Cited by 308Sperm and Testicular FunctionReproductive Health and TechnologiesMale Reproductive Health Studies

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Time to pregnancy and semen parameters: a cross-sectional study among fertile couples from four European cities

Slama, R.·2002·Human Reproduction

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Abstract

Background In fertile populations, little is known about the association between semen parameters and time to pregnancy (TTP). Methods Pregnant women from Copenhagen, Edinburgh, Paris and Turku who conceived without medical intervention were asked for their TTP (942 couples), and their partners provided a semen sample. The proportion of morphologically normal sperm and the multiple anomalies index (MAI, ratio of the total number of anomalies to the number of abnormal sperm) were centrally estimated. We estimated rate ratios for the occurrence of a pregnancy by a discrete survival model, adjusted for sexual activity and female factors affecting fecundity. Results Increasing sperm concentration influenced TTP up to 55 x 10(6)/ml. The proportion of morphologically normal sperm influenced TTP up to 39% according to David's criteria, and this association held among the subjects with a sperm concentration >55 x 10(6)/ml. For strict criteria, the threshold value was 19% normal sperm. An increase of 0.5 in MAI was associated with an adjusted rate ratio for the occurrence of a pregnancy of 0.68 (95% confidence interval: 0.54-0.85). Conclusions These results highlight the importance of sperm morphology parameters and indicate that the effect of proportion of normal sperm on TTP may be independent of sperm concentration.

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Authors: Slama, R.
Affiliations: Inserm (FR)
Corresponding author: Slama, R.
ORCID: Slama, R.
Venue: Human Reproduction
Publisher: Oxford University Press (OUP)
Published: 2002-02-01
Volume: 17
Issue: 2
Pages: 503-515
ISSN: 0268-1161 (ISSN-L)
1460-2350
DOI: 10.1093/humrep/17.2.503
OpenAlex: W2135968453
Cited by: 308
References: 46
Citations by year: 2026: 4 · 2025: 11 · 2024: 14 · 2023: 12 · 2022: 11 · 2021: 13 · 2020: 17 · 2019: 16 · 2018: 12 · 2017: 16 · 2016: 18 · 2015: 14 · 2014: 16 · 2013: 22 · 2012: 13
FWCI: 8.74
Type: journal article
Language: en
Open access: closed
Locations: Human Reproduction (publishedVersion)
PubMed (publishedVersion)
Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion)
Funders: European Commission
Topics: Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
Health Sciences › Medicine › Urology › Male Reproductive Health Studies
Keywords: time to pregnancy, semen parameters, sperm concentration, sperm morphology, spontaneous conception, fertility, fecundability
MeSH terms: Cross-Sectional Studies, Europe, Female, Fertility, Fertilization, Humans, Male, Pregnancy, Probability, Semen, Sperm Count, Spermatozoa, Time Factors

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Time to pregnancy and semen parameters: a cross-sectional study among fertile couples from four European cities

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