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Cited by 206Ovarian function and disordersGestational Diabetes Research and ManagementAssisted Reproductive Technology and Twin Pregnancy

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Obstetric outcome in women with polycystic ovarian syndrome

Mikola, M.·2001·Human Reproduction
DOI 10.1093/humrep/16.2.226
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Abstract

Women with polycystic ovarian syndrome (PCOS) often have insulin resistance and hyperinsulinaemia and may therefore be at an increased risk for gestational diabetes mellitus (GDM). Hyperinsulinaemia may also be associated with pre-eclampsia. Information concerning outcome of pregnancies in PCOS women is scanty and somewhat controversial. Therefore, 99 pregnancies were retrospectively evaluated in women with PCOS and the findings were compared with an unselected control population. The average body mass index (BMI) in PCOS patients was greater than that in controls (25.6 versus 23.0) (P < 0.0001), and PCOS patients were more often nulliparous than controls (76 versus 42%) (P < 0.001). The multiple pregnancy rate was 9.1% in PCOS patients and 1.1% in controls [odds ratio (OR) 9.0; 95% confidence interval (CI) 3.5-23.3]. GDM developed in 20% of the PCOS patients and in 8.9% of the controls (P < 0.001). After logistic regression analysis, BMI >25 seemed to be the greatest predictor for GDM (adjusted OR 5.1; CI 3.2-8.3), while PCOS remained as another independent predictor (adjusted OR 1.9; CI 1.0-3.5). In contrast, PCOS was not a significant predictor for pre-eclampsia, which was merely associated with nulliparity. Premature delivery (16.1% in PCOS and 6.5% in controls) was explained to a large extent by multiple pregnancies and marginally by nulliparity and PCOS. In singleton pregnancies, there was no difference in birth weights, Apgar scores or perinatal morbidity of infants. In conclusion, PCOS slightly increases the risk for GDM, but does not have an important effect on the rate of premature delivery and pre-eclampsia.

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Metadata

Authors
Mikola, M.
Affiliations
Helsinki University Hospital (FI)
Corresponding author
Mikola, M.
Venue
Human Reproduction
Publisher
Oxford University Press (OUP)
Published
2001-02-01
Volume
16
Issue
2
Pages
226-229
ISSN
  • 0268-1161 (ISSN-L)
  • 1460-2350
DOI
10.1093/humrep/16.2.226
OpenAlex
W2143877744
Cited by
206
References
3
Citations by year
2026: 4 · 2024: 6 · 2023: 3 · 2022: 9 · 2021: 7 · 2020: 9 · 2019: 5 · 2018: 10 · 2017: 4 · 2016: 6 · 2015: 10 · 2014: 12 · 2013: 7 · 2012: 7
FWCI
8.26
Type
journal article
Language
en
Open access
closed
Locations
  • Human Reproduction (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Assisted Reproductive Technology and Twin Pregnancy
Keywords
polycystic ovary syndrome, pregnancy outcomes, gestational diabetes mellitus, preeclampsia, preterm birth, multiple pregnancy, body mass index, nulliparity, insulin resistance, hyperinsulinemia, birth weight, perinatal morbidity
MeSH terms
Adult, Female, Humans, Infant, Newborn, Insulin Resistance, Obstetric Labor, Premature, Polycystic Ovary Syndrome, Pre-Eclampsia, Pregnancy, Pregnancy Complications, Pregnancy Outcome, Pregnancy, Multiple, Risk Factors, Case-Control Studies, Diabetes, Gestational

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