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Cited by 257Ovarian function and disordersGestational Diabetes Research and ManagementPregnancy and preeclampsia studies

Association between polycystic ovary syndrome and the risk of pregnancy complications: A PRISMA-compliant systematic review and meta-analysis

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Yu, Hai-Feng, Chen, Hong-Su, Rao, Da-Pang, Gong, Jian·2016·Medicine
DOI 10.1097/md.0000000000004863PMC PMC5181798
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Abstract

BACKGROUND: Polycystic ovary syndrome (PCOS) is inconsistently associated with increased risk of adverse pregnancy outcomes. The purpose of this meta-analysis was to summarize the evidence regarding the strength of the association between pregnancy in women with PCOS and pregnancy complications. METHODS: We systematically searched PubMed, EmBase, and the Cochrane Library to identify observational studies up to January 2016. The primary focus was pregnancy outcomes, including gestational diabetes mellitus (GDM), preeclampsia, pregnancy-induced hypertension (PIH), preterm delivery, cesarean delivery, oligohydramnios, and polyhydramnios. Effect estimates were pooled using the random-effects model. The analysis was further stratified by factors that could affect these associations. RESULTS: We included 40 observational studies that reported data on a total of 17,816 pregnancies with PCOS and 123,756 pregnancies without PCOS. Overall, PCOS in pregnancy was associated with greater risk of GDM, preeclampsia, PIH, preterm delivery, cesarean delivery, miscarriage, hypoglycemia, and perinatal death. However, PCOS in pregnancy had little or no effect on oligohydramnios, polyhydramnios, large-for-gestational age (LGA), small-for-gestational-age (SGA), fetal growth restriction (FGR), preterm premature membrane rupture, fasting blood glucose (FBG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglyceride, total cholesterol, congenital malformation, macrosomia, and respiratory distress syndrome. Subgroup analysis suggested that these associations might be influenced by study design and pre-BMI. CONCLUSION: PCOS in pregnancy is associated with a significantly increased risk of adverse pregnancy, fetal, and neonatal outcomes.

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  • Women with PCOS experience increased cardiometabolic risk, including metabolic syndrome, hypertension, insulin resistance, obesity, and dyslipidemia, predisposing them to increased risk for diabetes and cardiovascular disease.

    “Women with PCOS experience increased cardiometabolic risk—including the metabolic syndrome, hypertension, insulin resistance, obesity and dyslipidemia—predisposing them to increased risk for diabetes and cardiovascular disease (CVD).2,10,17, 18, 19, 20”

    From Increased Prevalence of Adverse Health Outcomes Across the Lifespan in Those Affected by Polycystic Ovary Syndrome: A Canadian Population Cohort (2024) · cites this paper as [19]

    The Discussion (page unavailable) reports increased risks of gestational diabetes and pregnancy-induced hypertension in pregnancies with PCOS, supporting part of the claim in that setting. It does not establish increased metabolic syndrome, obesity, dyslipidemia, or later cardiovascular disease risk in women with PCOS generally; it reports no significant overall difference in cardiovascular risk-factor levels between the pregnancy groups. (LLM, conf=0.86)

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Cited by

Sorted by citations

Authors
Yu, H.-F., Chen, H.-S., Rao, D.-P., & Gong, J.
Affiliations
  • Laboratoire Reproduction et Développement des Plantes (FR)
  • Wenzhou Medical University (CN)
Corresponding author
Gong, Jian
ORCID
Gong, Jian
Venue
Medicine
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2016-12
Volume
95
Issue
51
Pages
e4863
ISSN
0025-7974 (ISSN-L)
DOI
10.1097/md.0000000000004863
PMC
PMC5181798
OpenAlex
W2561609317
Cited by
257
References
6
Citations by year
2026: 21 · 2025: 27 · 2024: 36 · 2023: 25 · 2022: 40 · 2021: 34 · 2020: 26 · 2019: 20 · 2018: 17 · 2017: 11
FWCI
2.31
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • Medicine (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Keywords
polycystic ovary syndrome, pregnancy complications, gestational diabetes mellitus, preeclampsia, gestational hypertension, preterm birth, cesarean section, miscarriage, oligohydramnios, polyhydramnios, perinatal death, fetal growth restriction
MeSH terms
Female, Humans, Obstetric Labor, Premature, Polycystic Ovary Syndrome, Pre-Eclampsia, Pregnancy, Pregnancy Complications, Risk Factors, Diabetes, Gestational, Hypertension, Pregnancy-Induced

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