythm of wrist temperature in normal-living subjects
Sarabia, J. A., Rol, M. A., Mendiola, P., & Madrid, J. A. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2008.08.005 · Cited by 222 · see citing works
Post-ovulatory ageing of the human oocyte and embryo failure
Wilcox, A. J., Weinberg, C. R., & Baird, D. D. (1998) · Human Reproduction · doi:10.1093/humrep/13.2.394 · Cited by 215 · see citing works
Circadian Clues to Sleep Onset Mechanisms
Kräuchi, K. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00315-3 · Cited by 213 · see citing works
The circadian rhythm of body temperature
Refinetti, R. (2009) · Frontiers in bioscience · doi:10.2741/3634 · Cited by 203 · see citing works
Bigelow, J. L. (2004) · Human Reproduction · doi:10.1093/humrep/deh173 · Cited by 187 · see citing works
How is the circadian rhythm of core body temperature regulated?
Kr�uchi, K. (2002) · Clinical Autonomic Research · doi:10.1007/s10286-002-0043-9 · Cited by 174 · see citing works
Estrogen modifies the temperature effects of progesterone
Stachenfeld, N. S., Silva, C., & Keefe, D. L. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.88.5.1643 · Cited by 167 · see citing works
Colombo, B., & Masarotto, G. (2000) · Demographic Research · doi:10.4054/demres.2000.3.5 · Cited by 163 · see citing works
Timing intercourse to achieve pregnancy Current evidence
Stanford, J. B. (2002) · Obstetrics and Gynecology · doi:10.1016/s0029-7844(02)02382-7 · Cited by 157 · see citing works
Chronological aspects of ultrasonic, hormonal, and other indirect indices of ovulation
Ecochard, R., Boehringer, H., Rabilloud, M., & Marret, H. (2001) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2001.00194.x · Cited by 149 · see citing works
Kräuchi, K., Cajochen, C., Werth, E., & Wirz‐Justice, A. (2002) · Journal of Biological Rhythms · doi:10.1177/074873040201700409 · Cited by 146 · see citing works
Fall in skin temperature of exercising man.
Torii, M., Yamasaki, M., Sasaki, T., & Nakayama, H. (1992) · British Journal of Sports Medicine · doi:10.1136/bjsm.26.1.29 · Cited by 145 · see citing works
Royston, J. P. (1982) · Biometrics · doi:10.2307/2530453 · Cited by 143 · see citing works
Menstrual cycle phase and time of day alter reference signal controlling arm blood flow and sweating
Stephenson, L. A., & Kolka, M. A. (1985) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1985.249.2.r186 · Cited by 142 · see citing works
Effects of testosterone, estradiol, and temperature on neurons in preoptic tissue slices
Silva, N. L., & Boulant, J. A. (1986) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1986.250.4.r625 · Cited by 137 · see citing works
Reliability of Ovulation Tests in Infertile Women
Guermandi, E., VEGETTI, W., BIANCHI, M. M., UGLIETTI, A., RAGNI, G., & CROSIGNANI, P. (2001) · Obstetrics and Gynecology · doi:10.1016/s0029-7844(00)01083-8 · Cited by 128 · see citing works
Efficacy of methods for determining ovulation in a natural family planning program
Guida, M., Tommaselli, G. A., Palomba, S., Pellicano, M., Moccia, G., Carlo, C. D., & Nappi, C. (1999) · Fertility and Sterility · doi:10.1016/s0015-0282(99)00365-9 · Cited by 124 · see citing works
Hasselberg, M. J., McMahon, J. M., & Parker, K. P. (2011) · Sleep Medicine · doi:10.1016/j.sleep.2010.12.011 · Cited by 123 · see citing works
Estrogen replacement in middle-aged women: thermoregulatory responses to exercise in the heat
Tankersley, C. G., Nicholas, W. C., Deaver, D. R., Mikita, D., & Kenney, W. L. (1992) · Journal of Applied Physiology · doi:10.1152/jappl.1992.73.4.1238 · Cited by 116 · see citing works
Prior, J. C., Næss, M., Langhammer, A., & Forsmo, S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0134473 · Cited by 115 · see citing works
Action of progesterone on preoptic thermosensitive neurones
NAKAYAMA, T., SUZUKI, M., & ISHIZUKA, N. (1975) · Nature · doi:10.1038/258080a0 · Cited by 113 · see citing works
Esophageal temperature threshold for sweating decreases before ovulation in premenopausal women
Stephenson, L. A., Kolka, M. A., & Luca), (. T. T. A. O. J. D. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.86.1.22 · Cited by 112 · see citing works
Brooks, E. M., Morgan, A. L., Pierzga, J. M., Wladkowski, S. L., O’Gorman, J. T., Derr, J. A., & Kenney, W. L. (1997) · Journal of Applied Physiology · doi:10.1152/jappl.1997.83.2.477 · Cited by 111 · see citing works
Fertility Awareness-Based Methods: Another Option for Family Planning
Pallone, S. R., & BERGUS, G. R. (2009) · The Journal of the American Board of Family Medicine · doi:10.3122/jabfm.2009.02.080038 · Cited by 105 · see citing works
Assessment of Human Sperm Function After Recovery from the Female Reproductive Tract
Gould, J. E., Overstreet, J. W., & Hanson, F. W. (1984) · Biology of Reproduction · doi:10.1095/biolreprod31.5.888 · Cited by 102 · see citing works
Accuracy of Basal Body Temperature for Ovulation Detection
Moghissi, K. S. (1976) · Fertility and Sterility · doi:10.1016/s0015-0282(16)42257-0 · Cited by 97 · see citing works
Corbalán-Tutau, M. D., Madrid, J. A., Ordovás, J. M., Smith, C. E., Nicolás, F., & Garaulet, M. (2011) · Chronobiology International · doi:10.3109/07420528.2011.574766 · Cited by 94 · see citing works
Identification and prediction of the fertile window using NaturalCycles
Berglund Scherwitzl, E., Lindén Hirschberg, A., & Scherwitzl, R. (2015) · The European Journal of Contraception & Reproductive Health Care · doi:10.3109/13625187.2014.988210 · Cited by 90 · see citing works
A FIELD TRIAL OF THE BASAL-BODY-TEMPERATURE METHOD OF REGULATING BIRTHS
Marshall, J. (1968) · The Lancet · doi:10.1016/s0140-6736(68)92886-9 · Cited by 89 · see citing works
Assessment of anovulation in eumenorrheic women: comparison of ovulation detection algorithms
Lynch, K. E., Mumford, S. L., Schliep, K. C., Whitcomb, B. W., Zarek, S. M., Pollack, A. Z., Bertone‐Johnson, E. R., Danaher, M. R., Wactawski‐Wende, J., Gaskins, A. J., et al. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.04.035 · Cited by 83 · see citing works
Reproducibility of the cold-induced vasodilation response in the human finger
O’Brien, C. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00859.2004 · Cited by 81 · see citing works
Problems in using basal body temperature recordings in an infertility clinic.
Lenton, E. A., Weston, G. A., & Cooke, I. D. (1977) · BMJ · doi:10.1136/bmj.1.6064.803 · Cited by 80 · see citing works
Luciano, A. A., Peluso, J. J., Koch, E. I., MAIER, D. B., Kuslis, S. T., & Davison, E. (1990) · PubMed · Cited by 79 · see citing works
Basal Body Temperature Assessment
Barron, M. L., & Fehring, R. J. (2005) · MCN The American Journal of Maternal/Child Nursing · doi:10.1097/00005721-200509000-00004 · Cited by 74 · see citing works
Slowly Progressive Pure Word Deafness
Otsuki, M., Soma, Y., Sato, M., Homma, A., & Tsuji, S. (1998) · European Neurology · doi:10.1159/000007923 · Cited by 73 · see citing works
Comparison of Changes in Energy Expenditure and Body Temperatures after Caffeine Consumption
Koot, P., & Deurenberg, P. (1995) · Annals of Nutrition and Metabolism · doi:10.1159/000177854 · Cited by 73 · see citing works
Shilaih, M., Clerck, V. D., Falco, L., Kübler, F., & Leeners, B. (2017) · Scientific Reports · doi:10.1038/s41598-017-01433-9 · Cited by 69 · see citing works
Self-citationColantuoni, C., Henry, G., Zeger, S. L., & Pevsne, J. (2002) · BioTechniques · doi:10.2144/02326mt02 · Cited by 68 · see citing works
Uncovering Different Masking Factors on Wrist Skin Temperature Rhythm in Free-Living Subjects
Martínez-Nicolás, A., Ortiz‐Tudela, E., Rol, M. A., & Madrid, J. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061142 · Cited by 67 · see citing works
Natural Family Planning. II. Basal Body Temperature and Estimated Time of Ovulation
HILGERS, T. W., & BAILEY, A. J. (1980) · Obstetrics and Gynecology · doi:10.1097/00006250-198003000-00013 · Cited by 60 · see citing works
Leader, A., Wiseman, D. A., & Taylor, P. J. (1985) · Fertility and Sterility · doi:10.1016/s0015-0282(16)48436-0 · Cited by 55 · see citing works
At home testing: optimizing management for the infertility physician
Brezina, P. R., Haberl, E. M., & Wallach, E. E. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.01.001 · Cited by 54 · see citing works
Monophasic basal body temperature in ovulatory menstrual cycles
Johansson, E. D. B., Larsson‐Cohn, U., & GEMZELL, C. A. (1972) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(72)90659-x · Cited by 49 · see citing works
Inaccuracy of basal body temperature charts in predicting urinary luteinizing hormone surges
Quagliarello, J., & Arny, M. (1986) · Fertility and Sterility · doi:10.1016/s0015-0282(16)49212-5 · Cited by 48 · see citing works
Fehring, R. J., Schneider, M., Raviele, K. M., & Barron, M. L. (2007) · Journal of Obstetric, Gynecologic & Neonatal Nursing · doi:10.1111/j.1552-6909.2007.000129.x · Cited by 46 · see citing works
Kräuchi, K., Konieczka, K., Roescheisen-Weich, C., Gompper, B., Hauenstein, D., Schoetzau, A., Fraenkl, S., & Flammer, J. (2014) · Chronobiology International · doi:10.3109/07420528.2013.829482 · Cited by 46 · see citing works
Templeton, A., Penney, G. C., & Lees, M. M. (1982) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1982.tb04651.x · Cited by 45 · see citing works
Martinez, A. R., van Hooff, M. H., Schoute, E., van der Meer, M., Broekmans, F. J., & Hompes, P. G. A. (1992) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/0028-2243(92)90041-v · Cited by 43 · see citing works
Wood, S. W., Prior, L. D., Stephens, H. C., & Bowman, D. M. J. S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137811 · Cited by 39 · see citing works
New Low‐ and High‐Tech Calendar Methods of Family Planning
Fehring, R. J. (2005) · Journal of Midwifery & Women s Health · doi:10.1016/j.jmwh.2004.07.001 · Cited by 38 · see citing works
Fertility awareness and natural family planning
Pyper, C. (1997) · The European Journal of Contraception & Reproductive Health Care · doi:10.3109/13625189709167468 · Cited by 36 · see citing works
Timing of Sexual Intercourse in Relation to Ovulation
Wilcox, A. J., Weinberg, C. R., & Baird, D. D. (1996) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-199606000-00016 · Cited by 35 · see citing works
Brooks-Asplund, E. M., Cannon, J. G., & Kenney, W. L. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.279.3.r839 · Cited by 34 · see citing works
Blackwell, L. F., Pilar Vigil, P., Gross, B. A., d’Arcangues, C., Cooke, D. G., & Brown, J. B. (2011) · Human Reproduction · doi:10.1093/humrep/der409 · Cited by 33 · see citing works
Coffee induced thermogenesis and skin temperature.
Tagliabue, A., Terracina, D., Cena, H., Turconi, G. M. C., Lanzola, E., & Montomoli, C. (1994) · PubMed · Cited by 30 · see citing works
Devices for home evaluation of women’s health concerns
Scolaro, K. L., Lloyd, K. B., & Helms, K. L. (2008) · American Journal of Health-System Pharmacy · doi:10.2146/ajhp060565 · Cited by 28 · see citing works
Barratt, C. L. R., Cooke, S., Chauhan, M., & Cooke, I. D. (1989) · Fertility and Sterility · doi:10.1016/s0015-0282(16)60905-6 · Cited by 25 · see citing works
Freundl, G., Bremme, M., Frank‐Herrmann, P., Baur, S., Godehardt, E., & Sottong, U. (1996) · Advances in Contraception · doi:10.1007/bf01849632 · Cited by 25 · see citing works
Ethyl alcohol induced skin temperature changes evaluated by thermography. Preliminary results.
Mannara, G., Gc, S., & Gp, P. (1993) · PubMed · Cited by 18 · see citing works
Barratt, C. L. R., Cooke, S., Chauhan, M., & Cooke, I. (1990) · International Journal of Gynecology & Obstetrics · doi:10.1016/0020-7292(90)90945-h · Cited by 3 · see citing works
A novel contact free sensor for the prediction of ovulation and fertile window
Maman, E., Segal, E. M., Sarda, Y., Baum, M., & Hourvitz, A. (2017) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.07.992 · Cited by 2 · see citing works
Flagged first, then by citations
1 of the 71 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- [1]Raith-Paula E. (2008) Historische Entwicklung der Natürlichen Familienplanung. In Natürliche Familienplanung heute, pp. 9– 15, Springer Berlin Heidelberg, Berlin, Heidelberg
- [31]Barron M.L. and Fehring R.J. (2005) Basal body temperature assessment: is it useful to couples seeking pregnancy? MCN Am. J. Matern. Child. Nurs. 30, 290– 296 10.1097/00005721-200509000-00004 16132004 · DOI
Cited by
Sorted by citations
Real-world menstrual cycle characteristics of more than 600,000 menstrual cycles
Bull, J. R., Rowland, S. P., Scherwitzl, E. B., Scherwitzl, R., Danielsson, K. G., & Harper, J. (2019) · npj Digital Medicine · doi:10.1038/s41746-019-0152-7 · Cited by 404 · see citing works
The impact of wearable technologies in health research: scoping review
Huhn, S., Axt, M., Gunga, H.-C., Maggioni, M. A., Munga, S., Obor, D., Sié, A., Boudo, V., Bunker, A., Sauerborn, R., et al. (2022) · JMIR mHealth and uHealth · doi:10.2196/34384 · Cited by 379 · see citing works
Temperature regulation in women: Effects of the menstrual cycle
Baker, F. C., Siboza, F., & Fuller, A. (2020) · Temperature · doi:10.1080/23328940.2020.1735927 · Cited by 262 · see citing works
Transducer Technologies for Biosensors and Their Wearable Applications
Polat, E. O., Çetin, M. M., Tabak, A. F., Güven, E. B., Uysal, B. Ö., Arsan, T., Kabbani, A., Hamed, H., & GÜL, S. B. (2022) · Biosensors · doi:10.3390/bios12060385 · Cited by 209 · see citing works
Goodale, B. M., Shilaih, M., Falco, L., Dammeier, F., Hamvas, G., & Leeners, B. (2019) · Journal of Medical Internet Research · doi:10.2196/13404 · Cited by 123 · see citing works
Self-citationMaijala, A., Kinnunen, H., Koskimäki, H., Jämsä, T., & Kangas, M. (2019) · BMC Women's Health · doi:10.1186/s12905-019-0844-9 · Cited by 107 · see citing works
Doherty, C., Baldwin, M., Keogh, A., Caulfield, B., & Argent, R. (2024) · Sports Medicine · doi:10.1007/s40279-024-02077-2 · Cited by 114 · see citing works
Alzueta, E., de Zambotti, M., Javitz, H. S., Dulai, T., Albinni, B., Simon, K. C., Sattari, N., Zhang, J., Shuster, A., Mednick, S. C., et al. (2022) · International Journal of Women s Health · doi:10.2147/ijwh.s341917 · Cited by 85 · see citing works
Communication Requirements in 5G-Enabled Healthcare Applications: Review and Considerations
Qureshi, H. N., Manalastas, M., Ijaz, A., Imran, A., Liu, Y., & Kalaa, M. O. A. (2022) · Healthcare · doi:10.3390/healthcare10020293 · Cited by 84 · see citing works
The performance of wearable sensors in the detection of SARS-CoV-2 infection: a systematic review
Mitratza, M., Goodale, B. M., Shagadatova, A., Kovačević, V., van de Wijgert, J. H. H. M., Brakenhoff, T. B., Dobson, R., Franks, B., Veen, D., Folarin, A., et al. (2022) · The Lancet Digital Health · doi:10.1016/s2589-7500(22)00019-x · Cited by 71 · see citing works
Self-citationNissen, M., Slim, S., Jaeger, K. M., Flaucher, M., Huebner, H., Danzberger, N., Fasching, P. A., Beckmann, M. W., Gradl, S., & Eskofier, B. M. (2022) · JMIR Formative Research · doi:10.2196/33635 · Cited by 62 · see citing works
Yu, J., Su, Y.-F., Zhang, C., Li, J., Lin, X.-H., Chen, L., Huang, H., & Wu, Y. (2022) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-022-00993-4 · Cited by 64 · see citing works
ZHU, T. Y., Rothenbühler, M., Hamvas, G., Hofmann, A., Welter, J., Kahr, M. K., Kimmich, N., Shilaih, M., & Leeners, B. (2021) · Journal of Medical Internet Research · doi:10.2196/20710 · Cited by 59 · see citing works
Self-citationLyzwinski, L., Elgendi, M., & Menon, C. (2022) · Journal of Medical Internet Research · doi:10.2196/45139 · Cited by 58 · see citing works
Grant, A. D., Newman, M. S., & Kriegsfeld, L. J. (2020) · Scientific Reports · doi:10.1038/s41598-020-76236-6 · Cited by 48 · see citing works
Effect of sex and sex steroids on brown adipose tissue heat production in humans
Fuller‐Jackson, J., Dordevic, A. L., Clarke, I. J., & Henry, B. A. (2020) · European Journal of Endocrinology · doi:10.1530/eje-20-0184 · Cited by 45 · see citing works
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Tatsumi, T., Sampei, M., Saito, K., Honda, Y., Okazaki, Y., Arata, N., Narumi, K., Morisaki, N., Ishikawa, T., & Narumi, S. (2020) · Obstetrics and Gynecology · doi:10.1097/aog.0000000000003910 · Cited by 46 · see citing works
Stefanov, B.-A., Teixeira, A. P., Mansouri, M., Bertschi, A., Krawczyk, K., Hamri, G. C.-E., Xue, S., & Fussenegger, M. (2021) · Advancement of science · doi:10.1002/advs.202101813 · Cited by 38 · see citing works
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Werneke, U., Truedson, P., Wikström, H., & Ott, M. (2020) · Journal of Integrative Neuroscience · doi:10.31083/j.jin.2020.04.314 · Cited by 37 · see citing works
Alzueta, E., & Baker, F. C. (2023) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2023.06.003 · Cited by 49 · see citing works
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Uchida, Y., & Izumizaki, M. (2022) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2022.103290 · Cited by 27 · see citing works
Prediction of ovulation: new insight into an old challenge
Maman, E., Adashi, E. Y., Baum, M., & Hourvitz, A. (2023) · Scientific Reports · doi:10.1038/s41598-023-47241-2 · Cited by 26 · see citing works
Qin, J., Yang, D., Zhang, H., He, Z., Zhao, Y., Zhao, Y., Lu, Y., & Wang, D. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.169298 · Cited by 26 · see citing works
Webster, W., & Smarr, B. L. (2020) · Journal of Circadian Rhythms · doi:10.5334/jcr.200 · Cited by 25 · see citing works
Boßung, V., Singer, A., Ratz, T., Rothenbühler, M., Leeners, B., & Kimmich, N. (2023) · Sensors · doi:10.3390/s23146620 · Cited by 25 · see citing works
Self-citationWan, J., Xu, S., Lin, J., Ji, L., Cheng, J., Li, Z., Qu, X., & Li, C. (2025) · Small · doi:10.1002/smll.202504078 · Cited by 26 · see citing works
Oura Ring as a Tool for Ovulation Detection: Validation Analysis
Thigpen, N., Patel, S., & Zhang, X. (2024) · Journal of Medical Internet Research · doi:10.2196/60667 · Cited by 23 · see citing works
Survey analysis of quantitative and qualitative menstrual cycle tracking technologies
Stujenske, T. M., Mu, Q., Pérez Capotosto, M., & Bouchard, T. P. (2023) · Medicina · doi:10.3390/medicina59091509 · Cited by 22 · see citing works
Gombert, M., Alzueta, E., Perez-Amparan, E., Yüksel, D., Kiss, O., de Zambotti, M., Simon, K. C. N. S., Zhang, J., Shuster, A. E., Morehouse, A. B., et al. (2024) · Journal of Biological Rhythms · doi:10.1177/07487304241247893 · Cited by 21 · see citing works
COVID-19 vaccine side effects and long-term neutralizing antibody response
Dutcher, E., Epel, E. S., Mason, A. E., Hecht, F., Robinson, J. E., Drury, S. S., & Prather, A. (2024) · Annals of Internal Medicine · doi:10.7326/m23-2956 · Cited by 7 · see citing works
Advances in Precision Health and Emerging Diagnostics for Women
Fitzpatrick, M. B., & Thakor, A. S. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8101525 · Cited by 14 · see citing works
Écochard, R., Leiva, R. A., Bouchard, T. P., Boehringer, H., Iwaz, J., & Plotton, I. (2022) · Steroids · doi:10.1016/j.steroids.2022.108964 · Cited by 13 · see citing works
Brun, R., Girsberger, J., Rothenbühler, M., Argyle, C., Hutmacher, J., Haslinger, C., & Leeners, B. (2022) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-022-06753-4 · Cited by 12 · see citing works
Self-citationNulty, A. K., Chen, E. S., & Thompson, A. L. (2022) · Digital Health · doi:10.1177/20552076221084461 · Cited by 13 · see citing works
Sides, K., Kilungeja, G., Tapia, M., Kreidl, O. P., Brinkmann, B. H., & Nasseri, M. (2023) · Frontiers in Network Physiology · doi:10.3389/fnetp.2023.1227228 · Cited by 12 · see citing works
Reversible female contraceptives: historical, current, and future perspectives
Barton, B. E., Erickson, J. A., Allred, S., Jeffries, J. M., Stephens, K. K., Hunter, M. I., Woodall, K. A., & Winuthayanon, W. (2023) · Biology of Reproduction · doi:10.1093/biolre/ioad154 · Cited by 12 · see citing works
Can Wrist-Worn Medical Devices Correctly Identify Ovulation?
Niggli, A., Rothenbühler, M., Sachs, M., & Leeners, B. (2023) · Sensors · doi:10.3390/s23249730 · Cited by 10 · see citing works
Self-citationZhang, R., & Qian, K. (2023) · Advanced Sensor Research · doi:10.1002/adsr.202200052 · Cited by 11 · see citing works
IoT based Device for Fertility Monitoring
Prasannan, R., & Sarath, G. (2020) · International Conference on Communication and Electronics Systems (ICCES) · doi:10.1109/icces48766.2020.9137904 · Cited by 9 · see citing works
Network of Fuzzy Comparators for Ovulation Window Prediction
Sosnowski, Ł., Szymusik, I., & Penza, T. (2020) · Communications in computer and information science · doi:10.1007/978-3-030-50153-2_59 · Cited by 9 · see citing works
Grant, A. D., Wilbrecht, L., & Kriegsfeld, L. J. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.752363 · Cited by 9 · see citing works
Deep learning model using continuous skin temperature data predicts labor onset
Basavaraj, C., Grant, A. D., Aras, S. G., & Erickson, E. N. (2024) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-024-06862-9 · Cited by 8 · see citing works
Wang, Y., Park, J., Zhang, C.-Y., Jukic, A., Baird, D. D., Coull, B., Hauser, R., Mahalingaiah, S., Zhang, S., & Curry, C. (2025) · Human Reproduction · doi:10.1093/humrep/deaf005 · Cited by 8 · see citing works
Physiology, Ovulation And Basal Body Temperature
Steward, K., & Raja, A. (2021) · StatPearls · Cited by 8 · see citing works
Doherty, C., Baldwin, M., Argent, R., Keogh, A., & Caulfield, B. (2024) · doi:10.31219/osf.io/s8kg5 · Cited by 8 · see citing works
Neural substrates underlying rhythmic coupling of female reproductive and thermoregulatory circuits
Grant, A. D., & Kriegsfeld, L. J. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1254287 · Cited by 7 · see citing works
Zyklus-Apps zur Verhütung – sicher oder Gesellschaftsspiel?
Frank‐Herrmann, P., Freis, A., Freundl-Schütt, T., Wallwiener, L.-M., Baur, S., Freundl, G., Raith-Paula, E., & Strowitzki, T. (2018) · Der Gynäkologe · doi:10.1007/s00129-018-4358-6 · Cited by 7 · see citing works
Multivariate Ovulation Window Detection at OvuFriend
Fedorowicz, J., Sosnowski, Ł., Ślȩzak, D., Szymusik, I., Chaber, W., Miłobędzki, Ł., Penza, T., Sosnowska, J., Wójcicka, K., & Zaleski, K. (2019) · Lecture notes in computer science · doi:10.1007/978-3-030-22815-6_31 · Cited by 7 · see citing works
Murayama, Y., Uemura, A., Kitazawa, M., Toyotani, J., Taniuchi, A., & Togawa, T. (2023) · Advanced Biomedical Engineering · doi:10.14326/abe.12.28 · Cited by 7 · see citing works
Understanding wrist skin temperature changes to hormone variations across the menstrual cycle
Lin, G. E., Li, J. Y., Christofferson, K., Patel, S., Truong, K. N., & Mariakakis, A. T. (2024) · npj Women s Health · doi:10.1038/s44294-024-00037-9 · Cited by 6 · see citing works
Mitake, S., Wada‐Hiraike, O., Kashiwabara, K., Nakamura, A., Nasu, R., Hine, M., Matsuyama, Y., Fujii, T., & Osuga, Y. (2023) · Reproductive Medicine and Biology · doi:10.1002/rmb2.12516 · Cited by 6 · see citing works
AACC Guidance Document on the Use of Point-of-Care Testing in Fertility and Reproduction
Nichols, J. H., Ali, M., Anetor, J. I., Chen, L. S., Chen, Y., Collins, S. P., Das, S., Devaraj, S., Fu, L., Karon, B. S., et al. (2022) · The Journal of Applied Laboratory Medicine · doi:10.1093/jalm/jfac042 · Cited by 6 · see citing works
Luo, C. W., Su, Y.-F., Ren, Y., Zhang, Q., Li, R., Zhang, Q., Li, C., Hao, Y., Zhang, A., Zhang, H., et al. (2025) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2025.104795 · Cited by 5 · see citing works
Hunter, N. N., & Smith, M. A. (2024) · Seminars in Reproductive Medicine · doi:10.1055/s-0044-1791508 · Cited by 5 · see citing works
Shi, Y., Wang, C. B., Yang, Y., Li, Q., Chung, P. W., & Wang, Y. (2026) · npj Digital Medicine · doi:10.1038/s41746-025-02320-8 · Cited by 4 · see citing works
Markovic, A., Kovačević, V., Brakenhoff, T. B., Veen, D., Klaver, P., Mitratza, M., Downward, G. S., Grobbee, D. E., Cronin, M., & Goodale, B. M. (2024) · Journal of Medical Internet Research · doi:10.2196/51120 · Cited by 3 · see citing works
Self-citationWearable intelligence: can we transform fertility tracking through digital innovation?
Ali, Z. E., Ammar, O. F., Liperis, G., Sharma, K., Hall, J., Grace, B., & Fraire-Zamora, J. J. (2025) · Human Reproduction · doi:10.1093/humrep/deaf148 · Cited by 4 · see citing works
Male contraception: Focus on behavioral and barrier methods
Kopa, Z., Scafa, R., Graziani, A., Goulis, D. G., & Ferlin, A. (2024) · Andrology · doi:10.1111/andr.13722 · Cited by 4 · see citing works
Berdahl, C. T., Nguyen, A., Diniz, M. A., Henreid, A. J., Nuckols, T. K., Libby, C. P., & Pevnick, J. M. (2021) · Diagnosis · doi:10.1515/dx-2021-0020 · Cited by 4 · see citing works
Zhang, W., Bao, H., Li, C., Zhai, Y., Liu, J., & Gong, J. (2025) · CHI Conference Extended Abstracts on Human Factors in Computing Systems (CHI EA) · doi:10.1145/3706599.3720129 · Cited by 3 · see citing works
Understanding Fertile Window: A Key to Pregnancy as well as Contraception
Tiwari, P. K., Kadiri, S. K., Dubey, P., Singh, D., Khobragade, D. S., & Sahu, P. K. (2024) · Current Women s Health Reviews · doi:10.2174/0115734048282403240101112918 · Cited by 3 · see citing works
Dittmar, M., Möllgaard, L., & Engelhard, F. (2024) · Chronobiology International · doi:10.1080/07420528.2024.2342945 · Cited by 3 · see citing works
Physiological Changes in Women’s Skin During the Menstrual Cycle: A Scoping Review
Nguyen, M.-L., Nguyen, S., Sood, N., Marivada, S., Magaldino, A., & MAYROVITZ, H. N. (2024) · Cureus · doi:10.7759/cureus.75286 · Cited by 3 · see citing works
Similarity-based Detection of Fertile Days at OvuFriend
Sosnowski, Ł., Chaber, W., Miłobędzki, Ł., Penza, T., Sosnowska, J., Zaleski, K., Fedorowicz, J., Szymusik, I., & Ślȩzak, D. (2018) · IEEE International Conference on Big Data (BigData) · doi:10.1109/bigdata.2018.8622602 · Cited by 3 · see citing works
Ali, Z. E., Liperis, G., Mincheva, M. N., Serdarogullari, M., Uraji, J., Ammar, O. F., & Fraire-Zamora, J. J. (2023) · Human Reproduction · doi:10.1093/humrep/dead159 · Cited by 3 · see citing works
Lan, A., Ron, T., Stukalin, Y., Kronfeld‐Schor, N., & Einat, H. (2023) · Health Care For Women International · doi:10.1080/07399332.2023.2183206 · Cited by 3 · see citing works
Li, Y., Fang, Y., & Gu, S. (2025) · Revista da Escola de Enfermagem da USP · doi:10.1590/1980-220x-reeusp-2024-0454en · Cited by 9 · see citing works
Nolte, J., Pilz, M., Legerlotz, K., & Platen, P. (2026) · Frontiers in Sports and Active Living · doi:10.3389/fspor.2025.1732233 · Cited by 2 · see citing works
Familienplanung mit Zyklus-Apps – ein Update
Frank‐Herrmann, P., Freundl-Schütt, T., Wallwiener, L.-M., Baur, S., & Strowitzki, T. (2021) · Gynäkologische Endokrinologie · doi:10.1007/s10304-021-00391-w · Cited by 2 · see citing works
Shkodzik, K. (2024) · Seminars in Reproductive Medicine · doi:10.1055/s-0044-1793829 · Cited by 2 · see citing works
Murayama, Y., Tang, Z., Saito, K., Nakano, T., & Mitsui, M. (2024) · IEEE Access · doi:10.1109/access.2024.3511341 · Cited by 2 · see citing works
Ellerich-Groppe, N., Ott, T., Puzio, A., Weigold, S., & Mueller, R. (2024) · Zeitschrift für Ethik und Moralphilosophie · doi:10.1007/s42048-024-00203-3 · Cited by 2 · see citing works
IoT Based Monitoring System for Health During Menstruation
Khadse, C., Hajare, S., Sheikh, N., Dahule, R., & Kate, P. (2025) · International Conference on Sentiment Analysis and Deep Learning (ICSADL) · doi:10.1109/icsadl65848.2025.10933142 · Cited by 2 · see citing works
Mustika, I., Lusiana, N., Kusumawati, E., & Purnamasari, R. (2018) · Journal of Health Science and Prevention · doi:10.29080/jhsp.v2i1.112 · Cited by 2 · see citing works
Raith-Paula, E., & Frank‐Herrmann, P. (2020) · Springer eBooks · doi:10.1007/978-3-662-59311-0_14 · Cited by 2 · see citing works
Decoding menstrual health across the lifespan: a scoping review of digital health tools in research
Johnson, S. C., O’Day, J. J., Kraus, E., Delp, S. L., & Hicks, J. L. (2026) · npj Women s Health · doi:10.1038/s44294-026-00146-7 · Cited by 1 · see citing works
Kim, S. E., Kim, Y., & Park, B. (2026) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2026.118755 · Cited by 1 · see citing works
Prediction of Menstrual Cycle Phase by Wearable Heart Rate Sensor
Hayano, J., & Yuda, E. (2020) · Advances in computer and electrical engineering book series · doi:10.4018/978-1-7998-3970-5.ch001 · Cited by 1 · see citing works
Zyklus-Apps: zur Verhütung, zum Kinderwunsch oder doch nur Menstruationskalender?
Frank‐Herrmann, P., Freis, A., Freundl-Schütt, T., Wallwiener, L.-M., Baur, S., & Strowitzki, T. (2021) · Journal für Gynäkologische Endokrinologie/Österreich · doi:10.1007/s41974-020-00171-7 · Cited by 1 · see citing works
Review of Body Vitals Monitoring Systems for Disease Prediction
Patikar, S., Saha, P., Neogy, S., & Chowdhury, C. (2022) · Smart computing and intelligence · doi:10.1007/978-981-19-1408-9_9 · Cited by 1 · see citing works
Flyborg, J., Renvert, S., Anderberg, P., Isaksson, U., & Berglund, J. S. (2022) · SN Applied Sciences · doi:10.1007/s42452-022-05250-2 · Cited by 1 · see citing works
Valente, J. S., Moreira, O. C., da Costa, B. D. D., & de Oliveira, C. E. P. (2024) · Cuadernos de Educación y Desarrollo · doi:10.55905/cuadv16n5-045 · Cited by 1 · see citing works
Kontrazeptionsberatung bei Adoleszenten
Draths, R. (2021) · Gynäkologische Endokrinologie · doi:10.1007/s10304-021-00417-3 · Cited by 1 · see citing works
Zyklusformen im Leben einer Frau
Raith-Paula, E., & Frank‐Herrmann, P. (2020) · Springer eBooks · doi:10.1007/978-3-662-59311-0_9 · Cited by 1 · see citing works
Bohlen, H. L., Amin, A. P., Ninh, T. V., Baum, N. H., & Kahn, M. J. (2019) · Springer eBooks · doi:10.1007/978-3-030-27776-5_18
Experienced temperature, health and the implications for the built environment
Kennard, H. (2019) · UCL Discovery (University College London)
Zia, Y., Velloza, J., Oluoch, L. M., Momanyi, R., Mbugua, S., Njoroge, J., Gakuo, S., Mugo, E., Thuo, N. B., Kiptinness, C., et al. (2021) · Reproductive Health · doi:10.1186/s12978-021-01128-5
Acuna, J. M. (2021) · Trends in andrology and sexual medicine · doi:10.1007/978-3-030-70932-7_6
Prediction of Menstrual Cycle Phase by Wearable Heart Rate Sensor
Hayano, J., & Yuda, E. (2022) · IGI Global eBooks · doi:10.4018/978-1-6684-6299-7.ch028
Rahayu, T., Hasudungan, A., Afiya, R., Vinka Farradila, M., & Rachmawati, R. N. (2023) · International Journal of Applied Mathematics Sciences and Technology for National Defense · doi:10.58524/app.sci.def.v1i3.234
How Sensor Data Can Guide Females Through Training and Recovery According to Their Menstrual Cycle
Zinner, C. (2024) · Springer eBooks · doi:10.1007/978-3-031-45113-3_6
Kim, S. E., Kim, Y., & Park, B. (2024) · doi:10.2196/preprints.65865
Reliability of Cycle Applications for Pregnancy Planning and Contraception: A Systematic Review
Rabe, I., & Ehlers, J. P. (2025) · Mayo Clinic Proceedings Digital Health · doi:10.1016/j.mcpdig.2025.100239
A Systematic Approach to Menstrual Tracking: Proposed Methodology and Design
Khadse, C., & Mendhe, S. (2025) · International Conference on Intelligent Sustainable Systems (ICISS) · doi:10.1109/iciss63372.2025.11076209
Li, Y., Fang, Y., & Gu, S. (2025) · Revista da Escola de Enfermagem da USP · doi:10.1590/1980-220x-reeusp-2024-0454es
An Investigation into Alternative Ways of Menstrual Cycle Tracking in Professional Sports
Cabrera, M. D., & Karahanoğlu, A. (2025) · Annual Conference on Human-Computer Interaction and Sports (SportsHCI) · doi:10.1145/3749385.3749386 · Cited by 1 · see citing works
Abdula, C., Nishimwe, A., Batamuliza, J., António, V., & Bakunzibake, P. (2026) · Lecture notes in networks and systems · doi:10.1007/978-981-96-9048-0_51
Kiss, O., Gombert, M., Taitz, A., & Baker, F. C. (2026) · Journal of Biological Rhythms · doi:10.1177/07487304251409583
- Authors
- Shilaih, M., Goodale, B. M., Falco, L., Kübler, F., De Clerck, V., & Leeners, B.
- Affiliations
- University Hospital Zurich (CH)
- Ava AG, Zurich, Switzerland
- Corresponding author
- Leeners, Brigitte
- Venue
- Bioscience Reports
- Publisher
- Portland Press Ltd.
- Published
- 2018-11-30
- Volume
- 38
- Issue
- 6
- ISSN
- 0144-8463 (ISSN-L)
- 1573-4935
- PMC
- PMC6265623
- OpenAlex
- W2768584306
- Cited by
- 109
- References
- 71
- Citations by year
- 2026: 15 · 2025: 13 · 2024: 20 · 2023: 15 · 2022: 15 · 2021: 10 · 2020: 11 · 2019: 7 · 2018: 3
- FWCI
- 6.67
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Bioscience Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- Kommission für Technologie und Innovation
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Health and Contraception
- Health Sciences › Health Professions › General Health Professions › Mobile Health and mHealth Applications
- Keywords
- fertility awareness, basal body temperature, menstrual cycle, ovulation detection, fertile window, wearable sensors, fertility monitoring, luteal phase, non-invasive temperature measurement
- MeSH terms
- Wearable Electronic Devices, Adult, Body Temperature, Female, Fertility, Humans, Luteinizing Hormone, Menstrual Cycle, Ovulation, Wrist, Young Adult
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